| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor.
|
Mol Cancer Ther
|
2006
|
1.32
|
|
2
|
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
|
J Med Chem
|
2007
|
1.11
|
|
3
|
Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors.
|
J Med Chem
|
2005
|
1.04
|
|
4
|
Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors.
|
Bioorg Med Chem Lett
|
2007
|
0.93
|
|
5
|
Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors.
|
Bioorg Med Chem Lett
|
2006
|
0.90
|
|
6
|
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
|
J Med Chem
|
2008
|
0.84
|
|
7
|
1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
|
J Med Chem
|
2007
|
0.83
|
|
8
|
Isoindolinone ureas: a novel class of KDR kinase inhibitors.
|
Bioorg Med Chem Lett
|
2004
|
0.82
|
|
9
|
Distinct spatiotemporal pattern of CNS lesions revealed by USPIO-enhanced MRI in MOG-induced EAE rats implicates the involvement of spino-olivocerebellar pathways.
|
J Neuroimmunol
|
2009
|
0.81
|
|
10
|
Thienopyridine urea inhibitors of KDR kinase.
|
Bioorg Med Chem Lett
|
2006
|
0.79
|
|
11
|
1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors.
|
Bioorg Med Chem Lett
|
2006
|
0.78
|
|
12
|
Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases.
|
Bioorg Med Chem Lett
|
2006
|
0.75
|