Published in Org Biomol Chem on January 26, 2006
Fluorine in pharmaceuticals: looking beyond intuition. Science (2007) 8.98
Interactions with aromatic rings in chemical and biological recognition. Angew Chem Int Ed Engl (2003) 5.63
Aromatic rings in chemical and biological recognition: energetics and structures. Angew Chem Int Ed Engl (2011) 2.48
Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology. J Control Release (2005) 2.17
Control of in vitro tissue-engineered bone-like structures using human mesenchymal stem cells and porous silk scaffolds. Biomaterials (2006) 1.56
Orthogonal multipolar interactions in structural chemistry and biology. Angew Chem Int Ed Engl (2005) 1.54
Systematic investigation of halogen bonding in protein-ligand interactions. Angew Chem Int Ed Engl (2011) 1.54
Predicting and tuning physicochemical properties in lead optimization: amine basicities. ChemMedChem (2007) 1.48
Cartilage-like tissue engineering using silk scaffolds and mesenchymal stem cells. Tissue Eng (2006) 1.45
Silk fibroin as a vehicle for drug delivery applications. J Control Release (2010) 1.40
The pleasure and importance of printed journals. Nature (2009) 1.39
Silk fibroin spheres as a platform for controlled drug delivery. J Control Release (2008) 1.35
Localized delivery of growth factors for bone repair. Eur J Pharm Biopharm (2004) 1.30
Nerve conduits and growth factor delivery in peripheral nerve repair. J Peripher Nerv Syst (2007) 1.29
Molecular recognition in chemical and biological systems. Angew Chem Int Ed Engl (2015) 1.28
PEGylation as a tool for the biomedical engineering of surface modified microparticles. J Pharm Sci (2008) 1.23
Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: comparison of adenovirus mediated gene transfer and protein delivery of BMP-2. Biomaterials (2006) 1.22
Formulation aspects of biodegradable polymeric microspheres for antigen delivery. Adv Drug Deliv Rev (2005) 1.22
Quantification of cation-pi interactions in protein-ligand complexes: crystal-structure analysis of Factor Xa bound to a quaternary ammonium ion ligand. Angew Chem Int Ed Engl (2005) 1.20
On the biomedical promise of cell penetrating peptides: limits versus prospects. J Pharm Sci (2008) 1.18
Structural aspects of fullerene chemistry--a journey through fullerene chirality. Chem Rev (2006) 1.17
Phosphate recognition in structural biology. Angew Chem Int Ed Engl (2007) 1.17
Silk fibroin matrices for the controlled release of nerve growth factor (NGF). Biomaterials (2007) 1.17
Regio- and stereoselective tether-directed remote functionalization of C60 with derivatives of the Tröger base. Angew Chem Int Ed Engl (2004) 1.15
Transfer of lipophilic markers from PLGA and polystyrene nanoparticles to caco-2 monolayers mimics particle uptake. Pharm Res (2002) 1.12
Insulin-like growth factor I releasing silk fibroin scaffolds induce chondrogenic differentiation of human mesenchymal stem cells. J Control Release (2007) 1.12
Localized insulin-like growth factor I delivery to enhance new bone formation. Bone (2003) 1.12
Steroids in Molecular Recognition. Chem Rev (1997) 1.09
Chances and pitfalls of cell penetrating peptides for cellular drug delivery. Eur J Pharm Biopharm (2004) 1.09
Transport of surface-modified nanoparticles through cell monolayers. Chembiochem (2005) 1.08
Decoding the entry of two novel cell-penetrating peptides in HeLa cells: lipid raft-mediated endocytosis and endosomal escape. Biochemistry (2005) 1.08
Expanding the chemical space for push-pull chromophores by non-concerted [2+2] and [4+2] cycloadditions: access to a highly functionalised 6,6-dicyanopentafulvene with an intense, low-energy charge-transfer band. Chem Commun (Camb) (2011) 1.06
Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells. Vaccine (2005) 1.05
Optimization strategies for electrospun silk fibroin tissue engineering scaffolds. Biomaterials (2009) 1.03
Phagocytosis and phagosomal fate of surface-modified microparticles in dendritic cells and macrophages. Pharm Res (2003) 1.03
Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant. Adv Drug Deliv Rev (2013) 1.02
Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles. Chembiochem (2004) 0.99
Container molecules with portals: Reversibly switchable cycloalkane complexation. Angew Chem Int Ed Engl (2007) 0.99
Metabolic cleavage of cell-penetrating peptides in contact with epithelial models: human calcitonin (hCT)-derived peptides, Tat(47-57) and penetratin(43-58). Biochem J (2004) 0.98
Microporous silk fibroin scaffolds embedding PLGA microparticles for controlled growth factor delivery in tissue engineering. Biomaterials (2009) 0.98
Ligand-specific targeting of microspheres to phagocytes by surface modification with poly(L-lysine)-grafted poly(ethylene glycol) conjugate. Pharm Res (2003) 0.97
Modification of supramolecular binding motifs induced by substrate registry: formation of self-assembled macrocycles and chain-like patterns. Chemistry (2009) 0.97
Evaluation of pH-dependent membrane-disruptive properties of poly(acrylic acid) derived polymers. Eur J Pharm Biopharm (2003) 0.97
Concomitant delivery of a CTL-restricted peptide antigen and CpG ODN by PLGA microparticles induces cellular immune response. J Drug Target (2009) 0.97
Amphiphilic dendrimers: novel self-assembling vectors for efficient gene delivery. Angew Chem Int Ed Engl (2003) 0.96
Orthogonal dipolar interactions between amide carbonyl groups. Proc Natl Acad Sci U S A (2008) 0.95
Structure-based drug design: exploring the proper filling of apolar pockets at enzyme active sites. J Org Chem (2008) 0.95
Allenes in molecular materials. Angew Chem Int Ed Engl (2012) 0.95
Differentiation restricted endocytosis of cell penetrating peptides in MDCK cells corresponds with activities of Rho-GTPases. Pharm Res (2007) 0.95
Silk fibroin/hyaluronan scaffolds for human mesenchymal stem cell culture in tissue engineering. Biomaterials (2009) 0.95
Electrospun matrices for localized drug delivery: current technologies and selected biomedical applications. Eur J Pharm Biopharm (2012) 0.94
Pentafluorosulfanyl as a novel building block for enzyme inhibitors: trypanothione reductase inhibition and antiprotozoal activities of diarylamines. Chembiochem (2009) 0.94
DNA-loaded biodegradable microparticles as vaccine delivery systems and their interaction with dendritic cells. Adv Drug Deliv Rev (2005) 0.94
The cell penetrating peptides pVEC and W2-pVEC induce transformation of gel phase domains in phospholipid bilayers without affecting their integrity. Biochemistry (2006) 0.94
Cotton wool-like nanocomposite biomaterials prepared by electrospinning: in vitro bioactivity and osteogenic differentiation of human mesenchymal stem cells. J Biomed Mater Res B Appl Biomater (2008) 0.93
Supramolecular patterned surfaces driven by cooperative assembly of C60 and porphyrins on metal substrates. Angew Chem Int Ed Engl (2004) 0.93
Geometrically precisely defined multinanometer expansion/contraction motions in a resorcin[4]arene cavitand based molecular switch. Angew Chem Int Ed Engl (2005) 0.93
A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions. Org Biomol Chem (2004) 0.93
A weak attractive interaction between organic fluorine and an amide group. Angew Chem Int Ed Engl (2004) 0.92
Cation-pi interactions at the active site of factor Xa: dramatic enhancement upon stepwise N-alkylation of ammonium ions. Angew Chem Int Ed Engl (2009) 0.92
Non-invasive time-lapsed monitoring and quantification of engineered bone-like tissue. Ann Biomed Eng (2007) 0.91
Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate binding. J Mol Biol (2007) 0.91
Development of a dendritic manganese-enhanced magnetic resonance imaging (MEMRI) contrast agent: synthesis, toxicity (in vitro) and relaxivity (in vitro, in vivo) studies. Bioconjug Chem (2009) 0.90
Microparticle-mediated transfection of non-phagocytic cells in vitro. J Drug Target (2002) 0.90
The support of adenosine release from adenosine kinase deficient ES cells by silk substrates. Biomaterials (2006) 0.90
A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions. Angew Chem Int Ed Engl (2003) 0.90
