Molecular mechanisms of lipid-induced insulin resistance in muscle, liver and vasculature.

PubWeight™: 1.22‹?› | Rank: Top 10%

🔗 View Article (PMID 16219006)

Published in Diabetes Obes Metab on November 01, 2005

Authors

M Krebs1, M Roden

Author Affiliations

1: Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Articles citing this

Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities. Antioxid Redox Signal (2010) 2.11

Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults. J Appl Physiol (1985) (2008) 1.80

Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function. Lipids Health Dis (2012) 1.32

Characterization of the human skeletal muscle proteome by one-dimensional gel electrophoresis and HPLC-ESI-MS/MS. Mol Cell Proteomics (2007) 1.31

Exercise training improves relaxation response and SOD-1 expression in aortic and mesenteric rings from high caloric diet-fed rats. BMC Physiol (2008) 1.00

Global relationship between the proteome and transcriptome of human skeletal muscle. J Proteome Res (2008) 0.99

Muscle contraction, but not insulin, increases microvascular blood volume in the presence of free fatty acid-induced insulin resistance. Diabetes (2009) 0.98

Short-term hyperinsulinemia and hyperglycemia increase myocardial lipid content in normal subjects. Diabetes (2012) 0.96

Diet-induced obesity prevents interstitial dispersion of insulin in skeletal muscle. Diabetes (2009) 0.96

Experimental hyperlipidemia dramatically reduces access of insulin to canine skeletal muscle. Obesity (Silver Spring) (2009) 0.91

Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes. Am J Physiol Endocrinol Metab (2014) 0.89

Combined treatment of mulberry leaf and fruit extract ameliorates obesity-related inflammation and oxidative stress in high fat diet-induced obese mice. J Med Food (2013) 0.88

Geldanamycin derivative ameliorates high fat diet-induced renal failure in diabetes. PLoS One (2012) 0.88

A newly identified CG301269 improves lipid and glucose metabolism without body weight gain through activation of peroxisome proliferator-activated receptor alpha and gamma. Diabetes (2011) 0.88

Modulation of cellular insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cells. J Nutr Biochem (2013) 0.87

Effects of aging on basal fat oxidation in obese humans. Metabolism (2008) 0.84

Targeting mitochondria as therapeutic strategy for metabolic disorders. ScientificWorldJournal (2014) 0.83

Risk Factors for Incident Diabetes in a Cohort Taking First-Line Nonnucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy. Medicine (Baltimore) (2016) 0.82

Chronic peripheral hyperinsulinemia in type 1 diabetic patients after successful combined pancreas-kidney transplantation does not affect ectopic lipid accumulation in skeletal muscle and liver. Diabetes (2009) 0.80

Antecedent caloric intake and glucose excursion following a subsequent meal in Type 1 diabetes. J Diabetes (2009) 0.78

Mark4 promotes oxidative stress and inflammation via binding to PPARγ and activating NF-κB pathway in mice adipocytes. Sci Rep (2016) 0.76

Letter: effects of rosiglitazone on inflammation in Otsuka long-evans Tokushima Fatty rats (korean diabetes j 2010;34:191-9). Korean Diabetes J (2010) 0.75

Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked? J Biomed Sci (2016) 0.75

Effect of functional sympathetic nervous system impairment of the liver and abdominal visceral adipose tissue on circulating triglyceride-rich lipoproteins. PLoS One (2017) 0.75

Maternal Chromium Restriction Leads to Glucose Metabolism Imbalance in Mice Offspring through Insulin Signaling and Wnt Signaling Pathways. Int J Mol Sci (2016) 0.75

Articles by these authors

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia (1999) 8.17

A European evidence-based guideline for the prevention of type 2 diabetes. Horm Metab Res (2010) 3.15

Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med (1996) 2.92

Safety, tolerance, and pharmacokinetics of high-dose liposomal amphotericin B (AmBisome) in patients infected with Aspergillus species and other filamentous fungi: maximum tolerated dose study. Antimicrob Agents Chemother (2001) 2.03

Direct and indirect effects of amino acids on hepatic glucose metabolism in humans. Diabetologia (2003) 2.02

