Targeting protein kinase C and "non-kinase" phorbol ester receptors: emerging concepts and therapeutic implications.

PubWeight™: 1.02‹?› | Rank: Top 15%

🔗 View Article (PMID 16202672)

Published in Biochim Biophys Acta on September 12, 2005

Authors

Marcelo G Kazanietz1

Author Affiliations

1: Department of Pharmacology, University of Pennsylvania School of Medicine, 816 Biomedical Research Building II/III, 421 Curie Blvd., Philadelphia, PA 19104-6160, USA. marcelo@spirit.gcrc.upenn.edu

Articles citing this

Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta (2007) 4.74

PKC-delta and -eta, MEKK-1, MEK-6, MEK-3, and p38-delta are essential mediators of the response of normal human epidermal keratinocytes to differentiating agents. J Invest Dermatol (2010) 1.64

Wealth of opportunity - the C1 domain as a target for drug development. Curr Drug Targets (2008) 1.21

The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses. Org Lett (2009) 1.08

Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? Redox Biol (2015) 1.02

Light-dependent translocation of arrestin in rod photoreceptors is signaled through a phospholipase C cascade and requires ATP. Cell Signal (2010) 0.96

Probing the determinants of diacylglycerol binding affinity in the C1B domain of protein kinase Cα. J Mol Biol (2011) 0.88

Nutritional countermeasures targeting reactive oxygen species in cancer: from mechanisms to biomarkers and clinical evidence. Antioxid Redox Signal (2013) 0.86

RasGRPs are targets of the anti-cancer agent ingenol-3-angelate. PLoS One (2013) 0.84

Lipid second messengers and related enzymes in vertebrate rod outer segments. J Lipid Res (2009) 0.83

Charge density influences C1 domain ligand affinity and membrane interactions. Chembiochem (2014) 0.82

Phorbol esters isolated from Jatropha meal induced apoptosis-mediated inhibition in proliferation of chang and Vero cell lines. Int J Mol Sci (2012) 0.80

C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cells. PLoS One (2011) 0.79

Phytol-derived novel isoprenoid immunostimulants. Front Immunol (2012) 0.76

Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains. J Med Chem (2014) 0.76

Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3. Biochim Biophys Acta (2017) 0.75