Published in Oncology on September 19, 2005
Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. Gastroenterology (2006) 2.78
Post-transcriptional regulons coordinate the initiation and resolution of inflammation. Nat Rev Immunol (2010) 2.08
Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer. Neoplasia (2009) 1.66
Chemoprevention of head and neck cancer with celecoxib and erlotinib: results of a phase ib and pharmacokinetic study. Cancer Prev Res (Phila) (2013) 1.56
Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. Cell Metab (2008) 1.25
The tumor microenvironment in colorectal carcinogenesis. Cancer Microenviron (2010) 1.23
Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis. Gastroenterology (2009) 1.15
Pooled analysis of the association of PTGS2 rs5275 polymorphism and NSAID use with invasive ovarian carcinoma risk. Cancer Causes Control (2010) 1.07
LC/MS/MS method for analysis of E₂ series prostaglandins and isoprostanes. J Lipid Res (2011) 1.06
Use of nonsteroidal antiinflammatory agents and incidence of ovarian cancer in 2 large prospective cohorts. Am J Epidemiol (2009) 1.05
Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity. Cancer Prev Res (Phila) (2011) 1.03
IL-17 mediated inflammation promotes tumor growth and progression in the skin. PLoS One (2012) 1.01
Combination of sulindac and antimicrobial eradication of Helicobacter pylori prevents progression of gastric cancer in hypergastrinemic INS-GAS mice. Cancer Res (2009) 1.00
A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study. Breast Cancer Res (2007) 0.98
Effects of fish oil supplementation on prostaglandins in normal and tumor colon tissue: modulation by the lipogenic phenotype of colon tumors. J Nutr Biochem (2017) 0.97
Cyclooxygenase-2 gene disruption promotes proliferation of murine calvarial osteoblasts in vitro. Bone (2007) 0.95
The gastrointestinal microbiota and colorectal cancer. Am J Physiol Gastrointest Liver Physiol (2014) 0.94
The connection between lymphangiogenic signalling and prostaglandin biology: a missing link in the metastatic pathway. Oncotarget (2012) 0.94
Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. Mol Biol Cell (2009) 0.93
Role of cyclooxygenase-2 in tumor progression and survival of head and neck squamous cell carcinoma. Cancer Prev Res (Phila) (2009) 0.90
Cyclooxygenase-2/carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells. J Cell Mol Med (2008) 0.90
Tumour-derived prostaglandin E and transforming growth factor-beta synergize to inhibit plasmacytoid dendritic cell-derived interferon-alpha. Immunology (2009) 0.90
Urinary PGE-M levels are associated with risk of colorectal adenomas and chemopreventive response to anti-inflammatory drugs. Cancer Prev Res (Phila) (2014) 0.88
Lymphovascular and neural regulation of metastasis: shared tumour signalling pathways and novel therapeutic approaches. Best Pract Res Clin Anaesthesiol (2013) 0.85
A fast one-step extraction and UPLC-MS/MS analysis for E2/D 2 series prostaglandins and isoprostanes. Lipids (2013) 0.85
Evaluation of pro-inflammatory markers plasma C-reactive protein and urinary prostaglandin-E2 metabolite in colorectal adenoma risk. Mol Carcinog (2015) 0.82
The Mediterranean diet: effects on proteins that mediate fatty acid metabolism in the colon. Nutr Rev (2011) 0.82
Eicosanoid pathway in colorectal cancer: Recent updates. World J Gastroenterol (2015) 0.81
Interaction of fatty acid genotype and diet on changes in colonic fatty acids in a Mediterranean diet intervention study. Cancer Prev Res (Phila) (2013) 0.81
Eicosanoid profiling in colon cancer: emergence of a pattern. Prostaglandins Other Lipid Mediat (2012) 0.80
Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase. Br J Pharmacol (2012) 0.79
Hypoxia activates 15-PGDH and its metabolite 15-KETE to promote pulmonary artery endothelial cells proliferation via ERK1/2 signalling. Br J Pharmacol (2014) 0.79
Interaction between use of non-steroidal anti-inflammatory drugs and selected genetic polymorphisms in ovarian cancer risk. Int J Mol Epidemiol Genet (2010) 0.79
Somatostatin inhibits colon cancer cell growth through cyclooxygenase-2 downregulation. Br J Pharmacol (2008) 0.78
Effects of a Mediterranean Diet Intervention on Anti- and Pro-Inflammatory Eicosanoids, Epithelial Proliferation, and Nuclear Morphology in Biopsies of Normal Colon Tissue. Nutr Cancer (2015) 0.77
Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells. World J Gastroenterol (2009) 0.77
Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression. Oncotarget (2015) 0.76
A novel NSAID derivative, phospho-ibuprofen, prevents AOM-induced colon cancer in rats. Int J Oncol (2012) 0.76
Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. Nutr Cancer (2016) 0.75
Eicosanoids and cancer. Nat Rev Cancer (2010) 5.96
15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. J Biol Chem (2004) 2.55
Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention. J Clin Oncol (2005) 1.98
The role of prostaglandins and other eicosanoids in the gastrointestinal tract. Gastroenterology (2005) 1.83
CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis. Cancer Cell (2013) 1.71
COX-2 inhibition and colorectal cancer. Semin Oncol (2004) 1.53
Requirement of phospholipase D1 activity in H-RasV12-induced transformation. Proc Natl Acad Sci U S A (2005) 1.38
Cyclooxygenase-2: a potential target in breast cancer. Semin Oncol (2004) 1.25
APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. J Clin Invest (2011) 1.23
The tumor microenvironment in colorectal carcinogenesis. Cancer Microenviron (2010) 1.23
Cyclooxygenase-2-mediated DNA damage. J Biol Chem (2005) 1.18
The role of chemokines in intestinal inflammation and cancer. Curr Opin Pharmacol (2009) 1.16
Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. J Biol Chem (2005) 1.15
Cyclooxygenase-1 signaling is required for vascular tube formation during development. Dev Biol (2005) 1.15
Prostaglandins in cancer cell adhesion, migration, and invasion. Int J Cell Biol (2012) 1.09
Genetic polymorphisms in MicroRNA-related genes as predictors of clinical outcomes in colorectal adenocarcinoma patients. Clin Cancer Res (2012) 1.08
Bmp signaling is required for intestinal growth and morphogenesis. Dev Dyn (2006) 1.07
Human enhancer of filamentation 1 Is a mediator of hypoxia-inducible factor-1alpha-mediated migration in colorectal carcinoma cells. Cancer Res (2010) 1.04
Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res (2008) 1.04
Prostaglandin E2 regulates the complement inhibitor CD55/decay-accelerating factor in colorectal cancer. J Biol Chem (2004) 1.02
WNT and cyclooxygenase-2 cross-talk accelerates adenoma growth. Cell Cycle (2004) 1.01
Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer. Cancer Res (2007) 1.00
Controversy: PPARgamma as a target for treatment of colorectal cancer. Am J Physiol Gastrointest Liver Physiol (2002) 0.97
Epoxyeicosatrienoic acids: a double-edged sword in cardiovascular diseases and cancer. J Clin Invest (2011) 0.93
The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer. Cancers (Basel) (2011) 0.92
Prostaglandin E2 regulates pancreatic stellate cell activity via the EP4 receptor. Pancreas (2013) 0.91
Associations between obesity and cancer: the role of fatty acid synthase. J Natl Cancer Inst (2012) 0.90
Peroxisome proliferator-activated receptors and progression of colorectal cancer. PPAR Res (2008) 0.88
Role of inflammation and inflammatory mediators in colorectal cancer. Trans Am Clin Climatol Assoc (2014) 0.85
Biomarkers, bundled payments, and colorectal cancer care. Genes Cancer (2012) 0.84
Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells. Mol Cancer (2006) 0.80
The Jeremiah Metzger Lecture: Inflammation, Immune Modulators, and Chronic Disease. Trans Am Clin Climatol Assoc (2015) 0.78
Effects of transforming growth factor-alpha (TGF-alpha) in vitro and in vivo on reovirus replication. DNA Cell Biol (2004) 0.78
PPARγ agonists target aromatase via both PGE2 and BRCA1. Cancer Prev Res (Phila) (2012) 0.76
Will an aspirin a day keep the endoscope away? Gastroenterology (2003) 0.75
Restructuring MD-PhD programs: career training or broad education? Acad Med (2009) 0.75
Ras up-regulation of cyclooxygenase-2. Methods Enzymol (2006) 0.75
The physician-scientist in gastroenterology. Gastroenterology (2003) 0.75
The evolution of modern academic medicine continues. Gastroenterology (2002) 0.75
Disease prevention: the future is here. Gastroenterology (2004) 0.75
MEK activation suppresses CPT11-induced apoptosis in rat intestinal epithelial cells through a COX-2-dependent mechanism. Dig Dis Sci (2007) 0.75