Take action to prevent diabetes--the IMAGE toolkit for the prevention of type 2 diabetes in Europe. Horm Metab Res (2010) 1.99

Current patterns and trends in male mortality by social class (based on occupation). Popul Trends (1996) 1.43

Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study. J Clin Endocrinol Metab (2000) 1.27

1H NMR relaxation times of skeletal muscle metabolites at 3 T. MAGMA (2004) 1.22

Diagnostic efficacy of unconjugated plasma metanephrines for the detection of pheochromocytoma. Arch Intern Med (2000) 1.16

Nutrient-induced insulin resistance in human skeletal muscle. Curr Med Chem (2004) 1.12

Lipid-dependent control of hepatic glycogen stores in healthy humans. Diabetologia (2001) 1.12

Transcapillary insulin transfer in human skeletal muscle. Eur J Clin Invest (2003) 1.08

Quantitative ATP synthesis in human liver measured by localized 31P spectroscopy using the magnetization transfer experiment. NMR Biomed (2008) 1.07

Precision and accuracy of blood glucose measurements using three different instruments. Diabet Med (2012) 1.07

Metabolically healthy and unhealthy obese--the 2013 Stock Conference report. Obes Rev (2014) 1.04

Dynamic interleaved 1H/31P STEAM MRS at 3 Tesla using a pneumatic force-controlled plantar flexion exercise rig. MAGMA (2005) 1.03

Pro- and anti-inflammatory cytokines in latent autoimmune diabetes in adults, type 1 and type 2 diabetes patients: Action LADA 4. Diabetologia (2011) 1.03

Mitochondrial fitness and insulin sensitivity in humans. Diabetologia (2008) 1.02

ESCI Award 2006. Mitochondrial function and endocrine diseases. Eur J Clin Invest (2007) 1.00

Acute elevation of plasma lipids does not affect ATP synthesis in human skeletal muscle. Am J Physiol Endocrinol Metab (2010) 1.00

Measurement of fractional whole-body gluconeogenesis in humans from blood samples using 2H nuclear magnetic resonance spectroscopy. Diabetes (2003) 0.99

Modulation by leptin of proliferation and apoptosis in vascular endothelial cells. Int J Obes Relat Metab Disord (2002) 0.97

Elevated serum concentrations of interleukin-10 in nonneutropenic patients with invasive aspergillosis. J Infect Dis (2001) 0.97

Quality indicators for the prevention of type 2 diabetes in Europe--IMAGE. Horm Metab Res (2010) 0.97

Glucose turnover and intima media thickness of internal carotid artery in type 2 diabetes offspring. Eur J Clin Invest (2008) 0.96

Transmission of an azole-resistant isogenic strain of Candida albicans among human immunodeficiency virus-infected family members with oropharyngeal candidiasis. J Clin Microbiol (1999) 0.96

Free fatty acids inhibit the glucose-stimulated increase of intramuscular glucose-6-phosphate concentration in humans. J Clin Endocrinol Metab (2001) 0.96

Dietary patterns, subclinical inflammation, incident coronary heart disease and mortality in middle-aged men from the MONICA/KORA Augsburg cohort study. Eur J Clin Nutr (2011) 0.95

Estimated glucose requirement following massive insulin overdose in a patient with type 1 diabetes. Diabet Med (1994) 0.95

Effects of short-term improvement of insulin treatment and glycemia on hepatic glycogen metabolism in type 1 diabetes. Diabetes (2001) 0.95

Three-dimensional high-resolution magnetic resonance spectroscopic imaging for absolute quantification of 31P metabolites in human liver. Magn Reson Med (2008) 0.94

Prevention of in vitro lipolysis by tetrahydrolipstatin. Clin Chem (2000) 0.93

Direct thiazolidinedione action on isolated rat skeletal muscle fuel handling is independent of peroxisome proliferator-activated receptor-gamma-mediated changes in gene expression. Diabetes (2001) 0.93

Intracellular calcium in the isolated rat liver: correlation to glucose release, K(+) balance and bile flow. Cell Calcium (2001) 0.92

Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes. J Intern Med (2011) 0.92

The impact of risk factors and more stringent diagnostic criteria of gestational diabetes on outcomes in central European women. J Clin Endocrinol Metab (2008) 0.92

Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver. Hepatology (1999) 0.92

Neuropad: evaluation of three cut-off points of sudomotor dysfunction for early detection of polyneuropathy in recently diagnosed diabetes. Diabet Med (2011) 0.92

High incidence of esophageal motor disorders in consecutive patients with globus sensation. Gastroenterology (1991) 0.90

Imeglimin increases glucose-dependent insulin secretion and improves β-cell function in patients with type 2 diabetes. Diabetes Obes Metab (2015) 0.89

Cerebral glutamate metabolism during hypoglycaemia in healthy and type 1 diabetic humans. Eur J Clin Invest (2006) 0.87

Stringent allele/epitope requirements for MART-1/Melan A immunodominance: implications for peptide-based immunotherapy. J Immunol (1998) 0.85

Dendritic cells infected with poxviruses encoding MART-1/Melan A sensitize T lymphocytes in vitro. J Immunother (1997) 0.85

Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. Diabetologia (2005) 0.84

Acute troglitazone action in isolated perfused rat liver. Br J Pharmacol (1999) 0.84

Elevated serum free fatty acid concentrations inhibit T lymphocyte signaling. FASEB J (2000) 0.84

Brain energy metabolism during hypoglycaemia in healthy and type 1 diabetic subjects. Diabetologia (2004) 0.83

Teenage pregnancy and parenthood: outcomes for mother and child. J Adolesc Health Care (1982) 0.83

Exercise induces excessive normetanephrine responses in hypertensive diabetic patients. Eur J Clin Invest (2003) 0.83

Sex-related psychological effects on metabolic control in type 2 diabetes mellitus. Diabetologia (2009) 0.82

Effects of pioglitazone versus glimepiride exposure on hepatocellular fat content in type 2 diabetes. Diabetes Obes Metab (2013) 0.82

Fasting and meal-stimulated residual beta cell function is positively associated with serum concentrations of proinflammatory cytokines and negatively associated with anti-inflammatory and regulatory cytokines in patients with longer term type 1 diabetes. Diabetologia (2013) 0.82

Troglitazone directly inhibits CO(2) production from glucose and palmitate in isolated rat skeletal muscle. J Pharmacol Exp Ther (2000) 0.82

General practitioners' retirement plans and what influences them. Br Med J (Clin Res Ed) (1986) 0.81

Glucose metabolism in pregnancy at high altitude. Diabetes Care (2001) 0.81

Islet amyloid polypeptide inhibits insulin secretion in conscious rats. Am J Physiol (1994) 0.81

Increased serum concentrations of adhesion molecules but not of chemokines in patients with Type 2 diabetes compared with patients with Type 1 diabetes and latent autoimmune diabetes in adult age: action LADA 5. Diabet Med (2012) 0.80

Maternal plasma glucose at high altitude. BJOG (2001) 0.80

Effects of free fatty acids on carbohydrate metabolism and insulin signalling in perfused rat liver. Eur J Clin Invest (2007) 0.80

Elevation of plasma leptin concentrations in obese hyperinsulinaemic hypothyroidism before and after treatment. Eur J Clin Invest (1999) 0.80

Free fatty acids/triglycerides increase ocular and subcutaneous blood flow. Am J Physiol Regul Integr Comp Physiol (2001) 0.80

Blood glucose testing and primary prevention of Type 2 diabetes-evaluation of the effect of evidence-based patient information: a randomized controlled trial. Diabet Med (2012) 0.80

Acute non-insulin-like stimulation of rat muscle glucose metabolism by troglitazone in vitro. Br J Pharmacol (1997) 0.79

Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism. Br J Pharmacol (1999) 0.79

More marked stimulation by lithium than insulin of the glycogenic pathway in rat skeletal muscle. Am J Physiol (1997) 0.79

Use of recombinant poxviruses to stimulate anti-melanoma T cell reactivity. Ann Surg Oncol (1998) 0.78

In vivo and in vitro evidence for a hepatic modulation of the leptin signal in rats. Eur J Clin Invest (2004) 0.78

