Yukihiro Nishiyama

Author PubWeight™ 117.53‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment. J Biol Chem 2004 1.86
2 Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity. Mol Cell Biol 2004 1.85
3 Conserved protein kinases encoded by herpesviruses and cellular protein kinase cdc2 target the same phosphorylation site in eukaryotic elongation factor 1delta. J Virol 2003 1.72
4 Clinical and virological characteristics of 15 patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation. Clin Infect Dis 2008 1.54
5 Identification of proteins phosphorylated directly by the Us3 protein kinase encoded by herpes simplex virus 1. J Virol 2005 1.50
6 Reactivation of lytic replication from B cells latently infected with Epstein-Barr virus occurs with high S-phase cyclin-dependent kinase activity while inhibiting cellular DNA replication. J Virol 2003 1.39
7 Measuring Epstein-Barr virus (EBV) load: the significance and application for each EBV-associated disease. Rev Med Virol 2008 1.34
8 Herpes simplex virus 1-encoded protein kinase UL13 phosphorylates viral Us3 protein kinase and regulates nuclear localization of viral envelopment factors UL34 and UL31. J Virol 2006 1.33
9 Identification of a physiological phosphorylation site of the herpes simplex virus 1-encoded protein kinase Us3 which regulates its optimal catalytic activity in vitro and influences its function in infected cells. J Virol 2008 1.32
10 Rapid diagnosis of human herpesvirus 6 infection by a novel DNA amplification method, loop-mediated isothermal amplification. J Clin Microbiol 2004 1.24
11 Olfactory transmission of neurotropic viruses. J Neurovirol 2005 1.23
12 Identification of protein kinases responsible for phosphorylation of Epstein-Barr virus nuclear antigen leader protein at serine-35, which regulates its coactivator function. J Gen Virol 2003 1.21
13 Epstein-Barr virus protein kinase BGLF4 is a virion tegument protein that dissociates from virions in a phosphorylation-dependent process and phosphorylates the viral immediate-early protein BZLF1. J Virol 2006 1.20
14 Herpes simplex virus type 1 UL51 protein is involved in maturation and egress of virus particles. J Virol 2005 1.19
15 Rapid diagnosis of herpes simplex virus infection by a loop-mediated isothermal amplification method. J Clin Microbiol 2005 1.17
16 Inhibition of S-phase cyclin-dependent kinase activity blocks expression of Epstein-Barr virus immediate-early and early genes, preventing viral lytic replication. J Virol 2004 1.15
17 Quantitation of viral load in neonatal herpes simplex virus infection and comparison between type 1 and type 2. J Med Virol 2002 1.15
18 The role of protein kinase activity expressed by the UL13 gene of herpes simplex virus 1: the activity is not essential for optimal expression of UL41 and ICP0. Virology 2005 1.13
19 Simultaneous quantification of Epstein-Barr virus, cytomegalovirus, and human herpesvirus 6 DNA in samples from transplant recipients by multiplex real-time PCR assay. J Clin Microbiol 2007 1.08
20 Formation of aggresome-like structures in herpes simplex virus type 2-infected cells and a potential role in virus assembly. Exp Cell Res 2004 1.06
21 Identification and characterization of the UL56 gene product of herpes simplex virus type 2. J Virol 2002 1.06
22 Herpes simplex virus type 2 UL56 interacts with the ubiquitin ligase Nedd4 and increases its ubiquitination. J Virol 2008 1.06
23 Construction of recombinant herpes simplex virus type I expressing green fluorescent protein without loss of any viral genes. Microbes Infect 2004 1.05
24 Herpes simplex virus type 2 membrane protein UL56 associates with the kinesin motor protein KIF1A. J Gen Virol 2005 1.05
