Published in J Neurosci Res on May 01, 2006
Chemistry and biology of mammalian metallothioneins. J Biol Inorg Chem (2011) 1.28
Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury. J Biol Chem (2008) 1.03
Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins. J Biol Inorg Chem (2011) 0.90
The Balance between Life and Death of Cells: Roles of Metallothioneins. Biomark Insights (2007) 0.89
Clinical significance of metallothioneins in cell therapy and nanomedicine. Int J Nanomedicine (2013) 0.79
Gold ions bio-released from metallic gold particles reduce inflammation and apoptosis and increase the regenerative responses in focal brain injury. Histochem Cell Biol (2008) 0.79
Down-regulation of metallothionein 1 and 2 after exposure to electromagnetic field in mouse testis. Iran Biomed J (2011) 0.76
Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury. PLoS One (2012) 0.75
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science (2013) 3.41
Interleukin-6, a major cytokine in the central nervous system. Int J Biol Sci (2012) 2.01
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med (2013) 1.88
Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron (2011) 1.83
AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochem Biophys Res Commun (2004) 1.75
PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle. Am J Physiol Endocrinol Metab (2007) 1.71
Activity of metal-responsive transcription factor 1 by toxic heavy metals and H2O2 in vitro is modulated by metallothionein. Mol Cell Biol (2003) 1.56
Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome. Diabetes (2006) 1.44
Retracted Interleukin-6 receptor expression in contracting human skeletal muscle: regulating role of IL-6. FASEB J (2005) 1.39
The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in muscle. Am J Physiol Cell Physiol (2009) 1.36
PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in mice. Am J Physiol Endocrinol Metab (2009) 1.20
Advances in the structure and chemistry of metallothioneins. J Inorg Biochem (2002) 1.20
Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury. Exp Neurol (2003) 1.16
Metallothionein in the central nervous system: Roles in protection, regeneration and cognition. Neurotoxicology (2008) 1.15
Hypoxic preconditioning induces neuroprotective stanniocalcin-1 in brain via IL-6 signaling. Stroke (2007) 1.13
Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain. J Neurosci (2014) 1.10
A plant type 2 metallothionein (MT) from cork tissue responds to oxidative stress. J Exp Bot (2004) 1.10
Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells. Biochem J (2006) 1.08
Metallothionein reduces central nervous system inflammation, neurodegeneration, and cell death following kainic acid-induced epileptic seizures. J Neurosci Res (2005) 1.08
Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis. J Immunol (2009) 1.07
Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc Natl Acad Sci U S A (2011) 1.06
Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury. J Biol Chem (2008) 1.03
Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity. Nat Chem Biol (2008) 1.03
Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behavior. Brain Behav Immun (2012) 1.01
Role of PGC-1α in exercise and fasting-induced adaptations in mouse liver. Am J Physiol Regul Integr Comp Physiol (2011) 1.01
Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice. J Alzheimers Dis (2010) 0.98
Reaction of Zn7metallothionein with cis- and trans-[Pt(N-donor)2Cl2] anticancer complexes: trans-Pt(II) complexes retain their N-donor ligands. J Med Chem (2007) 0.97
Metallothionein-1+2 protect the CNS after a focal brain injury. Exp Neurol (2002) 0.96
A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain. J Alzheimers Dis (2009) 0.96
Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors. Structure (2006) 0.95
Brain response to traumatic brain injury in wild-type and interleukin-6 knockout mice: a microarray analysis. J Neurochem (2005) 0.93
Implications on zinc binding to S100A2. Biochim Biophys Acta (2006) 0.93
Retracted Metallothionein-mediated antioxidant defense system and its response to exercise training are impaired in human type 2 diabetes. Diabetes (2005) 0.93
Zn(II)-free dimethylargininase-1 (DDAH-1) is inhibited upon specific Cys-S-nitrosylation. J Biol Chem (2002) 0.92
Exercise normalises overexpression of TNF-alpha in knockout mice. Biochem Biophys Res Commun (2004) 0.92
Treatment with metallothionein prevents demyelination and axonal damage and increases oligodendrocyte precursors and tissue repair during experimental autoimmune encephalomyelitis. J Neurosci Res (2003) 0.91
Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide. J Neurosci Res (2003) 0.91
Megalin mediates renal uptake of heavy metal metallothionein complexes. Am J Physiol Renal Physiol (2004) 0.91
Metallothionein and brain inflammation. J Biol Inorg Chem (2011) 0.90
Activation of caspase-8 by tumour necrosis factor receptor 1 is necessary for caspase-3 activation and apoptosis in oxygen-glucose deprived cultured cortical cells. Neurobiol Dis (2009) 0.90
Exercise-induced liver chemokine CXCL-1 expression is linked to muscle-derived interleukin-6 expression. J Physiol (2011) 0.90
Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury. J Neurosci Res (2005) 0.90
Recent developments in quantification methods for metallothionein. J Inorg Biochem (2002) 0.89
RiboTag analysis of actively translated mRNAs in Sertoli and Leydig cells in vivo. PLoS One (2013) 0.88
Interaction of metallothionein-2 with platinum-modified 5'-guanosine monophosphate and DNA. Biochemistry (2008) 0.87
Generalization of DNA microarray dispersion properties: microarray equivalent of t-distribution. Biol Direct (2006) 0.86
Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury. J Neurochem (2009) 0.86
Metallothionein-I overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin-6. J Neuropathol Exp Neurol (2003) 0.86
Diverging mechanisms for TNF-alpha receptors in normal mouse brains and in functional recovery after injury: From gene to behavior. J Neurosci Res (2007) 0.85
LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer's disease. Behav Brain Res (2011) 0.85
Oxidative and nitrosative stress in acute pancreatitis. Modulation by pentoxifylline and oxypurinol. Biochem Pharmacol (2011) 0.84
Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice. Diabetes (2013) 0.84
Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat. Brain Behav Immun (2009) 0.84
Interferon-gamma regulates oxidative stress during experimental autoimmune encephalomyelitis. Exp Neurol (2002) 0.84
Metallothioneins I/II are involved in the neuroprotective effect of sildenafil in focal brain injury. Neurochem Int (2012) 0.84
Severely impaired learning and altered neuronal morphology in mice lacking NMDA receptors in medium spiny neurons. PLoS One (2011) 0.84
Reaction of human metallothionein-3 with cisplatin and transplatin. J Biol Inorg Chem (2009) 0.84
Effect of astrocyte-targeted production of IL-6 on traumatic brain injury and its impact on the cortical transcriptome. Dev Neurobiol (2008) 0.84
Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease. Cell Mol Life Sci (2012) 0.83
Specific reactions of S-nitrosothiols with cysteine hydrolases: A comparative study between dimethylargininase-1 and CTP synthetase. Protein Sci (2007) 0.83
Role of metallothionein-III following central nervous system damage. Neurobiol Dis (2003) 0.83
Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide. J Comp Neurol (2002) 0.83
Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis. Acta Neuropathol (2011) 0.83
Metallothionein and stress combine to affect multiple organ systems. Cell Stress Chaperones (2014) 0.83
Chemical foundation of the attenuation of methylmercury(II) cytotoxicity by metallothioneins. Eur J Biochem (2004) 0.82
Searching for DDAH inhibitors: S-nitroso-L-homocysteine is a chemical lead. J Am Chem Soc (2005) 0.82
Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6-aminonicotinamide. J Neurosci Res (2004) 0.82
Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6. Neurobiol Dis (2002) 0.81