Published in Bioorg Med Chem on September 19, 2005
Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities. Antimicrob Agents Chemother (2006) 1.25
Inhibition of S. aureus alpha-hemolysin and B. anthracis lethal toxin by beta-cyclodextrin derivatives. Bioorg Med Chem (2007) 1.07
Inhibition of anthrax protective antigen outside and inside the cell. Antimicrob Agents Chemother (2006) 0.94
Selective killing of HIV-1-positive macrophages and T cells by the Rev-dependent lentivirus carrying anthrolysin O from Bacillus anthracis. Retrovirology (2008) 0.90
New developments in vaccines, inhibitors of anthrax toxins, and antibiotic therapeutics for Bacillus anthracis. Curr Med Chem (2011) 0.88
Cyclodextrin derivatives as anti-infectives. Curr Opin Pharmacol (2013) 0.82
An overview of investigational toxin-directed therapies for the adjunctive management of Bacillus anthracis infection and sepsis. Expert Opin Investig Drugs (2015) 0.80
Obstructing toxin pathways by targeted pore blockage. Chem Rev (2012) 0.80
Click synthesis of estradiol-cyclodextrin conjugates as cell compartment selective estrogens. Bioorg Med Chem (2009) 0.79
Cationic PAMAM dendrimers as pore-blocking binary toxin inhibitors. Biomacromolecules (2014) 0.78
Symmetry requirements for effective blocking of pore-forming toxins: comparative study with alpha-, beta-, and gamma-cyclodextrin derivatives. Antimicrob Agents Chemother (2011) 0.78
Tailored cyclodextrin pore blocker protects mammalian cells from clostridium difficile binary toxin CDT. Toxins (Basel) (2014) 0.78
Channel-forming bacterial toxins in biosensing and macromolecule delivery. Toxins (Basel) (2014) 0.77
Inhibiting bacterial toxins by channel blockage. Pathog Dis (2015) 0.75
A pentasymmetric open channel blocker for Cys-loop receptor channels. PLoS One (2014) 0.75
Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res (2005) 2.70
Mechanistic plasticity of DNA topoisomerase IB: phosphate electrostatics dictate the need for a catalytic arginine. Structure (2005) 1.74
Selective tumor cell targeting by the disaccharide moiety of bleomycin. J Am Chem Soc (2013) 1.61
Treatment of anthrax infection with combination of ciprofloxacin and antibodies to protective antigen of Bacillus anthracis. FEMS Immunol Med Microbiol (2004) 1.46
Camptothecin: current perspectives. Bioorg Med Chem (2004) 1.42
Remote phosphate contacts trigger assembly of the active site of DNA topoisomerase IB. Structure (2004) 1.28
Javaniside, a novel DNA cleavage agent from Alangium javanicum having an unusual oxindole skeleton. Chem Commun (Camb) (2004) 1.25
Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities. Antimicrob Agents Chemother (2006) 1.25
Synthesis of a potent and selective inhibitor of p90 Rsk. Org Lett (2005) 1.17
Carbohydrate dependent targeting of cancer cells by bleomycin-microbubble conjugates. J Am Chem Soc (2009) 1.16
Structural basis for the activity of the RSK-specific inhibitor, SL0101. Bioorg Med Chem (2007) 1.12
Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping. J Biol Chem (2004) 1.11
Guarding the genome: electrostatic repulsion of water by DNA suppresses a potent nuclease activity of topoisomerase IB. Mol Cell (2003) 1.10
Enhanced D-amino acid incorporation into protein by modified ribosomes. J Am Chem Soc (2003) 1.10
Hairpin DNA sequences bound strongly by bleomycin exhibit enhanced double-strand cleavage. J Am Chem Soc (2014) 1.10
Solid-phase synthesis of bleomycin group antibiotics. Construction of a 108-member deglycobleomycin library. J Am Chem Soc (2003) 1.09
Prevention of lethal respiratory vaccinia infections in mice with interferon-alpha and interferon-gamma. FEMS Immunol Med Microbiol (2004) 1.07
