Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
|
Nat Genet
|
2010
|
23.08
|
2
|
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.
|
Cell
|
2011
|
6.56
|
3
|
Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
|
Hum Genet
|
2008
|
5.04
|
4
|
Retracted
Genetic signatures of exceptional longevity in humans.
|
Science
|
2010
|
4.33
|
5
|
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
PLoS Genet
|
2012
|
4.27
|
6
|
A genome-wide association study of pulmonary function measures in the Framingham Heart Study.
|
PLoS Genet
|
2009
|
3.78
|
7
|
Genetic signatures of exceptional longevity in humans.
|
PLoS One
|
2012
|
3.20
|
8
|
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
|
Ann Neurol
|
2012
|
2.20
|
9
|
The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study.
|
BMC Med
|
2008
|
2.10
|
10
|
A genome-wide scan for loci linked to plasma levels of glucose and HbA(1c) in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study.
|
Diabetes
|
2002
|
1.99
|
11
|
HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism.
|
Hum Mol Genet
|
2005
|
1.96
|
12
|
Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study.
|
Arch Neurol
|
2006
|
1.94
|
13
|
A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study.
|
Am J Hum Genet
|
2003
|
1.85
|
14
|
Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: the National Heart, Lung, and Blood Institute Family Heart Study.
|
Am J Hum Genet
|
2001
|
1.59
|
15
|
Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset.
|
Hum Mol Genet
|
2009
|
1.51
|
16
|
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
|
Am J Respir Crit Care Med
|
2012
|
1.49
|
17
|
Genetic loci influencing lung function: a genome-wide scan in the Framingham Study.
|
Am J Respir Crit Care Med
|
2002
|
1.47
|
18
|
Linkage of the cholesterol 7alpha-hydroxylase gene and low-density lipoprotein cholesterol conditional on apolipoprotein E association: the National Heart, Lung, and Blood Institute Family Heart Study.
|
Chin Med J (Engl)
|
2005
|
1.42
|
19
|
Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD study.
|
Mov Disord
|
2008
|
1.41
|
20
|
Genomewide linkage analysis to presbycusis in the Framingham Heart Study.
|
Arch Otolaryngol Head Neck Surg
|
2003
|
1.38
|
21
|
Genetic variability of adult body mass index: a longitudinal assessment in framingham families.
|
Obes Res
|
2002
|
1.34
|
22
|
Retraction.
|
Science
|
2011
|
1.32
|
23
|
Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.
|
Hum Mol Genet
|
2006
|
1.32
|
24
|
Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study.
|
BMC Med Genet
|
2006
|
1.30
|
25
|
Considerations for genomewide association studies in Parkinson disease.
|
Am J Hum Genet
|
2006
|
1.26
|
26
|
The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset.
|
Ann Hum Genet
|
2006
|
1.26
|
27
|
Linkage analysis of a composite factor for the multiple metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study.
|
Diabetes
|
2003
|
1.24
|
28
|
Genomewide association study for onset age in Parkinson disease.
|
BMC Med Genet
|
2009
|
1.24
|
29
|
The etiopathogenesis of Parkinson disease and suggestions for future research. Part I.
|
J Neuropathol Exp Neurol
|
2007
|
1.21
|
30
|
Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16.
|
Neurogenetics
|
2004
|
1.19
|
31
|
A genome-wide scan of pulmonary function measures in the National Heart, Lung, and Blood Institute Family Heart Study.
|
Am J Respir Crit Care Med
|
2003
|
1.19
|
32
|
PARK3 influences age at onset in Parkinson disease: a genome scan in the GenePD study.
|
Am J Hum Genet
|
2002
|
1.19
|
33
|
Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study.
|
PLoS Med
|
2013
|
1.18
|
34
|
Linkage and association with pulmonary function measures on chromosome 6q27 in the Framingham Heart Study.
|
Hum Mol Genet
|
2003
|
1.14
|
35
|
Genetic effect on blood pressure is modulated by age: the Hypertension Genetic Epidemiology Network Study.