Directed rotations of single porphyrin molecules controlled by localized force spectroscopy. ACS Nano (2012) 0.89
Inhibitors of the herbicidal target IspD: allosteric site binding. Angew Chem Int Ed Engl (2011) 0.88
The use of sulfonated silk fibroin derivatives to control binding, delivery and potency of FGF-2 in tissue regeneration. Biomaterials (2009) 0.88
The state of the art of chemical biology. Chembiochem (2009) 0.88
Phenotype and functional analysis of human monocyte-derived dendritic cells loaded with biodegradable poly(lactide-co-glycolide) microspheres for immunotherapy. J Immunol Methods (2004) 0.88
Improved inhibitors of trypanothione reductase by combination of motifs: synthesis, inhibitory potency, binding mode, and antiprotozoal activities. ChemMedChem (2010) 0.88
Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV. Angew Chem Int Ed Engl (2006) 0.87
Supramolecular [60]fullerene chemistry on surfaces. Chem Soc Rev (2006) 0.87
Biopolymer-based growth factor delivery for tissue repair: from natural concepts to engineered systems. Tissue Eng Part B Rev (2009) 0.87
Property tuning in charge-transfer chromophores by systematic modulation of the spacer between donor and acceptor. Chemistry (2007) 0.87
Molecular torsion balances: evidence for favorable orthogonal dipolar interactions between organic fluorine and amide groups. Angew Chem Int Ed Engl (2007) 0.87
Efficient stacking on protein amide fragments. ChemMedChem (2013) 0.87
Conjugated oligoenynes based on the diethynylethene unit. Chem Rev (2005) 0.87
From lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clusters. Chemistry (2012) 0.87
Remodeling of tissue-engineered bone structures in vivo. Eur J Pharm Biopharm (2013) 0.87
Metabolic cleavage and translocation efficiency of selected cell penetrating peptides: a comparative study with epithelial cell cultures. AAPS J (2008) 0.86
Controlled nerve growth factor release from multi-ply alginate/chitosan-based nerve conduits. Eur J Pharm Biopharm (2008) 0.86
Mannose-based molecular patterns on stealth microspheres for receptor-specific targeting of human antigen-presenting cells. Langmuir (2008) 0.86
The preservation of phenotype and functionality of dendritic cells upon phagocytosis of polyelectrolyte-coated PLGA microparticles. Biomaterials (2006) 0.85
One-step preparation of polyelectrolyte-coated PLGA microparticles and their functionalization with model ligands. J Control Release (2005) 0.85
Improved stimulation of human dendritic cells by receptor engagement with surface-modified microparticles. J Drug Target (2003) 0.85
Continuous contact- and contamination-free ultrasonic emulsification-a useful tool for pharmaceutical development and production. Ultrason Sonochem (2004) 0.85
Calculation of binding free energies of inhibitors to plasmepsin II. J Comput Chem (2011) 0.85
Molecular recognition at the active site of factor Xa: cation-π interactions, stacking on planar peptide surfaces, and replacement of structural water. Chemistry (2011) 0.85
Triply fused Zn(II)-porphyrin oligomers: synthesis, properties, and supramolecular interactions with single-walled carbon nanotubes (SWNTs). Chemistry (2006) 0.84
Halogen bonding of (iodoethynyl)benzene derivatives in solution. Org Lett (2014) 0.84
Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy. Angew Chem Int Ed Engl (2006) 0.84
Competitive adsorption of serum proteins at microparticles affects phagocytosis by dendritic cells. Biomaterials (2003) 0.84
A fluorine scan at the catalytic center of thrombin: C--F, C--OH, and C--OMe bioisosterism and fluorine effects on pKa and log D values. ChemMedChem (2006) 0.84
Cellular uptake but low permeation of human calcitonin-derived cell penetrating peptides and Tat(47-57) through well-differentiated epithelial models. Pharm Res (2004) 0.84
Synthesis of unsymmetrically substituted 1,3-butadiynes and 1,3,5-hexatriynes via alkylidene carbenoid rearrangements. J Org Chem (2003) 0.84
Magnetism in gold nanoparticles. Nanoscale (2012) 0.84
Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy. ChemMedChem (2007) 0.83