Ivermectin imposes selection pressure on P-glycoprotein from Onchocerca volvulus: linkage disequilibrium and genotype diversity.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMID 16280093)

Published in Parasitology on November 09, 2005

Authors

B F Ardelli1, S B Guerriero, R K Prichard

Author Affiliations

1: Institute of Parasitology, Macdonald Campus, McGill University, 21 111 Lakeshore Road, Ste. Anne de Bellevue, Quebec, Canada H9X 3V9.

Articles citing this

Genetic selection of low fertile Onchocerca volvulus by ivermectin treatment. PLoS Negl Trop Dis (2007) 1.44

Genetic consequences of mass human chemotherapy for Schistosoma mansoni: population structure pre- and post-praziquantel treatment in Tanzania. Am J Trop Med Hyg (2010) 1.31

Ivermectin resistance in Onchocerca volvulus: toward a genetic basis. PLoS Negl Trop Dis (2007) 1.20

P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: Prospects for reversing transport-dependent anthelmintic resistance. Int J Parasitol Drugs Drug Resist (2011) 1.20

Evolutionary concepts in predicting and evaluating the impact of mass chemotherapy schistosomiasis control programmes on parasites and their hosts. Evol Appl (2008) 1.13

Dynamics of Onchocerca volvulus microfilarial densities after ivermectin treatment in an ivermectin-naïve and a multiply treated population from Cameroon. PLoS Negl Trop Dis (2013) 0.96

Salmon lice (Lepeophtheirus salmonis) showing varying emamectin benzoate susceptibilities differ in neuronal acetylcholine receptor and GABA-gated chloride channel mRNA expression. BMC Genomics (2013) 0.94

Genetic knockdown and pharmacological inhibition of parasite multidrug resistance transporters disrupts egg production in Schistosoma mansoni. PLoS Negl Trop Dis (2011) 0.92

Anthelmintics are substrates and activators of nematode P glycoprotein. Antimicrob Agents Chemother (2011) 0.91

Pharmacology and potential physiological significance of schistosome multidrug resistance transporters. Exp Parasitol (2011) 0.90

An analysis of genetic diversity and inbreeding in Wuchereria bancrofti: implications for the spread and detection of drug resistance. PLoS Negl Trop Dis (2008) 0.80

The role of Brugia malayi ATP-binding cassette (ABC) transporters in potentiating drug sensitivity. Parasitol Res (2011) 0.79

ABC-B transporter genes in Dirofilaria immitis. Int J Parasitol Drugs Drug Resist (2016) 0.75

Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity. PLoS Negl Trop Dis (2017) 0.75

Articles by these authors

(truncated to the top 100)

The detection of anthelmintic resistance in nematodes of veterinary importance. Vet Parasitol (2006) 2.37

The problem of anthelmintic resistance in nematodes. Aust Vet J (1980) 1.22

A comparison of genetic polymorphism in populations of Onchocerca volvulus from untreated- and ivermectin-treated patients. Mol Biochem Parasitol (2005) 1.15

Clinical pharmacokinetics and metabolism of benzimidazole anthelmintics in ruminants. Drug Metab Rev (1993) 1.07

Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus. Mol Biochem Parasitol (1998) 1.07

Anthelmintic resistance: markers for resistance, or susceptibility? Parasitology (2010) 1.07

Ivermectin selection on beta-tubulin: evidence in Onchocerca volvulus and Haemonchus contortus. Mol Biochem Parasitol (2006) 1.05

An analysis of the population genetics of potential multi-drug resistance in Wuchereria bancrofti due to combination chemotherapy. Parasitology (2007) 1.04

Epidemiological study of parasite infection in a cow-calf beef herd in Quebec. Vet Parasitol (1992) 1.03

Genetic variability of the beta-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus. Genetics (1994) 1.03

Antioxidant systems in Schistosoma mansoni: correlation between susceptibility to oxidant killing and the levels of scavengers of hydrogen peroxide and oxygen free radicals. Int J Parasitol (1988) 1.01

The kinetics of triclabendazole disposition in sheep. J Vet Pharmacol Ther (1987) 0.99

Reversal of P-glycoprotein-associated multidrug resistance by ivermectin. Biochem Pharmacol (1997) 0.98

Interaction of benzimidazole anthelmintics with Haemonchus contortus tubulin: binding affinity and anthelmintic efficacy. Exp Parasitol (1991) 0.97

