Published in Am J Physiol Renal Physiol on January 05, 2006
Regulation of blood pressure and salt homeostasis by endothelin. Physiol Rev (2011) 2.22
Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. Proc Natl Acad Sci U S A (2007) 2.10
A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence. PLoS Genet (2006) 1.90
Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling. Am J Physiol Renal Physiol (2006) 1.72
TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease. J Am Soc Nephrol (2013) 1.60
Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors. Am J Physiol Gastrointest Liver Physiol (2008) 1.56
Polycystin-2 immunolocalization and function in zebrafish. J Am Soc Nephrol (2006) 1.50
A TRPM4-dependent current in murine renal primary cilia. Am J Physiol Renal Physiol (2015) 1.43
The Oak Ridge Polycystic Kidney mouse: modeling ciliopathies of mice and men. Dev Dyn (2008) 1.36
Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2+ signaling in human ADPKD cyst epithelial cells. Am J Physiol Renal Physiol (2009) 1.28
Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli. Cell Mol Life Sci (2013) 1.27
Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals. Purinergic Signal (2007) 1.27
Transient receptor potential (TRP) channels: a clinical perspective. Br J Pharmacol (2014) 1.25
Neuronal ciliary signaling in homeostasis and disease. Cell Mol Life Sci (2010) 1.17
Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation. Hum Mol Genet (2010) 1.11
The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. PLoS Genet (2011) 1.11
Dopamine receptor type 5 in the primary cilia has dual chemo- and mechano-sensory roles. Hypertension (2011) 1.10
Physiology of endothelin and the kidney. Compr Physiol (2011) 1.08
Intratubular hydrodynamic forces influence tubulointerstitial fibrosis in the kidney. Curr Opin Nephrol Hypertens (2010) 0.99
Ciliary dysfunction in polycystic kidney disease: an emerging model with polarizing potential. Front Biosci (2008) 0.97
Fluid shear stress induces renal epithelial gene expression through polycystin-2-dependent trafficking of extracellular regulated kinase. Nephron Physiol (2010) 0.97
OCRL1 modulates cilia length in renal epithelial cells. Traffic (2012) 0.96
Primary cilia: highly sophisticated biological sensors. Sensors (Basel) (2009) 0.95
TRPP2 and TRPV4 form an EGF-activated calcium permeable channel at the apical membrane of renal collecting duct cells. PLoS One (2013) 0.94
The ciliary flow sensor and polycystic kidney disease. Nephrol Dial Transplant (2013) 0.93
Molecular pathways and therapies in autosomal-dominant polycystic kidney disease. Physiology (Bethesda) (2015) 0.93
Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors. Am J Physiol Renal Physiol (2011) 0.92
Primary cilia and kidney injury: current research status and future perspectives. Am J Physiol Renal Physiol (2013) 0.90
Glomerulocystic kidney disease. Pediatr Nephrol (2010) 0.89
Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization. J Cell Physiol (2012) 0.88
Calcium-mediated mechanisms of cystic expansion. Biochim Biophys Acta (2010) 0.88
Protein composition and movements of membrane swellings associated with primary cilia. Cell Mol Life Sci (2015) 0.83
Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C. J Biol Chem (2013) 0.82
Chronic fluid flow is an environmental modifier of renal epithelial function. PLoS One (2011) 0.82
Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease. Am J Physiol Cell Physiol (2012) 0.82
Constructing and deconstructing roles for the primary cilium in tissue architecture and cancer. Methods Cell Biol (2009) 0.82
Cilia movement regulates expression of the Raf-1 kinase inhibitor protein. Am J Physiol Renal Physiol (2011) 0.81
Enhancement of renal epithelial cell functions through microfluidic-based coculture with adipose-derived stem cells. Tissue Eng Part A (2013) 0.81
Deciphering physiological role of the mechanosensitive TRPV4 channel in the distal nephron. Am J Physiol Renal Physiol (2014) 0.80
Sensing a sensor: identifying the mechanosensory function of primary cilia. Biosensors (Basel) (2014) 0.79
Activation of the intrarenal renin-angiotensin-system in murine polycystic kidney disease. Physiol Rep (2015) 0.79
Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium. J Vis Exp (2015) 0.79
The role of cilia in the pathogenesis of cystic kidney disease. Curr Opin Pediatr (2015) 0.78
Role of renal TRP channels in physiology and pathology. Semin Immunopathol (2015) 0.77
