Published in Gene Ther on January 01, 2006
Recombinant AAV9-TLK1B administration ameliorates fractionated radiation-induced xerostomia. Hum Gene Ther (2013) 0.93
Salivary epithelial cells: an unassuming target site for gene therapeutics. Int J Biochem Cell Biol (2010) 0.93
Long-term transduction of miniature pig parotid glands using serotype 2 adeno-associated viral vectors. J Gene Med (2009) 0.91
Systemic delivery of bioactive glucagon-like peptide 1 after adenoviral-mediated gene transfer in the murine salivary gland. Endocrinology (2010) 0.90
Progress toward a nonviral gene therapy protocol for the treatment of anemia. Hum Gene Ther (2007) 0.88
Human parathyroid hormone is secreted primarily into the bloodstream after rat parotid gland gene transfer. Hum Gene Ther (2011) 0.86
Targeting the splicing of mRNA in autoimmune diseases: BAFF inhibition in Sjögren's syndrome as a proof of concept. Mol Ther (2013) 0.84
Gene Therapies for Cancer: Strategies, Challenges and Successes. J Cell Physiol (2015) 0.83
Enhancing the utility of adeno-associated virus gene transfer through inducible tissue-specific expression. Hum Gene Ther Methods (2013) 0.82
Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands. Toxicol Sci (2011) 0.78
Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands. Oral Dis (2010) 0.77
Adeno-associated viral vectors engineered for macrolide-adjustable transgene expression in mammalian cells and mice. BMC Biotechnol (2007) 0.76
A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med (2013) 6.67
Pictorial review: adult intussusception--a CT diagnosis. Br J Radiol (2002) 4.68
Direct clone characterization from plaques and colonies by the polymerase chain reaction. Nucleic Acids Res (1989) 3.98
A humanized system for pharmacologic control of gene expression. Nat Med (1996) 3.69
The utility of MRI in suspected MS: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology (2003) 3.21
Analysis of the sequence-specific interactions between Cro repressor and operator DNA by systematic base substitution experiments. Proc Natl Acad Sci U S A (1989) 2.76
Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science (2000) 2.70
Subjective reports of xerostomia and objective measures of salivary gland performance. J Am Dent Assoc (1987) 2.35
A versatile synthetic dimerizer for the regulation of protein-protein interactions. Proc Natl Acad Sci U S A (1997) 2.04
Intravenous safety and pharmacokinetics of a novel dimerizer drug, AP1903, in healthy volunteers. J Clin Pharmacol (2001) 1.91
High frequency of BRCA1 185delAG mutation in ovarian cancer in Israel. National Israel Study of Ovarian Cancer. JAMA (1996) 1.90
Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc Natl Acad Sci U S A (1997) 1.76
Megavesicles implicated in the rapid transport of intracisternal aggregates across the Golgi stack. Cell (2000) 1.70
Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer. Science (1999) 1.57
Genomic integration and gene expression by a modified adenoviral vector. Nat Biotechnol (2000) 1.55
Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group. N Engl J Med (1995) 1.55
Xerostomia: evaluation of a symptom with increasing significance. J Am Dent Assoc (1985) 1.52
A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions. J Med Genet (2004) 1.46
Fibroblasts degrade newly synthesised collagen within the cell before secretion. Nature (1978) 1.44
Radioimmunodetection of colorectal cancer metastases with 131I-labeled monoclonal antibody B72.3: a pilot study to determine efficacy of detection and pharmacokinetics. Cancer Invest (1993) 1.42
Direct in vivo adenovirus-mediated gene transfer to salivary glands. Am J Physiol (1994) 1.40
Effect of cyclic AMP on the intracellular degradation of newly synthesized collagen. J Biol Chem (1980) 1.39
A ligand-reversible dimerization system for controlling protein-protein interactions. Proc Natl Acad Sci U S A (2000) 1.38
Investigating protein-ligand interactions with a mutant FKBP possessing a designed specificity pocket. J Med Chem (2000) 1.38