|
Hypertension
|
2008
|
1.10
|
36
|
LRRK2 is not a significant cause of Parkinson's disease in French-Canadians.
|
Can J Neurol Sci
|
2007
|
1.09
|
37
|
Longitudinal and age trends of metabolic syndrome and its risk factors: the Family Heart Study.
|
Nutr Metab (Lond)
|
2006
|
1.08
|
38
|
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons.
|
PLoS Biol
|
2012
|
1.08
|
39
|
Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region.
|
Am J Hum Genet
|
2012
|
1.05
|
40
|
A genome-wide scan for loci affecting normal adult height in the Framingham Heart Study.
|
Hum Hered
|
2003
|
1.04
|
41
|
Estimating the probability of de novo HD cases from transmissions of expanded penetrant CAG alleles in the Huntington disease gene from male carriers of high normal alleles (27-35 CAG).
|
Am J Med Genet A
|
2009
|
1.03
|
42
|
Copy number variation in familial Parkinson disease.
|
PLoS One
|
2011
|
1.02
|
43
|
Assessment of cortical and striatal involvement in 523 Huntington disease brains.
|
Neurology
|
2012
|
1.00
|
44
|
HaploBuild: an algorithm to construct non-contiguous associated haplotypes in family based genetic studies.
|
Bioinformatics
|
2007
|
0.98
|
45
|
An evaluation of the metabolic syndrome in the HyperGEN study.
|
Nutr Metab (Lond)
|
2005
|
0.97
|
46
|
Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: the NHLBI Family Heart Study follow-up examination.
|
Atherosclerosis
|
2007
|
0.97
|
47
|
State of the art review: molecular diagnosis of inherited movement disorders. Movement Disorders Society task force on molecular diagnosis.
|
Mov Disord
|
2003
|
0.96
|
48
|
Influence of apolipoprotein E, smoking, and alcohol intake on carotid atherosclerosis: National Heart, Lung, and Blood Institute Family Heart Study.
|
Stroke
|
2002
|
0.96
|
49
|
Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease.
|
Neurobiol Dis
|
2006
|
0.95
|
50
|
Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study.
|
Hypertension
|
2009
|
0.94
|
51
|
Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation.
|
PLoS Genet
|
2012
|
0.94
|
52
|
Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease.
|
Exp Neurol
|
2010
|
0.92
|
53
|
Replication of association between ELAVL4 and Parkinson disease: the GenePD study.
|
Hum Genet
|
2008
|
0.91
|
54
|
A genome-wide screen reveals evidence for a locus on chromosome 11 influencing variation in LDL cholesterol in the NHLBI Family Heart Study.
|
Hum Genet
|
2002
|
0.91
|
55
|
Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.
|
Hum Mol Genet
|
2011
|
0.91
|
56
|
Quantitative trait loci for metabolic syndrome in the Hypertension Genetic Epidemiology Network study.
|
Obes Res
|
2005
|
0.89
|
57
|
Evaluation of Parkinson disease risk variants as expression-QTLs.
|
PLoS One
|
2012
|
0.88
|
58
|
Is DFNA5 a susceptibility gene for age-related hearing impairment?
|
Eur J Hum Genet
|
2002
|
0.86
|
59
|
Sepiapterin reductase expression is increased in Parkinson's disease brain tissue.
|
Brain Res
|
2007
|
0.86
|
60
|
The etiopathogenesis of Parkinson disease and suggestions for future research. Part II.
|
J Neuropathol Exp Neurol
|
2007
|
0.86
|
61
|
Genome-wide admixture mapping for coronary artery calcification in African Americans: the NHLBI Family Heart Study.
|
Genet Epidemiol
|
2008
|
0.85
|
62
|
Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program.
|
BMC Med Genet
|
2006
|
0.85
|
63
|
Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study.
