Preclinical pharmacokinetics and metabolism of a potent non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.

PubWeight™: 0.84‹?›

🔗 View Article (PMID 16393860)

Published in Xenobiotica on January 05, 2006

Authors

C Giuliano1, F Fiore, A Di Marco, J Padron Velazquez, A Bishop, F Bonelli, O Gonzalez-Paz, I Marcucci, S Harper, F Narjes, B Pacini, E Monteagudo, G Migliaccio, M Rowley, R Laufer

Author Affiliations

1: Department of Pharmacology, Istituto di Ricerche di Biologia Molecolare (IRBM) P. Angeletti, Merck Research Laboratories Rome, Pomezia, Italy.

Articles by these authors

Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies: results in 123 patients. Ann Surg (1999) 5.25

Stem cell patterning and fate in human epidermis. Cell (1995) 5.22

Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci U S A (1995) 5.15

A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2-specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis. Rofecoxib Osteoarthritis Endoscopy Study Group. Gastroenterology (1999) 4.13

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev (1999) 4.07

Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet (1999) 3.37

Biosynthesis and biochemical properties of the hepatitis C virus core protein. J Virol (1994) 3.19

GRB 090423 at a redshift of z approximately 8.1. Nature (2009) 2.84

A recombinant hepatitis B core antigen polypeptide with the protamine-like domain deleted self-assembles into capsid particles but fails to bind nucleic acids. J Virol (1989) 2.72

Structural basis for selective inhibition of Src family kinases by PP1. Chem Biol (1999) 2.35

Broadband observations of the naked-eye gamma-ray burst GRB 080319B. Nature (2008) 2.16

Diabetic retinopathy is associated with a switch in splicing from anti- to pro-angiogenic isoforms of vascular endothelial growth factor. Diabetologia (2005) 2.09

Isolated microscopic haematuria in the genitourinary clinic: the value of renal biopsy. Int J STD AIDS (1997) 2.02

Haemoglobin switching in human embryos: asynchrony of zeta----alpha and epsilon----gamma-globin switches in primitive and definite erythropoietic lineage. Nature (1985) 1.87

Rifampicin, a general review. Arzneimittelforschung (1971) 1.80

Highly selective agonists for substance P receptor subtypes. EMBO J (1986) 1.80

Does treatment with L-thyroxine influence health status in middle-aged and older adults with subclinical hypothyroidism? J Gen Intern Med (1996) 1.74

Deficiency of the suppressor inducer subset of T lymphocytes in rheumatoid arthritis. Arthritis Rheum (1987) 1.70

Perceived barriers and benefits to cervical cancer screening in Latin America. Prev Med (2004) 1.70

Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts. Proc Natl Acad Sci U S A (1983) 1.68

Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67

Systematic analysis of peptide recoveries from in-gel digestions for protein identifications in proteome studies. J Biomol Tech (2000) 1.64

The NS2 protein of hepatitis C virus is a transmembrane polypeptide. J Virol (1995) 1.61

Transfusion guidelines for neonates and older children. Br J Haematol (2004) 1.61

Guidelines for pre-transfusion compatibility procedures in blood transfusion laboratories. British Committee for Standards in Haematology. Transfus Med (2012) 1.60

Clinical presentation of inhalational anthrax following bioterrorism exposure: report of 2 surviving patients. JAMA (2001) 1.57

Adriamycin (NSC-123,127): a new antibiotic with antitumor activity. Cancer Chemother Rep (1969) 1.56

Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56

Accentuated response to phenylhydrazine and erythropoietin in mice genetically impaired for their GATA-1 expression (GATA-1(low) mice). Blood (2001) 1.51

Palmitylation of viral membrane glycoproteins takes place after exit from the endoplasmic reticulum. J Biol Chem (1989) 1.45

Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proc Natl Acad Sci U S A (1985) 1.44

Observation of B(0)(s)-->Psi(2S)Phi and measurement of the ratio of branching fractions Beta(B(0)(s)-->Psi(2S)Phi)/Beta(B(0)(s)-->J/PsiPhi). Phys Rev Lett (2006) 1.40

Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins. J Biol Chem (1997) 1.40

A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates. Anal Biochem (1996) 1.40

Multi-centre phase II clinical trial of yttrium-90 resin microspheres alone in unresectable, chemotherapy refractory colorectal liver metastases. Br J Cancer (2010) 1.39

Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the yolk sac----liver transition. J Clin Invest (1986) 1.39

Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation. Proc Natl Acad Sci U S A (1999) 1.38

Comparative analysis of hematopoietic growth factors released by stromal cells from normal donors or transplanted patients. Blood (1990) 1.38

Typhoid fever: pathogenesis and disease. Curr Opin Infect Dis (2001) 1.37

Detecting 2009 pandemic influenza A (H1N1) virus infection: availability of diagnostic testing led to rapid pandemic response. Clin Infect Dis (2011) 1.36

Studies on translocation of immunoglobulins across intestinal epithelium. IV. Evidence for binding of IgA and IgM to secretory component in intestinal epithelium. Gastroenterology (1977) 1.36

Unrelated placental blood for bone marrow reconstitution: organization of the placental blood program. Blood Cells (1994) 1.35

Role of signal recognition particle in the membrane assembly of Sindbis viral glycoproteins. Eur J Biochem (1984) 1.34

Interaction of daunomycin and its derivatives with DNA. Biochim Biophys Acta (1972) 1.34

Synthetic Plasmodium falciparum circumsporozoite peptides elicit heterogenous L3T4+ T cell proliferative responses in H-2b mice. J Immunol (1986) 1.33

Nonintegrated plasmid-folded chromosome complexes: genetic studies on formation and possible relationship to plasmid replication. Plasmid (1978) 1.30

Progressive inactivation of the expression of an erythroid transcriptional factor in GM- and G-CSF-dependent myeloid cell lines. Nucleic Acids Res (1990) 1.30

Free diffusion to and from the inner nuclear membrane of newly synthesized plasma membrane glycoproteins. J Cell Biol (1987) 1.27

Interaction between Cdc37 and Cdk4 in human cells. Oncogene (1997) 1.25

Characterization of the hepatitis C virus NS2/3 processing reaction by using a purified precursor protein. J Virol (2001) 1.24

Embryonic----Fetal Hb switch in humans: studies on erythroid bursts generated by embryonic progenitors from yolk sac and liver. Proc Natl Acad Sci U S A (1984) 1.24

Measurement of the electron charge asymmetry in inclusive W production in pp collisions at sqrt[s]=7  TeV. Phys Rev Lett (2012) 1.23

The difficulties of assessing right ventricular function. Br Heart J (1995) 1.20

Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at √s = 7 TeV. Phys Rev Lett (2012) 1.19

Azimuthal anisotropy of charged particles at high transverse momenta in Pb-Pb collisions at sqrt[s(NN)] = 2.76  TeV. Phys Rev Lett (2012) 1.19

Biochemical fractionation and assembly of the membrane components that mediate nascent chain targeting and translocation. Cell (1991) 1.18

In vitro study of the NS2-3 protease of hepatitis C virus. J Virol (1997) 1.18

Cognitive demand and blood glucose. Physiol Behav (2001) 1.18

Calcitonin gene-related peptide elevates cyclic AMP levels in chick skeletal muscle: possible neurotrophic role for a coexisting neuronal messenger. EMBO J (1987) 1.16

The interaction of adriamycin and its beta anomer with DNA. Biochim Biophys Acta (1977) 1.16

Mechanism of action of daunomycin. Acta Genet Med Gemellol (Roma) (1968) 1.16

Some problems associated with war experience in men of the Vietnam generation. Arch Gen Psychiatry (1984) 1.15

Regioselective radiofluorodestannylation with [18F]F2 and [18F]CH3COOF: a high yield synthesis of 6-[18F]Fluoro-L-dopa. Int J Rad Appl Instrum A (1992) 1.15

