Novel function for vascular endothelial growth factor receptor-1 on epidermal keratinocytes.

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMC 1603795)

Published in Am J Pathol on November 01, 2005

Authors

Traci A Wilgus1, Annette M Matthies, Katherine A Radek, Julia V Dovi, Aime L Burns, Ravi Shankar, Luisa A DiPietro

Author Affiliations

1: Department of Surgery, Loyola University Medical Center, Burn and Shock Trauma Institute, 2160 S. First Ave., Maywood, IL 60153, USA.

Articles citing this

Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. J Cell Physiol (2008) 1.52

Uncovering Pandora's vase: the growing problem of new toxicities from novel anticancer agents. The case of sorafenib and sunitinib. Clin Exp Med (2008) 1.47

Hypertrophic scar formation following burns and trauma: new approaches to treatment. PLoS Med (2007) 1.42

Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis. Matrix Biol (2009) 1.40

Coordinated vascular endothelial growth factor expression and signaling during skeletal myogenic differentiation. Mol Biol Cell (2007) 1.26

Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair. Adv Wound Care (New Rochelle) (2014) 1.11

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice. J Clin Invest (2013) 1.11

Immunolocalization and expression of vascular endothelial growth factor receptors (VEGFRs) and neuropilins (NRPs) on keratinocytes in human epidermis. Mol Med (2006) 1.09

SPARC-induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion. Int J Cancer (2008) 1.06

Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. Am J Pathol (2008) 1.05

Neuropilins: expression and roles in the epithelium. Int J Exp Pathol (2012) 0.98

Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis. Am J Respir Crit Care Med (2009) 0.94

Cutaneous manipulation of vascular growth factors leads to alterations in immunocytes, blood vessels and nerves: Evidence for a cutaneous neurovascular unit. J Dermatol Sci (2010) 0.93

Brewing complications: the effect of acute ethanol exposure on wound healing. J Leukoc Biol (2009) 0.93

Overexpression of vascular endothelial growth factor (VEGF) receptors on keratinocytes in psoriasis: regulated by calcium independent of VEGF. J Cell Mol Med (2008) 0.92

Infectious spleen and kidney necrosis virus ORF48R functions as a new viral vascular endothelial growth factor. J Virol (2008) 0.89

The Roles of Growth Factors in Keratinocyte Migration. Adv Wound Care (New Rochelle) (2015) 0.88

Skin rejuvenation with non-invasive pulsed electric fields. Sci Rep (2015) 0.85

Multiple roles for VEGF in non-melanoma skin cancer: angiogenesis and beyond. J Skin Cancer (2012) 0.83

Epidermal expression of neuropilin 1 protects murine keratinocytes from UVB-induced apoptosis. PLoS One (2012) 0.82

Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas. Lab Invest (2014) 0.79

Role of VEGF receptors in normal and psoriatic human keratinocytes: evidence from irradiation with different UV sources. PLoS One (2013) 0.78

Tyrosine kinases in inflammatory dermatologic disease. J Am Acad Dermatol (2010) 0.76

VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors. Oncogene (2016) 0.76

VEGF involvement in psoriasis. Clujul Med (2015) 0.76

Anti-Angiogenic Drugs: Involvement in Cutaneous Side Effects and Wound-Healing Complication. Adv Wound Care (New Rochelle) (2014) 0.75

Keratinocytic vascular endothelial growth factor as a novel biomarker for pathological skin condition. Biomol Ther (Seoul) (2015) 0.75

From Inflammation to Current and Alternative Therapies Involved in Wound Healing. Int J Inflam (2017) 0.75

Articles cited by this

The biology of VEGF and its receptors. Nat Med (2003) 32.13

Vascular endothelial growth factor is a secreted angiogenic mitogen. Science (1989) 16.71

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood (1996) 5.31

Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med (1992) 4.39

Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem (1995) 3.30

Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol (2004) 3.13

Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med (1994) 3.09

Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am J Pathol (1998) 3.05

Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J Natl Cancer Inst (1995) 2.44

Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin. Am J Pathol (1996) 2.42

Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood (2001) 2.39

Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc Natl Acad Sci U S A (1993) 2.32

Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem (1997) 2.07

Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of flt-1. Circ Res (1998) 2.06

Control of hair growth and follicle size by VEGF-mediated angiogenesis. J Clin Invest (2001) 2.04

Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Blood (2003) 2.03

Impaired wound repair and delayed angiogenesis in aged mice. Lab Invest (1999) 1.67

Expression of vascular endothelial growth factor (VEGF) and its two receptors (VEGF-R1-Flt1 and VEGF-R2-Flk1/KDR) in non-small cell lung carcinomas (NSCLCs): correlation with angiogenesis and survival. J Pathol (1999) 1.63

VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development. Oncogene (1998) 1.61

Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells. J Invest Dermatol (1995) 1.39

Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: balance between growth and death signals. J Mol Cell Cardiol (1997) 1.32

Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis. Br J Dermatol (1999) 1.31

Tracking angiogenesis induced by skin wounding and contact hypersensitivity using a Vegfr2-luciferase transgenic mouse. Blood (2003) 1.31

Increased expression of vascular permeability factor (vascular endothelial growth factor) in bullous pemphigoid, dermatitis herpetiformis, and erythema multiforme. J Invest Dermatol (1995) 1.30

Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression. FASEB J (2003) 1.30

Specific binding of vascular permeability factor to endothelial cells. Biochem Biophys Res Commun (1991) 1.28

Adenovirus-mediated VEGF(165) gene transfer enhances wound healing by promoting angiogenesis in CD1 diabetic mice. Gene Ther (2002) 1.26

Strong expression of kinase insert domain-containing receptor, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma. Am J Pathol (1996) 1.23

Angiogenesis and malignant melanoma. Angiogenesis is related to the development of vertical (tumorigenic) growth phase. J Cutan Pathol (1997) 1.23

Loss of vascular endothelial growth factor a activity in murine epidermal keratinocytes delays wound healing and inhibits tumor formation. Cancer Res (2004) 1.23

Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels. Cancer Res (1996) 1.13

Mast cells modulate the inflammatory but not the proliferative response in healing wounds. Wound Repair Regen (2003) 1.12

Vascular endothelial growth factor production in normal epidermis and in benign and malignant epithelial skin tumors. Lab Invest (1996) 1.11

Vascular endothelial growth factor is an autocrine growth factor for hair dermal papilla cells. J Invest Dermatol (1996) 1.08

Production of VEGF and expression of the VEGF receptors Flt-1 and KDR in primary cultures of epithelial and stromal cells derived from breast tumours. Br J Cancer (1999) 1.06

Vascular endothelial growth factor VEGF189 induces human neutrophil chemotaxis in extravascular tissue via an autocrine amplification mechanism. Lab Invest (2004) 1.03

Identification and characterization of vascular endothelial growth factor receptor (Flt) in bovine retinal pericytes. Diabetes (1996) 1.02

Recombinant AAV vector encoding human VEGF165 enhances wound healing. Gene Ther (2002) 1.02

Uterine smooth muscle cells express functional receptors (flt-1 and KDR) for vascular permeability factor/vascular endothelial growth factor. Lab Invest (1997) 0.99

Discordant effects of a soluble VEGF receptor on wound healing and angiogenesis. Gene Ther (2004) 0.95

Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) in esophageal squamous cell carcinoma. Anticancer Res (2003) 0.95

Promoted growth of murine hair follicles through controlled release of vascular endothelial growth factor. Biomaterials (2002) 0.94

The effect of thrombocytopenia on dermal wound healing. J Invest Dermatol (2003) 0.94

Role of alpha(v) integrins and angiogenesis during wound repair. Wound Repair Regen (1999) 0.93

The angiogenesis inhibitor vasostatin does not impair wound healing at tumor-inhibiting doses. J Invest Dermatol (2001) 0.91

Vascular endothelial growth factor receptor-2-mediated mitogenesis is negatively regulated by vascular endothelial growth factor receptor-1 in tumor epithelial cells. Am J Pathol (2001) 0.91

