Sébastien Guiral

Author PubWeight™ 17.49^‹?›

Top papers

Rank	Title	Journal	Year	PubWeight™‹?›
1	Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: competence triggers stationary phase autolysis of ciaR mutant cells.	Mol Microbiol	2004	2.10
2	MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.	J Pharmacol Exp Ther	2008	1.23
3	Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.	Bioorg Med Chem Lett	2005	1.15
4	Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.	Nat Chem Biol	2013	1.10
5	Mutational dissection of the S/T-kinase StkP reveals crucial roles in cell division of Streptococcus pneumoniae.	Mol Microbiol	2012	1.09
6	Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.	Bioorg Med Chem Lett	2007	1.05
7	Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).	Bioorg Med Chem Lett	2009	0.95
8	Genome-scale analysis of Mycoplasma agalactiae loci involved in interaction with host cells.	PLoS One	2011	0.94
9	Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.	Bioorg Med Chem Lett	2009	0.93
10	Critical role of dispensable genes in Mycoplasma agalactiae interaction with mammalian cells.	Infect Immun	2010	0.93
11	Tyrosine-kinases in bacteria: from a matter of controversy to the status of key regulatory enzymes.	Amino Acids	2009	0.92
12	SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors.	Bioorg Med Chem Lett	2010	0.81
13	Trisubstituted ureas as potent and selective mPGES-1 inhibitors.	Bioorg Med Chem Lett	2011	0.79
14	Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series.	Bioorg Med Chem Lett	2011	0.78
15	Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1.	Bioorg Med Chem Lett	2010	0.77
16	Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors.	Bioorg Med Chem Lett	2011	0.75
17	An automated multistep high-throughput screening assay for the identification of lead inhibitors of the inducible enzyme mPGES-1.	J Biomol Screen	2005	0.75
18	Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series.	Bioorg Med Chem Lett	2011	0.75
19	Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors.	Bioorg Med Chem Lett	2011	0.75