25 Subcellular localization of herpes simplex virus type 1 UL51 protein and role of palmitoylation in Golgi apparatus targeting. J Virol 2003 1.05
26 Identification of Epstein-Barr virus (EBV)-infected lymphocyte subtypes by flow cytometric in situ hybridization in EBV-associated lymphoproliferative diseases. J Infect Dis 2009 1.04
27 Differences in the regulatory and functional effects of the Us3 protein kinase activities of herpes simplex virus 1 and 2. J Virol 2009 1.03
28 Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex. PLoS Pathog 2009 1.03
29 Detection of human herpesvirus 7 DNA by loop-mediated isothermal amplification. J Clin Microbiol 2004 1.03
30 One-step multiplex real-time PCR assay to analyse the latency patterns of Epstein-Barr virus infection. J Virol Methods 2007 1.01
31 Human herpesvirus 6 viremia in bone marrow transplant recipients: clinical features and risk factors. J Infect Dis 2002 1.01
32 Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Microbes Infect 2006 1.01
33 The vomeronasal chemosensory system as a route of neuroinvasion by herpes simplex virus. Virology 2005 0.98
34 Mitochondria and viruses. Mitochondrion 2010 0.98
35 Mast cells play a key role in host defense against herpes simplex virus infection through TNF-α and IL-6 production. J Invest Dermatol 2013 0.98
36 Monitoring of active HHV-6 infection in bone marrow transplant recipients by real time PCR; comparison to detection of viral DNA in plasma by qualitative PCR. Microbiol Immunol 2002 0.98
37 Pilot study of oncolytic viral therapy using mutant herpes simplex virus (HF10) against recurrent metastatic breast cancer. Ann Surg Oncol 2006 0.97
38 Quantitative analysis of Epstein-Barr virus (EBV)-related gene expression in patients with chronic active EBV infection. J Gen Virol 2009 0.96
39 Herpes simplex virus 1 protein kinase Us3 and major tegument protein UL47 reciprocally regulate their subcellular localization in infected cells. J Virol 2011 0.96
40 Monitoring herpesvirus DNA in three cases of acute retinal necrosis by real-time PCR. J Clin Virol 2004 0.94
41 Olfactory receptor neurons prevent dissemination of neurovirulent influenza A virus into the brain by undergoing virus-induced apoptosis. J Gen Virol 2002 0.94
42 Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 7. Microbiol Immunol 2009 0.94
43 Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T/natural killer cell lymphoproliferative diseases. Cancer Sci 2012 0.94
44 Clonality analysis by sequence variation of the latent membrane protein 1 gene in patients with chronic active Epstein-Barr virus infection. J Med Virol 2006 0.94
45 Oncolytic virotherapy for malignant melanoma with herpes simplex virus type 1 mutant HF10. J Dermatol Sci 2008 0.93
46 Herpes simplex virus type 2 UL14 gene product has heat shock protein (HSP)-like functions. J Cell Sci 2002 0.93
47 Intratumoral injection of herpes simplex virus HF10 in recurrent head and neck squamous cell carcinoma. Acta Otolaryngol 2006 0.93
48 Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription. Virology 2009 0.93
49 Herpes simplex virus type 2 US3 blocks apoptosis induced by sorbitol treatment. Microbes Infect 2002 0.93
50 Identification and characterization of the UL7 gene product of herpes simplex virus type 2. Virus Genes 2002 0.92
51 Epstein-Barr virus nuclear antigen leader protein induces expression of thymus- and activation-regulated chemokine in B cells. J Virol 2004 0.92
52 Apoptosis induction after herpes simplex virus infection differs according to cell type in vivo. Arch Virol 2010 0.91
53 Spatiotemporally different DNA repair systems participate in Epstein-Barr virus genome maturation. J Virol 2011 0.91