Retroviral delivery of dominant-negative vascular endothelial growth factor receptor type 2 to murine wounds inhibits wound angiogenesis. Wound Repair Regen (2002) 0.89

Loss of vascular endothelial growth factor in human alopecia hair follicles. J Invest Dermatol (1995) 0.89

Sox18 is transiently expressed during angiogenesis in granulation tissue of skin wounds with an identical expression pattern to Flk-1 mRNA. Lab Invest (2001) 0.89

Liposome-mediated transfer of vascular endothelial growth factor cDNA augments survival of random-pattern skin flaps in the rat. Wound Repair Regen (2004) 0.86

Evidence for vascular endothelial growth factor (VEGF) as a modifier gene in psoriasis. J Invest Dermatol (2004) 0.86

Vascular endothelial growth factor-mediated angiogenesis inhibition and postoperative wound healing in rats. J Surg Res (2002) 0.84

CM101 stimulates cutaneous wound healing through an anti-angiogenic mechanism. Angiogenesis (2001) 0.80

Articles by these authors

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature (2008) 7.10

Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med (2009) 3.32

Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. J Biol Chem (2007) 2.82

Selective and specific macrophage ablation is detrimental to wound healing in mice. Am J Pathol (2009) 2.45

Accelerated wound closure in neutrophil-depleted mice. J Leukoc Biol (2003) 2.35

The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury. Immunity (2012) 2.17

Aging and wound healing. World J Surg (2004) 2.12

Mast cells contribute to scar formation during fetal wound healing. J Invest Dermatol (2011) 1.79

Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections. J Invest Dermatol (2010) 1.79

Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Am J Pathol (2004) 1.77

Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest (2007) 1.72

Clinical and experimental applications of NIR-LED photobiomodulation. Photomed Laser Surg (2006) 1.67

Mechanical unloading impairs keratinocyte migration and angiogenesis during cutaneous wound healing. J Appl Physiol (1985) (2008) 1.47

Local burn injury impairs epithelial permeability and antimicrobial peptide barrier function in distal unburned skin. Crit Care Med (2014) 1.47

Energy dependence of response of new high sensitivity radiochromic films for megavoltage and kilovoltage radiation energies. Med Phys (2005) 1.44

Activated mesenchymal stem cells increase wound tensile strength in aged mouse model via macrophages. J Surg Res (2012) 1.44

Symptomatic and pathophysiologic predictors of hepatitis C virus progression in pediatric patients. Pediatr Infect Dis J (2009) 1.40

Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis. J Cell Biol (2007) 1.36

Modeling guidelines for integration into clinical workflow. Stud Health Technol Inform (2004) 1.32

Neutrophil function in the healing wound: adding insult to injury? Thromb Haemost (2004) 1.27

Positional differences in the wound transcriptome of skin and oral mucosa. BMC Genomics (2010) 1.20

De novo sequencing and characterization of Picrorhiza kurrooa transcriptome at two temperatures showed major transcriptome adjustments. BMC Genomics (2012) 1.19

Toll-like receptor 4 has an essential role in early skin wound healing. J Invest Dermatol (2012) 1.19

Diminished induction of skin fibrosis in mice with MCP-1 deficiency. J Invest Dermatol (2006) 1.18

Site-specific production of TGF-beta in oral mucosal and cutaneous wounds. Wound Repair Regen (2007) 1.17

Latent infection with Leishmania donovani in highly endemic villages in Bihar, India. PLoS Negl Trop Dis (2013) 1.16

Immunologic responses to critical injury and sepsis. J Intensive Care Med (2006) 1.12

Mast cells modulate the inflammatory but not the proliferative response in healing wounds. Wound Repair Regen (2003) 1.12

Acute ethanol exposure impairs angiogenesis and the proliferative phase of wound healing. Am J Physiol Heart Circ Physiol (2005) 1.11

Inflammation in surgical wound healing: friend or foe? Surgery (2005) 1.09

Neutrophil antimicrobial defense against Staphylococcus aureus is mediated by phagolysosomal but not extracellular trap-associated cathelicidin. J Leukoc Biol (2009) 1.08

