Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study.

PubWeight™: 10.05‹?› | Rank: Top 0.1%

🔗 View Article (PMID 16476843)

Published in Circulation on February 13, 2006

Authors

Bryan Williams1, Peter S Lacy, Simon M Thom, Kennedy Cruickshank, Alice Stanton, David Collier, Alun D Hughes, H Thurston, Michael O'Rourke, CAFE Investigators, Anglo-Scandinavian Cardiac Outcomes Trial Investigators, CAFE Steering Committee and Writing Committee

Author Affiliations

1: Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

Associated clinical trials:

Radiofrequency Ablation for ADPKD Blood Pressure and Disease Progression Control (RAFALE) | NCT01932450

Effect of Pharmacological Heart Rate Reduction on Visco-elastic Properties of the Arterial Wall (BRADYVASC) (BRADYVASC) | NCT02584439

Pulse Wave Velocity as a Predictor for Postoperative Cardiovascular Events | NCT03223441

Relationship Between Blood Pressure and Pulse Wave Velocity Measurements in Peritoneal Dialysis | NCT03607747

Articles citing this

(truncated to the top 100)

Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ (2009) 17.73

Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation (2010) 9.09

Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality? J Hypertens (2009) 3.47

Derivation and validation of diagnostic thresholds for central blood pressure measurements based on long-term cardiovascular risks. J Am Coll Cardiol (2013) 2.79

Predictors and outcomes of resistant hypertension among patients with coronary artery disease and hypertension. J Hypertens (2014) 2.28

Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association. Hypertension (2015) 2.01

Reduced ascending aortic strain and distensibility: earliest manifestations of vascular aging in humans. Hypertension (2010) 1.91

High central pulse pressure is independently associated with adverse cardiovascular outcome the strong heart study. J Am Coll Cardiol (2009) 1.79

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. J Appl Physiol (1985) (2009) 1.76

Dyslipidemia in youth with diabetes: to treat or not to treat? J Pediatr (2008) 1.72

Central versus ambulatory blood pressure in the prediction of all-cause and cardiovascular mortalities. J Hypertens (2011) 1.70

The RAAS in the pathogenesis and treatment of diabetic nephropathy. Nat Rev Nephrol (2010) 1.65

Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels. Med Clin North Am (2009) 1.59

Effects of antihypertensive drugs on arterial stiffness. Cardiol Rev (2012) 1.52

End organ damage in hypertension. Dtsch Arztebl Int (2010) 1.51

Role of arterial stiffness in cardiovascular disease. JRSM Cardiovasc Dis (2012) 1.46

Nebivolol, but not metoprolol, lowers blood pressure in nitric oxide-sensitive human hypertension. Hypertension (2014) 1.44

Central blood pressure: current evidence and clinical importance. Eur Heart J (2014) 1.43

Ethnic Differences in Arterial Wave Reflection Are Mostly Explained by Differences in Body Height - Cross-Sectional Analysis of the HELIUS Study. PLoS One (2016) 1.41

The fixed-dose combination of olmesartan/amlodipine was superior in central aortic blood pressure reduction compared with perindopril/amlodipine: a randomized, double-blind trial in patients with hypertension. Adv Ther (2013) 1.40

Noninvasive continuous hemodynamic monitoring. J Clin Monit Comput (2012) 1.36

The arterial reservoir pressure increases with aging and is the major determinant of the aortic augmentation index. Am J Physiol Heart Circ Physiol (2009) 1.35

Arginase and vascular aging. J Appl Physiol (1985) (2008) 1.33

SGLT2 Inhibitors and Cardiovascular Risk: Lessons Learned From the EMPA-REG OUTCOME Study. Diabetes Care (2016) 1.29

Vascular stiffness and increased pulse pressure in the aging cardiovascular system. Cardiol Res Pract (2011) 1.28

Aortic pulse wave velocity is associated with measures of subclinical target organ damage. JACC Cardiovasc Imaging (2011) 1.24

Arterial aging--hemodynamic changes and therapeutic options. Nat Rev Cardiol (2010) 1.24

Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5. Heart Fail Rev (2010) 1.24

Validated methods for assessment of subclinical atherosclerosis in rheumatology. Nat Rev Rheumatol (2012) 1.23