54 US3 protein kinase of herpes simplex virus type 2 is required for the stability of the UL46-encoded tegument protein and its association with virus particles. J Gen Virol 2005 0.91
55 Association of two membrane proteins encoded by herpes simplex virus type 2, UL11 and UL56. Virus Genes 2006 0.90
56 Phosphorylation of cytokeratin 17 by herpes simplex virus type 2 US3 protein kinase. Microbiol Immunol 2002 0.90
57 Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in mice. J Virol 2009 0.90
58 Intraepithelial gammadelta T cells may bridge a gap between innate immunity and acquired immunity to herpes simplex virus type 2. J Virol 2004 0.90
59 Reactivation of HSV-1 in the brain of patients with familial Alzheimer's disease. J Med Virol 2004 0.89
60 The UL14 tegument protein of herpes simplex virus type 1 is required for efficient nuclear transport of the alpha transinducing factor VP16 and viral capsids. J Virol 2007 0.89
61 Rapid detection of varicella-zoster virus infection by a loop-mediated isothermal amplification method. J Med Virol 2004 0.89
62 Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions. Virol J 2009 0.88
63 A regulatory role of interleukin 15 in wound healing and mucosal infection in mice. J Leukoc Biol 2007 0.88
64 Latent infection of human herpesvirus 6 in astrocytoma cell line and alteration of cytokine synthesis. J Med Virol 2002 0.87
65 Herpes simplex virus protein UL11 but not UL51 is associated with lipid rafts. Virus Genes 2007 0.87
66 Oncolytic viral therapy with a combination of HF10, a herpes simplex virus type 1 variant and granulocyte-macrophage colony-stimulating factor for murine ovarian cancer. Int J Cancer 2013 0.87
67 Bortezomib induces apoptosis in T lymphoma cells and natural killer lymphoma cells independent of Epstein-Barr virus infection. Int J Cancer 2011 0.86
68 Antitumor activities of valproic acid on Epstein-Barr virus-associated T and natural killer lymphoma cells. Cancer Sci 2011 0.86
69 Herpes simplex virus requires poly(ADP-ribose) polymerase activity for efficient replication and induces extracellular signal-related kinase-dependent phosphorylation and ICP0-dependent nuclear localization of tankyrase 1. J Virol 2011 0.86
70 Virus-induced neuronal apoptosis as pathological and protective responses of the host. Rev Med Virol 2004 0.86
71 Microarray analysis of transcriptional responses to infection by herpes simplex virus types 1 and 2 and their US3-deficient mutants. Microbes Infect 2008 0.85
72 Herpes simplex virus US3 protein kinase regulates virus-induced apoptosis in olfactory and vomeronasal chemosensory neurons in vivo. Microbes Infect 2006 0.85
73 Iba1-expressing microglia respond to herpes simplex virus infection in the mouse trigeminal ganglion. Brain Res Mol Brain Res 2003 0.85
74 Herpes simplex virus and varicella-zoster virus: why do these human alphaherpesviruses behave so differently from one another? Rev Med Virol 2005 0.85
75 Successful protection by amantadine hydrochloride against lethal encephalitis caused by a highly neurovirulent recombinant influenza A virus in mice. Virology 2002 0.84
76 Herpes simplex virus UL14 protein blocks apoptosis. Microbiol Immunol 2003 0.84
77 Serological examination of human herpesvirus 6 and 7 in patients with coronary artery disease. J Med Virol 2002 0.84
78 Detection of human cytomegalovirus DNA in perilymph of patients with sensorineural hearing loss using real-time PCR. J Med Virol 2003 0.83
79 Herpes simplex virus UL56 interacts with and regulates the Nedd4-family ubiquitin ligase Itch. Virol J 2010 0.83
80 Anti-apoptotic protein kinase of herpes simplex virus. Trends Microbiol 2002 0.83
81 Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome. FASEB J 2002 0.83
