What causes the onset of psychosis?

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings. J Neurodev Disord (2012) 1.73

Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging. Curr Pharm Des (2009) 1.51

Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: the role of stress and of antipsychotic treatment. Schizophr Res (2009) 1.48

Schizophrenia. BMJ (2007) 1.37

A social deafferentation hypothesis for induction of active schizophrenia. Schizophr Bull (2007) 1.26

Disorganization/cognitive and negative symptom dimensions in the at-risk mental state predict subsequent transition to psychosis. Schizophr Bull (2010) 1.23

Gamma oscillation deficits and the onset and early progression of schizophrenia. Harv Rev Psychiatry (2010) 1.17

Mood instability and psychosis: analyses of British national survey data. Schizophr Bull (2013) 1.16

A neuropsychiatric model of biological and psychological processes in the remission of delusions and auditory hallucinations. Schizophr Bull (2006) 1.07

Cognitive, emotional, and social processes in psychosis: refining cognitive behavioral therapy for persistent positive symptoms. Schizophr Bull (2006) 1.02

Abnormal relationship between medial temporal lobe and subcortical dopamine function in people with an ultra high risk for psychosis. Schizophr Bull (2011) 0.97

Drug-induced psychosis: how to avoid star gazing in schizophrenia research by looking at more obvious sources of light. Front Behav Neurosci (2011) 0.94

Unemployment, social isolation, achievement-expectation mismatch and psychosis: findings from the AESOP Study. Soc Psychiatry Psychiatr Epidemiol (2008) 0.89

How anxiety induces verbal hallucinations. Conscious Cogn (2015) 0.89

Prefrontal function at presentation directly related to clinical outcome in people at ultrahigh risk of psychosis. Schizophr Bull (2009) 0.89

The psychosis continuum in the general population: findings from the São Paulo Epidemiologic Catchment Area Study. Eur Arch Psychiatry Clin Neurosci (2011) 0.88

Brain-wide functional inter-hemispheric disconnection is a potential biomarker for schizophrenia and distinguishes it from depression. Neuroimage Clin (2013) 0.87

From the prodrome to chronic schizophrenia: the neurobiology underlying psychotic symptoms and cognitive impairments. Curr Pharm Des (2012) 0.86

Editorial: research progress in early-onset schizophrenia. Schizophr Bull (2007) 0.83

The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia. Front Pharmacol (2014) 0.82

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI-EEG study. J Psychiatry Neurosci (2011) 0.82

Abnormal effective connectivity and psychopathological symptoms in the psychosis high-risk state. J Psychiatry Neurosci (2014) 0.82

Predictors of methamphetamine psychosis: history of ADHD-relevant childhood behaviors and drug exposure. Psychiatry Res (2013) 0.78

A high-fidelity virtual environment for the study of paranoia. Schizophr Res Treatment (2013) 0.77

The Influence of the CB1 Receptor Ligands on the Schizophrenia-Like Effects in Mice Induced by MK-801. Neurotox Res (2016) 0.76

Prophylactic valproic acid treatment prevents schizophrenia-related behaviour in Disc1-L100P mutant mice. PLoS One (2012) 0.76

Psychosis, agnosia, and confabulation: an alternative two-factor account. Cogn Neuropsychiatry (2013) 0.75

The Impact of CB2 Receptor Ligands on the MK-801-Induced Hyperactivity in Mice. Neurotox Res (2017) 0.75

Aging of cerebral white matter. Ageing Res Rev (2016) 0.75

Epistemic Benefits of Elaborated and Systematized Delusions in Schizophrenia. Br J Philos Sci (2015) 0.75

Rethinking Social Cognition in Light of Psychosis: Reciprocal Implications for Cognition and Psychopathology. Clin Psychol Sci (2017) 0.75

Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23

Common variants conferring risk of schizophrenia. Nature (2009) 10.37

Randomized controlled trial of the effect on Quality of Life of second- vs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1). Arch Gen Psychiatry (2006) 9.44

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48

Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44

Causal association between cannabis and psychosis: examination of the evidence. Br J Psychiatry (2004) 5.95

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56

Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet (2003) 4.91

Regionally localized thinning of the cerebral cortex in schizophrenia. Arch Gen Psychiatry (2003) 4.84

Disruption of the neurexin 1 gene is associated with schizophrenia. Hum Mol Genet (2008) 4.78

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42

Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet (2012) 4.05

Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry (2002) 4.03

A twin study of genetic relationships between psychotic symptoms. Am J Psychiatry (2002) 3.95

Elevated striatal dopamine function linked to prodromal signs of schizophrenia. Arch Gen Psychiatry (2009) 3.67

Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder: results from a longitudinal birth cohort. Arch Gen Psychiatry (2002) 3.59

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet (2012) 3.40

Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: findings from the 3-center AeSOP study. Arch Gen Psychiatry (2006) 3.35

Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet (2010) 3.34

Static and dynamic cognitive deficits in childhood preceding adult schizophrenia: a 30-year study. Am J Psychiatry (2010) 3.05

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet (2011) 2.99

Incidence of schizophrenia and other psychoses in ethnic minority groups: results from the MRC AESOP Study. Psychol Med (2006) 2.79

Symmetries in human brain language pathways correlate with verbal recall. Proc Natl Acad Sci U S A (2007) 2.78

Randomized controlled trial of effect of prescription of clozapine versus other second-generation antipsychotic drugs in resistant schizophrenia. Schizophr Bull (2006) 2.71

Early detection and intervention evaluation for people at risk of psychosis: multisite randomised controlled trial. BMJ (2012) 2.70

Prevalence and correlates of self-reported psychotic symptoms in the British population. Br J Psychiatry (2004) 2.44

