Published in Heart on October 01, 2005
Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene. Circulation (2007) 2.88
Recurrent intrauterine fetal loss due to near absence of HERG: clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation. Heart Rhythm (2008) 1.62
Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction. Nat Genet (2010) 1.47
Expression and function of the K+ channel KCNQ genes in human arteries. Br J Pharmacol (2011) 1.38
Optical mapping of optogenetically shaped cardiac action potentials. Sci Rep (2014) 1.16
Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias. Front Physiol (2012) 1.15
High prevalence of four long QT syndrome founder mutations in the Finnish population. Ann Med (2009) 1.08
Potassium-channel mutations and cardiac arrhythmias--diagnosis and therapy. Nat Rev Cardiol (2012) 1.04
Screening children with a family history of sudden cardiac death. Heart (2006) 0.92
Age-and sex-dependent mRNA expression of KCNQ1 and HERG in patients with long QT syndrome type 1 and 2. Arch Med Sci (2011) 0.91
Genetics of atrial fibrillation. Med Clin North Am (2008) 0.88
Modeling heart disease in a dish: from somatic cells to disease-relevant cardiomyocytes. Trends Cardiovasc Med (2013) 0.86
Sudden infant death syndrome: do ion channels play a role? Heart Rhythm (2008) 0.85
Motivation to pursue genetic testing in individuals with a personal or family history of cardiac events or sudden cardiac death. J Genet Couns (2014) 0.83
Congenital Long QT Syndrome: An Update and Present Perspective in Saudi Arabia. Front Pediatr (2013) 0.81
GENCOR: a national registry for patients and families suffering from a familial heart disease in the Netherlands. Neth Heart J (2006) 0.81
Recurrent and Founder Mutations in the Netherlands: the Long-QT Syndrome. Neth Heart J (2010) 0.80
The current status of iPS cells in cardiac research and their potential for tissue engineering and regenerative medicine. Stem Cell Rev (2014) 0.80
The Finnish Cardiovascular Study (FINCAVAS): characterising patients with high risk of cardiovascular morbidity and mortality. BMC Cardiovasc Disord (2006) 0.80
Disclosing Genetic Information to Family Members About Inherited Cardiac Arrhythmias: An Obligation or a Choice? J Genet Couns (2014) 0.79
Expression and distribution of voltage-gated ion channels in ferret sinoatrial node. Physiol Genomics (2010) 0.76
A1180V of cardiac sodium channel gene (SCN5A): is it a risk factor for dilated cardiomyopathy or just a common variant in Han Chinese? Dis Markers (2013) 0.76
Genetic predisposition for sudden cardiac death in myocardial ischaemia: the Arrhythmia Genetics in the NEtherlandS study. Neth Heart J (2011) 0.76
Assessing the knowledge of sudden unexpected death in the young among Canadian medical students and recent graduates: a cross-sectional study. BMJ Open (2012) 0.75
Cardiogenetic counselling in a non-university hospital. Neth Heart J (2007) 0.75
Not just any ICD device in patients with long-QT syndrome. Neth Heart J (2007) 0.75
The mitochondrial DNA mutations associated with cardiac arrhythmia investigated in an LQTS family. Iran J Basic Med Sci (2014) 0.75
Genetic Basis of Ventricular Arrhythmias. Curr Cardiovasc Risk Rep (2010) 0.75
Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol (1992) 12.18
Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation (2001) 7.47
Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell (2004) 7.45
Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature (2003) 5.94
Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science (2002) 4.40
Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome. Cell (2001) 4.25
Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. JAMA (2005) 3.89
A single Na(+) channel mutation causing both long-QT and Brugada syndromes. Circ Res (2000) 3.68
Influence of genotype on the clinical course of the long-QT syndrome. International Long-QT Syndrome Registry Research Group. N Engl J Med (1998) 3.41
Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers. JAMA (2004) 3.24
Proposed diagnostic criteria for the Brugada syndrome. Eur Heart J (2002) 3.01
