Published in Oncogene on February 20, 2006
The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell (2010) 2.50
The Paf1 complex: platform or player in RNA polymerase II transcription? Biochim Biophys Acta (2010) 2.03
Genic and global functions for Paf1C in chromatin modification and gene expression in Arabidopsis. PLoS Genet (2008) 1.63
Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification. Mol Cell Biol (2007) 1.40
The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states. Biochim Biophys Acta (2012) 1.32
Ctr9, a key subunit of PAFc, affects global estrogen signaling and drives ERα-positive breast tumorigenesis. Genes Dev (2015) 1.14
The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesis. J Biol Chem (2010) 1.09
RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells. Stem Cells (2009) 1.05
Identification of a role for histone H2B ubiquitylation in noncoding RNA 3'-end formation through mutational analysis of Rtf1 in Saccharomyces cerevisiae. Genetics (2011) 0.95
The human RNA polymerase II-associated factor 1 (hPaf1): a new regulator of cell-cycle progression. PLoS One (2009) 0.94
Genomic analysis of severe hypersensitivity to hygromycin B reveals linkage to vacuolar defects and new vacuolar gene functions in Saccharomyces cerevisiae. Curr Genet (2009) 0.90
The Roles of the Paf1 Complex and Associated Histone Modifications in Regulating Gene Expression. Genet Res Int (2011) 0.90
The Paf1 complex represses SER3 transcription in Saccharomyces cerevisiae by facilitating intergenic transcription-dependent nucleosome occupancy of the SER3 promoter. Eukaryot Cell (2011) 0.87
19q13 amplification is associated with high grade and stage in pancreatic cancer. Genes Chromosomes Cancer (2010) 0.86
Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation. Mol Cell Biol (2012) 0.85
Paf1 restricts Gcn4 occupancy and antisense transcription at the ARG1 promoter. Mol Cell Biol (2012) 0.85
IL-1β-specific recruitment of GCN5 histone acetyltransferase induces the release of PAF1 from chromatin for the de-repression of inflammatory response genes. Nucleic Acids Res (2013) 0.84
Novel role of pancreatic differentiation 2 in facilitating self-renewal and drug resistance of pancreatic cancer stem cells. Br J Cancer (2014) 0.84
PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia. Oncotarget (2014) 0.80
The Kinase Mirk/dyrk1B: A Possible Therapeutic Target in Pancreatic Cancer. Cancers (Basel) (2010) 0.78
Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma. Oncotarget (2016) 0.76
Protein Degradation of RNA Polymerase II-Association Factor 1(PAF1) Is Controlled by CNOT4 and 26S Proteasome. PLoS One (2015) 0.75
hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells. Oncotarget (2017) 0.75
A gene map of the human genome. Science (1996) 14.32
A physical map of 30,000 human genes. Science (1998) 12.43
Randomized clinical trial on the effect of coffee on postoperative ileus following elective colectomy. Br J Surg (2012) 4.01
Functional interactions of the simian virus 40 core origin of replication with flanking regulatory sequences. J Virol (1986) 3.15
Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression. Am J Physiol (1999) 2.93
Domain structure of the simian virus 40 core origin of replication. Mol Cell Biol (1986) 2.72
Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. Cancer Res (1995) 2.67
Finding new genes faster than ever. Nat Genet (1993) 2.61
The adenine-thymine domain of the simian virus 40 core origin directs DNA bending and coordinately regulates DNA replication. Mol Cell Biol (1986) 2.31
Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. Clin Cancer Res (2001) 2.24
Cloning and sequencing of a human pancreatic tumor mucin cDNA. J Biol Chem (1990) 2.22
Stem cells: a revolution in therapeutics-recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies. Clin Pharmacol Ther (2007) 2.19
Nucleotide sequence and organization of the mouse adenine phosphoribosyltransferase gene: presence of a coding region common to animal and bacterial phosphoribosyltransferases that has a variable intron/exon arrangement. Proc Natl Acad Sci U S A (1985) 2.17
Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells. Oncogene (2010) 2.10
The T-antigen-binding domain of the simian virus 40 core origin of replication. J Virol (1987) 2.08
Serum antibodies to carbonic anhydrase I and II in patients with idiopathic chronic pancreatitis and Sjögren's syndrome. Gastroenterology (1996) 2.01
Single pass sequencing and physical and genetic mapping of human brain cDNAs. Nat Genet (1992) 2.01
Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro. Gut (2003) 2.00
Systemic RNAi in Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol (2006) 1.99
The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene. Oncogene (2011) 1.95
Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia. Br J Cancer (2008) 1.93
Simian virus 40 large tumor antigen requires three core replication origin domains for DNA unwinding and replication in vitro. Proc Natl Acad Sci U S A (1987) 1.89
Structural organization and classification of the human mucin genes. Front Biosci (2001) 1.86
MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells. Oncogene (2011) 1.86
Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene (2009) 1.85
Inhibition of viral and cellular promoters by human wild-type p53. J Virol (1992) 1.83
Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy. Br J Cancer (2004) 1.77
Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3. J Biol Chem (1997) 1.72
Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII). Biochem J (1997) 1.72
Genetically engineered tetravalent single-chain Fv of the pancarcinoma monoclonal antibody CC49: improved biodistribution and potential for therapeutic application. Cancer Res (2000) 1.71
MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. J Clin Pathol (2005) 1.65
99mTc-labeled divalent and tetravalent CC49 single-chain Fv's: novel imaging agents for rapid in vivo localization of human colon carcinoma. J Nucl Med (2001) 1.59
Tolerance and immunity to MUC1 in a human MUC1 transgenic murine model. Cancer Res (1998) 1.59
Oligosaccharides expressed on MUC1 produced by pancreatic and colon tumor cell lines. J Biol Chem (1997) 1.59
Use of 3' untranslated sequences of human cDNAs for rapid chromosome assignment and conversion to STSs: implications for an expression map of the genome. Nucleic Acids Res (1991) 1.55
Invasion-specific genes in malignancy: serial analysis of gene expression comparisons of primary and passaged cancers. Cancer Res (2001) 1.49
Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers. J Cell Mol Med (2007) 1.48
MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells. Oncogene (2010) 1.48
MUC5B and MUC7 are differentially expressed in mucous and serous cells of submucosal glands in human bronchial airways. Am J Respir Cell Mol Biol (1998) 1.47
C-reactive protein as early predictor for infectious postoperative complications in rectal surgery. Int J Colorectal Dis (2007) 1.45
Diphyllobothriasis: update on human cases, foci, patterns and sources of human infections and future considerations. Southeast Asian J Trop Med Public Health (2001) 1.45
Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells. Br J Cancer (2007) 1.44
p53 binds to the TATA-binding protein-TATA complex. J Biol Chem (1993) 1.42
Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins. J Cell Biol (1998) 1.42
Human RNA polymerase II-associated factor complex: dysregulation in cancer. Oncogene (2007) 1.41
Pharmacokinetics and biodistribution of genetically-engineered antibodies. Q J Nucl Med (1998) 1.41
A white paper: the product of a pancreas cancer think tank. Cancer Res (2001) 1.39
Omnatax in acute urinary tract infection. A clinical study. J Assoc Physicians India (1989) 1.38
Transcriptional activation of the human epidermal growth factor receptor promoter by human p53. Mol Cell Biol (1996) 1.37
Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma 2L subunit. Neuron (1991) 1.36
Expression of ras oncogene p21 in prostate cancer. N Engl J Med (1986) 1.35
High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential. Biochem Biophys Res Commun (1999) 1.35
Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors. Mol Pharmacol (1993) 1.34
