Published in Genome Inform on January 01, 2005
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A (2008) 17.41
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature (2010) 17.31
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature (2010) 16.12
IRE1 signaling affects cell fate during the unfolded protein response. Science (2007) 9.01
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med (2012) 6.93
Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science (2005) 5.53
Inhibitor hijacking of Akt activation. Nat Chem Biol (2009) 4.91
A critical assessment of Mus musculus gene function prediction using integrated genomic evidence. Genome Biol (2008) 4.78
Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol Cell (2009) 4.71
The unfolded protein response signals through high-order assembly of Ire1. Nature (2008) 3.87
Bypassing a kinase activity with an ATP-competitive drug. Science (2003) 3.71
Predictome: a database of putative functional links between proteins. Nucleic Acids Res (2002) 3.32
Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell (2006) 3.32
Vemurafenib: the first drug approved for BRAF-mutant cancer. Nat Rev Drug Discov (2012) 3.09
A chemical-genetic approach to studying neurotrophin signaling. Neuron (2005) 2.93
VisANT: an online visualization and analysis tool for biological interaction data. BMC Bioinformatics (2004) 2.88
VisANT: an integrative framework for networks in systems biology. Brief Bioinform (2008) 2.85
Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. Genes Dev (2003) 2.79
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell (2003) 2.72
Selective amygdalohippocampectomy versus anterior temporal lobectomy in the management of mesial temporal lobe epilepsy: a meta-analysis of comparative studies. J Neurosurg (2013) 2.71
VisANT 3.5: multi-scale network visualization, analysis and inference based on the gene ontology. Nucleic Acids Res (2009) 2.71
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design. Nat Biotechnol (2005) 2.51
High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates. Cancer Res (2007) 2.48
Gene expression in lung adenocarcinomas of smokers and nonsmokers. Am J Respir Cell Mol Biol (2003) 2.45
Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat Chem Biol (2007) 2.43
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proc Natl Acad Sci U S A (2007) 2.37
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Sci Signal (2010) 2.36
Identification of functional links between genes using phylogenetic profiles. Bioinformatics (2003) 2.33
JNK2 is a positive regulator of the cJun transcription factor. Mol Cell (2006) 2.32
Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma. Nature (2010) 2.25
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Mol Cell (2007) 2.22
An integrated platform of genomic assays reveals small-molecule bioactivities. Nat Chem Biol (2008) 2.21
Towards zoomable multidimensional maps of the cell. Nat Biotechnol (2007) 2.20
TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. Mol Cell Biol (2009) 2.20
VisANT 3.0: new modules for pathway visualization, editing, prediction and construction. Nucleic Acids Res (2007) 2.17
Re-emerging superconductivity at 48 kelvin in iron chalcogenides. Nature (2012) 2.13
An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol (2005) 2.11
The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med (2015) 2.07
Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol (2010) 2.07
The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. J Cell Biol (2002) 2.04
Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain. Proc Natl Acad Sci U S A (2003) 1.93
Identifying functional links between genes using conserved chromosomal proximity. Trends Genet (2002) 1.91
A global representation of the protein fold space. Proc Natl Acad Sci U S A (2003) 1.88
Gene set enrichment analysis: performance evaluation and usage guidelines. Brief Bioinform (2011) 1.84
Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. Mol Cell Biol (2009) 1.82
Functional fingerprints of folds: evidence for correlated structure-function evolution. J Mol Biol (2003) 1.80
Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma. J Mol Biol (2005) 1.79
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol (2009) 1.78
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. N Engl J Med (2015) 1.75
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II. Nat Struct Mol Biol (2012) 1.74
Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis. Curr Biol (2005) 1.70
Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. Genes Dev (2008) 1.68
Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A (2007) 1.67
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1. Proc Natl Acad Sci U S A (2005) 1.67
TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. Mol Cell (2009) 1.66
Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast. Mol Biol Cell (2003) 1.66
A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases. Mol Cell (2004) 1.64
Global mapping of the protein structure space and application in structure-based inference of protein function. Proc Natl Acad Sci U S A (2005) 1.59
The society of genes: networks of functional links between genes from comparative genomics. Genome Biol (2002) 1.55
Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. PLoS One (2010) 1.50
The importance of thermodynamic equilibrium for high throughput gene expression arrays. Biophys J (2003) 1.50
Pharmacodynamic characterization of the efficacy signals due to selective BRAF inhibition with PLX4032 in malignant melanoma. Neoplasia (2010) 1.48
[Responses of spatial distribution pattern of Artemisia ordosica population to the precipitation gradient on Ordos Plateau]. Ying Yong Sheng Tai Xue Bao (2009) 1.44
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. J Biol Chem (2007) 1.43
Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. J Biol Chem (2007) 1.42
Human Ago2 is required for efficient microRNA 122 regulation of hepatitis C virus RNA accumulation and translation. J Virol (2010) 1.42
A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol (2010) 1.42
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol (2007) 1.42
Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation. Biomaterials (2011) 1.41
A computational framework for optimal masking in the synthesis of oligonucleotide microarrays. Nucleic Acids Res (2002) 1.40
Towards the identification of essential genes using targeted genome sequencing and comparative analysis. BMC Genomics (2006) 1.39
Design and use of analog-sensitive protein kinases. Curr Protoc Mol Biol (2004) 1.37
Room temperature giant and linear magnetoresistance in topological insulator Bi2Te3 nanosheets. Phys Rev Lett (2012) 1.34
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol Cancer Ther (2007) 1.33
Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current. J Neurosci (2008) 1.32
Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells. Mol Cell (2008) 1.32
Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe. Nat Protoc (2007) 1.32
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell (2008) 1.32
The effect of poloxamer 188 on nanoparticle morphology, size, cancer cell uptake, and cytotoxicity. Nanomedicine (2009) 1.32
Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. Cancer Res (2003) 1.32
Intraglottal pressure distributions for a symmetric and oblique glottis with a uniform duct. J Acoust Soc Am (2002) 1.31
Rapid self-healing hydrogels. Proc Natl Acad Sci U S A (2012) 1.29
Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. Mol Biol Cell (2012) 1.28
Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. J Cell Biol (2003) 1.27
Identification of functional modules that correlate with phenotypic difference: the influence of network topology. Genome Biol (2010) 1.25
The COMBREX project: design, methodology, and initial results. PLoS Biol (2013) 1.24
Internal fixation of distal tibiofibular syndesmotic injuries: a systematic review with meta-analysis. Int Orthop (2013) 1.23
FastContact: rapid estimate of contact and binding free energies. Bioinformatics (2005) 1.22
Comparative assessment of performance and genome dependence among phylogenetic profiling methods. BMC Bioinformatics (2006) 1.22
Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation. Mol Cell (2011) 1.21
Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. J Med Chem (2013) 1.19
Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation. Proc Natl Acad Sci U S A (2008) 1.18
Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase. Proc Natl Acad Sci U S A (2006) 1.18
Portraits of breast cancer progression. BMC Bioinformatics (2007) 1.17
Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. J Biol Chem (2008) 1.15
Chemical inactivation of cdc7 kinase in budding yeast results in a reversible arrest that allows efficient cell synchronization prior to meiotic recombination. Genetics (2006) 1.15
Integrating genomic data to predict transcription factor binding. Genome Inform (2005) 1.15
Label-free microarray imaging for direct detection of DNA hybridization and single-nucleotide mismatches. Biosens Bioelectron (2010) 1.15
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol (2011) 1.14
Adcyap1r1 genotype, posttraumatic stress disorder, and depression among women exposed to childhood maltreatment. Depress Anxiety (2012) 1.13