Idiopathic short QT interval: a new clinical syndrome? Cardiology (2000) 2.85
A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill. Circ Res (2003) 2.15
Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more? Cardiovasc Res (2005) 2.06
Cardiac ion channels. Annu Rev Physiol (2002) 1.90
Compound heterozygosity for mutations (W156X and R225W) in SCN5A associated with severe cardiac conduction disturbances and degenerative changes in the conduction system. Circ Res (2003) 1.82
Genetic control of sodium channel function. Cardiovasc Res (2003) 1.48
Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels. Physiol Rev (2005) 1.26
Catecholaminergic polymorphic ventricular tachycardia: recent mechanistic insights. Cardiovasc Res (2005) 1.23
Predicting the long-QT genotype from clinical data: from sense to science. Circulation (2000) 0.90
Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study. Circulation (2005) 3.30
Mutation in the KCNQ1 gene leading to the short QT-interval syndrome. Circulation (2004) 2.82
Familial sudden death is an important risk factor for primary ventricular fibrillation: a case-control study in acute myocardial infarction patients. Circulation (2006) 2.63
Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients. J Am Coll Cardiol (2002) 2.58
Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J Clin Invest (2008) 2.54
Genetic variation in SCN10A influences cardiac conduction. Nat Genet (2010) 2.30
A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families. J Mol Cell Cardiol (2005) 2.21
A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill. Circ Res (2003) 2.15
Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families. Circ Res (2003) 2.14
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96
Long QT syndrome caused by a large duplication in the KCNH2 (HERG) gene undetectable by current polymerase chain reaction-based exon-scanning methodologies. Heart Rhythm (2006) 1.90
Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology. Circ Res (2012) 1.77
Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD. Circulation (2006) 1.76
Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch. Heart Rhythm (2009) 1.73
Cardiac sodium channel overlap syndromes: different faces of SCN5A mutations. Trends Cardiovasc Med (2008) 1.68
Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits. Hum Mutat (2010) 1.59
Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies. Heart Rhythm (2008) 1.56
Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease. Circulation (2012) 1.53
Polymorphisms in human connexin40 gene promoter are associated with increased risk of hypertension in men. J Hypertens (2006) 1.52
Genetic control of sodium channel function. Cardiovasc Res (2003) 1.48
A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Circ Cardiovasc Genet (2011) 1.48
Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer. J Clin Invest (2012) 1.43
Variants in the 3' untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner. Eur Heart J (2011) 1.41
Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. PLoS Genet (2011) 1.38
Intercalated disc abnormalities, reduced Na(+) current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes. Cardiovasc Res (2012) 1.32
Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation. Am J Hum Genet (2009) 1.31
Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Nat Genet (2013) 1.23
Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction. Cardiovasc Res (2009) 1.22
Fever-induced QTc prolongation and ventricular arrhythmias in individuals with type 2 congenital long QT syndrome. J Clin Invest (2008) 1.18
Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy. J Exp Med (2009) 1.18
A common genetic variant within SCN10A modulates cardiac SCN5A expression. J Clin Invest (2014) 1.17
Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias. Front Physiol (2012) 1.15
Exclusion of multiple candidate genes and large genomic rearrangements in SCN5A in a Dutch Brugada syndrome cohort. Heart Rhythm (2007) 1.13
