Published in Endocrinology on September 08, 2005
ENaC at the cutting edge: regulation of epithelial sodium channels by proteases. J Biol Chem (2009) 2.57
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell (2009) 2.45
Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. J Biol Chem (2008) 2.00
Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage. Proc Natl Acad Sci U S A (2006) 1.60
Seven-transmembrane receptors and ubiquitination. Circ Res (2007) 1.52
Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC). Pflugers Arch (2009) 1.44
Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking. J Neurochem (2011) 1.44
Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol (2007) 1.43
Extracellular chloride regulates the epithelial sodium channel. J Biol Chem (2009) 1.40
Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance. Proc Natl Acad Sci U S A (2011) 1.36
Multiple interactions drive adaptor-mediated recruitment of the ubiquitin ligase rsp5 to membrane proteins in vivo and in vitro. Mol Biol Cell (2007) 1.31
Extracellular protons regulate human ENaC by modulating Na+ self-inhibition. J Biol Chem (2008) 1.31
Pendrin modulates ENaC function by changing luminal HCO3-. J Am Soc Nephrol (2010) 1.29
Epithelial Na+ channel (ENaC), hormones, and hypertension. J Biol Chem (2010) 1.22
Essential role of vasopressin-regulated urea transport processes in the mammalian kidney. Pflugers Arch (2008) 1.21
Activation of the epithelial Na+ channel in the collecting duct by vasopressin contributes to water reabsorption. Am J Physiol Renal Physiol (2009) 1.20
Regulation of the epithelial Na+ channel by peptidases. Curr Top Dev Biol (2007) 1.17
The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones. Mol Biol Cell (2010) 1.17
Physiologic regulation of the epithelial sodium channel by phosphatidylinositides. Curr Opin Nephrol Hypertens (2008) 1.14
Phosphoproteomic profiling reveals vasopressin-regulated phosphorylation sites in collecting duct. J Am Soc Nephrol (2010) 1.13
Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes. J Biol Chem (2010) 1.13
Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium. Am J Physiol Cell Physiol (2009) 1.12
Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species. FASEB J (2009) 1.12
Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel. Am J Physiol Renal Physiol (2008) 1.10
Intracellular sodium regulates proteolytic activation of the epithelial sodium channel. J Biol Chem (2008) 1.10
Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases. Pflugers Arch (2010) 1.08
Identification of epithelial Na+ channel (ENaC) intersubunit Cl- inhibitory residues suggests a trimeric alpha gamma beta channel architecture. J Biol Chem (2010) 1.03
Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung. Am J Physiol Lung Cell Mol Physiol (2011) 1.02
Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels. Am J Physiol Renal Physiol (2010) 1.02
Regulation of epithelial sodium channel trafficking by ubiquitination. Proc Am Thorac Soc (2010) 1.00
Regulation of the epithelial sodium channel (ENaC) by membrane trafficking. Biochim Biophys Acta (2010) 0.99
Regulation and dysregulation of epithelial Na+ channels. Clin Exp Nephrol (2011) 0.98
Small heat shock protein alphaA-crystallin regulates epithelial sodium channel expression. J Biol Chem (2007) 0.98
Dual control of cardiac Na+ Ca2+ exchange by PIP(2): analysis of the surface membrane fraction by extracellular cysteine PEGylation. J Physiol (2007) 0.97
Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface. Biochem J (2007) 0.97
Regulation of ENaC expression at the cell surface by Rab11. Biochem Biophys Res Commun (2008) 0.96
Alpha(1)-antitrypsin inhibits epithelial Na+ transport in vitro and in vivo. Am J Respir Cell Mol Biol (2009) 0.96
Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J Biol Chem (2008) 0.95
Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1. Neurochem Int (2008) 0.95
ENaC, renal sodium excretion and extracellular ATP. Purinergic Signal (2009) 0.95
Structure of human prostasin, a target for the regulation of hypertension. J Biol Chem (2008) 0.95