Identification of MUC1 proteolytic cleavage sites in vivo. Biochem Biophys Res Commun (2001) 1.34
Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat. J Biol Chem (1998) 1.34
Multiphoton multifocal microscopy exploiting a diffractive optical element. Opt Lett (2003) 1.32
A regulatory element in intron 1 of the cystic fibrosis transmembrane conductance regulator gene. J Biol Chem (1996) 1.31
Enhanced expression of annexin II in human pancreatic carcinoma cells and primary pancreatic cancers. Carcinogenesis (1993) 1.30
Enhancement of metastatic properties of pancreatic cancer cells by MUC1 gene encoding an anti-adhesion molecule. Int J Cancer (2000) 1.27
ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma. J Exp Med (1985) 1.26
The lectin domain of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-T4 directs its glycopeptide specificities. J Biol Chem (2000) 1.26
MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells. Br J Cancer (2008) 1.25
Recent advances on the molecular mechanisms involved in the drug resistance of cancer cells and novel targeting therapies. Clin Pharmacol Ther (2007) 1.25
The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF. Oncogene (2010) 1.23
FISH ordering of reference markers and of the gene for the alpha 5 subunit of the gamma-aminobutyric acid receptor (GABRA5) within the Angelman and Prader-Willi syndrome chromosomal regions. Hum Mol Genet (1993) 1.22
Activated KrasG¹²D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin. Br J Cancer (2011) 1.21
Regulation of matrix metalloproteinase expressions in astrocytes, microglia and neurons. Neuroimmunomodulation (1997) 1.20
Chromosomal distribution of 320 genes from a brain cDNA library. Nat Genet (1993) 1.19
A cluster of three GABAA receptor subunit genes is deleted in a neurological mutant of the mouse p locus. Nature (1993) 1.19
Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK-RhoA signaling pathway. Oncogene (2009) 1.19
Optimization of benzoyl peroxide concentration in an experimental bone cement based on poly(methyl methacrylate). J Mater Sci Mater Med (1997) 1.19
'Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain. Oncogene (1998) 1.17
Interplay of distinct growth factors during epithelial mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies. Ann Oncol (2007) 1.17
Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin. Br J Cancer (2009) 1.17
Comparison of the two time schedules for endoscopic sclerotherapy: a prospective randomised controlled study. Gut (1986) 1.16
A retrospective study by oligonucleotide array-CGH analysis in 50 fetuses with multiple malformations. Prenat Diagn (2010) 1.16
Wild-type human p53 activates the human epidermal growth factor receptor promoter. Oncogene (1994) 1.16
DUF1220 domains, cognitive disease, and human brain evolution. Cold Spring Harb Symp Quant Biol (2009) 1.13
A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates. FEBS Lett (1999) 1.10
Analysis of the herpes simplex virus type 1 OriS sequence: mapping of functional domains. J Virol (1991) 1.10
A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5. Genomics (1992) 1.10
A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family. J Biol Chem (1998) 1.10
Efficient double stranded sequencing of cDNA clones containing long poly(A) tails using anchored poly(dT) primers. Nucleic Acids Res (1991) 1.10
Phylogenetic relationships of north American field crickets inferred from mitochondrial DNA data. Mol Phylogenet Evol (2000) 1.09
The tumor suppressor p53 and the oncoprotein simian virus 40 T antigen bind to overlapping domains on the MDM2 protein. Mol Cell Biol (1993) 1.09
Human MUC4 mucin cDNA and its variants in pancreatic carcinoma. J Biochem (2000) 1.09
Tumor antigens in astrocytic gliomas. Glia (1995) 1.09
N-terminal 130 amino acids of MDM2 are sufficient to inhibit p53-mediated transcriptional activation. Oncogene (1995) 1.08
Overexpression of MUC1 reconfigures the binding properties of tumor cells. Int J Cancer (2001) 1.08
Denture esophageal impaction refractory to endoscopic removal in a psychiatric patient. J Emerg Med (2000) 1.08
Inguinal herniorrhaphy reduced to basic principles. J R Coll Surg Edinb (1969) 1.07