Protein kinase A and its role in human neoplasia: the Carney complex paradigm. Endocr Relat Cancer (2004) 1.38
Saliva inhibits HIV-1 infectivity. J Am Dent Assoc (1988) 1.36
Systemic action of human growth hormone following adenovirus-mediated gene transfer to rat submandibular glands. Gene Ther (1998) 1.35
Increased fluid secretion after adenoviral-mediated transfer of the human aquaporin-1 cDNA to irradiated miniature pig parotid glands. Mol Ther (2005) 1.33
Immediate inflammatory responses to adenovirus-mediated gene transfer in rat salivary glands. Hum Gene Ther (1996) 1.27
Destruction of a major extracellular adhesive glycoprotein (fibronectin) of human fibroblasts by neutral proteases from polymorphonuclear leukocyte granules. Lab Invest (1979) 1.25
Double-blind evaluation of glycerol therapy in acute cerebral infarction. Lancet (1972) 1.25
Salivary gland cytokine expression in NOD and normal BALB/c mice. Clin Immunol (1999) 1.24
Transcriptional squelching re-examined. Nature (1997) 1.23
A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease. Blood (2001) 1.23
How much saliva is enough? 'Normal' function defined. J Am Dent Assoc (1991) 1.21
The serum response factor is extensively modified by phosphorylation following its synthesis in serum-stimulated fibroblasts. Mol Cell Biol (1991) 1.21
Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjogren's syndrome. Ann Rheum Dis (2005) 1.20
Isolation of milligram quantities of a group of histidine-rich polypeptides from human parotid saliva. Infect Immun (1984) 1.20
Unstimulated and stimulated parotid salivary flow rate in individuals of different ages. J Dent Res (1984) 1.18
Specific and nonspecific immune factors in dental plaque fluid and saliva from young and old populations. Infect Immun (1981) 1.17
Enhanced transduction of mouse salivary glands with AAV5-based vectors. Gene Ther (2006) 1.17
Delivery of a stringent dimerizer-regulated gene expression system in a single retroviral vector. Proc Natl Acad Sci U S A (2000) 1.16
Refill status of the agonist-sensitive Ca2+ pool regulates Mn2+ influx into parotid acini. J Biol Chem (1990) 1.16
Salivary inhibition of HIV-1 infectivity: functional properties and distribution in men, women, and children. J Am Dent Assoc (1989) 1.15
Taste thresholds: quality specific variation with human aging. J Gerontol (1982) 1.14
Repetitive adenovirus administration to the parotid gland: role of immunological barriers and induction of oral tolerance. Hum Gene Ther (1998) 1.14
Association in normal human fibroblasts of elevated levels of adenosine 3':5'-monophosphate with a selective decrease in collagen production. J Biol Chem (1978) 1.12
Polarized distribution of key membrane transport proteins in the rat submandibular gland. Pflugers Arch (1997) 1.11
Cancer cells suppress p53 in adjacent fibroblasts. Oncogene (2008) 1.10
L-type voltage-sensitive calcium channel activation stimulates gene expression by a serum response factor-dependent pathway. J Biol Chem (1994) 1.10
Evidence for the systemic delivery of a transgene product from salivary glands. Hum Gene Ther (1996) 1.08
Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins. Bioorg Med Chem (1998) 1.08
Adenovirus-mediated expression of aquaporin-5 in epithelial cells. J Biol Chem (1996) 1.06
AAV2-mediated transfer of the human aquaporin-1 cDNA restores fluid secretion from irradiated miniature pig parotid glands. Gene Ther (2010) 1.06
Elevation of salivary antimicrobial proteins following HIV-1 infection. J Acquir Immune Defic Syndr (1990) 1.05
Evidence for a Na+/K+/Cl- cotransport system in basolateral membrane vesicles from the rabbit parotid. J Membr Biol (1986) 1.05
Establishment and characterization of an epithelial cell line from the rat submandibular gland. J Oral Pathol Med (1989) 1.04
Differential sorting of human parathyroid hormone after transduction of mouse and rat salivary glands. Hum Gene Ther (2008) 1.04