Renin: friend or foe? Heart (2007) 1.16

Noninvasive measurement of central vascular pressures with arterial tonometry: clinical revival of the pulse pressure waveform? Mayo Clin Proc (2010) 1.14

Cardiovascular drug therapy in the elderly: benefits and challenges. Nat Rev Cardiol (2010) 1.13

Adult height and the risk of cardiovascular disease among middle aged men and women in Japan. Eur J Epidemiol (2010) 1.09

Review article: implications of vascular aging. Anesth Analg (2011) 1.09

Physical exercise, fitness and dietary pattern and their relationship with circadian blood pressure pattern, augmentation index and endothelial dysfunction biological markers: EVIDENT study protocol. BMC Public Health (2010) 1.08

Racial differences in arterial stiffness and microcirculatory function between Black and White Americans. J Am Heart Assoc (2013) 1.07

Arterial wave reflection and subclinical left ventricular systolic dysfunction. J Hypertens (2011) 1.03

Arterial stiffness and cardiovascular therapy. Biomed Res Int (2014) 1.03

Arterial stiffness, central hemodynamics, and cardiovascular risk in hypertension. Vasc Health Risk Manag (2011) 1.02

Meta-analysis of the comparative effects of different classes of antihypertensive agents on brachial and central systolic blood pressure, and augmentation index. Br J Clin Pharmacol (2013) 1.01

Renal sympathetic denervation: applications in hypertension and beyond. Nat Rev Cardiol (2013) 1.00

Beta-blocker use for the stages of heart failure. Mayo Clin Proc (2009) 1.00

Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients. BMC Med (2010) 0.99

Clinical appraisal of arterial stiffness: the Argonauts in front of the Golden Fleece. Heart (2005) 0.99

Augmentation index derived from peripheral arterial tonometry correlates with cardiovascular risk factors. Cardiol Res Pract (2011) 0.98

Excess pressure integral predicts cardiovascular events independent of other risk factors in the conduit artery functional evaluation substudy of Anglo-Scandinavian Cardiac Outcomes Trial. Hypertension (2014) 0.97

Exploration of association of 1,25-OH2D3 with augmentation index, a composite measure of arterial stiffness. Clin J Am Soc Nephrol (2008) 0.97

Nitrite and nitric oxide metabolism in peripheral artery disease. Nitric Oxide (2012) 0.97

Arterial stiffness, hypertension, and rational use of nebivolol. Vasc Health Risk Manag (2009) 0.97

The effects of sleep-disordered breathing on arterial stiffness are modulated by age. Sleep (2010) 0.97

Changes in the practice of cardiology: therapies at the forefront of science. Singapore Med J (2016) 0.97

Cumulative community-level lead exposure and pulse pressure: the normative aging study. Environ Health Perspect (2007) 0.96

Beneficial effects on arterial stiffness and pulse-wave reflection of combined enalapril and candesartan in chronic kidney disease--a randomized trial. PLoS One (2012) 0.96

Central blood pressure and pulse wave velocity: relationship to target organ damage and cardiovascular morbidity-mortality in diabetic patients or metabolic syndrome. An observational prospective study. LOD-DIABETES study protocol. BMC Public Health (2010) 0.96

Arterial stiffness is associated with cardiovascular, renal, retinal, and autonomic disease in type 1 diabetes. Diabetes Care (2012) 0.95

Clinical Assessment of Central Blood Pressure. Curr Hypertens Rev (2012) 0.95

Blood pressure measurement: clinic, home, ambulatory, and beyond. Am J Kidney Dis (2012) 0.94

Management of hypertension in the elderly patient. Clin Interv Aging (2009) 0.93

A review of the safety and efficacy of nebivolol in the mildly hypertensive patient. Vasc Health Risk Manag (2007) 0.93

Better management of cardiovascular diseases by pulse wave velocity: combining clinical practice with clinical research using evidence-based medicine. Clin Med Res (2007) 0.92

Current perspectives on combination therapy in the management of hypertension. Integr Blood Press Control (2013) 0.92

Aortic pulse pressure is associated with carotid IMT in chronic kidney disease: report from Chronic Renal Insufficiency Cohort. Am J Hypertens (2009) 0.91

Vascular and renal hemodynamic changes after renal denervation. Clin J Am Soc Nephrol (2013) 0.91

INVEST revisited: review of findings from the International Verapamil SR-Trandolapril Study. Expert Rev Cardiovasc Ther (2009) 0.90

