PubRank

Brian J Bacskai

Author PubWeight™ 129.12‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature 2008 6.89
2 Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci 2005 4.71
3 Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron 2008 3.46
4 Caspase activation precedes and leads to tangles. Nature 2010 3.24
5 Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol 2002 3.12
6 Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation. Neuroimage 2007 3.07
7 Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J Biol Chem 2003 3.00
8 Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis 2006 2.96
9 Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science 2009 2.65
10 Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron 2004 2.53
11 Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. J Neurosci 2010 2.46
12 The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. J Biol Chem 2005 2.08
13 A time domain fluorescence tomography system for small animal imaging. IEEE Trans Med Imaging 2008 2.05
14 Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques. J Neurosci 2004 1.99
15 Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models. PLoS One 2008 1.95
16 Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. J Clin Invest 2005 1.94
17 Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. Nat Med 2004 1.91
18 Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. J Neurosci 2003 1.81
19 A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorg Med Chem Lett 2002 1.79
20 In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci 2008 1.77
21 Time resolved fluorescence tomography of turbid media based on lifetime contrast. Opt Express 2006 1.70
22 Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. J Neurosci 2005 1.70
23 Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model. Am J Pathol 2007 1.69
24 Fluorescence-lifetime-based tomography for turbid media. Opt Lett 2005 1.66
25 Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease. J Neurosci 2012 1.64
26 Rapid cell death is preceded by amyloid plaque-mediated oxidative stress. Proc Natl Acad Sci U S A 2013 1.61
27 Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo. J Cereb Blood Flow Metab 2006 1.60
28 In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers. Angew Chem Int Ed Engl 2005 1.60
29 Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain 2007 1.55
30 Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. J Neurosci 2010 1.50
31 Lifetime-based tomographic multiplexing. J Biomed Opt 2010 1.45
32 Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. J Neurosci 2008 1.43
33 In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy. J Neurosci 2003 1.43
34 Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. Neuron 2009 1.42
35 CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Blood 2007 1.38
36 Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. PLoS One 2009 1.34
37 Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide. J Neurosci 2012 1.32
38 In vivo imaging of amyloid-beta deposits in mouse brain with multiphoton microscopy. Methods Mol Biol 2005 1.30
39 Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease. Neurobiol Dis 2008 1.29
40 Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J Am Chem Soc 2009 1.26
41 Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neurosci 2006 1.24
42 Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. J Neuropathol Exp Neurol 2006 1.22
43 Comparison of frequency-domain and time-domain fluorescence lifetime tomography. Opt Lett 2008 1.19
44 Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging 2008 1.17
45 Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo. Proc Natl Acad Sci U S A 2013 1.16
46 Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models. Acta Neuropathol 2013 1.15
47 Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. J Neurosci 2003 1.14
48 The membrane organization of leukotriene synthesis. Proc Natl Acad Sci U S A 2004 1.13
49 Cerebrovascular lesions induce transient β-amyloid deposition. Brain 2011 1.10
50 Physical and functional connection between auxilin and dynamin during endocytosis. EMBO J 2006 1.10
51 Detection of myelination using a novel histological probe. J Histochem Cytochem 2005 1.09
52 Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice. J Neurochem 2009 1.08
53 Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. J Neurosci 2007 1.07
54 Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575. Mol Neurodegener 2009 1.07
55 Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography. Neuroimaging Clin N Am 2003 1.07
56 Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast. Opt Lett 2009 1.07
57 Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain. PLoS One 2011 1.06
58 A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice. J Neurosci 2009 1.05
59 Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease. J Neuropathol Exp Neurol 2005 0.99
60 Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay. J Neurosci 2012 0.99
61 Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model. J Neurosci 2013 0.98
62 Tomographic lifetime imaging using combined early- and late-arriving photons. Opt Lett 2014 0.98
63 Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging. Methods 2010 0.92
64 Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons. J Biomed Opt 2009 0.92
65 Rapid β-amyloid deposition and cognitive impairment after cholinergic denervation in APP/PS1 mice. J Neuropathol Exp Neurol 2013 0.92
66 Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice. Neurobiol Aging 2009 0.91
67 P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. J Immunol 2009 0.89
68 A limited role for microglia in antibody mediated plaque clearance in APP mice. Neurobiol Dis 2007 0.89
69 Development and screening of contrast agents for in vivo imaging of Parkinson's disease. Mol Imaging Biol 2013 0.87
70 Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays. J Biomed Opt 2006 0.86
71 Assays and functional properties of auxilin-dynamin interactions. Methods Enzymol 2005 0.86
72 Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. Brain Res 2006 0.85
73 Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity. Traffic 2014 0.85
74 Differential recognition of vascular and parenchymal beta amyloid deposition. Neurobiol Aging 2009 0.85
75 Stable size distribution of amyloid plaques over the course of Alzheimer disease. J Neuropathol Exp Neurol 2012 0.83
76 In vivo detection of amyloid-β deposits using heavy chain antibody fragments in a transgenic mouse model for Alzheimer's disease. PLoS One 2012 0.82
77 Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV. Acta Neuropathol Commun 2014 0.82
78 Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology. J Biomed Opt 2005 0.82
79 Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. PLoS One 2013 0.81
80 Monitoring proteins in intact cells. Sci Aging Knowledge Environ 2003 0.80
81 Genetic animal models of cerebral vasculopathies. Prog Mol Biol Transl Sci 2012 0.79
82 Modular design for in vivo optical imaging and ultrasound treatment in the murine brain. IEEE Trans Ultrason Ferroelectr Freq Control 2007 0.79
83 Preclinical characterization of amyloid imaging probes with multiphoton microscopy. J Alzheimers Dis 2006 0.79
84 Techniques for brain imaging in vivo. Neuromolecular Med 2004 0.79
85 Reducing available soluble β-amyloid prevents progression of cerebral amyloid angiopathy in transgenic mice. J Neuropathol Exp Neurol 2012 0.78
86 Bringing amyloid into focus. Nat Biotechnol 2005 0.78
87 Activated Notch1 associates with a presenilin-1/gamma-secretase docking site. J Neurochem 2003 0.77
88 Optimal estimator for tomographic fluorescence lifetime multiplexing. Opt Lett 2016 0.75
89 Comparison of tomographic fluorescence spectral and lifetime multiplexing. Opt Lett 2016 0.75