Published in Int Immunol on December 16, 2005
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet (2003) 7.04
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet (2003) 4.61
Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon. J Biol Chem (2004) 1.54
TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. J Immunol (2003) 1.20
OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker. Drug Metab Dispos (2006) 1.19
The Us3 protein kinase of herpes simplex virus 1 blocks apoptosis and induces phosporylation of the Bcl-2 family member Bad. Exp Cell Res (2003) 1.10
Edoxaban transport via P-glycoprotein is a key factor for the drug's disposition. Drug Metab Dispos (2014) 1.06
Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen. Toxicol Pathol (2009) 1.00
Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro. Eur J Pharmacol (2012) 0.99
Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3. Biochem Pharmacol (2012) 0.96
Molecular mechanism investigation of cycloheximide-induced hepatocyte apoptosis in rat livers by morphological and microarray analysis. Toxicology (2005) 0.93
Molecular mechanism investigation of phenobarbital-induced serum cholesterol elevation in rat livers by microarray analysis. Arch Toxicol (2004) 0.93
Determination of sites citrullinated by peptidylarginine deiminase using 18O stable isotope labeling and mass spectrometry. Rapid Commun Mass Spectrom (2005) 0.92
Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem (2013) 0.91
Enhancement of a sense of coherence and natural killer cell activity which occurred in subjects who improved their exercise habits through health education in the workplace. J Occup Health (2003) 0.90
Efficient antibody production upon suppression of O mannosylation in the yeast Ogataea minuta. Appl Environ Microbiol (2007) 0.89
Distribution of KAI-9803, a novel δ-protein kinase C inhibitor, after intravenous administration to rats. Drug Metab Dispos (2011) 0.88
Identification of molecular target of AMP-activated protein kinase activator by affinity purification and mass spectrometry. Anal Chem (2005) 0.88
Antirheumatic effects of humanized anti-Fas monoclonal antibody in human rheumatoid arthritis/SCID mouse chimera. J Rheumatol (2002) 0.88
Inhibitory effects of angiotensin receptor blockers on CYP2C9 activity in human liver microsomes. Drug Metab Pharmacokinet (2007) 0.88
Ethylene glycol monomethyl ether-induced toxicity is mediated through the inhibition of flavoprotein dehydrogenase enzyme family. Toxicol Sci (2010) 0.88
Sorafenib and its derivative SC-49 sensitize hepatocellular carcinoma cells to CS-1008, a humanized anti-TNFRSF10B (DR5) antibody. Br J Pharmacol (2013) 0.87
Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine. J Biol Chem (2010) 0.87
Evidence for the involvement of a pulmonary first-pass effect via carboxylesterase in the disposition of a propranolol ester derivative after intravenous administration. J Pharmacol Exp Ther (2003) 0.87
Anti-HIV-1 activities and pharmacokinetics of new arylpiperazinyl fluoroquinolones. Bioorg Med Chem Lett (2002) 0.87
Suppression of osteoclastogenesis in rheumatoid arthritis by induction of apoptosis in activated CD4+ T cells. Arthritis Rheum (2003) 0.86
A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity. Drug Metab Pharmacokinet (2011) 0.85
Tissue distribution of humanized anti-human Fas monoclonal antibody (R-125224) based on fas antigen-antibody reaction in collagen-induced arthritis monkeys. Life Sci (2007) 0.85
Effect of glutathione (GSH) depletion on DNA damage and blood chemistry in aged and young rats. J Toxicol Sci (2008) 0.85
Microarray analysis of T-2 toxin-induced liver, placenta and fetal liver lesions in pregnant rats. Exp Toxicol Pathol (2005) 0.84
Activation of T cell death-associated gene 8 attenuates inflammation by negatively regulating the function of inflammatory cells. Eur J Pharmacol (2011) 0.84
A Novel Natural Product-Derived Compound, Vestaine A1, Exerts both Pro-Angiogenic and Anti-Permeability Activity via a Different Pathway from VEGF. Cell Physiol Biochem (2016) 0.83
Shotgun protein analysis by liquid chromatography-tandem mass spectrometry. Methods Mol Biol (2009) 0.83
Influence of coronary artery disease on operative mortality and long-term survival after abdominal aortic aneurysm repair. Surg Today (2004) 0.83
Morphological and microarray analysis of T-2 toxin-induced rat fetal brain lesion. Food Chem Toxicol (2004) 0.82