Peripheral and central arterial pressure and its relationship to vascular target organ damage in carotid artery, retina and arterial stiffness. Development and validation of a tool. The Vaso risk study. BMC Public Health (2011) 0.90

Assessments of arterial stiffness and endothelial function using pulse wave analysis. Int J Vasc Med (2012) 0.90

Central pulse pressure in chronic kidney disease: a chronic renal insufficiency cohort ancillary study. Hypertension (2010) 0.89

Comparison of cardiovascular risk factors for high brachial pulse pressure in blacks versus whites (Charleston Heart Study, Evans County Study, NHANES I and II Studies). Am J Cardiol (2008) 0.88

Effects of smoking cessation on central blood pressure and arterial stiffness. Vasc Health Risk Manag (2011) 0.88

Blood pressure control and primary prevention of stroke: summary of the recent clinical trial data and meta-analyses. Curr Hypertens Rep (2013) 0.88

Effect of lisinopril and atenolol on aortic stiffness in patients on hemodialysis. Clin J Am Soc Nephrol (2015) 0.87

Effects of CPAP on "vascular" risk factors in patients with obstructive sleep apnea and arterial hypertension. Vasc Health Risk Manag (2013) 0.87

Central aortic pressure is independently associated with diastolic function. Am Heart J (2010) 0.87

Waiting a few extra minutes before measuring blood pressure has potentially important clinical and research ramifications. J Hum Hypertens (2013) 0.86

Timeline of History of Hypertension Treatment. Front Cardiovasc Med (2016) 0.86

Exenatide induces aortic vasodilation increasing hydrogen sulphide, carbon monoxide and nitric oxide production. Cardiovasc Diabetol (2014) 0.86

An introduction to biomarkers: applications to chronic kidney disease. Pediatr Nephrol (2007) 0.86

Pulse pressure and subclinical cardiovascular disease in the multi-ethnic study of atherosclerosis. Am J Hypertens (2013) 0.86

Association of left ventricular diastolic dysfunction with 24-h aortic ambulatory blood pressure: the SAFAR study. J Hum Hypertens (2014) 0.86

A randomized pilot study of aortic waveform guided therapy in chronic heart failure. J Am Heart Assoc (2014) 0.86

Cardiovascular and musculskeletal co-morbidities in patients with alpha 1 antitrypsin deficiency. Respir Res (2010) 0.86

Therapeutic modification of arterial stiffness: An update and comprehensive review. World J Cardiol (2015) 0.85

Non-invasive measurement of local pulse pressure by pulse wave-based ultrasound manometry (PWUM). Physiol Meas (2011) 0.84

Blood Pressure-Lowering Mechanisms of the DASH Dietary Pattern. J Nutr Metab (2012) 0.84

Primary stroke prevention and hypertension treatment: which is the first-line strategy? Neurol Int (2011) 0.84

Acute β-adrenergic blockade increases aortic wave reflection in young men and women: differing mechanisms between sexes. Hypertension (2011) 0.84

The effect of simvastatin, ezetimibe and their combination on the lipid profile, arterial stiffness and inflammatory markers. Eur J Clin Pharmacol (2007) 0.84

Pulsology rediscovered: commentary on the Conduit Artery Function Evaluation (CAFE) study. Circulation (2006) 0.84

Ankle blood pressure and pulse pressure as predictors of cerebrovascular morbidity and mortality in a prospective follow-up study. Stroke Res Treat (2011) 0.84

Eplerenone attenuates pulse wave reflection in chronic kidney disease stage 3-4--a randomized controlled study. PLoS One (2013) 0.84

Effects of Azelnidipine plus OlmesaRTAn versus amlodipine plus olmesartan on central blood pressure and left ventricular mass index: the AORTA study. Vasc Health Risk Manag (2011) 0.84

Prescribing of Antihypertensive Agents in Public Primary Care Clinics - is it in Accordance with Current Evidence? Malays Fam Physician (2010) 0.84

Aortic stiffness: pathophysiology, clinical implications, and approach to treatment. Integr Blood Press Control (2014) 0.84

Reproducibility of pulse wave velocity measurements with phase contrast magnetic resonance and applanation tonometry. Int J Cardiovasc Imaging (2011) 0.84

