Published in FASEB J on January 10, 2006
Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. Br J Pharmacol (2011) 1.51
Preferential uptake of the non steroid anti-inflammatory drug diclofenac into inflamed tissues after a single oral dose in rats. BMC Pharmacol (2009) 0.86
Formulation and in vitro characterization of Eudragit® L100 and Eudragit® L100-PLGA nanoparticles containing diclofenac sodium. AAPS PharmSciTech (2010) 0.82
Diclofenac causes more leakage than naproxen in anastomoses in the small intestine of the rat. Int J Colorectal Dis (2013) 0.75
Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. FASEB J (2004) 2.75
The safety and side effects of monoclonal antibodies. Nat Rev Drug Discov (2010) 2.23
Circulating microRNAs as novel biomarkers for platelet activation. Circ Res (2013) 2.22
Peroxisome proliferator-activated receptors and inflammation. Pharmacol Ther (2005) 1.77
Pharmacology and therapeutic potential of interferons. Pharmacol Ther (2012) 1.76
Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis. Arterioscler Thromb Vasc Biol (2006) 1.74
Intestinal injury and endotoxemia in children undergoing surgery for congenital heart disease. Am J Respir Crit Care Med (2011) 1.57
Dual antiplatelet therapy in cardiovascular disease: does aspirin increase clinical risk in the presence of potent P2Y12 receptor antagonists? Heart (2010) 1.57
Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress. Cardiovasc Res (2011) 1.53
Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum? Proc Natl Acad Sci U S A (2002) 1.44
The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas. J Clin Endocrinol Metab (2008) 1.42
Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system. Proc Natl Acad Sci U S A (2012) 1.35
The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression. Cancer Res (2006) 1.31
COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs. Lancet (2008) 1.29
Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration. Arterioscler Thromb Vasc Biol (2007) 1.22
Role of nuclear receptor signaling in platelets: antithrombotic effects of PPARbeta. FASEB J (2005) 1.18
Cellular mechanisms of acetaminophen: role of cyclo-oxygenase. FASEB J (2005) 1.18
Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia. J Appl Physiol (1985) (2007) 1.18
Targeting PPAR receptors in the airway for the treatment of inflammatory lung disease. Br J Pharmacol (2009) 1.13
Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle. Respir Res (2005) 1.12
Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites. J Biol Chem (2009) 1.12
Cigarette smoke activates human monocytes by an oxidant-AP-1 signaling pathway: implications for steroid resistance. Mol Pharmacol (2005) 1.11
Antiplatelet actions of statins and fibrates are mediated by PPARs. Arterioscler Thromb Vasc Biol (2009) 1.10
Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock. Am J Respir Crit Care Med (2010) 1.10
Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo. Am J Respir Crit Care Med (2007) 1.09
Evidence for the involvement of type I interferon in pulmonary arterial hypertension. Circ Res (2013) 1.08
Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts. Am J Respir Cell Mol Biol (2005) 1.08
Analysing the eosinophil cationic protein--a clue to the function of the eosinophil granulocyte. Respir Res (2011) 1.07
Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse. PLoS One (2011) 1.06
Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets. Blood (2007) 1.05
Differential effects of Gram-positive versus Gram-negative bacteria on NOSII and TNFalpha in macrophages: role of TLRs in synergy between the two. Br J Pharmacol (2006) 1.04
The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo. PLoS One (2009) 1.04
Innate immunity in human embryonic stem cells: comparison with adult human endothelial cells. PLoS One (2010) 1.02
Epoxygenases and peroxisome proliferator-activated receptors in mammalian vascular biology. Exp Physiol (2007) 1.02
Stronger inhibition by nonsteroid anti-inflammatory drugs of cyclooxygenase-1 in endothelial cells than platelets offers an explanation for increased risk of thrombotic events. FASEB J (2006) 1.02
Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia. Circ Res (2012) 1.01
Anti-inflammatory effects of epoxyeicosatrienoic acids. Int J Vasc Med (2012) 1.01
Elucidation of the temporal relationship between endothelial-derived NO and EDHF in mesenteric vessels. Am J Physiol Heart Circ Physiol (2007) 1.01
Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms. Arterioscler Thromb Vasc Biol (2010) 1.00
Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle. Proc Natl Acad Sci U S A (2005) 0.99
Endogenous epoxygenases are modulators of monocyte/macrophage activity. PLoS One (2011) 0.99
Activation of PPARbeta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J Leukoc Biol (2009) 0.99
Scanning ion conductance microscopy: a convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells. J R Soc Interface (2011) 0.98
