Published in Dev Cell on February 01, 2006
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Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress. Blood (2008) 2.04
Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor. Proc Natl Acad Sci U S A (2008) 1.81
Lysosome-related organelles: unusual compartments become mainstream. Curr Opin Cell Biol (2013) 1.59
Functional architecture of Weibel-Palade bodies. Blood (2011) 1.55
Rate, extent and concentration dependence of histamine-evoked Weibel-Palade body exocytosis determined from individual fusion events in human endothelial cells. J Physiol (2007) 1.36
Actomyosin II contractility expels von Willebrand factor from Weibel-Palade bodies during exocytosis. J Cell Biol (2011) 1.35
A pH-regulated dimeric bouquet in the structure of von Willebrand factor. EMBO J (2011) 1.34
Biology and physics of von Willebrand factor concatamers. J Thromb Haemost (2011) 1.33
An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF. Blood (2009) 1.27
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von Willebrand factor, Jedi knight of the bloodstream. Blood (2014) 1.15
Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor. Nat Med (2013) 1.13
Structural organization of Weibel-Palade bodies revealed by cryo-EM of vitrified endothelial cells. Proc Natl Acad Sci U S A (2009) 1.12
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. Blood (2009) 1.11
A two-tier Golgi-based control of organelle size underpins the functional plasticity of endothelial cells. Dev Cell (2014) 1.06
Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor. J Biol Chem (2011) 1.03
Assembly and activation of alternative complement components on endothelial cell-anchored ultra-large von Willebrand factor links complement and hemostasis-thrombosis. PLoS One (2013) 0.98
The role of autophagy in vascular biology. Circ Res (2015) 0.96
Differential effect of extracellular acidosis on the release and dispersal of soluble and membrane proteins secreted from the Weibel-Palade body. J Biol Chem (2009) 0.96
Protein mobilities and P-selectin storage in Weibel-Palade bodies. J Cell Sci (2010) 0.92
Intracellular storage and regulated secretion of von Willebrand factor in quantitative von Willebrand disease. J Biol Chem (2011) 0.89
Role of von Willebrand factor in the haemostasis. Blood Transfus (2011) 0.87
Genetic alteration of the D2 domain abolishes von Willebrand factor multimerization and trafficking into storage. J Thromb Haemost (2009) 0.86
In vivo imaging analysis of the interaction between unusually large von Willebrand factor multimers and platelets on the surface of vascular wall. Pflugers Arch (2011) 0.86
Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells. Mol Biol Cell (2008) 0.86
The mutation N528S in the von Willebrand factor (VWF) propeptide causes defective multimerization and storage of VWF. Blood (2010) 0.85
Local elongation of endothelial cell-anchored von Willebrand factor strings precedes ADAMTS13 protein-mediated proteolysis. J Biol Chem (2011) 0.84
Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings. PLoS One (2015) 0.80
Insights into pathological mechanisms of missense mutations in C-terminal domains of von Willebrand factor causing qualitative or quantitative von Willebrand disease. Haematologica (2013) 0.80
Storage of factor VIII variants with impaired von Willebrand factor binding in Weibel-Palade bodies in endothelial cells. PLoS One (2011) 0.80
Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells. J Cell Sci (2016) 0.80
Omega-3 fatty acids modulate Weibel-Palade body degranulation and actin cytoskeleton rearrangement in PMA-stimulated human umbilical vein endothelial cells. Mar Drugs (2013) 0.78
Fluvastatin inhibits regulated secretion of endothelial cell von Willebrand factor in response to diverse secretagogues. Biochem J (2007) 0.78
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BLOC-2 subunit HPS6 deficiency affects the tubulation and secretion of von Willebrand factor from mouse endothelial cells. J Genet Genomics (2016) 0.75
Von Willebrand factor folds into a bouquet. EMBO J (2011) 0.75