Influence of Kupffer cell inactivation on cycloheximide-induced hepatic injury. Toxicology (2007) 0.82
Practical application of toxicogenomics for profiling toxicant-induced biological perturbations. Int J Mol Sci (2010) 0.82
Combination of two-dimensional electrophoresis and shotgun peptide sequencing in comparative proteomics. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 0.81
Generation and functional characterization of mice with a disrupted glutathione S-transferase, theta 1 gene. Drug Metab Dispos (2007) 0.81
Characterization of phenotypes in Gstm1-null mice by cytosolic and in vivo metabolic studies using 1,2-dichloro-4-nitrobenzene. Drug Metab Dispos (2006) 0.81
Interindividual variability of carboxymethylenebutenolidase homolog, a novel olmesartan medoxomil hydrolase, in the human liver and intestine. Drug Metab Dispos (2013) 0.80
Evaluation of glutathione deficiency in rat livers by microarray analysis. Biochem Pharmacol (2004) 0.80
Metabolic stability and uptake by human hepatocytes of pitavastatin, a new inhibitor of HMG-CoA reductase. Arzneimittelforschung (2004) 0.80
Pharmacological and pharmacokinetic study of olmesartan medoxomil in animal diabetic retinopathy models. Eur J Pharmacol (2005) 0.80
Toxicogenomic biomarkers for liver toxicity. J Toxicol Pathol (2009) 0.80
Paraoxonase 1 as a major bioactivating hydrolase for olmesartan medoxomil in human blood circulation: molecular identification and contribution to plasma metabolism. Drug Metab Dispos (2011) 0.80
Different hydrolases involved in bioactivation of prodrug-type angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1. Drug Metab Dispos (2013) 0.79
Crystal structure of the antigen-binding fragment of apoptosis-inducing mouse anti-human Fas monoclonal antibody HFE7A. J Biochem (2002) 0.78
Gene expression profiles in pregnant rats treated with T-2 toxin. Exp Toxicol Pathol (2004) 0.78
Gene set-level network analysis using a toxicogenomics database. Genomics (2010) 0.78
Humanization of the mouse anti-Fas antibody HFE7A and crystal structure of the humanized HFE7A Fab fragment. Biol Pharm Bull (2002) 0.78
Scoring multiple toxicological endpoints using a toxicogenomic database. Toxicol Lett (2009) 0.78
Protective effects of HFE7A, mouse anti-human/mouse Fas monoclonal antibody against acute and lethal hepatic injury induced by Jo2. Cytotechnology (2009) 0.78
In SCID mice with transplanted joint tissues from rheumatism patients, a model mice of human rheumatoid arthritis, anti-human fas antibody (R-125224) distributes specifically to human synovium. Pharm Res (2006) 0.77
Hepatic transcriptome and proteome responses against diethyl maleate-induced glutathione depletion in the rat. Arch Toxicol (2010) 0.76
Effect of serum cholesterol on the mRNA content of amyloid precursor protein in rat livers. Toxicol Lett (2004) 0.76
Drug discovery targeting apoptosis. Nat Rev Drug Discov (2008) 0.76
PEGylation of osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF) results in decreased uptake into rats and human liver. J Pharm Pharmacol (2010) 0.76
Phylogenetic tree facilitates the understanding of gene expression data on drug metabolizing enzymes obtained by microarray analysis. Toxicol Lett (2003) 0.75
Utilization of a toxicogenomic biomarker for evaluation of chemical-induced glutathione deficiency in rat livers across the GeneChip data of different generations. Toxicol Lett (2005) 0.75
Comprehensive analysis of hepatic gene and protein expression profiles on phenobarbital- or clofibrate-induced hepatic hypertrophy in dogs. J Toxicol Sci (2009) 0.75
Expression of the theta class GST isozyme, YdfYdf, in low GST dogs. Arch Toxicol (2005) 0.75
Relationship between GST Yp induction and hepatocyte proliferation in rats treated with phase II drug metabolizing enzyme inducers. Toxicol Pathol (2008) 0.75
Caspase-independent cell death by Fas ligation in human thymus-derived T cell line, HPB-ALL cells. Microbiol Immunol (2007) 0.75
In vitro cytotoxicity assay to evaluate the toxicity of an electrophilic reactive metabolite using glutathione-depleted rat primary cultured hepatocytes. Chem Biol Interact (2010) 0.75
Relationship between DNA damage and micronucleus in mouse liver. J Toxicol Sci (2010) 0.75
Toxicoproteomic investigation of the molecular mechanisms of cycloheximide-induced hepatocellular apoptosis in rat liver. Toxicology (2006) 0.75