82 Multiplex real-time PCR assay for simultaneous quantification of BK polyomavirus, JC polyomavirus, and adenovirus DNA. J Clin Microbiol 2010 0.82
83 Oncolytic viral therapy for human ovarian cancer using a novel replication-competent herpes simplex virus type I mutant in a mouse model. Gynecol Oncol 2003 0.82
84 Herpes simplex virus induces extensive modification and dynamic relocalisation of the nuclear mitotic apparatus (NuMA) protein in interphase cells. J Cell Sci 2008 0.82
85 Non-engineered, naturally oncolytic herpes simplex virus HSV1 HF-10: applications for cancer gene therapy. Curr Gene Ther 2008 0.82
86 Oncolytic viral therapy for breast cancer with herpes simplex virus type 1 mutant HF 10. J Surg Oncol 2004 0.81
87 Variation of human herpesvirus 7 shedding in saliva. J Infect Dis 2003 0.81
88 Accessory genes define the relationship between the herpes simplex virus and its host. Microbes Infect 2006 0.81
89 Differential activation of the c-Jun N-terminal kinase/stress-activated protein kinase and p38 mitogen-activated protein kinase signal transduction pathways in the mouse brain upon infection with neurovirulent influenza A virus. J Gen Virol 2003 0.81
90 Fatal adult case of severe lymphocytopenia associated with reactivation of human herpesvirus 6. J Med Virol 2002 0.81
91 Oligonucleotide microarray analysis of gene expression profiles followed by real-time reverse-transcriptase polymerase chain reaction assay in chronic active Epstein-Barr virus infection. J Infect Dis 2008 0.81
92 Enhanced antitumoral activity of oncolytic herpes simplex virus with gemcitabine using colorectal tumor models. Int J Cancer 2012 0.81
93 Effective treatment of disseminated peritoneal colon cancer with new replication-competent herpes simplex viruses. Hepatogastroenterology 2003 0.81
94 Excretion of herpes simplex virus type 2 glycoprotein D into the culture medium. J Gen Virol 2002 0.81
95 Detection of herpesvirus DNAs in perilymph obtained from patients with sensorineural hearing loss by real-time polymerase chain reaction. Laryngoscope 2004 0.81
96 Enhanced cytotoxicity with a novel system combining the paclitaxel-2'-ethylcarbonate prodrug and an HSV amplicon with an attenuated replication-competent virus, HF10 as a helper virus. Cancer Lett 2009 0.80
97 Rapid detection of Epstein-Barr virus DNA by loop-mediated isothermal amplification method. J Clin Virol 2006 0.80
98 Development of a human herpesvirus 6 species-specific immunoblotting assay. J Clin Microbiol 2012 0.80
99 Replication-competent, oncolytic herpes simplex virus type 1 mutants induce a bystander effect following ganciclovir treatment. J Gene Med 2007 0.80
100 Human herpesvirus 7-associated meningitis and optic neuritis in a patient after allogeneic stem cell transplantation. J Med Virol 2003 0.80
101 Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss. Eur Arch Otorhinolaryngol 2008 0.80
102 Immunologic and virologic analyses in pediatric liver transplant recipients with chronic high Epstein-Barr virus loads. J Infect Dis 2010 0.80
103 Development of a monoclonal antibody against Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) that can detect EBNA-LP expressed in P3HR1 cells. Microbiol Immunol 2005 0.79
104 Gene directed enzyme prodrug therapy for ovarian cancer: could GDEPT become a promising treatment against ovarian cancer? Anticancer Agents Med Chem 2008 0.79
105 Latent infection of human herpesvirus 7 in CD4(+) T lymphocytes. J Med Virol 2006 0.79
106 Evaluation of active human herpesvirus 6 infection by reverse transcription-PCR. J Med Virol 2003 0.78
107 Phase I Dose-escalation Clinical Trial of HF10 Oncolytic Herpes Virus in 17 Japanese Patients with Advanced Cancer. Hepatogastroenterology 2014 0.78