Weibel-Palade body size modulates the adhesive activity of its von Willebrand Factor cargo in cultured endothelial cells. Sci Rep (2016) 0.75
Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes. Mol Biol Cell (2005) 2.56
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Common VWF exon 28 polymorphisms in African Americans affecting the VWF activity assay by ristocetin cofactor. Blood (2010) 2.09
Constitutive sharing of recycling synaptic vesicles between presynaptic boutons. Nat Neurosci (2006) 1.87
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest (2002) 1.81
VWF mutations and new sequence variations identified in healthy controls are more frequent in the African-American population. Blood (2011) 1.80
Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. Blood (2003) 1.62
CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin. Blood (2011) 1.62
The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes. Traffic (2002) 1.59
Clathrin potentiates vaccinia-induced actin polymerization to facilitate viral spread. Cell Host Microbe (2012) 1.58
The Hippo pathway regulates apical-domain size independently of its growth-control function. J Cell Sci (2009) 1.50
Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis. Nature (2012) 1.48
Endothelial von Willebrand factor regulates angiogenesis. Blood (2010) 1.47
Imaging transient blood vessel fusion events in zebrafish by correlative volume electron microscopy. PLoS One (2009) 1.44
Formation and function of Weibel-Palade bodies. J Cell Sci (2008) 1.40
Active tissue factor pathway inhibitor is expressed on the surface of coated platelets. Blood (2006) 1.39
G protein-dependent basal and evoked endothelial cell vWF secretion. Blood (2013) 1.39
Actomyosin II contractility expels von Willebrand factor from Weibel-Palade bodies during exocytosis. J Cell Biol (2011) 1.35
Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D. J Exp Med (2004) 1.32
An AP-1/clathrin coat plays a novel and essential role in forming the Weibel-Palade bodies of endothelial cells. J Cell Biol (2005) 1.31
Membranous structures transfer cell surface proteins across NK cell immune synapses. Traffic (2007) 1.27
Analysis of intracellular storage and regulated secretion of 3 von Willebrand disease-causing variants of von Willebrand factor. Blood (2003) 1.26
The dystonia-associated protein torsinA modulates synaptic vesicle recycling. J Biol Chem (2007) 1.23
Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells. Blood (2013) 1.22
Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A. Nat Commun (2013) 1.20
Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type. J Cell Sci (2003) 1.19
A function retained by the common mutant CLN3 protein is responsible for the late onset of juvenile neuronal ceroid lipofuscinosis. Hum Mol Genet (2007) 1.15
High-pressure freezing provides insights into Weibel-Palade body biogenesis. J Cell Sci (2007) 1.14
Selective and signal-dependent recruitment of membrane proteins to secretory granules formed by heterologously expressed von Willebrand factor. Mol Biol Cell (2002) 1.11
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. Blood (2009) 1.11
CLN6, which is associated with a lysosomal storage disease, is an endoplasmic reticulum protein. Exp Cell Res (2004) 1.10
In vitro reconstitution of fusion between immature autophagosomes and endosomes. Autophagy (2009) 1.10
A human genome-wide screen for regulators of clathrin-coated vesicle formation reveals an unexpected role for the V-ATPase. Nat Cell Biol (2013) 1.09
Actin coats and rings promote regulated exocytosis. Trends Cell Biol (2012) 1.08
The role of the D1 domain of the von Willebrand factor propeptide in multimerization of VWF. Blood (2002) 1.08
How to roll an endothelial cigar: the biogenesis of Weibel-Palade bodies. Traffic (2004) 1.05
Gain-of-function GPIb ELISA assay for VWF activity in the Zimmerman Program for the Molecular and Clinical Biology of VWD. Blood (2010) 1.05
Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin. Mol Biol Cell (2004) 1.02
P-selectin and CD63 use different mechanisms for delivery to Weibel-Palade bodies. Traffic (2006) 1.01
