Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine.

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🔗 View Article (PMID 16128682)

Published in Aliment Pharmacol Ther on September 01, 2005

Authors

M P Sparrow1, S A Hande, S Friedman, W C Lim, S I Reddy, D Cao, S B Hanauer

Author Affiliations

1: Section of Gastroenterology, University of Chicago Medical Center, Chicago, IL 60637, USA. msparrow@medicine.bsd.uchicago.edu

Associated clinical trials:

A Pilot Study of Allopurinol As A Modifier of 6-MP Metabolism in Pediatric ALL | NCT02046694

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Nucleotide sequence and expression of the gene encoding the EcoRII modification enzyme. Nucleic Acids Res (1987) 2.68

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Comparative tolerability of treatments for inflammatory bowel disease. Drug Saf (2000) 1.15

The parasitic ecology of the rodent mite, Myobia musculi. III. Lesions in certain host strains. Lab Anim Sci (1976) 1.15

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Infliximab in Crohn's disease: first anniversary clinical experience. Am J Gastroenterol (2000) 1.14

Abnormal precipitation of oxyhemoglobin S by mechanical shaking. Proc Natl Acad Sci U S A (1974) 1.14

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