Pulse Pressure Is Useful for Determining the Choice of Antihypertensive Drugs in Postmenopausal Women. Pulse (Basel) (2014) 0.84

Childhood Obesity Associates Haemodynamic and Vascular Changes That Result in Increased Central Aortic Pressure with Augmented Incident and Reflected Wave Components, without Changes in Peripheral Amplification. Int J Vasc Med (2016) 0.83

The role of the endogenous antioxidant enzymes and malondialdehyde in essential hypertension. J Clin Diagn Res (2013) 0.83

I brazilian position paper on antihypertensive drug combination. Arq Bras Cardiol (2014) 0.83

Very high central aortic systolic pressures in a young hypertensive patient on telmisartan: Is central aortic systolic pressure associated with white coat hypertension? Int J Angiol (2010) 0.83

Bringing prevention in geriatrics: evidences from cardiovascular medicine supporting the new challenge. Exp Gerontol (2012) 0.83

Articles by these authors

2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J (2013) 12.73

Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44

Effect of spironolactone on blood pressure in subjects with resistant hypertension. Hypertension (2007) 5.61

Superiority of ambulatory over clinic blood pressure measurement in predicting mortality: the Dublin outcome study. Hypertension (2005) 5.05

Development and validation of a new adenosine-independent index of stenosis severity from coronary wave-intensity analysis: results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) study. J Am Coll Cardiol (2011) 4.99

Effects of a fixed-dose combination strategy on adherence and risk factors in patients with or at high risk of CVD: the UMPIRE randomized clinical trial. JAMA (2013) 4.82

Failure to detect the novel retrovirus XMRV in chronic fatigue syndrome. PLoS One (2010) 4.66

Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay. J Am Coll Cardiol (2011) 4.43

Classification performance of instantaneous wave-free ratio (iFR) and fractional flow reserve in a clinical population of intermediate coronary stenoses: results of the ADVISE registry. EuroIntervention (2013) 4.30

Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. Lancet Neurol (2007) 2.88

Improvement of a retinal blood vessel segmentation method using the Insight Segmentation and Registration Toolkit (ITK). Conf Proc IEEE Eng Med Biol Soc (2007) 2.84

Test-retest repeatability of cardiopulmonary exercise test variables in patients with cardiac or respiratory disease. Eur J Prev Cardiol (2014) 2.75

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53

Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate. Hypertension (2012) 2.48

Evidence of a dominant backward-propagating "suction" wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy. Circulation (2006) 2.44

The relationship between metabolic risk factors and incident cardiovascular disease in Europeans, South Asians, and African Caribbeans: SABRE (Southall and Brent Revisited) -- a prospective population-based study. J Am Coll Cardiol (2013) 2.36

Arterial pulse wave dynamics after percutaneous aortic valve replacement: fall in coronary diastolic suction with increasing heart rate as a basis for angina symptoms in aortic stenosis. Circulation (2011) 2.34

Use of diazoxide in hypertension with renal failure. Br Med J (1971) 2.28

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genet (2010) 2.24

Exercise central (aortic) blood pressure is predominantly driven by forward traveling waves, not wave reflection. Hypertension (2013) 2.17

Hybrid iFR-FFR decision-making strategy: implications for enhancing universal adoption of physiology-guided coronary revascularisation. EuroIntervention (2013) 2.15

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15

Applicability of the iterative technique for cardiac resynchronization therapy optimization: full-disclosure, 50-sequential-patient dataset of transmitral Doppler traces, with implications for future research design and guidelines. Europace (2013) 2.13

Ethnicity and prediction of cardiovascular disease: performance of QRISK2 and Framingham scores in a U.K. tri-ethnic prospective cohort study (SABRE--Southall And Brent REvisited). Heart (2013) 2.12

Real-time dynamic carbon dioxide administration: a novel treatment strategy for stabilization of periodic breathing with potential application to central sleep apnea. J Am Coll Cardiol (2010) 2.09

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet (2009) 2.04

The routine requirement for anaesthetists in local anaesthetic cataract surgery. Clin Experiment Ophthalmol (2007) 2.02

Hydrallazine in hypertension: is there a safe dose? Br Med J (1980) 1.99

Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. J Psychiatr Res (2010) 1.98

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96

Multinational evaluation of the interpretability of the iterative method of optimisation of AV delay for CRT. Int J Cardiol (2012) 1.93