Metabolic fate of the major cell surface protein of normal human fibroblasts. Biochem Biophys Res Commun (1977) 1.03
Cells, collagen and idiopathic pulmonary fibrosis. Lung (1978) 1.02
Hydroxychloroquine enhances the endocrine secretion of adenovirus-directed growth hormone from rat submandibular glands in vivo. Hum Gene Ther (2001) 1.02
cAMP-mediated protein phosphorylation of microsomal membranes increases mannosylphosphodolichol synthase activity. Proc Natl Acad Sci U S A (1987) 1.01
Pharmacologic control of a humanized gene therapy system implanted into nude mice. J Clin Invest (1997) 1.01
Treatment with glycerol of cerebral oedema due to acute cerebral infarction. Lancet (1971) 1.00
Evidence that M3 muscarinic receptors in rat parotid gland couple to two second messenger systems. Am J Physiol (1991) 1.00
Transfer of a gene encoding the anticandidal protein histatin 3 to salivary glands. Hum Gene Ther (1996) 1.00
Polyacrylamide gel electrophoresis of human salivary histidine-rich-polypeptides. J Dent Res (1977) 0.99
Long-term salivary effects of single-dose head and neck irradiation in the rat. Arch Oral Biol (1998) 0.99
Interferon-gamma induced cell death in a cultured human salivary gland cell line. J Cell Physiol (1996) 0.99
Examination of rat salivary glands for the presence of the aquaporin CHIP. Pflugers Arch (1994) 0.99
Preferential recognition of TCR hypervariable regions by human anti-idiotypic T cells induced by T cell vaccination. J Immunol (2000) 0.99
A polarized salivary cell monolayer useful for studying transepithelial fluid movement in vitro. Pflugers Arch (1998) 0.99
Orally administered betahistine and regional cerebral blood flow in cerebrovascular disease. J Clin Pharmacol (1974) 0.98
Pilocarpine treatment of salivary gland hypofunction and dry mouth (xerostomia). Arch Intern Med (1991) 0.98
Studies on histidine-rich polypeptides from human parotid saliva. Arch Biochem Biophys (1976) 0.97
Beta-adrenergic receptor stimulation induces inositol trisphosphate production and Ca2+ mobilization in rat parotid acinar cells. J Biol Chem (1988) 0.97
NOD mouse model for Sjögren's syndrome: lack of longitudinal stability. Oral Dis (2006) 0.97
Cationic liposome-mediated gene transfer to rat salivary epithelial cells in vitro and in vivo. J Gene Med (2001) 0.97
The interaction of collagen with alpha1-acid glycoprotein. Biochim Biophys Acta (1976) 0.97
Aging and oral motor function: evidence for altered performance among older persons. J Dent Res (1983) 0.96
T cell responses to myelin basic protein in patients with spinal cord injury and multiple sclerosis. J Neuroimmunol (1999) 0.96
Relationship of dental and oral pathology to systemic illness. JAMA (2000) 0.96
Gender differences in serotype 2 adeno-associated virus biodistribution after administration to rodent salivary glands. Hum Gene Ther (2007) 0.95
Early growth, pubertal development, body mass index and final height of patients with congenital adrenal hyperplasia: factors influencing the outcome. Clin Endocrinol (Oxf) (2002) 0.95
Primary culture of polarized human salivary epithelial cells for use in developing an artificial salivary gland. Tissue Eng (2005) 0.95
Interferon beta induces T-helper 2 immune deviation in MS. Neurology (1999) 0.95
beta-Adrenergic regulation of protein phosphorylation and its relationship to exocrine secretion in dispersed rat parotid gland acinar cells. J Biol Chem (1981) 0.95
Neurologic deficit in patients at high risk with thoracoabdominal aortic aneurysms: the role of cerebral spinal fluid drainage and distal aortic perfusion. J Vasc Surg (1994) 0.95
Tissue-transglutaminase in rat and human brain: light and electron immunocytochemical analysis and in situ hybridization study. Brain Res Bull (2001) 0.95
Vertebrobasilar arterial insufficiency with dementia. Controlled trials of treatment with betahistine hydrochloride. J Am Geriatr Soc (1974) 0.94
Evaluation of stimulated parotid saliva flow rate in different age groups. J Dent Res (1981) 0.94
Urodynamic pattern changes in multiple sclerosis. Urology (2001) 0.94