Published in J Neurosci on October 19, 2005
Molecular mechanisms of neurodegeneration in Alzheimer's disease. Hum Mol Genet (2010) 1.90
Interruption of beta-catenin signaling reduces neurogenesis in Alzheimer's disease. J Neurosci (2009) 1.72
Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons. Cell Cycle (2012) 1.62
Parkinson's disease and cancer: two wars, one front. Nat Rev Cancer (2011) 1.45
An unusual member of the Cdk family: Cdk5. Cell Mol Neurobiol (2008) 1.36
Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons. Proc Natl Acad Sci U S A (2008) 1.31
Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. J Neurosci (2008) 1.23
The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. Mol Neurodegener (2009) 1.23
Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. J Neurosci (2010) 1.21
Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J (2010) 1.14
CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression. Sci Rep (2013) 1.11
Making a neuron: Cdk5 in embryonic and adult neurogenesis. Trends Neurosci (2009) 1.08
Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation. J Biol Chem (2010) 1.06
Vitamin D and differentiation in cancer. Crit Rev Clin Lab Sci (2009) 1.05
Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches. BMB Rep (2009) 1.04
Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons. Mol Biol Cell (2012) 1.04
Molecular pathology of neuro-AIDS (CNS-HIV). Int J Mol Sci (2009) 1.04
Cdk5 and the non-catalytic arrest of the neuronal cell cycle. Cell Cycle (2008) 1.00
Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration. Am J Pathol (2009) 0.95
p57(KIP2) regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex. Development (2012) 0.95
Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease. Cell Death Dis (2011) 0.95
MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin. BMC Neurosci (2012) 0.93
Targeting Cdk5 activity in neuronal degeneration and regeneration. Cell Mol Neurobiol (2009) 0.91
Regulation of sirtuin function by posttranslational modifications. Front Pharmacol (2012) 0.91
CDK5 activator protein p25 preferentially binds and activates GSK3β. Proc Natl Acad Sci U S A (2014) 0.89
CDK5 is a major regulator of the tumor suppressor DLC1. J Cell Biol (2014) 0.89
Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1). J Neurosci (2011) 0.88
The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics. J Biol Chem (2011) 0.87
Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation. Mol Biol Cell (2010) 0.87
Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders. Genes Cells (2013) 0.87
Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase. J Biol Chem (2012) 0.85
Cyclin-dependent kinase 5, a node protein in diminished tauopathy: a systems biology approach. Front Aging Neurosci (2014) 0.83
Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression. Oncol Rep (2014) 0.83
Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation. Dev Biol (2013) 0.82
The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins. J Neurochem (2008) 0.81
Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5. Neurosci Lett (2006) 0.81
Protein kinase Czeta regulates Cdk5/p25 signaling during myogenesis. Mol Biol Cell (2010) 0.80
The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation. Cell Mol Life Sci (2011) 0.79
Cyclin-dependent kinase 5 is required for normal cerebellar development. Mol Cell Neurosci (2012) 0.79
Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. Curr HIV Res (2015) 0.79
Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo. Biochem Biophys Res Commun (2009) 0.79
Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells. Hum Mol Genet (2014) 0.78
The evolutionary young miR-1290 favors mitotic exit and differentiation of human neural progenitors through altering the cell cycle proteins. Cell Death Dis (2014) 0.78
Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. Br J Pharmacol (2014) 0.78
Fibroblast growth factor receptor 3 regulates microtubule formation and cell surface mechanical properties in the developing organ of Corti. Bioarchitecture (2012) 0.78
Nucleocytoplasmic transfer of cyclin dependent kinase 5 and its binding to puromycin-sensitive aminopeptidase in Dictyostelium discoideum. Histochem Cell Biol (2011) 0.78
The roles of Cdk5-mediated subcellular localization of FOXO1 in neuronal death. J Neurosci (2015) 0.78
A Unified Hypothesis of Early- and Late-Onset Alzheimer's Disease Pathogenesis. J Alzheimers Dis (2015) 0.77
Early postnatal in vivo gliogenesis from nestin-lineage progenitors requires cdk5. PLoS One (2013) 0.76
p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1). PLoS One (2014) 0.76