Impact of statin therapy on central aortic pressures and hemodynamics: principal results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study. Circulation (2008) 1.88

Is impaired set-shifting an endophenotype of anorexia nervosa? Am J Psychiatry (2005) 1.86

Development and validation of a novel method to derive central aortic systolic pressure from the radial pressure waveform using an n-point moving average method. J Am Coll Cardiol (2011) 1.85

Segmentation of blood vessels from red-free and fluorescein retinal images. Med Image Anal (2007) 1.82

Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker. Hypertension (2006) 1.81

A meta-analysis of the mechanism of blood pressure change with aging. J Am Coll Cardiol (2009) 1.78

Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy. Br Med J (1972) 1.76

Ethnic differences in blood pressure response to first and second-line antihypertensive therapies in patients randomized in the ASCOT Trial. Am J Hypertens (2010) 1.75

Abnormalities of retinal microvascular structure and risk of mortality from ischemic heart disease and stroke. Hypertension (2006) 1.74

Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun (2003) 1.74

Hemodynamic response to intravenous adenosine and its effect on fractional flow reserve assessment: results of the Adenosine for the Functional Evaluation of Coronary Stenosis Severity (AFFECTS) study. Circ Cardiovasc Interv (2013) 1.67

The limit of plausibility for predictors of response: application to biventricular pacing. JACC Cardiovasc Imaging (2012) 1.67

Telomere length in small-for-gestational-age babies. BJOG (2006) 1.66

Evaluation of C-reactive protein prior to and on-treatment as a predictor of benefit from atorvastatin: observations from the Anglo-Scandinavian Cardiac Outcomes Trial. Eur Heart J (2011) 1.66

Predictors and outcomes of scleroderma renal crisis: the high-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis trial. Arthritis Rheum (2002) 1.62

Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimens. Arthritis Rheum (2006) 1.62

Novel description of the 24-hour circadian rhythms of brachial versus central aortic blood pressure and the impact of blood pressure treatment in a randomized controlled clinical trial: The Ambulatory Central Aortic Pressure (AmCAP) Study. Hypertension (2013) 1.58

Altered immune phenotype in peripheral blood cells of patients with scleroderma-associated pulmonary hypertension. Clin Transl Sci (2010) 1.56

Retinal vascular tree morphology: a semi-automatic quantification. IEEE Trans Biomed Eng (2002) 1.56

Evaluation of C-reactive protein before and on-treatment as a predictor of benefit of atorvastatin: a cohort analysis from the Anglo-Scandinavian Cardiac Outcomes Trial lipid-lowering arm. J Am Coll Cardiol (2013) 1.54

Recombinant human relaxin in the treatment of systemic sclerosis with diffuse cutaneous involvement: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum (2009) 1.53

The atrioventricular delay of cardiac resynchronization can be optimized hemodynamically during exercise and predicted from resting measurements. Heart Rhythm (2007) 1.52

Salt and hypertension. Lancet (1984) 1.52

Ethnicity and left ventricular diastolic function in hypertension an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy. J Am Coll Cardiol (2008) 1.51

Impedance cardiography for determination of stroke index. J Appl Physiol (1976) 1.50

Impact of size at birth on the microvasculature: the Avon Longitudinal Study of Parents and Children. Pediatrics (2007) 1.49

Impact of heart rate on central aortic pressures and hemodynamics: analysis from the CAFE (Conduit Artery Function Evaluation) study: CAFE-Heart Rate. J Am Coll Cardiol (2009) 1.49

Endothelial von Willebrand factor regulates angiogenesis. Blood (2010) 1.47

Rationale and design of the AdRem study: evaluating the effects of blood pressure lowering and intensive glucose control on vascular retinal disorders in patients with type 2 diabetes mellitus. Contemp Clin Trials (2006) 1.47

Src family tyrosine kinases mediate contraction of rat isolated tail arteries in response to a hyposmotic stimulus. J Hypertens (2007) 1.46

What is the role of the aorta in directing coronary blood flow? Heart (2008) 1.46

Randomized comparison of ultrasonic aspiration versus conventional electrocautery for dissection of the human internal thoracic artery. J Thorac Cardiovasc Surg (1996) 1.45

First-in-man safety evaluation of renal denervation for chronic systolic heart failure: primary outcome from REACH-Pilot study. Int J Cardiol (2012) 1.45