Using an integrated ontology and information model for querying and reasoning about phenotypes: The case of autism. AMIA Annu Symp Proc (2008) 1.08

Exercise accelerates cutaneous wound healing and decreases wound inflammation in aged mice. Am J Physiol Regul Integr Comp Physiol (2007) 1.08

Effects of acute ethanol exposure on the early inflammatory response after excisional injury. Alcohol Clin Exp Res (2007) 1.01

Mechanisms of vessel regression: toward an understanding of the resolution of angiogenesis. Curr Top Microbiol Immunol (2013) 1.01

Three years of medical humanities at a new Nepalese medical school. Educ Health (Abingdon) (2011) 1.00

Norepinephrine modulates the inflammatory and proliferative phases of wound healing. J Trauma (2006) 0.99

Adrenergic modulation of splenic macrophage cytokine release in polymicrobial sepsis. Am J Physiol Cell Physiol (2004) 0.99

Inhibition of multidrug-resistant Acinetobacter baumannii by nonviral expression of hCAP-18 in a bioengineered human skin tissue. Mol Ther (2009) 0.98

Selectivity- and size-induced segregation of molecular and nanoscale species in microphase-ordered triblock copolymers. Nano Lett (2006) 0.98

Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells. Am J Physiol Heart Circ Physiol (2008) 0.97

Bone marrow norepinephrine mediates development of functionally different macrophages after thermal injury and sepsis. Ann Surg (2004) 0.97

TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice. Lab Invest (2010) 0.96

Bioluminescence imaging of calvarial bone repair using bone marrow and adipose tissue-derived mesenchymal stem cells. Biomaterials (2007) 0.95

Importance of housekeeping gene selection for accurate reverse transcription-quantitative polymerase chain reaction in a wound healing model. Wound Repair Regen (2010) 0.95

Murine hematopoietic stem cells and progenitors express adrenergic receptors. J Neuroimmunol (2007) 0.95

Fibroblast function and wound breaking strength is impaired by acute ethanol intoxication. Alcohol Clin Exp Res (2010) 0.95

Propranolol restores the tumor necrosis factor-alpha response of circulating inflammatory monocytes and granulocytes after burn injury and sepsis. J Burn Care Res (2009) 0.94

The effect of thrombocytopenia on dermal wound healing. J Invest Dermatol (2003) 0.94

An epidemiological study on pattern and incidence of mandibular fractures. Plast Surg Int (2012) 0.93

Brewing complications: the effect of acute ethanol exposure on wound healing. J Leukoc Biol (2009) 0.93

Lessons learned from psoriatic plaques concerning mechanisms of tissue repair, remodeling, and inflammation. J Investig Dermatol Symp Proc (2006) 0.92

Chronic alcohol exposure renders epithelial cells vulnerable to bacterial infection. PLoS One (2013) 0.91

Reliability of radiological classifications used in Legg-Calve-Perthes disease. J Pediatr Orthop B (2006) 0.91

Burn injury and pulmonary sepsis: development of a clinically relevant model. J Trauma (2004) 0.91

The effect of MCP-1 depletion on chemokine and chemokine-related gene expression: evidence for a complex network in acute inflammation. Cytokine (2005) 0.90

The effect of sepsis on wound healing. J Surg Res (2002) 0.90

Perturbed bone marrow monocyte development following burn injury and sepsis promote hyporesponsive monocytes. J Burn Care Res (2008) 0.90

Norepinephrine-mediated suppression of phagocytosis by wound neutrophils. J Surg Res (2008) 0.90

Expression of epidermal CAMP changes in parallel with permeability barrier status. J Invest Dermatol (2011) 0.90

The association of mast cells and serotonin in children with chronic abdominal pain of unknown etiology. BMC Res Notes (2010) 0.89

Severity of burn injury and sepsis determines the cytokine responses of bone marrow progenitor-derived macrophages. J Trauma (2007) 0.89

Norepinephrine suppresses wound macrophage phagocytic efficiency through alpha- and beta-adrenoreceptor dependent pathways. Surgery (2007) 0.89