Cyclin-dependent kinase 5 activity is required for allogeneic T cell responses after hematopoietic cell transplantation in mice. Blood (2016) 0.75
Transient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice. Oncotarget (2016) 0.75
Cdk5 links with DNA damage response and cancer. Mol Cancer (2017) 0.75
The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and Myelination. J Neurosci (2016) 0.75
ATM and the epigenetics of the neuronal genome. Mech Ageing Dev (2013) 0.75
Effect of GAPT extract on expression of tau protein and its phosphorylation related enzymes in hippocampal neurons of APPV717I transgenic mice. Chin J Integr Med (2017) 0.75
Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. J Neurosci (2003) 2.14
Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci (2008) 1.84
The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc Natl Acad Sci U S A (2002) 1.64
Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models. J Neurosci (2006) 1.60
Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Nat Med (2012) 1.42
Cell division in the CNS: protective response or lethal event in post-mitotic neurons? Biochim Biophys Acta (2006) 1.41
Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism. J Neurosci (2005) 1.40
Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons. Proc Natl Acad Sci U S A (2008) 1.31
Cytoplasmic ATM in neurons modulates synaptic function. Curr Biol (2009) 1.26
Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. J Neurosci (2008) 1.23
The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. Mol Neurodegener (2009) 1.23
NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J Clin Invest (2009) 1.23
Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. J Neurosci (2010) 1.21
A question of balance: a proposal for new mouse models of autism. Int J Dev Neurosci (2005) 1.16
EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia. Nat Neurosci (2013) 1.06
Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation. J Biol Chem (2010) 1.06
Factors in the genetic background suppress the engrailed-1 cerebellar phenotype. J Neurosci (2003) 1.04
Cdk5 and the non-catalytic arrest of the neuronal cell cycle. Cell Cycle (2008) 1.00
E2F1 works as a cell cycle suppressor in mature neurons. J Neurosci (2007) 1.00
Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons. Cell Cycle (2011) 0.97
Modulation of neuritogenesis by a protein implicated in X-linked mental retardation. J Neurosci (2009) 0.97
Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease. Neurobiol Aging (2010) 0.97
The mouse Engrailed genes: a window into autism. Behav Brain Res (2006) 0.95
A comparative study of five mouse models of Alzheimer's disease: cell cycle events reveal new insights into neurons at risk for death. Int J Alzheimers Dis (2011) 0.93
Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasia. J Neurosci (2011) 0.93
Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress. PLoS One (2012) 0.92
Effects of Alzheimer's disease on different cortical layers: the role of intrinsic differences in Abeta susceptibility. J Neurosci (2007) 0.89
DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's disease. Mol Neurodegener (2010) 0.87
Use of live theater to increase minority participation in Alzheimer disease research. Alzheimer Dis Assoc Disord (2006) 0.87
Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase. J Biol Chem (2012) 0.85
Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation. Dev Biol (2013) 0.82
A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype. Brain Res (2006) 0.79
Selective vulnerability of neurons in primary cultures and in neurodegenerative diseases. Rev Neurosci (2008) 0.79
The effect of garden designs on mood and heart output in older adults residing in an assisted living facility. HERD (2013) 0.78
Cell number in the inferior olive of nervous and leaner mutant mice. J Neurogenet (2004) 0.77
Dissecting complex genetic interactions that influence the Engrailed-1 limb phenotype. Mamm Genome (2004) 0.77
Correction: The Interaction of the Atm Genotype with Inflammation and Oxidative Stress. PLoS One (2015) 0.76
Purkinje cell expression of the mouse aldolase C gene in transgenic mice is directed by an upstream regulatory element. Brain Res Mol Brain Res (2005) 0.76
Cell loss in the inferior olive of the staggerer mutant mouse is an indirect effect of the gene. J Neurogenet (2007) 0.76
Development of cerebellar modules: extrinsic control of late-phase zebrin II pattern and the exploration of rat/mouse species differences. Mol Cell Neurosci (2003) 0.76
Remote gaze tracking system for 3D environments. Conf Proc IEEE Eng Med Biol Soc (2017) 0.75