Inhibition of S. aureus alpha-hemolysin and B. anthracis lethal toxin by beta-cyclodextrin derivatives. Bioorg Med Chem (2007) 1.07
Does oxidative stress contribute to the pathology of Friedreich's ataxia? A radical question. FASEB J (2010) 1.07
The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure. J Am Chem Soc (2014) 1.06
The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern. J Am Chem Soc (2009) 1.04
The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules. J Am Chem Soc (2014) 1.02
RNA cleavage and inhibition of protein synthesis by bleomycin. Chem Biol (2003) 1.01
(+)-Myristinin A, a naturally occurring DNA polymerase beta inhibitor and potent DNA-damaging agent. J Am Chem Soc (2005) 0.99
In vivo efficacy of beta-cyclodextrin derivatives against anthrax lethal toxin. Antimicrob Agents Chemother (2008) 0.96
Fluorescence resonance energy transfer between unnatural amino acids in a structurally modified dihydrofolate reductase. J Am Chem Soc (2002) 0.96
The disaccharide moiety of bleomycin facilitates uptake by cancer cells. J Am Chem Soc (2014) 0.95
Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore. Bioorg Med Chem (2006) 0.95
Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK. Bioorg Med Chem (2006) 0.95
(+)-Myristinins A and D from Knema elegans, which inhibit DNA polymerase beta and cleave DNA. J Nat Prod (2005) 0.95
Luotonin A. A naturally occurring human DNA topoisomerase I poison. J Am Chem Soc (2003) 0.94
The carbamoylmannose moiety of bleomycin mediates selective tumor cell targeting. Biochemistry (2014) 0.94
Inhibitors of DNA polymerase beta: activity and mechanism. Bioorg Med Chem (2008) 0.93
Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta. J Nat Prod (2004) 0.93
Detection of dihydrofolate reductase conformational change by FRET using two fluorescent amino acids. J Am Chem Soc (2013) 0.93
14-azacamptothecin: a potent water-soluble topoisomerase I poison. J Am Chem Soc (2005) 0.92
Design and optimization of camptothecin conjugates of triple helix-forming oligonucleotides for sequence-specific DNA cleavage by topoisomerase I. J Biol Chem (2001) 0.92
Synthesis of proteins containing modified arginine residues. Biochemistry (2007) 0.91
Characterization of bleomycin cleavage sites in strongly bound hairpin DNAs. J Am Chem Soc (2010) 0.90
Construction of modified ribosomes for incorporation of D-amino acids into proteins. Biochemistry (2006) 0.89
Bioactive isomalabaricane triterpenoids from Rhabdastrella globostellata that stabilize the binding of DNA polymerase beta to DNA. J Nat Prod (2006) 0.89
Chemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry. J Biol Chem (2008) 0.88
A stereocontrolled synthesis of delta-trans-tocotrienoloic acid. Org Lett (2005) 0.87
Induction of autophagy by anthrax lethal toxin. Biochem Biophys Res Commun (2008) 0.87
The N-pentenoyl protecting group for aminoacyl-tRNAs. Methods (2005) 0.87
Implication of human herpesviruses in oncogenesis through immune evasion and supression. Infect Agent Cancer (2014) 0.87
Two pyrenylalanines in dihydrofolate reductase form an excimer enabling the study of protein dynamics. J Am Chem Soc (2012) 0.87
Identification and cleavage site analysis of DNA sequences bound strongly by bleomycin. J Am Chem Soc (2009) 0.87
Identification of strong DNA binding motifs for bleomycin. J Am Chem Soc (2008) 0.86
Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase. Bioorg Med Chem (2005) 0.86
Site-specific incorporation of glycosylated serine and tyrosine derivatives into proteins. J Am Chem Soc (2007) 0.86
Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center. Bioorg Med Chem (2013) 0.86
β-Puromycin selection of modified ribosomes for in vitro incorporation of β-amino acids. Biochemistry (2011) 0.85