Labile blood pressure after bilateral carotid body tumour surgery. Eur J Vasc Endovasc Surg (1995) 1.45

Impact of comorbidities on the measurement of health in patients with ankle osteoarthritis. J Bone Joint Surg Am (2006) 1.43

Atorvastatin treatment is associated with less augmentation of the carotid pressure waveform in hypertension: a substudy of the Anglo-Scandinavian Cardiac Outcome Trial (ASCOT). Hypertension (2009) 1.41

A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample. Proc Natl Acad Sci U S A (2006) 1.40

Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans. Am J Physiol Heart Circ Physiol (2005) 1.39

Development of extrapyramidal symptoms in hypertensive patients treated with diazoxide. Br Med J (1973) 1.36

The arterial reservoir pressure increases with aging and is the major determinant of the aortic augmentation index. Am J Physiol Heart Circ Physiol (2009) 1.35

Effects of the CACNA1C risk allele for bipolar disorder on cerebral gray matter volume in healthy individuals. Am J Psychiatry (2009) 1.35

Differences in smoking associated DNA methylation patterns in South Asians and Europeans. Clin Epigenetics (2014) 1.33

A 3-Mb map of a large Segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. Genomics (2002) 1.31

Association between the neuregulin 1 gene and schizophrenia: a systematic review. Schizophr Bull (2005) 1.30

Tissue Doppler E/E' ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudy. Eur Heart J (2009) 1.30

Evidence against potassium as an endothelium-derived hyperpolarizing factor in rat mesenteric small arteries. Br J Pharmacol (2000) 1.29

Insulin resistance and truncal obesity as important determinants of the greater incidence of diabetes in Indian Asians and African Caribbeans compared with Europeans: the Southall And Brent REvisited (SABRE) cohort. Diabetes Care (2012) 1.29

Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals. Atherosclerosis (2010) 1.27

Metabolic syndrome and autoimmune diabetes: action LADA 3. Diabetes Care (2008) 1.27

Diagnostic classification of the instantaneous wave-free ratio is equivalent to fractional flow reserve and is not improved with adenosine administration. Results of CLARIFY (Classification Accuracy of Pressure-Only Ratios Against Indices Using Flow Study). J Am Coll Cardiol (2013) 1.26

Leucocyte membrane sodium transport in normotensive populations: dissociation of abnormalities of sodium efflux from raised blood-pressure. Lancet (1982) 1.26

The use of structural distal femoral allografts for acetabular reconstruction. Average ten-year follow-up. J Bone Joint Surg Am (2005) 1.25

Wave intensity analysis and the development of the reservoir-wave approach. Med Biol Eng Comput (2009) 1.25

Pulse pressure and resistance artery structure in the elderly. Hypertension (1995) 1.23

Trials within trials? Researcher, funder and ethical perspectives on the practicality and acceptability of nesting trials of recruitment methods in existing primary care trials. BMC Med Res Methodol (2010) 1.22

Determinants of new-onset diabetes among 19,257 hypertensive patients randomized in the Anglo-Scandinavian Cardiac Outcomes Trial--Blood Pressure Lowering Arm and the relative influence of antihypertensive medication. Diabetes Care (2008) 1.22

Metabolic profiles of second-generation antipsychotics in early psychosis: findings from the CAFE study. Schizophr Res (2009) 1.17

Prior receptor occupancy as a determinant of the pressor activity of infused angiotensin II in the rat. Circ Res (1975) 1.16

Determination of optimal atrioventricular delay for cardiac resynchronization therapy using acute non-invasive blood pressure. Europace (2006) 1.15

Wave reflection predicts cardiovascular events in hypertensive individuals independent of blood pressure and other cardiovascular risk factors: an ASCOT (Anglo-Scandinavian Cardiac Outcome Trial) substudy. J Am Coll Cardiol (2010) 1.13

Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia. Arch Gen Psychiatry (2011) 1.12

Fluid structure interaction of patient specific abdominal aortic aneurysms: a comparison with solid stress models. Biomed Eng Online (2006) 1.12

Converting enzyme inhibitor and saralasin infusion in rats. Evidence for an additional vasodepressor property of converting enzyme inhibitor. Circ Res (1978) 1.11

Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression. Nat Genet (2011) 1.10

Body fat is associated with reduced aortic stiffness until middle age. Hypertension (2013) 1.10