Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile.
|
J Biol Chem
|
2004
|
1.29
|
2
|
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.
|
Bioorg Med Chem Lett
|
2005
|
1.15
|
3
|
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
|
Bioorg Med Chem Lett
|
2007
|
1.05
|
4
|
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.
|
Bioorg Med Chem Lett
|
2009
|
0.93
|
5
|
Substituted coumarins as potent 5-lipoxygenase inhibitors.
|
Bioorg Med Chem Lett
|
2006
|
0.93
|
6
|
Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing.
|
J Biol Chem
|
2007
|
0.92
|
7
|
In vivo inhibition of serine protease processing requires a high fractional inhibition of cathepsin C.
|
Mol Pharmacol
|
2008
|
0.86
|
8
|
5-oxo-6,8,11,14-eicosatetraenoic acid stimulates the release of the eosinophil survival factor granulocyte/macrophage colony-stimulating factor from monocytes.
|
J Biol Chem
|
2004
|
0.81
|
9
|
Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C.
|
Bioorg Med Chem Lett
|
2009
|
0.80
|
10
|
Trisubstituted ureas as potent and selective mPGES-1 inhibitors.
|
Bioorg Med Chem Lett
|
2011
|
0.79
|
11
|
Substituted 2-pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors.
|
Bioorg Med Chem Lett
|
2003
|
0.78
|
12
|
An automated multistep high-throughput screening assay for the identification of lead inhibitors of the inducible enzyme mPGES-1.
|
J Biomol Screen
|
2005
|
0.75
|
13
|
Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.
|
Bioorg Med Chem Lett
|
2005
|
0.75
|