108 HF10, an attenuated herpes simplex virus (HSV) type 1 clone, lacks neuroinvasiveness and protects mice against lethal challenge with HSV types 1 and 2. Microbes Infect 2005 0.78
109 Diabetic mice show an aggravated course of herpes-simplex virus-induced facial nerve paralysis. Otol Neurotol 2012 0.78
110 New estimation method for highly sensitive quantitation of human immunodeficiency virus type 1 DNA and its application. J Virol Methods 2005 0.78
111 Generation and Characterization of UL21-Null Herpes Simplex Virus Type 1. Front Microbiol 2012 0.78
112 The US3 protein kinase of herpes simplex virus attenuates the activation of the c-Jun N-terminal protein kinase signal transduction pathway in infected piriform cortex neurons of C57BL/6 mice. Neurosci Lett 2003 0.78
113 Immunization with a highly attenuated replication-competent herpes simplex virus type 1 mutant, HF10, protects mice from genital disease caused by herpes simplex virus type 2. Front Microbiol 2012 0.78
114 Herpes simplex virus type 1 mutant HF10 oncolytic viral therapy for bladder cancer. Urology 2005 0.78
115 Treatment of solid sarcomas in immunocompetent mice with novel, oncolytic herpes simplex viruses. Otolaryngol Head Neck Surg 2004 0.78
116 Intercellular trafficking of herpes simplex virus type 2 UL14 deletion mutant proteins. Biochem Biophys Res Commun 2002 0.77
117 Herpes simplex virus type 1 UL14 tegument protein regulates intracellular compartmentalization of major tegument protein VP16. Virol J 2011 0.77
118 Intercellular trafficking activity of herpes simplex virus US11 gene product in the mouse brain. Brain Res Mol Brain Res 2005 0.77
119 Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0. Virol J 2011 0.77
120 Axonal injury in experimental herpes simplex encephalitis. Brain Res 2005 0.77
121 PCR search for the herpes simplex virus type 1 genome in brain sections of patients with familial Alzheimer's disease. J Clin Microbiol 2004 0.77
122 Oncotarget Strategies For Herpes Simplex Virus-1. Curr Gene Ther 2016 0.76
123 Auditory and vestibular defects induced by experimental labyrinthitis following herpes simplex virus in mice. Acta Otolaryngol 2011 0.76
124 Paclitaxel-2'-Ethylcarbonate prodrug can circumvent P-glycoprotein-mediated cellular efflux to increase drug cytotoxicity. Pharm Res 2007 0.75
125 The alpha4 residues of human DNA topoisomerase IIalpha function in enzymatic activity and anticancer drug sensitivity. Nucleic Acids Res 2004 0.75
126 [Novel treatment with oncolytic herpes simplex virus, 'HF10' against breast cancer]. Nihon Rinsho 2004 0.75
127 HHV-6 and 7 DNA loads in lung tissues collected from patients with interstitial pneumonia. J Med Virol 2005 0.75
128 Identification of Epstein-Barr virus-infected CD27+ memory B-cells in liver or stem cell transplant patients. J Gen Virol 2011 0.75
129 Beneficial effect of GB virus C co-infection in Human Immunodeficiency Virus type 1-infected individuals. Microbiol Immunol 2007 0.75
130 Establishment of a novel foreign gene delivery system combining an HSV amplicon with an attenuated replication-competent virus, HSV-1 HF10. J Virol Methods 2006 0.75
131 Intercellular trafficking and cytotoxicity of recombinant HSV-1 thymidine kinase fused with HSV-2 US11 RXP repeat peptide. Virus Genes 2006 0.75
132 Human herpesvirus 6 infection of human epidermal cell line: pathogenesis of skin manifestations. J Med Virol 2003 0.75
133 [Replication mechanisms and molecular pathogenesis of herpes simplex viruses]. Tanpakushitsu Kakusan Koso 2009 0.75
134 [Varicella-zoster virus]. Nihon Rinsho 2003 0.75
135 Human herpesvirus 6 fulminant hepatic failure treated by living donor liver transplantation. Pediatr Int 2004 0.75