PubRank

David L Farrens

Author PubWeight™ 23.68‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mapping proximity within proteins using fluorescence spectroscopy. A study of T4 lysozyme showing that tryptophan residues quench bimane fluorescence. Biochemistry 2002 1.40
2 Rhodopsin self-associates in asolectin liposomes. Proc Natl Acad Sci U S A 2006 1.39
3 Rhodopsin activation exposes a key hydrophobic binding site for the transducin alpha-subunit C terminus. J Biol Chem 2004 1.36
4 Monomeric rhodopsin is the minimal functional unit required for arrestin binding. J Mol Biol 2010 1.33
5 Dynamics of arrestin-rhodopsin interactions: arrestin and retinal release are directly linked events. J Biol Chem 2004 1.31
6 High-throughput protein structural analysis using site-directed fluorescence labeling and the bimane derivative (2-pyridyl)dithiobimane. Biochemistry 2004 1.24
7 Stability of dark state rhodopsin is mediated by a conserved ion pair in intradiscal loop E-2. J Biol Chem 2003 1.15
8 Distance mapping in proteins using fluorescence spectroscopy: the tryptophan-induced quenching (TrIQ) method. Biochemistry 2010 1.15
9 Role of the retinal hydrogen bond network in rhodopsin Schiff base stability and hydrolysis. J Biol Chem 2004 1.15
10 The magnitude of the light-induced conformational change in different rhodopsins correlates with their ability to activate G proteins. J Biol Chem 2009 1.09
11 Cysteine residues in the human cannabinoid receptor: only C257 and C264 are required for a functional receptor, and steric bulk at C386 impairs antagonist SR141716A binding. Biochemistry 2005 1.07
12 A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569. J Biol Chem 2012 1.04
13 Dynamics of arrestin-rhodopsin interactions: loop movement is involved in arrestin activation and receptor binding. J Biol Chem 2007 1.02
14 Dynamics of arrestin-rhodopsin interactions: acidic phospholipids enable binding of arrestin to purified rhodopsin in detergent. J Biol Chem 2006 1.00
15 Arrestin can act as a regulator of rhodopsin photochemistry. Vision Res 2006 0.95
16 Rhodopsin in nanodiscs has native membrane-like photointermediates. Biochemistry 2011 0.91
17 Assessing structural elements that influence Schiff base stability: mutants E113Q and D190N destabilize rhodopsin through different mechanisms. Vision Res 2003 0.91
18 The conformations of the manganese transport regulator of Bacillus subtilis in its metal-free state. J Mol Biol 2006 0.89
19 A constitutively activating mutation alters the dynamics and energetics of a key conformational change in a ligand-free G protein-coupled receptor. J Biol Chem 2013 0.89
20 The membrane proximal region of the cannabinoid receptor CB1 N-terminus can allosterically modulate ligand affinity. Biochemistry 2013 0.85
21 Rhodopsin TM6 can interact with two separate and distinct sites on arrestin: evidence for structural plasticity and multiple docking modes in arrestin-rhodopsin binding. Biochemistry 2014 0.82
22 Distance mapping in proteins using fluorescence spectroscopy: tyrosine, like tryptophan, quenches bimane fluorescence in a distance-dependent manner. Biochemistry 2014 0.81