PubRank

Erkki Ruoslahti

Author PubWeight™ 141.83‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science 2010 6.01
2 Nanocrystal targeting in vivo. Proc Natl Acad Sci U S A 2002 5.35
3 Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nat Mater 2009 4.77
4 Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell 2009 4.02
5 Nanoparticles that communicate in vivo to amplify tumour targeting. Nat Mater 2011 3.83
6 Biomimetic amplification of nanoparticle homing to tumors. Proc Natl Acad Sci U S A 2007 3.26
7 Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 2004 3.09
8 A tumor-homing peptide with a targeting specificity related to lymphatic vessels. Nat Med 2002 2.77
9 Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels. J Cell Biol 2003 2.68
10 Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 2003 2.56
11 C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration. Proc Natl Acad Sci U S A 2009 2.41
12 A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo. Proc Natl Acad Sci U S A 2002 2.35
13 Targeted quantum dot conjugates for siRNA delivery. Bioconjug Chem 2007 2.31
14 Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting. Small 2009 2.16
15 Mitochondrial/cell-surface protein p32/gC1qR as a molecular target in tumor cells and tumor stroma. Cancer Res 2008 2.13
16 Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma. Cancer Cell 2003 2.07
17 Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol 2010 2.05
18 Targeting the prostate for destruction through a vascular address. Proc Natl Acad Sci U S A 2002 2.01
19 Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging. Adv Mater 2008 2.01
20 In vivo tumor cell targeting with "click" nanoparticles. Bioconjug Chem 2008 2.01
21 Targeting of albumin-embedded paclitaxel nanoparticles to tumors. Nanomedicine 2008 1.90
22 Cooperative nanomaterial system to sensitize, target, and treat tumors. Proc Natl Acad Sci U S A 2009 1.82
23 Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells. Proc Natl Acad Sci U S A 2004 1.82
24 Targeting atherosclerosis by using modular, multifunctional micelles. Proc Natl Acad Sci U S A 2009 1.76
25 A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. Cell 2004 1.73
26 Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery. Angew Chem Int Ed Engl 2008 1.71
27 Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds. Proc Natl Acad Sci U S A 2006 1.68
28 Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma. Proc Natl Acad Sci U S A 2011 1.68
29 Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels. Cancer Cell 2012 1.56
30 R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. Nat Med 2005 1.51
31 Peptides targeting inflamed synovial vasculature attenuate autoimmune arthritis. Proc Natl Acad Sci U S A 2011 1.45
32 Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity. J Biol Chem 2003 1.44
33 Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Sci Transl Med 2012 1.42
34 Proteolytic actuation of nanoparticle self-assembly. Angew Chem Int Ed Engl 2006 1.39
35 Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium. Proc Natl Acad Sci U S A 2013 1.37
36 Nanoparticle-induced vascular blockade in human prostate cancer. Blood 2010 1.30
37 Molecular specialization of breast vasculature: a breast-homing phage-displayed peptide binds to aminopeptidase P in breast vasculature. Proc Natl Acad Sci U S A 2002 1.26
38 Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery. Adv Mater 2010 1.26
39 A high-throughput label-free nanoparticle analyser. Nat Nanotechnol 2011 1.24
40 Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion. Cancer Res 2010 1.23
41 Cell spreading controls endoplasmic and nuclear calcium: a physical gene regulation pathway from the cell surface to the nucleus. Proc Natl Acad Sci U S A 2003 1.22
42 Anastellin, an FN3 fragment with fibronectin polymerization activity, resembles amyloid fibril precursors. J Mol Biol 2003 1.21
43 Mapping of vascular ZIP codes by phage display. Methods Enzymol 2012 1.21
44 Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance. Biomaterials 2009 1.19
45 Lymphatic zip codes in premalignant lesions and tumors. Cancer Res 2006 1.18
46 Synthetic surfaces for human embryonic stem cell culture. J Biotechnol 2010 1.13
47 De novo design of a tumor-penetrating peptide. Cancer Res 2012 1.12
48 Molecular profiling of heart endothelial cells. Circulation 2005 1.11
49 Protein kinase D is a positive regulator of Bit1 apoptotic function. J Biol Chem 2008 1.11
50 Anoikis effector Bit1 negatively regulates Erk activity. Proc Natl Acad Sci U S A 2008 1.11
51 Targeting bladder tumor cells in vivo and in the urine with a peptide identified by phage display. Mol Cancer Res 2007 1.10
52 Lymphangiogenesis and cancer: meeting report. Cancer Res 2004 1.10
53 Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature. Proc Natl Acad Sci U S A 2005 1.10
54 Molecular changes in the vasculature of injured tissues. Am J Pathol 2007 1.08
