PubRank

George R Stark

Author PubWeight™ 100.16‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Interferons at age 50: past, current and future impact on biomedicine. Nat Rev Drug Discov 2007 6.33
2 Complex modulation of cell type-specific signaling in response to type I interferons. Immunity 2006 4.48
3 SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 2003 3.69
4 Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling. Trends Immunol 2002 3.64
5 Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev 2007 3.57
6 Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation. Cancer Res 2005 3.10
7 Roles of unphosphorylated STATs in signaling. Cell Res 2008 2.27
8 Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J Biol Chem 2001 2.21
9 IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA. Proc Natl Acad Sci U S A 2002 2.20
10 Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. Proc Natl Acad Sci U S A 2005 2.14
11 Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. Proc Natl Acad Sci U S A 2009 2.10
12 Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci U S A 2010 2.06
13 Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell 2011 2.04
14 Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3. Cancer Res 2006 2.03
15 NFkappaB-dependent signaling pathways. Exp Hematol 2002 1.98
16 Alternative activation of STAT1 and STAT3 in response to interferon-gamma. J Biol Chem 2004 1.88
17 The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci U S A 2003 1.80
18 Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes. Proc Natl Acad Sci U S A 2009 1.78
19 Transposon-based mutagenesis identifies short RIP1 as an activator of NFkappaB. Cell Cycle 2008 1.49
20 Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB. Proc Natl Acad Sci U S A 2009 1.49
21 The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins. J Interferon Cytokine Res 2010 1.48
22 Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells. Proc Natl Acad Sci U S A 2004 1.45
23 Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways. Proc Natl Acad Sci U S A 2007 1.42
24 Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control. J Biol Chem 2009 1.42
25 p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2. J Cell Sci 2005 1.39
26 Secretion of cytokines and growth factors as a general cause of constitutive NFkappaB activation in cancer. Oncogene 2004 1.38
27 Identification of a human NF-kappaB-activating protein, TAB3. Proc Natl Acad Sci U S A 2004 1.37
28 Cytokine overexpression and constitutive NFkappaB in cancer. Cell Cycle 2004 1.34
29 G2 arrest in response to topoisomerase II inhibitors: the role of p53. Cancer Res 2003 1.31
30 Overexpression of kinesins mediates docetaxel resistance in breast cancer cells. Cancer Res 2009 1.31
31 IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage. EMBO J 2013 1.26
32 Major differences in the responses of primary human leukocyte subsets to IFN-beta. J Immunol 2010 1.26
33 PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB. Proc Natl Acad Sci U S A 2013 1.17
34 Down-regulation of p53 by double-stranded RNA modulates the antiviral response. J Virol 2005 1.17
35 Mutagenesis by reversible promoter insertion to study the activation of NF-kappaB. Proc Natl Acad Sci U S A 2005 1.17
36 Mutant human cells with constitutive activation of NF-kappaB. Proc Natl Acad Sci U S A 2003 1.14
37 Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors. Proc Natl Acad Sci U S A 2006 1.11
38 Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-κB-mediated mechanism. Proc Natl Acad Sci U S A 2013 1.11
39 DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation. Proc Natl Acad Sci U S A 2008 1.10
40 STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor. Proc Natl Acad Sci U S A 2013 1.10
41 Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development. Circulation 2007 1.09
42 Limited role of N-terminal phosphoserine residues in the activation of transcription by p53. Oncogene 2004 1.09
43 Hdm2 nuclear export, regulated by insulin-like growth factor-I/MAPK/p90Rsk signaling, mediates the transformation of human cells. J Biol Chem 2006 1.08
44 p53-mediated growth suppression in response to Nutlin-3 in cyclin D1 transformed cells occurs independently of p21. Cancer Res 2007 1.07
45 Inhibitor of kappaB kinase is required to activate a subset of interferon gamma-stimulated genes. Proc Natl Acad Sci U S A 2004 1.04
46 Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation. J Biol Chem 2004 1.04
47 Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis. Mol Cell Biol 2002 1.03
48 PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65. Nat Commun 2013 1.02
49 FAM83B mediates EGFR- and RAS-driven oncogenic transformation. J Clin Invest 2012 1.00
50 Roles of IKK-beta, IRF1, and p65 in the activation of chemokine genes by interferon-gamma. J Interferon Cytokine Res 2009 0.95
51 Use of forward genetics to discover novel regulators of NF-kappaB. Cold Spring Harb Perspect Biol 2009 0.93
52 Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene. J Biol Chem 2002 0.93
53 Role of lysine methylation of NF-κB in differential gene regulation. Proc Natl Acad Sci U S A 2013 0.92
54 Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation. J Biol Chem 2011 0.89
55 FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB. Proc Natl Acad Sci U S A 2011 0.88
56 Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2. J Biol Chem 2001 0.86
57 IRAK-dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression. J Interferon Cytokine Res 2003 0.86
58 Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (Stat1). J Interferon Cytokine Res 2002 0.86
59 The dual functions of IL-1 receptor-associated kinase 2 in TLR9-mediated IFN and proinflammatory cytokine production. J Immunol 2011 0.86
60 Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer. Breast Cancer Res Treat 2011 0.85
61 The role of cell type-specific responses in IFN-β therapy of multiple sclerosis. Proc Natl Acad Sci U S A 2011 0.84
62 Activation of a subset of genes by IFN-gamma requires IKKbeta but not interferon-dependent activation of NF-kappaB. J Interferon Cytokine Res 2007 0.84
63 Interferon signaling is dependent on specific tyrosines located within the intracellular domain of IFNAR2c. Expression of IFNAR2c tyrosine mutants in U5A cells. J Biol Chem 2001 0.83
64 Using sequential immunoprecipitation and mass spectrometry to identify methylation of NF-κB. Methods Mol Biol 2015 0.78
65 Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs. Int J Cancer 2014 0.78
66 Pillars article: A protein tyrosine kinase in the interferon α/β signaling pathway. Cell. 1992. 70: 313-322. J Immunol 2011 0.76
67 Activation of cAMP-responsive-element-binding protein by PI3 kinase and p38 MAPK is essential for elevated expression of transforming growth factor β2 in cancer cells. J Interferon Cytokine Res 2010 0.76