Tubulin polymerization modifies cardiac sodium channel expression and gating. Cardiovasc Res (2009) 1.11
Sudden cardiac arrest associated with use of a non-cardiac drug that reduces cardiac excitability: evidence from bench, bedside, and community. Eur Heart J (2013) 1.08
The primary arrhythmia syndromes: same mutation, different manifestations. Are we starting to understand why? J Cardiovasc Electrophysiol (2008) 1.07
Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy. Circ Res (2009) 1.06
Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes. PLoS One (2013) 1.04
Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome. Cardiovasc Res (2005) 1.03
Common genetic variation modulating cardiac ECG parameters and susceptibility to sudden cardiac death. J Mol Cell Cardiol (2012) 0.98
Sodium channel (dys)function and cardiac arrhythmias. Cardiovasc Ther (2010) 0.97
Voltage-gated sodium channels: action players with many faces. Ann Med (2006) 0.95
Arrhythmogenic cardiomyopathy: transgenic animal models provide novel insights into disease pathobiology. Circ Cardiovasc Genet (2011) 0.93
Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction. PLoS Genet (2012) 0.93
Dilated cardiomyopathy due to sodium channel dysfunction: what is the connection? Circ Arrhythm Electrophysiol (2008) 0.92
Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse. J Mol Cell Cardiol (2010) 0.92
A connexin40 mutation associated with a malignant variant of progressive familial heart block type I. Circ Arrhythm Electrophysiol (2012) 0.91
Diagnostic value of flecainide testing in unmasking SCN5A-related Brugada syndrome. J Cardiovasc Electrophysiol (2006) 0.91
Na+ channel mutation leading to loss of function and non-progressive cardiac conduction defects. J Mol Cell Cardiol (2003) 0.89
Characterization of a novel SCN5A mutation associated with Brugada syndrome reveals involvement of DIIIS4-S5 linker in slow inactivation. Cardiovasc Res (2007) 0.88
Reduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract. Circ Res (2013) 0.87
The role of renin-angiotensin-aldosterone system polymorphisms in phenotypic expression of MYBPC3-related hypertrophic cardiomyopathy. Eur J Hum Genet (2012) 0.87
Developmental aspects of cardiac arrhythmogenesis. Cardiovasc Res (2011) 0.84
A novel LQT3 mutation implicates the human cardiac sodium channel domain IVS6 in inactivation kinetics. Cardiovasc Res (2003) 0.83
Developmental aspects of long QT syndrome type 3 and Brugada syndrome on the basis of a single SCN5A mutation in childhood. J Am Coll Cardiol (2005) 0.82
The chemical compound PTC124 does not affect cellular electrophysiology of cardiac ventricular myocytes. Cardiovasc Drugs Ther (2012) 0.82
Early repolarization pattern: its ECG characteristics, arrhythmogeneity and heritability. J Interv Card Electrophysiol (2014) 0.80
A complex double deletion in LMNA underlies progressive cardiac conduction disease, atrial arrhythmias, and sudden death. Circ Cardiovasc Genet (2011) 0.80
The molecular genetics of arrhythmias. Cardiovasc Res (2005) 0.80
Genetic modulation of cardiac repolarization reserve. Heart Rhythm (2007) 0.80
Arrhythmogenic right ventricular cardiomyopathy: growing evidence for complex inheritance. Circ Cardiovasc Genet (2013) 0.79
Substitution of a conserved alanine in the domain IIIS4-S5 linker of the cardiac sodium channel causes long QT syndrome. Cardiovasc Res (2005) 0.79
Pharmacological rescue of mutant ion channels. Cardiovasc Res (2002) 0.78
Genetics of lone atrial fibrillation. Europace (2010) 0.76
GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability. Am J Hum Genet (2016) 0.76
KCND3 mutations in Brugada syndrome: the plot thickens. Heart Rhythm (2011) 0.76
Cardiac desmosomal (dys)function and myocyte viability. Cell Cycle (2010) 0.76
Dilation of the Aorta Ascendens Forms Part of the Clinical Spectrum of HCN4 Mutations. J Am Coll Cardiol (2016) 0.75
Genetic Basis of Ventricular Arrhythmias. Curr Cardiovasc Risk Rep (2010) 0.75
Genomics of cardiac electrical function. Brief Funct Genomics (2013) 0.75
Complex inheritance for susceptibility to sudden cardiac death. Curr Pharm Des (2013) 0.75