Characterization of bleomycin-mediated cleavage of a hairpin DNA library. Biochemistry (2013) 0.84
An efficient mammalian transfer RNA target for bleomycin. J Am Chem Soc (2006) 0.84
Modeling the reactive properties of tandemly activated tRNAs. Org Biomol Chem (2008) 0.84
Dynamics of bleomycin interaction with a strongly bound hairpin DNA substrate, and implications for cleavage of the bound DNA. J Am Chem Soc (2012) 0.84
Analogues of vaccinia virus DNA topoisomerase I modified at the active site tyrosine. J Am Chem Soc (2005) 0.84
Tandemly activated tRNAs as participants in protein synthesis. J Biol Chem (2006) 0.84
p-Thiophenylalanine-induced DNA cleavage and religation activity of a modified vaccinia topoisomerase IB. Biochemistry (2011) 0.83
Improving the affinity of SL0101 for RSK using structure-based design. ACS Med Chem Lett (2012) 0.83
Calothrixins, a new class of human DNA topoisomerase I poisons. J Nat Prod (2009) 0.82
DNA-damaging agents from Crypteronia paniculata. J Nat Prod (2002) 0.82
Effects of modification of the active site tyrosine of human DNA topoisomerase I. Biochemistry (2006) 0.82
Site-specific incorporation of (aminooxy)acetic acid into proteins. Biochemistry (2002) 0.82
Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids. Biochemistry (2007) 0.81
Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK. Bioorg Med Chem (2006) 0.81
Chemically mediated site-specific proteolysis. Alteration of protein-protein interaction. Biochemistry (2002) 0.81
Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates. Mol Cell Biol (2006) 0.81
Modified bleomycin disaccharides exhibiting improved tumor cell targeting. Biochemistry (2014) 0.81
One-pot regio- and stereoselective synthesis of α'-methoxy-γ-pyrones: biological evaluation as mitochondrial respiratory complex inhibitors. J Org Chem (2011) 0.81
Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases. Bioorg Med Chem (2012) 0.81
Water-soluble camptothecin derivatives that are intrinsic topoisomerase I poisons. Org Lett (2004) 0.80
Nucleic acids: expanding the structural and functional horizons. J Am Chem Soc (2009) 0.80
Anthrax toxin induces hemolysis: an indirect effect through polymorphonuclear cells. J Infect Dis (2003) 0.80
Childhood cancers: what is a possible role of infectious agents? Infect Agent Cancer (2013) 0.80
Total synthesis of the topopyrones: a new class of topoisomerase I poisons. J Org Chem (2008) 0.80
Significantly reduced CCR5-tropic HIV-1 replication in vitro in cells from subjects previously immunized with Vaccinia Virus. BMC Immunol (2010) 0.80
Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria. Bioorg Med Chem (2010) 0.80
A novel DNA hairpin substrate for bleomycin. Org Lett (2008) 0.80
Biochemical evaluation of a 108-member deglycobleomycin library: viability of a selection strategy for identifying bleomycin analogues with altered properties. J Am Chem Soc (2007) 0.80
Pathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm? Infect Agent Cancer (2012) 0.80
Site- and subunit-specific incorporation of unnatural amino acids into HIV-1 reverse transcriptase. Protein Expr Purif (2004) 0.80
Solid-phase synthesis of bleomycin A(5) and three monosaccharide analogues: exploring the role of the carbohydrate moiety in RNA cleavage. J Am Chem Soc (2002) 0.80
Symmetry complementarity-guided design of anthrax toxin inhibitors based on β-cyclodextrin: Synthesis and relative activities of face-selective functionalized polycationic clusters. ChemMedChem (2011) 0.79
Synthesis and biological activities of topopyrones. J Nat Prod (2012) 0.79
Alkaloids from Alangium javanicum and Alangium grisolleoides that mediate Cu2+-dependent DNA strand scission. J Nat Prod (2005) 0.79