1
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Genomic responses in mouse models poorly mimic human inflammatory diseases.
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Proc Natl Acad Sci U S A
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2013
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16.74
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A network-based analysis of systemic inflammation in humans.
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Nature
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2005
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12.60
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3
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A genomic storm in critically injured humans.
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J Exp Med
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2011
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6.67
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4
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Trial of short-course antimicrobial therapy for intraabdominal infection.
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N Engl J Med
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2015
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5.21
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5
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Application of genome-wide expression analysis to human health and disease.
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Proc Natl Acad Sci U S A
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2005
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3.49
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6
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Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections.
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J Infect Dis
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2002
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2.76
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7
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Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach.
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Mol Cell Proteomics
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2005
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2.50
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8
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Acute inflammatory response to endotoxin in mice and humans.
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Clin Diagn Lab Immunol
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2005
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2.47
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9
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Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry.
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Proteomics
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2005
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1.94
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10
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In vivo endotoxin synchronizes and suppresses clock gene expression in human peripheral blood leukocytes.
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Crit Care Med
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2010
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1.76
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Inflammation and the Host Response to Injury, a large-scale collaborative project: Patient-Oriented Research Core--standard operating procedures for clinical care. I. Guidelines for mechanical ventilation of the trauma patient.
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J Trauma
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2005
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1.73
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12
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Gender influences in vivo human responses to endotoxin.
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Shock
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2006
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1.61
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13
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The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells.
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Carcinogenesis
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2003
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1.41
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14
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Integrins are required for the differentiation of visceral endoderm.
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J Cell Sci
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2009
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1.26
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15
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Roles of SIRT1 in the acute and restorative phases following induction of inflammation.
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J Biol Chem
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2010
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1.18
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16
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Modeling the influence of circadian rhythms on the acute inflammatory response.
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J Theor Biol
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2010
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1.18
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17
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Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VIII--Nutritional support of the trauma patient.
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J Trauma
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2008
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1.12
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18
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Low-dose steroid alters in vivo endotoxin-induced systemic inflammation but does not influence autonomic dysfunction.
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J Endotoxin Res
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2007
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1.08
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19
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Agent-based modeling of endotoxin-induced acute inflammatory response in human blood leukocytes.
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PLoS One
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2010
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1.08
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20
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Effects of drotrecogin alfa (activated) in human endotoxemia.
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Shock
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2004
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1.07
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21
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Postoperative sepsis in the United States.
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Ann Surg
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2010
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1.06
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22
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Infectious complications after elective vascular surgical procedures.
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J Vasc Surg
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2009
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1.04
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23
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In silico simulation of corticosteroids effect on an NFkB- dependent physicochemical model of systemic inflammation.
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PLoS One
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2009
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1.04
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24
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Lipopolysaccharide and sepsis-associated myocardial dysfunction.
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Curr Opin Infect Dis
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2011
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1.03
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25
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Relationship of basal heart rate variability to in vivo cytokine responses after endotoxin exposure.
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Shock
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2010
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1.00
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26
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Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients.
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Clin Chem
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2008
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0.99
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27
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Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis.
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Mol Cell Biol
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2011
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0.97
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28
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Influence of acute epinephrine infusion on endotoxin-induced parameters of heart rate variability: a randomized controlled trial.
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Ann Surg
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2009
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0.96
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29
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Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation.
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J Immunol
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2005
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0.96
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30
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Modeling autonomic regulation of cardiac function and heart rate variability in human endotoxemia.
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Physiol Genomics
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2011
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0.95
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31
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Significant reduction in incidence of wound contamination by skin flora through use of microbial sealant.
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Arch Surg
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2008
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0.92
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32
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Rac1 is essential for basement membrane-dependent epiblast survival.
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Mol Cell Biol
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2010
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0.92
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33
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Benefit/risk profile of drotrecogin alfa (activated) in surgical patients with severe sepsis.
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Am J Surg
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2004
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0.92
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34
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A novel model of common Toll-like receptor 4- and injury-induced transcriptional themes in human leukocytes.
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Crit Care
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2010
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0.91
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35
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Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure.
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Crit Care Med
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2003
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0.91
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36
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Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4).
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Clin Immunol
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2006
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0.91
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37
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Modulation of the lipopolysaccharide receptor complex (CD14, TLR4, MD-2) and toll-like receptor 2 in systemic inflammatory response syndrome-positive patients with and without infection: relationship to tolerance.