Primary cilia regulate the osmotic stress response of renal epithelial cells through TRPM3. Am J Physiol Renal Physiol (2017) 0.75
RAPAMYCIN INCREASES LENGTH AND MECHANOSENSORY FUNCTION OF PRIMARY CILIA IN RENAL EPITHELIAL AND VASCULAR ENDOTHELIAL CELLS. Int Educ Res J (2016) 0.75
Volume progression in polycystic kidney disease. N Engl J Med (2006) 7.16
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet (2005) 6.15
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell (2004) 6.10
The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J Am Soc Nephrol (2002) 5.58
Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort. Kidney Int (2003) 4.84
Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development (2005) 4.64
Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nat Genet (2010) 3.99
Fibrosis--a common pathway to organ injury and failure. N Engl J Med (2015) 3.94
Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet (2007) 3.79
Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease. Curr Biol (2007) 3.76
The primary cilium as a complex signaling center. Curr Biol (2009) 3.73
Comprehensive molecular diagnostics in autosomal dominant polycystic kidney disease. J Am Soc Nephrol (2007) 3.26
PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. Am J Hum Genet (2002) 3.21
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis. J Cell Biol (2011) 3.11
An incredible decade for the primary cilium: a look at a once-forgotten organelle. Am J Physiol Renal Physiol (2005) 3.07
Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT(1) receptors. J Am Soc Nephrol (2002) 3.04
Intraflagellar transport is essential for endochondral bone formation. Development (2006) 2.90
Ciliary dysfunction in developmental abnormalities and diseases. Curr Top Dev Biol (2008) 2.88
HLA class II polymorphisms associated with the physiologic characteristics defined by Traditional Chinese Medicine: linking modern genetics with an ancient medicine. J Altern Complement Med (2007) 2.61
Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort. Clin J Am Soc Nephrol (2005) 2.37
Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus. Development (2005) 2.36
Cyst number but not the rate of cystic growth is associated with the mutated gene in autosomal dominant polycystic kidney disease. J Am Soc Nephrol (2006) 2.21
Primary cilia and signaling pathways in mammalian development, health and disease. Nephron Physiol (2009) 2.09
Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J Clin Invest (2002) 2.07
Focal adhesion kinase in netrin-1 signaling. Nat Neurosci (2004) 1.99
Angiotensin I conversion to angiotensin II stimulates cortical collecting duct sodium transport. Hypertension (2003) 1.99
The primary cilium in cell signaling and cancer. Cancer Res (2006) 1.97
Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool. J Neurosci (2007) 1.92
Normal ciliogenesis requires synergy between the cystic kidney disease genes MKS-3 and NPHP-4. J Am Soc Nephrol (2010) 1.85
A classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis. Hepatology (2011) 1.84
Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles. Mol Biol Cell (2007) 1.82
Cystin localizes to primary cilia via membrane microdomains and a targeting motif. J Am Soc Nephrol (2009) 1.79
Mixed transition-metal oxides: design, synthesis, and energy-related applications. Angew Chem Int Ed Engl (2014) 1.77
Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia. Am J Physiol Cell Physiol (2005) 1.74
Loss of the Tg737 protein results in skeletal patterning defects. Dev Dyn (2003) 1.71
A modified rabbit model of reperfused myocardial infarction for cardiac MR imaging research. Int J Cardiovasc Imaging (2008) 1.67
Mechanoregulation of intracellular Ca2+ concentration is attenuated in collecting duct of monocilium-impaired orpk mice. Am J Physiol Renal Physiol (2005) 1.66
Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance. Biochem Pharmacol (2012) 1.65
Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts. Cell Physiol Biochem (2010) 1.63
Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis. Mol Biol Cell (2008) 1.59
Characterization of large rearrangements in autosomal dominant polycystic kidney disease and the PKD1/TSC2 contiguous gene syndrome. Kidney Int (2008) 1.58
XBX-1 encodes a dynein light intermediate chain required for retrograde intraflagellar transport and cilia assembly in Caenorhabditis elegans. Mol Biol Cell (2003) 1.57
Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1. J Mol Med (Berl) (2014) 1.56