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc Natl Acad Sci U S A (1997) 1.15

Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice. Blood (2000) 1.14

Behavioural effects of receptor-specific substance P agonists. Pain (1987) 1.14

Characterization of a neurokinin B receptor site in rat brain using a highly selective radioligand. J Biol Chem (1986) 1.13

Enhancing B- and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer. J Virol (2000) 1.13

Interaction of Epstein-Barr virus nuclear antigen 1 with the viral latent origin of replication. J Virol (1992) 1.13

Response to erythropoietin in erythroid subclones of the factor-dependent cell line 32D is determined by translocation of the erythropoietin receptor to the cell surface. Proc Natl Acad Sci U S A (1991) 1.12

Collagen antibodies in rheumatoid arthritis. Significance of antibodies to denatured collagen and their association with HLA-DR4. Arthritis Rheum (1986) 1.11

Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium. J Allergy Clin Immunol (2001) 1.11

Regulation of muscle AChR alpha subunit gene expression by electrical activity: involvement of protein kinase C and Ca2+. Neuron (1989) 1.11

First observation of the decay Bs0-->Ds-Ds+ and measurement of its branching ratio. Phys Rev Lett (2008) 1.11

Complementary studies of the gastrointestinal safety of the cyclo-oxygenase-2-selective inhibitor etoricoxib. Aliment Pharmacol Ther (2003) 1.11

Effector gammadelta T cells and tumor cells as immune targets of zoledronic acid in multiple myeloma. Leukemia (2005) 1.10

Search for a W' or techni-ρ decaying into WZ in pp Collisions at sqrt[s] = 7  TeV. Phys Rev Lett (2012) 1.10

Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy. Phys Rev Lett (2012) 1.09

Search for supersymmetry at the LHC in events with jets and missing transverse energy. Phys Rev Lett (2011) 1.08

Measurement of sigma chi c2 B(chi c2-->J/psi gamma)/sigma chi c1 B(chi c1 -->J/psi gamma) in pp collisions at square root s=1.96 TeV. Phys Rev Lett (2007) 1.07

Crucial points at diagnosis. Type 2 diabetes or slow type 1 diabetes. Diabetes Care (1999) 1.07

Search for stopped Gluinos in pp collisions at square root s=7 TeV. Phys Rev Lett (2011) 1.07

Intracardiac echocardiography in electrophysiology. Minerva Cardioangiol (2010) 1.06

Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system. Gene Ther (2002) 1.05

Measurement of the Υ1S, Υ2S, and Υ3S polarizations in pp collisions at sqrt[s] = 7 TeV. Phys Rev Lett (2013) 1.05

Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes. J Biol Chem (2000) 1.04

Direct measurement of the W production charge asymmetry in pp collisions at square root s=1.96 TeV. Phys Rev Lett (2009) 1.04

Search for long-lived massive charged particles in 1.96 TeV pp collisions. Phys Rev Lett (2009) 1.03

In vivo expansion of purified hematopoietic stem cells transplanted in nonablated W/Wv mice. Exp Hematol (1999) 1.03

AN APPARENT LUNAR PERIODICITY IN THE SEXUAL CYCLE OF CERTAIN PROSIMIANS. Proc Natl Acad Sci U S A (1962) 1.03

A pragmatic randomised controlled trial of the effectiveness and cost-effectiveness of 'PhysioDirect' telephone assessment and advice services for physiotherapy. Health Technol Assess (2013) 1.02

Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain. Eur J Pain (2012) 1.02

Substrate specificity of the hepatitis C virus serine protease NS3. J Biol Chem (1997) 1.01

A rapid method for semi-quantitative analysis of neurite outgrowth from chick DRG explants using image analysis. J Neurosci Methods (1999) 1.01

[pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype. J Med Chem (1986) 1.01

Antibody-producing capacity in human cancer. Br J Cancer (1970) 1.00

Platelet transfusions in haematology patients: are we using them appropriately? Vox Sang (2012) 1.00