Haemonchus contortus: selection at a glutamate-gated chloride channel gene in ivermectin- and moxidectin-selected strains. Exp Parasitol (1998) 0.97

Mode of action of the anthelminthic thiabendazole in Haemonchus contortus. Nature (1970) 0.96

Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. I. In vivo and in vitro effects of the amines. Int Arch Allergy Appl Immunol (1974) 0.95

Specific interaction of benzimidazole anthelmintics with tubulin: high-affinity binding and benzimidazole resistance in Haemonchus contortus. Mol Biochem Parasitol (1990) 0.94

Seroepidemiological study for five different zoonotic parasites in northern Quebec. Can J Public Health (1987) 0.94

Schistosoma mansoni: levels of antioxidants and resistance to oxidants increase during development. Exp Parasitol (1990) 0.94

Genetic variability of glutamate-gated chloride channel genes in ivermectin-susceptible and -resistant strains of Cooperia oncophora. Parasitology (2004) 0.91

Identification of variant ABC-transporter genes among Onchocerca volvulus collected from ivermectin-treated and untreated patients in Ghana, West Africa. Ann Trop Med Parasitol (2004) 0.91

Comparative plasma disposition kinetics of albendazole, fenbendazole, oxfendazole and their metabolites in adult sheep. J Vet Pharmacol Ther (1995) 0.91

Effect of oesophageal groove closure on the pharmacokinetic behaviour and efficacy of oxfendazole in sheep. Res Vet Sci (1981) 0.90

Antioxidant systems in Schistosoma mansoni: evidence for their role in protection of the adult worms against oxidant killing. Int J Parasitol (1988) 0.90

Comparison of inhibition of polymerisation of mammalian tubulin and helminth ovicidal activity by benzimidazole carbamates. Vet Parasitol (1987) 0.88

Identification and stage-specific expression of two putative P-glycoprotein coding genes in Onchocerca volvulus. Mol Biochem Parasitol (1999) 0.88

Population genetics of concurrent selection with albendazole and ivermectin or diethylcarbamazine on the possible spread of albendazole resistance in Wuchereria bancrofti. Parasitology (2006) 0.87

Effects of the multidrug-resistance-reversing agents verapamil and CL 347,099 on the efficacy of ivermectin or moxidectin against unselected and drug-selected strains of Haemonchus contortus in jirds (Meriones unguiculatus). Parasitol Res (1999) 0.87

Genetic polymorphism of the beta-tubulin gene of Onchocerca volvulus in ivermectin naïve patients from Cameroon, and its relationship with fertility of the worms. Parasitology (2005) 0.87

Cloning two full-length beta-tubulin isotype cDNAs from Cooperia oncophora, and screening for benzimidazole resistance-associated mutations in two isolates. Parasitology (2003) 0.86

The fumarate reductase reaction of Haemonchus contortus and the mode of action of some anthelmintics. Int J Parasitol (1973) 0.86

Haemonchus contortus: effects of glutamate, ivermectin, and moxidectin on inulin uptake activity in unselected and ivermectin-selected adults. Exp Parasitol (1999) 0.86

Three beta-tubulin cDNAs from the parasitic nematode Haemonchus contortus. Mol Biochem Parasitol (1992) 0.85

Changes in anthelmintic resistance status of Haemonchus contortus and Trichostrongylus colubriformis exposed to different anthelmintic selection pressures in grazing sheep. Int J Parasitol (1989) 0.85

Reduced genetic variation of an Onchocerca volvulus ABC transporter gene following treatment with ivermectin. Trans R Soc Trop Med Hyg (2007) 0.84

The glycolytic pathway in adult liver fluke, Fasciola hepatica. Comp Biochem Physiol (1968) 0.84

Hypobiosis of Haemonchus contortus in natural infections of sheep and goats in a semi-arid area of Kenya. Vet Parasitol (1998) 0.84

Differential effects of oltipraz and its oxy-analogue on the viability of Schistosoma mansoni and the activity of glutathione S-transferase. Biochem Pharmacol (1991) 0.84

Beta-tubulin and benzimidazole resistance in the sheep nematode Haemonchus contortus. Mol Biochem Parasitol (1991) 0.84

Expression of cloned beta-tubulin genes of Haemonchus contortus in Escherichia coli: interaction of recombinant beta-tubulin with native tubulin and mebendazole. Mol Biochem Parasitol (1993) 0.84