Comprehensive transcriptomic study on horse gram (Macrotyloma uniflorum): De novo assembly, functional characterization and comparative analysis in relation to drought stress. BMC Genomics (2013) 0.89

Flanking region sequence information to refine microRNA target predictions. J Biosci (2010) 0.89

Inverse relationship of interleukin-6 and mast cells in children with inflammatory and non-inflammatory abdominal pain phenotypes. World J Gastrointest Pathophysiol (2012) 0.88

Absence of CD4 or CD8 lymphocytes changes infiltration of inflammatory cells and profiles of cytokine expression in skin wounds, but does not impair healing. Exp Dermatol (2014) 0.88

Analysis of progenitor cell-scaffold combinations by in vivo non-invasive photonic imaging. Biomaterials (2007) 0.88

Complex roles for VEGF in dermal wound healing. J Invest Dermatol (2011) 0.88

Adrenergic modulation of cytokine release in bone marrow progenitor-derived macrophage following polymicrobial sepsis. J Neuroimmunol (2005) 0.88

Matrix proteolytic activity during wound healing: modulation by acute ethanol exposure. Alcohol Clin Exp Res (2007) 0.88

Thermal injury and sepsis modulates beta-adrenergic receptors and cAMP responses in monocyte-committed bone marrow cells. J Neuroimmunol (2005) 0.88

The candidate tumor suppressor gene Ecrg4 as a wound terminating factor in cutaneous injury. Arch Dermatol Res (2012) 0.87

Neuropilin-1 participates in wound angiogenesis. Am J Pathol (2002) 0.87

De novo transcriptome sequencing and analysis for Venturia inaequalis, the devastating apple scab pathogen. PLoS One (2013) 0.87

Sprouty2 downregulates angiogenesis during mouse skin wound healing. Am J Physiol Heart Circ Physiol (2010) 0.87

A mouse model of burn wounding and sepsis. Methods Mol Med (2003) 0.86

Spironolactone does not prevent acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial by SPACE Trial Group (spironolactone and acetazolamide trial in the prevention of acute mountain sickness group). Wilderness Environ Med (2010) 0.86

Acetazolamide fails to decrease pulmonary artery pressure at high altitude in partially acclimatized humans. High Alt Med Biol (2008) 0.86

Nonviral human beta defensin-3 expression in a bioengineered human skin tissue: a therapeutic alternative for infected wounds. Wound Repair Regen (2012) 0.86

Sugar-coating wound repair: a review of FGF-10 and dermatan sulfate in wound healing and their potential application in burn wounds. J Burn Care Res (2012) 0.86

Cholinergic regulation of keratinocyte innate immunity and permeability barrier integrity: new perspectives in epidermal immunity and disease. J Invest Dermatol (2011) 0.85

Dendritic cell depletion in burn patients is regulated by MafB expression. J Burn Care Res (2012) 0.85

Psychological stress regulates antimicrobial peptide expression by both glucocorticoid and β-adrenergic mechanisms. Eur J Dermatol (2011) 0.85

Hepatitis C progressing to hepatocellular carcinoma: the HCV dialysis patient in dilemma. J Viral Hepat (2009) 0.85

IV insulin during acute cerebral infarction in diabetic patients. Neurology (2004) 0.85

Classifying transfusions related to the anemia of critical illness in burn patients. J Trauma (2011) 0.85

Galactorrhea and amenorrhea in burn patients. Burns (2008) 0.84

Mesenchymal stem cells facilitate fracture repair in an alcohol-induced impaired healing model. J Orthop Trauma (2012) 0.83

High MafB expression following burn augments monocyte commitment and inhibits DC differentiation in hemopoietic progenitors. J Leukoc Biol (2011) 0.83

Exogenous pro-angiogenic stimuli cannot prevent physiologic vessel regression. J Surg Res (2006) 0.83

Employing machine learning for reliable miRNA target identification in plants. BMC Genomics (2011) 0.83

Alcohol exposure and mechanisms of tissue injury and repair. Alcohol Clin Exp Res (2010) 0.83

Exercise speeds cutaneous wound healing in high-fat diet-induced obese mice. Med Sci Sports Exerc (2012) 0.82