Published in Mutat Res on January 04, 2006
A novel piperazine derivative potently induces caspase-dependent apoptosis of cancer cells via inhibition of multiple cancer signaling pathways. Am J Transl Res (2013) 0.80
A Phase I clinical trial of the combination of imatinib and paclitaxel in patients with advanced or metastatic solid tumors refractory to standard therapy. Cancer Chemother Pharmacol (2012) 0.77
UV Differentially Induces Oxidative Stress, DNA Damage and Apoptosis in BCR-ABL1-Positive Cells Sensitive and Resistant to Imatinib. Int J Mol Sci (2015) 0.77
Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest (2010) 2.44
BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance. Blood (2006) 2.18
BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks. Blood (2004) 1.95
Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. J Immunol (2002) 1.89
Polymorphisms of the promoter regions of matrix metalloproteinases genes MMP-1 and MMP-9 in breast cancer. Breast Cancer Res Treat (2005) 1.66
Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis. Mol Cell Biol (2002) 1.60
The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells. EMBO J (2002) 1.55
Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy (2013) 1.34
Chronic myelogenous leukemia molecular signature. Oncogene (2003) 1.31
miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner. Mol Cell (2012) 1.27
BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells. DNA Repair (Amst) (2005) 1.23
BCR/ABL inhibits mismatch repair to protect from apoptosis and induce point mutations. Cancer Res (2008) 1.22
Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination. Mol Cell Biol (2003) 1.21
Tyrosine kinase blockers: new hope for successful cancer therapy. Anticancer Agents Med Chem (2009) 1.19
BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair. Cancer Res (2008) 1.17
Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571. Oncogene (2002) 1.17
Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis. Blood (2002) 1.16
Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile. Blood (2013) 1.16
Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors. Blood (2012) 1.16
Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells. Blood (2013) 1.13
ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks. Cell Cycle (2006) 1.12
T-antigen of the human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51. J Cell Physiol (2006) 1.08
The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment. Acta Biochim Pol (2012) 1.07
Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer--a case control study. Mol Biol Rep (2010) 1.07
PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation. Mol Cell Biol (2012) 1.05
Association between DNA damage, DNA repair genes variability and clinical characteristics in breast cancer patients. Mutat Res (2008) 1.05
Evaluation of oxidative stress markers in pathogenesis of primary open-angle glaucoma. Exp Mol Pathol (2011) 1.01
Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop. Leuk Lymphoma (2012) 1.01
Polymorphisms of the BRCA2 and RAD51 genes in breast cancer. Breast Cancer Res Treat (2005) 1.01
Association between vascular endothelial growth factor gene polymorphisms and age-related macular degeneration in a Polish population. Exp Mol Pathol (2009) 0.99
Id1 transcription inhibitor-matrix metalloproteinase 9 axis enhances invasiveness of the breakpoint cluster region/abelson tyrosine kinase-transformed leukemia cells. Cancer Res (2006) 0.98
p210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation. Blood (2003) 0.96
Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences. Mol Cell Biol (2005) 0.95
BCR/ABL stimulates WRN to promote survival and genomic instability. Cancer Res (2010) 0.94
Cisplatin-evoked DNA fragmentation in normal and cancer cells and its modulation by free radical scavengers and the tyrosine kinase inhibitor STI571. Chem Biol Interact (2004) 0.93
Genotoxicity and cytotoxicity of 2-hydroxyethyl methacrylate. Mutat Res (2010) 0.92
Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia. Blood (2011) 0.92