Interactions of benzimidazoles (BZ) with tubulin from BZ-sensitive and BZ-resistant isolates of Haemonchus contortus. Mol Biochem Parasitol (1986) 0.83

Interaction of host physiology and efficacy of antiparasitic drugs. Vet Parasitol (1985) 0.83

Benzimidazoles, potent anti-mitotic drugs: substrates for the P-glycoprotein transporter in multidrug-resistant cells. Biochem Pharmacol (1994) 0.82

Decreased ivermectin and moxidectin sensitivity in Haemonchus contortus selected with moxidectin over 14 generations. Vet Parasitol (1999) 0.82

Tubulin and benzimidazole-resistance in Trichostrongylus colubriformis (Nematoda). J Parasitol (1985) 0.82

Characterization of rhodamine 123 binding to P-glycoprotein in human multidrug-resistant cells. Mol Pharmacol (1994) 0.81

Pharmacokinetics of ivermectin in sheep following intravenous, intra-abomasal or intraruminal administration. J Vet Pharmacol Ther (1985) 0.81

Depression of hydrogen peroxide dependent killing of schistosomula in vitro by peritoneal exudate cells from Schistosoma mansoni infected mice. Am J Trop Med Hyg (1989) 0.81

Influence on the antithyroid compound methimazole on the plasma disposition of fenbendazole and oxfendazole in sheep. Res Vet Sci (1995) 0.81

Haemonchus contortus: the role of two beta-tubulin gene subfamilies in the resistance to benzimidazole anthelmintics. Biochem Pharmacol (1994) 0.81

Methimazole increases the plasma concentrations of the albendazole metabolites of netobimin in sheep. Biopharm Drug Dispos (1992) 0.80

The effect of iron and protein deficiency on plasma levels and parasite uptake of [14C] fenbendazole in rats infected with Nippostrongylus brasiliensis. Aust J Exp Biol Med Sci (1981) 0.80

Relationship between pharmacological properties and clinical efficacy of ruminant anthelmintics. Vet Parasitol (1993) 0.80

Assessment of benzimidazole resistance in Haemonchus contortus in sheep flocks in Ontario, Canada: comparison of detection methods for drug resistance. Vet Parasitol (2013) 0.80

Efficacy of ivermectin in calves against a resistant Cooperia oncophora field isolate. Parasitol Res (2004) 0.80

Assessment of benzimidazole binding to individual recombinant tubulin isotypes from Haemonchus contortus. Parasitology (2001) 0.80

The effect of corticosteroid treatment on the development of inhibited Ostertagia ostertagi larvae. Res Vet Sci (1974) 0.79

Effect of selection pressure for thiabendazole resistance on fitness of Haemonchus contortus in sheep. Parasitology (1990) 0.79

Effects of three nematode anthelmintic treatment regimes on flock performance of sheep and goats under extensive management in semi-arid Kenya. Vet Parasitol (1997) 0.79

Parasitic zoonoses in relation to fish and wildlife harvesting by Inuit communities in northern Quebec, Canada. Arctic Med Res (1988) 0.79

Individual expression of recombinant alpha- and beta-tubulin from Haemonchus contortus: polymerization and drug effects. Protein Expr Purif (2001) 0.79

Glutathione redox state, lipid peroxide levels, and activities of glutathione enzymes in oltipraz-treated adult Schistosoma mansoni. Biochem Pharmacol (1989) 0.79

Oltipraz-induced decrease in the activity of cytosolic glutathione S-transferase in Schistosoma mansoni. Int J Parasitol (1991) 0.78

Specific interaction of benzimidazole anthelmintics with tubulin from developing stages of thiabendazole-susceptible and -resistant Haemonchus contortus. Biochem Pharmacol (1991) 0.78

Characterization of a beta-tubulin gene and a beta-tubulin gene products of Brugia pahangi. Mol Biochem Parasitol (1991) 0.78

Characterisation of Fasciola hepatica cytochrome c peroxidase as an enzyme with potential antioxidant activity in vitro. Int J Parasitol (1999) 0.78

Controlled release of anthelmintic drugs: a new concept for prevention of helminthosis in sheep. Res Vet Sci (1980) 0.78

Gastrointestinal distribution of albendazole metabolites following netobimin administration to cattle: relationship with plasma disposition kinetics. J Vet Pharmacol Ther (1993) 0.78