A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in chlamydomonas and Mammalian cells. Mol Biol Cell (2003) 1.56
Myosin X regulates netrin receptors and functions in axonal path-finding. Nat Cell Biol (2007) 1.55
Neuronal nitric oxide synthase: its role and regulation in macula densa cells. J Am Soc Nephrol (2003) 1.54
Magnetic resonance measurements of renal blood flow and disease progression in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol (2006) 1.53
Purinergic receptor signaling at the basolateral membrane of macula densa cells. J Am Soc Nephrol (2002) 1.52
Luminal NaCl delivery regulates basolateral PGE2 release from macula densa cells. J Clin Invest (2003) 1.49
Sonographic assessment of the severity and progression of autosomal dominant polycystic kidney disease: the Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP). Am J Kidney Dis (2005) 1.49
cDNA microarray analysis of differential gene expression in Candida albicans biofilm exposed to farnesol. Antimicrob Agents Chemother (2005) 1.48
N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct. Am J Physiol Renal Physiol (2011) 1.48
Magnetic resonance measurements of renal blood flow as a marker of disease severity in autosomal-dominant polycystic kidney disease. Kidney Int (2003) 1.45
The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perception. J Cell Sci (2005) 1.44
Polyductin undergoes notch-like processing and regulated release from primary cilia. Hum Mol Genet (2007) 1.44
Development of the post-natal growth plate requires intraflagellar transport proteins. Dev Biol (2007) 1.44
Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet (2007) 1.43
Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm. Kidney Int (2004) 1.42
Cloning and characterization of a novel human pantothenate kinase gene. Int J Biochem Cell Biol (2002) 1.42
Escherichia coli K1 RS218 interacts with human brain microvascular endothelial cells via type 1 fimbria bacteria in the fimbriated state. Infect Immun (2005) 1.41
Soluble levels of cytosolic tubulin regulate ciliary length control. Mol Biol Cell (2011) 1.41
Stromal cell-derived factor-1/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro. Stem Cells (2006) 1.39
Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation. Cancer Res (2002) 1.38
Identification of CHE-13, a novel intraflagellar transport protein required for cilia formation. Exp Cell Res (2003) 1.38
Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice. Lab Invest (2005) 1.38
Comparison of methods for determining renal function decline in early autosomal dominant polycystic kidney disease: the consortium of radiologic imaging studies of polycystic kidney disease cohort. J Am Soc Nephrol (2006) 1.37
The Oak Ridge Polycystic Kidney mouse: modeling ciliopathies of mice and men. Dev Dyn (2008) 1.36
Positional cloning of jcpk/bpk locus of the mouse. Mamm Genome (2003) 1.35
Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses. J Immunol (2003) 1.35
Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells. J Biol Chem (2008) 1.34
Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone. Biochem Biophys Res Commun (2006) 1.33
Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition. Circ Res (2011) 1.31
Primary cilia are decreased in breast cancer: analysis of a collection of human breast cancer cell lines and tissues. J Histochem Cytochem (2010) 1.31
Primary cilia regulate Shh activity in the control of molar tooth number. Development (2009) 1.31
Selected-control synthesis of ZnO nanowires and nanorods via a PEG-assisted route. Inorg Chem (2003) 1.30
Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes. J Biol Chem (2006) 1.30
Defect-rich MoS2 ultrathin nanosheets with additional active edge sites for enhanced electrocatalytic hydrogen evolution. Adv Mater (2013) 1.30
Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells. Cancer Res (2005) 1.30
Apoptotic cells protect mice against lipopolysaccharide-induced shock. J Immunol (2008) 1.29
Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas. Clin Cancer Res (2005) 1.29
Controllable disorder engineering in oxygen-incorporated MoS2 ultrathin nanosheets for efficient hydrogen evolution. J Am Chem Soc (2013) 1.28
Real-time imaging of renin release in vitro. Am J Physiol Renal Physiol (2004) 1.28
Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals. Purinergic Signal (2007) 1.27
Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines. Dev Dyn (2008) 1.27