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Shock
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2003
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0.91
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38
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Entrainment of peripheral clock genes by cortisol.
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Physiol Genomics
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2012
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0.90
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39
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A dual negative regulation model of Toll-like receptor 4 signaling for endotoxin preconditioning in human endotoxemia.
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Math Biosci
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2011
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0.89
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40
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Multiscale model for the assessment of autonomic dysfunction in human endotoxemia.
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Physiol Genomics
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2010
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0.89
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41
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In-hospital delay of elective surgery for high volume procedures: the impact on infectious complications.
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J Am Coll Surg
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2010
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0.87
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42
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Trends in postoperative sepsis: are we improving outcomes?
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Surg Infect (Larchmt)
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2009
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0.87
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43
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Computational identification of transcriptional regulators in human endotoxemia.
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PLoS One
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2011
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0.86
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44
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A physiological model for autonomic heart rate regulation in human endotoxemia.
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Shock
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2011
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0.86
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45
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Transcriptional implications of ultradian glucocorticoid secretion in homeostasis and in the acute stress response.
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Physiol Genomics
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2011
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0.85
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46
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Impact of infectious complications after elective surgery on hospital readmission and late deaths in the U.S. Medicare population.
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Surg Infect (Larchmt)
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2012
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0.82
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47
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An agent-based model of cellular dynamics and circadian variability in human endotoxemia.
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PLoS One
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2013
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0.82
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48
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Voluntarily produced increases in heart rate variability modulate autonomic effects of endotoxin induced systemic inflammation: an exploratory study.
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Appl Psychophysiol Biofeedback
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2010
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0.80
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49
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Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis.
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Arterioscler Thromb Vasc Biol
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2011
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0.79
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50
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Cellular metabolic regulators: novel indicators of low-grade inflammation in humans.
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Ann Surg
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2014
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0.79
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51
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Influence of the TNF-alpha and TNF-beta polymorphisms upon infectious risk and outcome in surgical intensive care patients.
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Surg Infect (Larchmt)
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2003
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0.79
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52
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Pulsatile glucocorticoid secretion: origins and downstream effects.
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IEEE Trans Biomed Eng
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2011
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0.79
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53
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A single nucleotide polymorphism in the Mdm2 promoter and risk of sepsis.
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Am J Surg
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2008
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0.78
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54
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Safety of drotrecogin alfa (activated) in surgical patients with severe sepsis.
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Surg Infect (Larchmt)
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2004
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0.78
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55
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Activated protein C suppresses adrenomedullin and ameliorates lipopolysaccharide-induced hypotension.
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Shock
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2007
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0.78
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56
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Fas-mediated neutrophil apoptosis and associated A1 protein expression during systemic inflammation are regulated independently of both tumor necrosis factor receptors.
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Shock
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2003
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0.78
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57
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The impact of hospital volume on the development of infectious complications after elective abdominal aortic surgery in the Medicare population.
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Vasc Endovascular Surg
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2011
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0.78
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58
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Physiologic variability at the verge of systemic inflammation: multiscale entropy of heart rate variability is affected by very low doses of endotoxin.
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Shock
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2015
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0.78
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59
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Continuous enteral and parenteral feeding each reduces heart rate variability but differentially influences monocyte gene expression in humans.
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Shock
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2012
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0.77
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60
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Tumor necrosis factor receptor regulation of bone marrow cell apoptosis during endotoxin-induced systemic inflammation.
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Shock
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2006
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0.77
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61
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Polymorphisms of heat shock protein-70 (HSPA1B and HSPA1L loci) do not influence infection or outcome risk in critically ill surgical patients.
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Shock
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2006
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0.77
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62
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Alterations in immunocyte tumor necrosis factor receptor and apoptosis in patients with congestive heart failure.
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Ann Surg
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2002
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0.75
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63
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Predictors of educational outcome: factors impacting performance on a standardized clinical evaluation.
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J Surg Res
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2002
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0.75
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Perspectives on healthcare from the 2011 Edward J. Ill Excellence in Medicine honorees.
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MD Advis
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2011
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0.75
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65
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University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School.
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Acad Med
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2010
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0.75
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66
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Insulin-like growth factor binding protein-3 is upregulated in LPS-treated THP-1 cells.
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Surg Infect (Larchmt)
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2002
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0.75
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