Kainate receptor physiology.

Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability. Am J Hum Genet (2011) 2.86

A transmembrane accessory subunit that modulates kainate-type glutamate receptors. Neuron (2009) 2.07

Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. Nat Neurosci (2011) 2.00

The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels. Br J Pharmacol (2013) 1.88

Kainate receptors coming of age: milestones of two decades of research. Trends Neurosci (2011) 1.66

Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction. Ann N Y Acad Sci (2010) 1.64

Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania. Mol Psychiatry (2008) 1.36

Autoinactivation of neuronal AMPA receptors via glutamate-regulated TARP interaction. Neuron (2009) 1.30

Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis. Proc Natl Acad Sci U S A (2011) 1.17

Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors. Ann Neurol (2009) 1.14

Non-synaptic receptors and transporters involved in brain functions and targets of drug treatment. Br J Pharmacol (2010) 1.11

AMPA receptors and stargazin-like transmembrane AMPA receptor-regulatory proteins mediate hippocampal kainate neurotoxicity. Proc Natl Acad Sci U S A (2007) 1.11

Neto1 and Neto2: auxiliary subunits that determine key properties of native kainate receptors. J Physiol (2012) 1.10

Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function. Nat Rev Neurosci (2012) 1.09

Mechanisms Underlying Tolerance after Long-Term Benzodiazepine Use: A Future for Subtype-Selective GABA(A) Receptor Modulators? Adv Pharmacol Sci (2012) 1.08

PKC-dependent autoregulation of membrane kainate receptors. EMBO J (2007) 1.05

Bidirectional regulation of kainate receptor surface expression in hippocampal neurons. J Biol Chem (2008) 1.05

Physiology and pathology of calcium signaling in the brain. Front Pharmacol (2012) 1.05

Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density. J Neurochem (2006) 0.99

Synaptic neurotransmitter-gated receptors. Cold Spring Harb Perspect Biol (2012) 0.98

Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. Nat Neurosci (2010) 0.96

A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder. Proc Natl Acad Sci U S A (2008) 0.96

Calcium-permeable presynaptic kainate receptors involved in excitatory short-term facilitation onto somatostatin interneurons during natural stimulus patterns. J Neurophysiol (2008) 0.89

Domoic acid as a developmental neurotoxin. Neurotoxicology (2010) 0.89

Novel analogs and stereoisomers of the marine toxin neodysiherbaine with specificity for kainate receptors. J Pharmacol Exp Ther (2007) 0.88

Intracellular machinery for the transport of AMPA receptors. Br J Pharmacol (2007) 0.87

Homeostatic control of synaptic transmission by distinct glutamate receptors. Neuron (2013) 0.86

Subunit-dependent postsynaptic expression of kainate receptors on hippocampal interneurons in area CA1. J Neurosci (2009) 0.86

Glutamate signaling through the kainate receptor enhances human immunoglobulin production. J Neuroimmunol (2011) 0.86

Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists. Neuropharmacology (2010) 0.85

Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activation. Circ Res (2009) 0.84

Differential contribution of kainate receptors to excitatory postsynaptic currents in superficial layer neurons of the rat medial entorhinal cortex. Neuroscience (2007) 0.83

Ligands for ionotropic glutamate receptors. Prog Mol Subcell Biol (2009) 0.83

Therapeutic potential of kainate receptors. CNS Neurosci Ther (2010) 0.83

Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor. J Cell Biol (2008) 0.82

Kainate receptor signaling in pain pathways. Mol Pharmacol (2012) 0.81

Channel-opening kinetic mechanism for human wild-type GluK2 and the M867I mutant kainate receptor. Biochemistry (2010) 0.81

Identification of C-terminal domain residues involved in protein kinase A-mediated potentiation of kainate receptor subtype 6. Neuroscience (2007) 0.81

At immature mossy fibers-CA3 connections, activation of presynaptic GABA(B) receptors by endogenously released GABA contributes to synapses silencing. Front Cell Neurosci (2009) 0.80

Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE) and neuropsychiatric SLE, Sjogren's syndrome, schizophrenia, mania or stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor's expression, impair glutamate-induced signaling and function, activate blood brain barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and ataxia in animal models, and can be removed or silenced in some patients by immunotherapy. J Neural Transm (Vienna) (2014) 0.80

Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310. Mol Pharmacol (2010) 0.79

Contribution of different classes of glutamate receptors in the corticostriatal polysynaptic responses from striatal direct and indirect projection neurons. BMC Neurosci (2013) 0.79

The neurotransmitter glutamate and human T cells: glutamate receptors and glutamate-induced direct and potent effects on normal human T cells, cancerous human leukemia and lymphoma T cells, and autoimmune human T cells. J Neural Transm (Vienna) (2014) 0.79

Postsynaptic kainate receptor recycling and surface expression are regulated by metabotropic autoreceptor signalling. Traffic (2013) 0.79

The effect of aging-associated impaired mitochondrial status on kainate-evoked hippocampal gamma oscillations. Neurobiol Aging (2012) 0.77

Channel-opening kinetic mechanism of wild-type GluK1 kainate receptors and a C-terminal mutant. Biochemistry (2012) 0.77

Synaptic drive at developing synapses: transient upregulation of kainate receptors. Dev Neurobiol (2010) 0.77

GluK2-mediated excitability within the superficial layers of the entorhinal cortex. PLoS One (2009) 0.76

Genome scan in familial late-onset Alzheimer's disease: a locus on chromosome 6 contributes to age-at-onset. Am J Med Genet B Neuropsychiatr Genet (2013) 0.76

Pharmacological Preconditioning with GYKI 52466: A Prophylactic Approach to Neuroprotection. Front Neurosci (2010) 0.76

Regulation of Neuronal Protein Trafficking and Translocation by SUMOylation. Biomolecules (2012) 0.75

Effects of LY466195, a selective kainate receptor antagonist, on ethanol preference and drinking in rats. Neurosci Lett (2016) 0.75

Expression of KA1 kainate receptor subunit in the substantia gelatinosa of the trigeminal subnucleus caudalis in mice. J Vet Sci (2010) 0.75

Glutamate, T cells and multiple sclerosis. J Neural Transm (Vienna) (2017) 0.75