55 Cell surface nucleolin antagonist causes endothelial cell apoptosis and normalization of tumor vasculature. Angiogenesis 2009 1.08
56 A surface-charge study on cellular-uptake behavior of F3-peptide-conjugated iron oxide nanoparticles. Small 2009 1.07
57 Tumor-penetrating peptides. Front Oncol 2013 1.06
58 Effect of the lipid chain melting transition on the stability of DSPE-PEG(2000) micelles. Langmuir 2009 1.06
59 Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity. Proc Natl Acad Sci U S A 2003 1.04
60 alpha5beta1 integrin stimulates Bcl-2 expression and cell survival through Akt, focal adhesion kinase, and Ca2+/calmodulin-dependent protein kinase IV. J Cell Biochem 2005 1.04
61 Dynamic imaging of arginine-rich heart-targeted vehicles in a mouse model. Biomaterials 2008 1.03
62 Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads. Small 2010 1.02
63 TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells. Mol Cancer Res 2012 0.98
64 Target-seeking antifibrotic compound enhances wound healing and suppresses scar formation in mice. Proc Natl Acad Sci U S A 2010 0.97
65 Selection of phage-displayed peptides on live adherent cells in microfluidic channels. Proc Natl Acad Sci U S A 2011 0.97
66 X-ray computed tomography imaging of breast cancer by using targeted peptide-labeled bismuth sulfide nanoparticles. Angew Chem Int Ed Engl 2011 0.96
67 Proapoptotic peptide-mediated cancer therapy targeted to cell surface p32. Mol Ther 2013 0.95
68 Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A 2011 0.95
69 Enhanced baculovirus-mediated transduction of human cancer cells by tumor-homing peptides. J Virol 2006 0.95
70 Metastasis of tumor cells is enhanced by downregulation of Bit1. PLoS One 2011 0.94
71 The multicompartmental p32/gClqR as a new target for antibody-based tumor targeting strategies. J Biol Chem 2010 0.94
72 Peptide-directed highly selective targeting of pulmonary arterial hypertension. Am J Pathol 2011 0.93
73 Application of a proapoptotic peptide to intratumorally spreading cancer therapy. Cancer Res 2012 0.93
74 Peptide targeting of tumor lymph vessels. Ann N Y Acad Sci 2008 0.92
75 Recognition of dextran-superparamagnetic iron oxide nanoparticle conjugates (Feridex) via macrophage scavenger receptor charged domains. Bioconjug Chem 2012 0.91
76 Ligand-modified vesicular stomatitis virus glycoprotein displays a temperature-sensitive intracellular trafficking and virus assembly phenotype. Mol Ther 2004 0.91
77 Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation. Proc Natl Acad Sci U S A 2007 0.90
78 Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies. Proc Natl Acad Sci U S A 2013 0.90
79 Binding of a C-end rule peptide to the neuropilin-1 receptor: a molecular modeling approach. Biochemistry 2011 0.87
80 Activated SRC oncogene phosphorylates R-ras and suppresses integrin activity. J Biol Chem 2001 0.86
81 Site-specific targeting of antibody activity in vivo mediated by disease-associated proteases. J Control Release 2012 0.85
82 Different effect of hydrogelation on antifouling and circulation properties of dextran-iron oxide nanoparticles. Mol Pharm 2012 0.84
83 In silico molecular engineering for a targeted replacement in a tumor-homing peptide. J Phys Chem B 2009 0.83
84 (64)Cu-labeled LyP-1-dendrimer for PET-CT imaging of atherosclerotic plaque. Bioconjug Chem 2014 0.82
85 Contact activation of kallikrein-kinin system by superparamagnetic iron oxide nanoparticles in vitro and in vivo. J Control Release 2009 0.81
86 Identification of endothelial genes up-regulated in vivo. Gene 2005 0.81
87 Bit1 in anoikis resistance and tumor metastasis. Cancer Lett 2013 0.80
88 Nanoparticle amplification via photothermal unveiling of cryptic collagen binding sites. J Mater Chem B Mater Biol Med 2013 0.79
89 Enhanced magnetic resonance contrast of Fe₃O₄ nanoparticles trapped in a porous silicon nanoparticle host. Adv Mater 2011 0.79
90 The anti-angiogenic peptide anginex disrupts the cell membrane. J Mol Biol 2005 0.79
91 Clot-targeted micellar formulation improves anticoagulation efficacy of bivalirudin. ACS Nano 2014 0.78
92 Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy. Cancer Res 2013 0.78
93 Vascular histomolecular analysis by sequential endoarterial biopsy in a shunt model of pulmonary hypertension. Pulm Circ 2013 0.77
94 Engineering strategy to improve peptide analogs: from structure-based computational design to tumor homing. J Comput Aided Mol Des 2012 0.77
95 In vivo selection of tumor-specific antibodies. Oncotarget 2013 0.76
96 Access granted: iRGD helps silicasome-encased drugs breach the tumor barrier. J Clin Invest 2017 0.75
97 Drug identification through in vivo screening of chemical libraries. Chembiochem 2004 0.75
98 Ratiometric in vivo auditioning of targeted silver nanoparticles. Nanoscale 2017 0.75
99 Composite Porous Silicon-Silver Nanoparticles as Theranostic Antibacterial Agents. ACS Appl Mater Interfaces 2016 0.75