Drugs, QTc interval prolongation and final ICH E14 guideline : an important milestone with challenges ahead.

Drug-induced long QT syndrome. Pharmacol Rev (2010) 2.55

Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current. Circulation (2014) 1.86

Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives. Br J Pharmacol (2009) 1.57

Principles of safety pharmacology. Br J Pharmacol (2008) 1.27

Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice. Br J Clin Pharmacol (2013) 1.19

Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study. Eur J Clin Pharmacol (2007) 1.12

hERG gating microdomains defined by S6 mutagenesis and molecular modeling. J Gen Physiol (2008) 1.10

Discovery, development, and clinical application of sugammadex sodium, a selective relaxant binding agent. Drug Des Devel Ther (2009) 0.97

Exposure to antibacterial agents with QT liability in 14 European countries: trends over an 8-year period. Br J Clin Pharmacol (2008) 0.92

Does artesunate prolong the electrocardiograph QT interval in patients with severe malaria? Am J Trop Med Hyg (2009) 0.92

On the relationship among QT interval, atrial fibrillation, and torsade de pointes. Europace (2007) 0.86

Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator. Sci Adv (2015) 0.85

Stem cell-derived cardiomyocytes as a tool for studying proarrhythmia: a better canary in the coal mine? Circulation (2013) 0.83

Biological therapies: concepts and challenges. Wien Klin Wochenschr (2006) 0.83

Detection of QT prolongation using a novel electrocardiographic analysis algorithm applying intelligent automation: prospective blinded evaluation using the Cardiac Safety Research Consortium electrocardiographic database. Am Heart J (2012) 0.81

Management of chemotherapy-induced nausea and vomiting by risk profile: role of netupitant/palonosetron. Ther Clin Risk Manag (2016) 0.75

Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety? Sci Rep (2016) 0.75

Assessing risk of a prolonged QT interval-a survey of emergency physicians. Int J Emerg Med (2008) 0.75

Editors' review of 2006 and the BJCP prize. Br J Clin Pharmacol (2007) 0.75