High-potency cannabis and the risk of psychosis. Br J Psychiatry (2009) 2.41

Dopamine synthesis capacity before onset of psychosis: a prospective [18F]-DOPA PET imaging study. Am J Psychiatry (2011) 2.37

Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses. PLoS One (2012) 2.33

Meta-analysis of the P300 and P50 waveforms in schizophrenia. Schizophr Res (2004) 2.30

The hallucinating brain: a review of structural and functional neuroimaging studies of hallucinations. Neurosci Biobehav Rev (2007) 2.25

Diffusion tensor imaging in schizophrenia. Biol Psychiatry (2005) 2.14

Schizophrenia in the offspring of antenatally depressed mothers in the northern Finland 1966 birth cohort: relationship to family history of psychosis. Am J Psychiatry (2009) 2.11

Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. J Psychiatr Res (2010) 1.98

Adolescents who were born very preterm have decreased brain volumes. Brain (2002) 1.97

Temporal course of auditory hallucinations. Br J Psychiatry (2004) 1.95

Reliability and comparability of psychosis patients' retrospective reports of childhood abuse. Schizophr Bull (2009) 1.94

White matter integrity and cognitive impairment in first-episode psychosis. Am J Psychiatry (2010) 1.92

Grey and white matter distribution in very preterm adolescents mediates neurodevelopmental outcome. Brain (2007) 1.91

Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Arch Gen Psychiatry (2004) 1.87

Learning and cognitive flexibility: frontostriatal function and monoaminergic modulation. Curr Opin Neurobiol (2010) 1.85

Regional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder: computational morphometry study. Br J Psychiatry (2005) 1.83

Regional gray matter volume abnormalities in the at risk mental state. Biol Psychiatry (2006) 1.81

Tract-specific anisotropy measurements in diffusion tensor imaging. Psychiatry Res (2005) 1.79

Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis. Arch Gen Psychiatry (2006) 1.78

Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: findings in a second cohort. Biol Psychiatry (2013) 1.76

Increased pituitary volume in antipsychotic-free and antipsychotic-treated patients of the AEsop first-onset psychosis study. Neuropsychopharmacology (2005) 1.76

Self-harm in first-episode psychosis. Br J Psychiatry (2008) 1.72

Substance use in a population-based clinic sample of people with first-episode psychosis. Br J Psychiatry (2007) 1.71

A diffusion tensor imaging study of fasciculi in schizophrenia. Am J Psychiatry (2007) 1.71

Neural responses to sad facial expressions in major depression following cognitive behavioral therapy. Biol Psychiatry (2008) 1.70

Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. Arch Gen Psychiatry (2009) 1.69

Distribution of symptom dimensions across Kraepelinian divisions. Br J Psychiatry (2006) 1.67

Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users. Biol Psychiatry (2012) 1.64

Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology (2009) 1.62

Neural systems underlying British Sign Language and audio-visual English processing in native users. Brain (2002) 1.60

Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data. Biol Psychiatry (2010) 1.60

Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives. Am J Med Genet B Neuropsychiatr Genet (2007) 1.59

Pathways to schizophrenia: the impact of environmental factors. Int J Neuropsychopharmacol (2004) 1.58

Comorbid depressive and anxiety disorders in 509 individuals with an at-risk mental state: impact on psychopathology and transition to psychosis. Schizophr Bull (2012) 1.58

Migration, ethnicity, and psychosis: toward a sociodevelopmental model. Schizophr Bull (2010) 1.58

Predictors of schizophrenia: evidence from the Northern Finland 1966 Birth Cohort and other sources. Br J Psychiatry Suppl (2005) 1.56

Corpus callosum size and very preterm birth: relationship to neuropsychological outcome. Brain (2004) 1.55

Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study. Eur Psychiatry (2006) 1.54

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nat Genet (2012) 1.52

Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study. Arch Gen Psychiatry (2010) 1.52

Searching for psychosis: INTREPID (1): systems for detecting untreated and first-episode cases of psychosis in diverse settings. Soc Psychiatry Psychiatr Epidemiol (2015) 1.50

Glutamate dysfunction in people with prodromal symptoms of psychosis: relationship to gray matter volume. Biol Psychiatry (2009) 1.49

Substantial shared genetic influences on schizophrenia and event-related potentials. Am J Psychiatry (2007) 1.48

Abnormal cortisol levels during the day and cortisol awakening response in first-episode psychosis: the role of stress and of antipsychotic treatment. Schizophr Res (2009) 1.48

Meta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorder. Biol Psychiatry (2004) 1.45

Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9-12 years. Schizophr Res (2007) 1.44

Reductions in frontal, temporal and parietal volume associated with the onset of psychosis. Schizophr Res (2008) 1.43

Gender differences in incidence and age at onset of mania and bipolar disorder over a 35-year period in Camberwell, England. Am J Psychiatry (2005) 1.42

Cannabis use and outcome of recent onset psychosis. Eur Psychiatry (2005) 1.42

A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample. Proc Natl Acad Sci U S A (2006) 1.40

Neighbourhood-level effects on psychoses: re-examining the role of context. Psychol Med (2007) 1.38

Preterm birth and psychiatric disorders in young adult life. Arch Gen Psychiatry (2012) 1.38

Schizophrenia. BMJ (2007) 1.37

Association between BDNF val66 met genotype and episodic memory. Am J Med Genet B Neuropsychiatr Genet (2005) 1.36

Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives. Am J Psychiatry (2006) 1.35

The structural brain correlates of neurological soft signs in AESOP first-episode psychoses study. Brain (2003) 1.35

Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder. BMC Psychiatry (2011) 1.34

The characteristic features of auditory verbal hallucinations in clinical and nonclinical groups: state-of-the-art overview and future directions. Schizophr Bull (2012) 1.34