An association between vascular endothelial growth factor gene promoter polymorphisms and diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol (2007) 0.92
HIV-1 Tat increases cell survival in response to cisplatin by stimulating Rad51 gene expression. Oncogene (2004) 0.92
Oxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy. Int J Mol Sci (2013) 0.92
Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD). Biogerontology (2013) 0.92
Polymorphism of the homologous recombination repair genes RAD51 and XRCC3 in breast cancer. Exp Mol Pathol (2009) 0.92
DNA damage and repair in gastric cancer--a correlation with the hOGG1 and RAD51 genes polymorphisms. Mutat Res (2006) 0.90
The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling. Sci Signal (2013) 0.89
Cytotoxicity and genotoxicity of glycidyl methacrylate. Chem Biol Interact (2009) 0.89
Cellular and molecular mechanisms of age-related macular degeneration: from impaired autophagy to neovascularization. Int J Biochem Cell Biol (2013) 0.89
Common polymorphisms in the XPD and hOGG1 genes are not associated with the risk of colorectal cancer in a Polish population. Tohoku J Exp Med (2009) 0.88
Dental methacrylates may exert genotoxic effects via the oxidative induction of DNA double strand breaks and the inhibition of their repair. Mol Biol Rep (2012) 0.88
Polymorphisms of the DNA polymerase beta gene in breast cancer. Breast Cancer Res Treat (2006) 0.88
DNA damage and repair in endometrial cancer in correlation with the hOGG1 and RAD51 genes polymorphism. Mol Biol Rep (2010) 0.88
Polymorphisms of the DNA mismatch repair gene HMSH2 in breast cancer occurence and progression. Breast Cancer Res Treat (2005) 0.87
DNA damage and repair in age-related macular degeneration. Mutat Res (2009) 0.87
Therapeutic effect of melatonin in patients with functional dyspepsia. J Clin Gastroenterol (2007) 0.87
Efficacy of DNA double-strand breaks repair in breast cancer is decreased in carriers of the variant allele of the UBC9 gene c.73G>A polymorphism. Mutat Res (2010) 0.86
Zinc salts differentially modulate DNA damage in normal and cancer cells. Cell Biol Int (2009) 0.86
BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin. Oncogene (2005) 0.86
Impaired homologous recombination DNA repair and enhanced sensitivity to DNA damage in prostate cancer cells exposed to anchorage-independence. Oncogene (2005) 0.86
DNA damage and repair in children with Down's syndrome. Mutat Res (2007) 0.86
The Cys326 allele of the 8-oxoguanine DNA N-glycosylase 1 gene as a risk factor in smoking- and drinking-associated larynx cancer. Tohoku J Exp Med (2009) 0.85
UPR-inducible miRNAs contribute to stressful situations. Trends Biochem Sci (2013) 0.85
Genotoxicity of urethane dimethacrylate, a tooth restoration component. Toxicol In Vitro (2009) 0.84
NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner. Exp Hematol (2004) 0.84
The DNA-damaging potential of tamoxifen in breast cancer and normal cells. Arch Toxicol (2007) 0.84
Resveratrol may reduce oxidative stress induced by platinum compounds in human plasma, blood platelets and lymphocytes. Anticancer Drugs (2005) 0.84
DNA damage and repair in Helicobacter pylori-infected gastric mucosa cells. Mutat Res (2005) 0.84
DNA damage and repair in Fuchs endothelial corneal dystrophy. Mol Biol Rep (2012) 0.83
Polymorphism of the ERalpha and CYP1B1 genes in endometrial cancer in a Polish subpopulation. J Obstet Gynaecol Res (2010) 0.83
Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation. Leuk Lymphoma (2012) 0.83
Protective action of melatonin against oxidative DNA damage: chemical inactivation versus base-excision repair. Mutat Res (2007) 0.83
Does the bcr/abl-mediated increase in the efficacy of DNA repair play a role in the drug resistance of cancer cells? Cell Biol Int (2002) 0.83
Independent and combined cytotoxicity and genotoxicity of triethylene glycol dimethacrylate and urethane dimethacrylate. Mol Biol Rep (2010) 0.82
STI571 reduces NER activity in BCR/ABL-expressing cells. Mutat Res (2008) 0.82
Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation. Cell Cycle (2014) 0.82
Association between sorbitol dehydrogenase gene polymorphisms and type 2 diabetic retinopathy. Exp Eye Res (2008) 0.82