Published in Q Rev Biophys on December 09, 2005
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol (2013) 15.51
AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell (2008) 4.13
Computational redesign of endonuclease DNA binding and cleavage specificity. Nature (2006) 4.06
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med (2010) 2.81
Homing endonucleases: from microbial genetic invaders to reagents for targeted DNA modification. Structure (2011) 2.43
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito. Nature (2011) 2.20
Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease. Nucleic Acids Res (2009) 2.14
Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics. Biol Direct (2012) 2.05
Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems. Mol Cell (2015) 1.89
Targeting the absence: homozygous DNA deletions as immutable signposts for cancer therapy. Proc Natl Acad Sci U S A (2007) 1.84
Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease. Proc Natl Acad Sci U S A (2009) 1.79
Natural and engineered nicking endonucleases--from cleavage mechanism to engineering of strand-specificity. Nucleic Acids Res (2010) 1.66
Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs. Nucleic Acids Res (2010) 1.58
Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos. Nucleic Acids Res (2007) 1.56
Phylogenomic analysis of the GIY-YIG nuclease superfamily. BMC Genomics (2006) 1.56
T4-related bacteriophage LIMEstone isolates for the control of soft rot on potato caused by 'Dickeya solani'. PLoS One (2012) 1.52
Coevolution of a homing endonuclease and its host target sequence. J Mol Biol (2007) 1.49
Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation. Nucleic Acids Res (2008) 1.44
Exceptional structured noncoding RNAs revealed by bacterial metagenome analysis. Nature (2009) 1.43
High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display. Nucleic Acids Res (2009) 1.43
An equivalent metal ion in one- and two-metal-ion catalysis. Nat Struct Mol Biol (2008) 1.41
Tapping natural reservoirs of homing endonucleases for targeted gene modification. Proc Natl Acad Sci U S A (2011) 1.39
Requirements for effective malaria control with homing endonuclease genes. Proc Natl Acad Sci U S A (2011) 1.33
Targeting individual subunits of the FokI restriction endonuclease to specific DNA strands. Nucleic Acids Res (2009) 1.32
Bacterial genome instability. Microbiol Mol Biol Rev (2014) 1.31
Engineering variants of the I-SceI homing endonuclease with strand-specific and site-specific DNA-nicking activity. J Mol Biol (2008) 1.24
The vasa regulatory region mediates germline expression and maternal transmission of proteins in the malaria mosquito Anopheles gambiae: a versatile tool for genetic control strategies. BMC Mol Biol (2009) 1.23
Type II restriction endonucleases--a historical perspective and more. Nucleic Acids Res (2014) 1.22
The restriction fold turns to the dark side: a bacterial homing endonuclease with a PD-(D/E)-XK motif. EMBO J (2007) 1.15
Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins. Nucleic Acids Res (2009) 1.14
Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif. Proc Natl Acad Sci U S A (2010) 1.13
Crystal structure of the beta beta alpha-Me type II restriction endonuclease Hpy99I with target DNA. Nucleic Acids Res (2009) 1.13
Characterization and genome sequencing of phage Abp1, a new phiKMV-like virus infecting multidrug-resistant Acinetobacter baumannii. Curr Microbiol (2013) 1.12
Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI. Structure (2010) 1.11
Genome characteristics of a novel phage from Bacillus thuringiensis showing high similarity with phage from Bacillus cereus. PLoS One (2012) 1.10
Activity and specificity of the bacterial PD-(D/E)XK homing endonuclease I-Ssp6803I. J Mol Biol (2008) 1.10
Mapping metal-binding sites in the catalytic domain of bacterial RNase P RNA. RNA (2008) 1.09
The genome of Polaromonas sp. strain JS666: insights into the evolution of a hydrocarbon- and xenobiotic-degrading bacterium, and features of relevance to biotechnology. Appl Environ Microbiol (2008) 1.09
Survey of group I and group II introns in 29 sequenced genomes of the Bacillus cereus group: insights into their spread and evolution. Nucleic Acids Res (2008) 1.08
Assessment of the optimization of affinity and specificity at protein-DNA interfaces. Nucleic Acids Res (2009) 1.07
Inteins, introns, and homing endonucleases: recent revelations about the life cycle of parasitic genetic elements. BMC Evol Biol (2006) 1.07
A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage. Genes Dev (2015) 1.06
Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA. Nucleic Acids Res (2013) 1.06
Fractured genes: a novel genomic arrangement involving new split inteins and a new homing endonuclease family. Nucleic Acids Res (2009) 1.05
Gene flow and biological conflict systems in the origin and evolution of eukaryotes. Front Cell Infect Microbiol (2012) 1.04
Distinctive architecture of the chloroplast genome in the chlorophycean green alga Stigeoclonium helveticum. Mol Genet Genomics (2006) 1.04
Update on gene therapy for immunodeficiencies. Clin Immunol (2010) 1.03
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases. Nucleic Acids Res (2012) 1.02
A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI. Nucleic Acids Res (2010) 1.02
Crystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineering. Proc Natl Acad Sci U S A (2008) 1.01
Thermodynamics of DNA target site recognition by homing endonucleases. Nucleic Acids Res (2007) 1.01
Modelling the spatial spread of a homing endonuclease gene in a mosquito population. J Appl Ecol (2013) 1.00
Evidence that binding of C5 protein to P RNA enhances ribozyme catalysis by influencing active site metal ion affinity. RNA (2007) 1.00