Cloning, sequencing, and developmental expression levels of a novel glutamate-gated chloride channel homologue in the parasitic nematode Haemonchus contortus. Biochem Biophys Res Commun (1999) 0.78

Enhancement of the plasma concentration of albendazole sulphoxide in sheep following coadministration of parenteral netobimin and liver oxidase inhibitors. Res Vet Sci (1991) 0.78

Cloning and characterization of cDNAs encoding beta-tubulin from Dirofilaria immitis and Onchocerca volvulus. J Parasitol (1998) 0.78

Susceptibility to IVM in a field strain of Haemonchus contortus subjected to four treatments in a closed sheep-goat flock in Kenya. Vet Parasitol (2003) 0.78

Methimazole-mediated modulation of netobimin biotransformation in sheep: a pharmacokinetic assessment. J Vet Pharmacol Ther (1992) 0.78

Effects of methimazole on the kinetics of netobimin metabolites in cattle. Xenobiotica (1992) 0.77

Mechanisms of inactivation of Schistosoma mansoni and mammalian glutathione S-transferase activity by the antischistosomal drug oltipraz. Biochem Pharmacol (1992) 0.77

Metabolite concentrations in plasma following treatment of cattle with five anthelmintics. Res Vet Sci (1985) 0.77

Identification of a novel Brugia pahangi beta-tubulin gene (beta 2) and a 22-nucleotide spliced leader sequence on beta 1-tubulin mRNA. Mol Biochem Parasitol (1992) 0.77

Comparison of pharmacokinetic variables for two injectable formulations of netobimin administered to calves. Am J Vet Res (1990) 0.77

Comparison of the properties of tubulin from Nippostrongylus brasiliensis with mammalian brain tubulin. Mol Biochem Parasitol (1988) 0.77

Efficacy of moxidectin against naturally acquired nematode infections in cattle. Vet Parasitol (1992) 0.77

A comparative study of the tricarboxylic acid cycle enzymes in Fasciola hepatica and rat liver. Comp Biochem Physiol (1968) 0.77

Endocrine responses of sheep to infection with Trichostrongylus colubriformis. Res Vet Sci (1974) 0.76

Genetic variability in cysteine protease genes of Haemonchus contortus. Parasitology (2004) 0.76

The effect of praziquantel on calcium in Hymenolepis diminuta. Mol Biochem Parasitol (1982) 0.76

Fenbendazole and thiabendazole in cattle: partition of gastrointestinal absorption and pharmacokinetic behaviour. J Vet Pharmacol Ther (1981) 0.76

Nematode reinfection following treatment of cattle with doramectin and ivermectin. Vet Parasitol (1997) 0.76

Identification of tubulin isoforms in different tissues of Ascaris suum using anti-tubulin monoclonal antibodies. Int J Parasitol (1991) 0.76

The disposition of albendazole in sheep. J Vet Pharmacol Ther (1989) 0.75

Comparative sulphoxidation of albendazole by sheep and cattle liver microsomes and the inhibitory effect of methimazole. Xenobiotica (1993) 0.75

Veterinary parasitology in the 21st Century. Trends Parasitol (2001) 0.75

p-Azidosalicyl-5-amino-6-phenoxybenzimidazole photolabels the N-terminal 63-103 amino acids of Haemonchus contortus beta-tubulin 1. J Biol Chem (1996) 0.75

Fasciola hepatica: cytochrome c oxidoreductases and effects of oxygen tension and inhibitors. Exp Parasitol (1971) 0.75

Persistent efficacy of doramectin pour-on against artificially induced infections of nematodes in cattle. Vet Parasitol (1999) 0.75

Haemonchus contortus: characterization of a glutamate binding site in unselected and ivermectin-selected larvae and adults. Exp Parasitol (1999) 0.75

Relationship among particle size distribution, dissolution profile, plasma values, and anthelmintic efficacy of oxfendazole. Am J Vet Res (1980) 0.75

The relationship of some intermediary metabolites to the production of volatile fatty acids by adult Fasciola hepatica. Comp Biochem Physiol B (1971) 0.75

Deaths in cattle after administration of large doses of thiabendazole. Aust Vet J (1979) 0.75

Functioning of the thyroid gland in sheep infected with Trichostrongylus colubriformis. Res Vet Sci (1981) 0.75

The metabolic profile of adult Fasciola hepatica obtained from rafoxanide-treated sheep. Parasitology (1978) 0.75