Toll-like receptor 2 is essential for the sensing of oxidants during inflammation. Am J Respir Crit Care Med (2008) 0.97
Prostaglandins and the regulation of tumor growth. J Environ Pathol Toxicol Oncol (2002) 0.97
Cyclo-oxygenase-2 inhibitors and cardiovascular events. Lancet (2002) 0.96
Not so EEZE: the 'EDHF' antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries. Eur J Pharmacol (2004) 0.95
Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness. Thromb Haemost (2009) 0.94
Role for nuclear factor-kappaB and signal transducer and activator of transcription 1/interferon regulatory factor-1 in cytokine-induced endothelin-1 release in human vascular smooth muscle cells. Mol Pharmacol (2003) 0.93
Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α. Gut (2012) 0.93
Inflammatory transcriptome profiling of human monocytes exposed acutely to cigarette smoke. PLoS One (2012) 0.92
Proteome-wide analysis and CXCL4 in systemic sclerosis. N Engl J Med (2014) 0.92
Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis. J Immunol (2009) 0.91
Endothelin-1 as a mediator and potential biomarker for interferon induced pulmonary toxicity. Pulm Circ (2012) 0.90
PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status. Biochem J (2011) 0.90
The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells. Biochem Biophys Res Commun (2006) 0.90
COX-2 in cardiovascular disease. Arterioscler Thromb Vasc Biol (2006) 0.89
LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression. PLoS One (2013) 0.88
Novel role for P2X receptor activation in endothelium-dependent vasodilation. Br J Pharmacol (2004) 0.88
The PPARbeta/delta agonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension. PLoS One (2010) 0.87
Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis. Life Sci (2002) 0.87
The effects and metabolic fate of nitroflurbiprofen in healthy volunteers. Clin Pharmacol Ther (2004) 0.87
Inducible CYP2J2 and its product 11,12-EET promotes bacterial phagocytosis: a role for CYP2J2 deficiency in the pathogenesis of Crohn's disease? PLoS One (2013) 0.87
Heme oxygenase is expressed in human pulmonary artery smooth muscle where carbon monoxide has an anti-proliferative role. Eur J Pharmacol (2003) 0.87
Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension. Mol Pharmacol (2002) 0.86
Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide. Proc Natl Acad Sci U S A (2013) 0.86
Homeostatic role of Toll-like receptor 4 in the endothelium and heart. J Cardiovasc Pharmacol Ther (2007) 0.85
Carbon monoxide inhibits endothelin-1 release by human pulmonary artery smooth muscle cells. Eur J Pharmacol (2004) 0.85
Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells. Respir Res (2008) 0.85
PPARbeta/delta agonists modulate platelet function via a mechanism involving PPAR receptors and specific association/repression of PKCalpha--brief report. Arterioscler Thromb Vasc Biol (2009) 0.85
Roles of the epoxygenase CYP2J2 in the endothelium. Prostaglandins Other Lipid Mediat (2013) 0.85
COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma. FASEB J (2008) 0.85
A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses. PLoS One (2012) 0.84
Stem cell-derived endothelial cells for cardiovascular disease: a therapeutic perspective. Br J Clin Pharmacol (2013) 0.84
Transition from placental to air breathing stimulates haem-oxygenase-1 expression without functional consequence for pulmonary vascular adaptation in pigs and mice. Br J Pharmacol (2005) 0.83
Gram-positive and Gram-negative bacteria synergize with oxidants to release CXCL8 from innate immune cells. Mol Med (2008) 0.83
Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies. Biochem Biophys Res Commun (2013) 0.83
Cyclooxygenases 1, 2, and 3 and the production of prostaglandin I2: investigating the activities of acetaminophen and cyclooxygenase-2-selective inhibitors in rat tissues. J Pharmacol Exp Ther (2004) 0.82
Modulation by colony stimulating factors of human epithelial colon cancer cell apoptosis. Cytokine (2002) 0.82
Endothelium-dependent relaxation and endothelial hyperpolarization by P2Y receptor agonists in rat-isolated mesenteric artery. Br J Pharmacol (2003) 0.82
Dissecting the role of eosinophil cationic protein in upper airway disease. Curr Opin Allergy Clin Immunol (2012) 0.81
Viral Toll Like Receptor activation of pulmonary vascular smooth muscle cells results in endothelin-1 generation; relevance to pathogenesis of pulmonary arterial hypertension. Biochem Biophys Res Commun (2012) 0.81
Nitric oxide supports atrial function in sepsis: relevance to side effects of inhibitors in shock. Eur J Pharmacol (2002) 0.80
Reduced endothelial dependent vasodilation in vessels from TLR4(-/-) mice is associated with increased superoxide generation. Biochem Biophys Res Commun (2011) 0.80
Shape and compliance of endothelial cells after shear stress in vitro or from different aortic regions: scanning ion conductance microscopy study. PLoS One (2012) 0.80
Peroxisome proliferator-activated receptor beta/delta goes vascular. Circ Res (2008) 0.79