HNH proteins are a widespread component of phage DNA packaging machines. Proc Natl Acad Sci U S A (2014) 0.98
Comprehensive computational design of mCreI homing endonuclease cleavage specificity for genome engineering. Nucleic Acids Res (2011) 0.97
The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo. J Cell Sci (2012) 0.97
Role of the translocation partner in protection against AID-dependent chromosomal translocations. Proc Natl Acad Sci U S A (2009) 0.96
The protein gp74 from the bacteriophage HK97 functions as a HNH endonuclease. Protein Sci (2012) 0.95
Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His-Cys box homing endonucleases. Nucleic Acids Res (2008) 0.94
Crystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathway. Nucleic Acids Res (2008) 0.94
Cofactor requirement of HpyAV restriction endonuclease. PLoS One (2010) 0.94
Phage T4 SegB protein is a homing endonuclease required for the preferred inheritance of T4 tRNA gene region occurring in co-infection with a related phage. Nucleic Acids Res (2008) 0.92
Mobile elements in a single-filament orange Guaymas Basin Beggiatoa ("Candidatus Maribeggiatoa") sp. draft genome: evidence for genetic exchange with cyanobacteria. Appl Environ Microbiol (2013) 0.92
The design and in vivo evaluation of engineered I-OnuI-based enzymes for HEG gene drive. PLoS One (2013) 0.91
The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease. Structure (2009) 0.91
Non-specific protein-DNA interactions control I-CreI target binding and cleavage. Nucleic Acids Res (2012) 0.91
Hpy188I-DNA pre- and post-cleavage complexes--snapshots of the GIY-YIG nuclease mediated catalysis. Nucleic Acids Res (2010) 0.90
The binding process of a nonspecific enzyme with DNA. Biophys J (2011) 0.90
5'-Cytosine-phosphoguanine (CpG) methylation impacts the activity of natural and engineered meganucleases. J Biol Chem (2012) 0.90
The a2 mating-type locus genes lga2 and rga2 direct uniparental mitochondrial DNA (mtDNA) inheritance and constrain mtDNA recombination during sexual development of Ustilago maydis. Genetics (2008) 0.90
Native homing endonucleases can target conserved genes in humans and in animal models. Nucleic Acids Res (2011) 0.90
Whole genome sequencing and comparative genomic analyses of two Vibrio cholerae O139 Bengal-specific Podoviruses to other N4-like phages reveal extensive genetic diversity. Virol J (2013) 0.90
Evidence for inter-specific recombination among the mitochondrial genomes of Fusarium species in the Gibberella fujikuroi complex. BMC Genomics (2013) 0.90
Post-transcriptional control of chloroplast gene expression. Gene Regul Syst Bio (2009) 0.89
Structures of the Ultra-High-Affinity Protein-Protein Complexes of Pyocins S2 and AP41 and Their Cognate Immunity Proteins from Pseudomonas aeruginosa. J Mol Biol (2015) 0.88
The casposon-encoded Cas1 protein from Aciduliprofundum boonei is a DNA integrase that generates target site duplications. Nucleic Acids Res (2015) 0.88
A functional homing endonuclease in the Bacillus anthracis nrdE group I intron. J Bacteriol (2007) 0.88
Altered target site specificity variants of the I-PpoI His-Cys box homing endonuclease. Nucleic Acids Res (2007) 0.88
In vivo characterization of the homing endonuclease within the polB gene in the halophilic archaeon Haloferax volcanii. PLoS One (2011) 0.87
Creating highly specific nucleases by fusion of active restriction endonucleases and catalytically inactive homing endonucleases. Nucleic Acids Res (2011) 0.87
DNA recognition and transcriptional regulation by the WhiA sporulation factor. Sci Rep (2011) 0.87
Unwinding and rewinding: double faces of helicase? J Nucleic Acids (2012) 0.86
Mining endonuclease cleavage determinants in genomic sequence data. J Biol Chem (2011) 0.86
A group II intron encodes a functional LAGLIDADG homing endonuclease and self-splices under moderate temperature and ionic conditions. RNA (2010) 0.86
High-efficiency scarless genetic modification in Escherichia coli by using lambda red recombination and I-SceI cleavage. Appl Environ Microbiol (2014) 0.86
Knocking down gene function with an RNA aptamer expressed as part of an intron. Nucleic Acids Res (2010) 0.86
Divalent metal ion differentially regulates the sequential nicking reactions of the GIY-YIG homing endonuclease I-BmoI. PLoS One (2011) 0.85
Sex-determination system in the diploid yeast Zygosaccharomyces sapae. G3 (Bethesda) (2014) 0.85
Context dependence between subdomains in the DNA binding interface of the I-CreI homing endonuclease. Nucleic Acids Res (2011) 0.85
Homing endonuclease I-TevIII: dimerization as a means to a double-strand break. Nucleic Acids Res (2007) 0.84
Home and away- the evolutionary dynamics of homing endonucleases. BMC Evol Biol (2011) 0.83
Cyanobacterial ribosomal RNA genes with multiple, endonuclease-encoding group I introns. BMC Evol Biol (2007) 0.82
Creating directed double-strand breaks with the Ref protein: a novel RecA-dependent nuclease from bacteriophage P1. J Biol Chem (2010) 0.82
Pyrobaculum yellowstonensis Strain WP30 Respires on Elemental Sulfur and/or Arsenate in Circumneutral Sulfidic Geothermal Sediments of Yellowstone National Park. Appl Environ Microbiol (2015) 0.82
Comparison of genomes of three Xanthomonas oryzae bacteriophages. BMC Genomics (2007) 0.81
The monomeric GIY-YIG homing endonuclease I-BmoI uses a molecular anchor and a flexible tether to sequentially nick DNA. Nucleic Acids Res (2013) 0.81
A parasitic selfish gene that affects host promiscuity. Proc Biol Sci (2013) 0.81
Chemical and biological approaches to improve the efficiency of homologous recombination in human cells mediated by artificial restriction DNA cutter. Nucleic Acids Res (2012) 0.81