|
BMC Med Genet
|
2008
|
0.85
|
64
|
Quantitative trait loci on chromosome 8q24 for pancreatic beta-cell function and 7q11 for insulin sensitivity in obese nondiabetic white and black families: evidence from genome-wide linkage scans in the NHLBI Hypertension Genetic Epidemiology Network (HyperGEN) study.
|
Diabetes
|
2006
|
0.84
|
65
|
Multiple genes influence BMI on chromosome 7q31-34: the NHLBI Family Heart Study.
|
Obesity (Silver Spring)
|
2009
|
0.84
|
66
|
LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion.
|
Atherosclerosis
|
2008
|
0.84
|
67
|
Evidence for a gene influencing heart rate on chromosome 4 among hypertensives.
|
Hum Genet
|
2002
|
0.84
|
68
|
Genetic analysis of the GRIK2 modifier effect in Huntington's disease.
|
BMC Neurosci
|
2006
|
0.84
|
69
|
Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain.
|
Parkinsons Dis
|
2012
|
0.83
|
70
|
Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset.
|
Hum Genet
|
2012
|
0.83
|
71
|
Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN study.
|
Diabetes
|
2007
|
0.83
|
72
|
Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network study.
|
Diabetes
|
2004
|
0.82
|
73
|
Genomewide linkage study of modifiers of LRRK2-related Parkinson's disease.
|
Mov Disord
|
2011
|
0.82
|
74
|
Estrogen-related and other disease diagnoses preceding Parkinson's disease.
|
Clin Epidemiol
|
2010
|
0.81
|
75
|
Evidence of QTL on 15q21 for high-density lipoprotein cholesterol: the National Heart, Lung, and Blood Institute Family Heart Study (NHLBI FHS).
|
Atherosclerosis
|
2006
|
0.81
|
76
|
Genome-wide linkage analyses for age at diagnosis of hypertension and early-onset hypertension in the HyperGEN study.
|
Am J Hypertens
|
2004
|
0.81
|
77
|
TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease.
|
Biochem Biophys Res Commun
|
2012
|
0.81
|
78
|
A QTL on 12q influencing an inflammation marker and obesity in white women: the NHLBI Family Heart Study.
|
Obesity (Silver Spring)
|
2008
|
0.79
|
79
|
Risk of Parkinson's disease after tamoxifen treatment.
|
BMC Neurol
|
2010
|
0.79
|
80
|
Monozygotic twins discordant for Huntington disease after 7 years.
|
Arch Neurol
|
2005
|
0.78
|
81
|
The analysis of survival data with a non-susceptible fraction and dual censoring mechanisms.
|
Stat Med
|
2003
|
0.78
|
82
|
Apolipoprotein E polymorphism modifies the alcohol-HDL association observed in the National Heart, Lung, and Blood Institute Family Heart Study.
|
Am J Clin Nutr
|
2004
|
0.78
|
83
|
Evidence for three novel QTLs for adiposity on chromosome 2 with epistatic interactions: the NHLBI Family Heart Study.
|
Obesity (Silver Spring)
|
2009
|
0.77
|
84
|
Genome-wide scan identifies novel QTLs for cholesterol and LDL levels in F2[Dahl RxS]-intercross rats.
|
Circ Res
|
2004
|
0.77
|
85
|
Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset.
|
Neurogenetics
|
2013
|
0.77
|
86
|
Feasibility of Huntington disease trials in the disease prodrome.
|
Neurology
|
2014
|
0.76
|
87
|
Absence of linkage or association for osteoarthritis with the vitamin D receptor/type II collagen locus: the Framingham Osteoarthritis Study.
|
J Rheumatol
|
2002
|
0.76
|
88
|
Correction: RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression.
|
PLoS One
|
2016
|
0.75
|
89
|
The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study.
|
Am J Hypertens
|
2009
|
0.75
|
90
|
Comprehensive linkage and linkage heterogeneity analysis of 4344 sibling pairs affected with hypertension from the Family Blood Pressure Program.
|
Genet Epidemiol
|
2007
|
0.75
|