PubRank

Jocelyne Guay

Author PubWeight™ 15.36‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model. J Immunol 2003 1.35
2 Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886. Bioorg Med Chem Lett 2005 1.15
3 Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett 2007 1.05
4 Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem 2011 0.97
5 Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett 2009 0.95
6 Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett 2009 0.93
7 Substituted coumarins as potent 5-lipoxygenase inhibitors. Bioorg Med Chem Lett 2006 0.93
8 Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone], in multiple preclinical species. Eur J Pharmacol 2007 0.92
9 Thiazole analog as stearoyl-CoA desaturase 1 inhibitor. Bioorg Med Chem Lett 2009 0.88
10 Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors. Bioorg Med Chem Lett 2010 0.83
11 SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors. Bioorg Med Chem Lett 2010 0.81
12 Nicotinic acids: liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy. Bioorg Med Chem Lett 2011 0.80
13 Trisubstituted ureas as potent and selective mPGES-1 inhibitors. Bioorg Med Chem Lett 2011 0.79
14 Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. Bioorg Med Chem Lett 2008 0.79
15 A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J Biomol Screen 2010 0.79
16 Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors. Bioorg Med Chem Lett 2011 0.75
17 An automated multistep high-throughput screening assay for the identification of lead inhibitors of the inducible enzyme mPGES-1. J Biomol Screen 2005 0.75
18 Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors. Bioorg Med Chem Lett 2011 0.75