Diane Ethier

Author PubWeight™ 11.00‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile. J Biol Chem 2004 1.29
2 Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886. Bioorg Med Chem Lett 2005 1.15
3 Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett 2007 1.05
4 Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett 2009 0.93
5 Substituted coumarins as potent 5-lipoxygenase inhibitors. Bioorg Med Chem Lett 2006 0.93
6 Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem 2007 0.92
7 In vivo inhibition of serine protease processing requires a high fractional inhibition of cathepsin C. Mol Pharmacol 2008 0.86
8 5-oxo-6,8,11,14-eicosatetraenoic acid stimulates the release of the eosinophil survival factor granulocyte/macrophage colony-stimulating factor from monocytes. J Biol Chem 2004 0.81
9 Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C. Bioorg Med Chem Lett 2009 0.80
10 Trisubstituted ureas as potent and selective mPGES-1 inhibitors. Bioorg Med Chem Lett 2011 0.79
11 Substituted 2-pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors. Bioorg Med Chem Lett 2003 0.78
12 An automated multistep high-throughput screening assay for the identification of lead inhibitors of the inducible enzyme mPGES-1. J Biomol Screen 2005 0.75
13 Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor. Bioorg Med Chem Lett 2005 0.75