ENaC activity is increased in isolated, split-open cortical collecting ducts from protein kinase Cα knockout mice. Am J Physiol Renal Physiol (2013) 0.92
Inter-α-inhibitor blocks epithelial sodium channel activation and decreases nasal potential differences in ΔF508 mice. Am J Respir Cell Mol Biol (2014) 0.92
AICAR activates AMPK and alters PIP2 association with the epithelial sodium channel ENaC to inhibit Na+ transport in H441 lung epithelial cells. J Physiol (2008) 0.91
The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel. J Biol Chem (2013) 0.89
Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC). Adv Genet (2011) 0.88
AF17 facilitates Dot1a nuclear export and upregulates ENaC-mediated Na+ transport in renal collecting duct cells. PLoS One (2011) 0.88
Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. PLoS One (2010) 0.87
Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9). J Biol Chem (2012) 0.86
Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways. J Biol Chem (2010) 0.86
Ubiquitin-specific peptidase 8 (USP8) regulates endosomal trafficking of the epithelial Na+ channel. J Biol Chem (2013) 0.86
Acute rejection modulates gene expression in the collecting duct. J Am Soc Nephrol (2008) 0.86
Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. J Biol Chem (2012) 0.85
The epsin protein family: coordinators of endocytosis and signaling. Biomol Concepts (2012) 0.85
Regulation of epithelial sodium transport via epithelial Na+ channel. J Biomed Biotechnol (2011) 0.84
Angiotensin II regulation of renal vascular ENaC proteins. Am J Hypertens (2009) 0.84
Filamin interacts with epithelial sodium channel and inhibits its channel function. J Biol Chem (2012) 0.83
Aldosterone regulates microRNAs in the cortical collecting duct to alter sodium transport. J Am Soc Nephrol (2014) 0.82
Ubiquitylation of Fe65 adaptor protein by neuronal precursor cell expressed developmentally down regulated 4-2 (Nedd4-2) via the WW domain interaction with Fe65. Exp Mol Med (2009) 0.81
Pivotal role of the kidney in hypertension. Am J Med Sci (2010) 0.81
Identification of extracellular domain residues required for epithelial Na+ channel activation by acidic pH. J Biol Chem (2012) 0.81
Dehydration-induced modulation of kappa-opioid inhibition of vasopressin neurone activity. J Physiol (2009) 0.81
Nedd4-2 interacts with occludin to inhibit tight junction formation and enhance paracellular conductance in collecting duct epithelia. Am J Physiol Renal Physiol (2010) 0.81
Regulation of ENaC trafficking in rat kidney. J Gen Physiol (2016) 0.80
ENaC activity and expression is decreased in the lungs of protein kinase C-α knockout mice. Am J Physiol Lung Cell Mol Physiol (2014) 0.79
Intersubunit conformational changes mediate epithelial sodium channel gating. J Gen Physiol (2014) 0.79
The fetal sheep lung does not respond to cortisol infusion during the late canalicular phase of development. Physiol Rep (2013) 0.78
Vasopressin Proves Es-sense-tial: Vasopressin and the Modulation of Sensory Processing in Mammals. Front Endocrinol (Lausanne) (2015) 0.77
Intoxicated Na(+) channels. Focus on "ethanol stimulates epithelial sodium channels by elevating reactive oxygen species". Am J Physiol Cell Physiol (2012) 0.77
Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiae. Physiol Genomics (2015) 0.76
Pore positioning: current concepts in Pannexin channel trafficking. Channels (Austin) (2013) 0.76
Cholera toxin enhances Na(+) absorption across MCF10A human mammary epithelia. Am J Physiol Cell Physiol (2013) 0.75
Restoration of Epithelial Sodium Channel Function by Synthetic Peptides in Pseudohypoaldosteronism Type 1B Mutants. Front Pharmacol (2017) 0.75
Interactions Between Intersubunit Transmembrane Domains Regulate the Chaperone Dependent Degradation of an Oligomeric Membrane Protein. Biochem J (2016) 0.75
Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation. J Biol Chem (2015) 0.75
The Epithelial Sodium Channel and the Processes of Wound Healing. Biomed Res Int (2016) 0.75
Genetic variation and association analyses of NEDD4 gene in Kazak Chinese patients with hypertension. Int J Mol Epidemiol Genet (2010) 0.75