|
1
|
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
|
Nature
|
2012
|
31.78
|
|
2
|
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
|
Nature
|
2010
|
14.62
|
|
3
|
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.
|
Proc Natl Acad Sci U S A
|
2006
|
3.83
|
|
4
|
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.
|
J Med Chem
|
2013
|
3.27
|
|
5
|
An efficient rapid system for profiling the cellular activities of molecular libraries.
|
Proc Natl Acad Sci U S A
|
2006
|
2.51
|
|
6
|
Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.
|
Biochem J
|
2010
|
1.96
|
|
7
|
Ba/F3 cells and their use in kinase drug discovery.
|
Curr Opin Oncol
|
2007
|
1.88
|
|
8
|
FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation.
|
Mol Cell Biol
|
2002
|
1.26
|
|
9
|
Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase.
|
Bioorg Med Chem Lett
|
2008
|
1.17
|
|
10
|
Co-catalytic effects of CoS2 on activity of MoS2 catalyst for electrochemical hydrogen evolution.
|
Langmuir
|
2017
|
0.75
|
|
11
|
InGaN/GaN light-emitting diode having direct hole injection plugs and its high-current operation.
|
Opt Express
|
2017
|
0.75
|