An ultrastructural readout of fluorescence recovery after photobleaching using correlative light and electron microscopy. Nat Protoc (2006) 1.01
P-selectin binds to the D'-D3 domains of von Willebrand factor in Weibel-Palade bodies. Blood (2006) 1.01
Loss of the Batten disease gene CLN3 prevents exit from the TGN of the mannose 6-phosphate receptor. Traffic (2008) 0.99
Acute manipulation of diacylglycerol reveals roles in nuclear envelope assembly & endoplasmic reticulum morphology. PLoS One (2012) 0.98
Antibody ligation of murine Ly-6G induces neutropenia, blood flow cessation, and death via complement-dependent and independent mechanisms. J Leukoc Biol (2008) 0.96
Cryo-soft X-ray tomography: a journey into the world of the native-state cell. Protoplasma (2013) 0.96
Combined anticoagulant and antiselectin treatments prevent lethal intravascular coagulation. Blood (2002) 0.95
An E2-F12 complex is required for intracellular enveloped virus morphogenesis during vaccinia infection. Cell Microbiol (2009) 0.94
Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells. Traffic (2011) 0.93
Intersection of mechanisms of type 2A VWD through defects in VWF multimerization, secretion, ADAMTS-13 susceptibility, and regulated storage. Blood (2012) 0.92
Biogenesis of Weibel-Palade bodies. Semin Cell Dev Biol (2002) 0.92
Towards native-state imaging in biological context in the electron microscope. J Chem Biol (2009) 0.89
L- and P-selectins collaborate to support leukocyte rolling in vivo when high-affinity P-selectin-P-selectin glycoprotein ligand-1 interaction is inhibited. Am J Pathol (2005) 0.89
Glycosulfopeptides modeled on P-selectin glycoprotein ligand 1 inhibit P-selectin-dependent leukocyte rolling in vivo. FASEB J (2002) 0.88
Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells. Mol Biol Cell (2008) 0.86
Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis. J Clin Invest (2016) 0.85
Collagen binding provides a sensitive screen for variant von Willebrand disease. Clin Chem (2013) 0.84
The anti-inflammatory effects of a selectin ligand mimetic, TBC-1269, are not a result of competitive inhibition of leukocyte rolling in vivo. J Leukoc Biol (2004) 0.82
Correlative light and volume electron microscopy: using focused ion beam scanning electron microscopy to image transient events in model organisms. Methods Cell Biol (2012) 0.81
No increase in bleeding identified in type 1 VWD subjects with D1472H sequence variation. Blood (2013) 0.81
Cell-specific abnormal prenylation of Rab proteins in platelets and melanocytes of the gunmetal mouse. Br J Haematol (2002) 0.80
Polymers bearing sLex-mimetics are superior inhibitors of E-selectin-dependent leukocyte rolling in vivo. FASEB J (2003) 0.80
Modeling human neural functionality in vitro: three-dimensional culture for dopaminergic differentiation. Tissue Eng Part A (2014) 0.79
Genetic mutations in von Willebrand disease identified by DHPLC and DNA sequence analysis. Mol Genet Metab (2006) 0.78
The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1-dependent manner. Blood (2012) 0.78
Von Willebrand disease in the United States: a perspective from Wisconsin. Semin Thromb Hemost (2011) 0.77
Amorosia littoralis gen. sp. nov., a new genus and species name for the scorpinone and caffeine-producing hyphomycete from the littoral zone in The Bahamas. Mycol Res (2006) 0.77
P-selectin targeting to secretory lysosomes of Rbl-2H3 cells. J Biol Chem (2002) 0.77
Compromised shear-dependent cleavage of type 2N von Willebrand factor variants by ADAMTS13 in the presence of factor VIII. Thromb Haemost (2013) 0.75
Erratum: Weibel-Palade body size modulates the adhesive activity of its von Willebrand Factor cargo in cultured endothelial cells. Sci Rep (2016) 0.75
A radiochemical technique with potential for revealing novel fungal metabolites according to expression of specific biosynthetic activities. Mycol Res (2007) 0.75
Synaptotagmin I-DeltaC2B. A novel synaptotagmin isoform with a single C2 domain in the bovine adrenal medulla. Biochim Biophys Acta (2002) 0.75