Improved glucose tolerance by acute vanadate but not by selenate exposure in genetically obese rats (fa/fa). Int J Obes Relat Metab Disord (1995) 0.78

Endocrine patterns in patients with benign and malignant prostatic diseases. Prostate (2000) 0.78

Low-power water suppression by hyperbolic secant pulses with controlled offsets and delays (WASHCODE). J Magn Reson (2001) 0.78

Changes in hepatic glycogen cycling during a glucose load in healthy humans. Diabetologia (2005) 0.78

Effect of systemic vitamin C on free fatty acid-induced lipid peroxidation. Diabetes Metab (2004) 0.77

Inherited platelet glycoprotein polymorphisms and a risk for coronary heart disease in young central Europeans. Thromb Res (1998) 0.77

Effects of insulin-like growth factor I on basal and stimulated glucose fluxes in rat liver. Biochem J (2000) 0.77

Characterization of hepatic and brain metabolism in young adults with glycogen storage disease type 1: a magnetic resonance spectroscopy study. Am J Physiol Endocrinol Metab (2007) 0.77

Effect of near physiologic insulin therapy on hypoglycemia counterregulation in type-1 diabetes. Horm Res (2001) 0.77

News in gut-brain communication: a role of peptide YY (PYY) in human obesity and following bariatric surgery? Eur J Clin Invest (2005) 0.77

Insulin-like growth factor-I inhibits insulin and amylin secretion in conscious rats. Endocrinology (1994) 0.77

In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469. Naunyn Schmiedebergs Arch Pharmacol (2013) 0.77

Acute and chronic exposure to tumor necrosis factor-alpha fails to affect insulin-stimulated glucose metabolism of isolated rat soleus muscle. Endocrinology (1997) 0.77

Free fatty acids exert a greater effect on ocular and skin blood flow than triglycerides in healthy subjects. Eur J Clin Invest (2004) 0.77

Acute myopathy in a type 2 diabetic patient on combination therapy with metformin, fenofibrate and rosiglitazone. Diabetologia (2005) 0.76

Interferon beta treatment does not induce organ-specific autoantibodies in multiple sclerosis. Neurology (2009) 0.76

Spontaneous obesity-linked type 2 diabetes in the absence of islet amyloid in a cynomolgus monkey infected with bovine spongiform encephalopathy. Vet Pathol (2013) 0.76

Splenectomy in a child with chronic Mycobacterium avium complex infection and splenic sequestration. J Pediatr Surg (1998) 0.76

Failure of leptin to affect basal and insulin-stimulated glucose metabolism of rat skeletal muscle in vitro. Diabetologia (1998) 0.76

Effect of combined oral proteases and flavonoid treatment in subjects at risk of Type 1 diabetes. Diabet Med (2009) 0.76

Drug-testing in patients with pulmonary hypertension of unknown cause. Eur Heart J (1992) 0.76

Non-esterified fatty acid dynamics during oral glucose tolerance test in women with former gestational diabetes. Diabet Med (2012) 0.76

Pioglitazone elicits long-term improvements in insulin sensitivity in patients with type 2 diabetes: comparisons with gliclazide-based regimens. Diabetologia (2005) 0.76

In vivo magnetic resonance micro-imaging of the human toe at 3 Tesla. Magn Reson Imaging (2001) 0.75

[Rare cause of recurrent hypoglycaemia in type 1 diabetes mellitus--case 6/2013]. Dtsch Med Wochenschr (2013) 0.75

[Diabetes and the liver]. Dtsch Med Wochenschr (2013) 0.75

Effect of endothelin-1 in man--impact on basal and stimulated concentrations of luteinizing hormone, follicle-stimulating hormone, thyrotropin, growth hormone, corticotropin, and prolactin. Metabolism (1993) 0.75

Increase in skeletal muscle blood flow but not in renal blood flow during euglycemic hyperinsulinemia in man. Horm Metab Res (1993) 0.75

Insulin resistance caused by amylin in conscious rats is independent of induced hypocalcemia and fades during long-term exposure. Acta Endocrinol (Copenh) (1993) 0.75

Vanadium-induced Cl(-)-secretion in rabbit descending colon is mediated by prostaglandins. Biochim Biophys Acta (1992) 0.75