Published in J Biomol Struct Dyn on April 01, 2006
The draft genome of sweet orange (Citrus sinensis). Nat Genet (2012) 2.81
Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia? EMBO Rep (2009) 1.97
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J Gastroenterol (2004) 1.58
Protein domain structure uncovers the origin of aerobic metabolism and the rise of planetary oxygen. Structure (2012) 1.53
The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL. J Lipid Res (2008) 1.39
Estimation of scavenging activity of phenolic compounds using the ABTS(*+) assay. J Agric Food Chem (2004) 1.30
Rational drug repositioning by medical genetics. Nat Biotechnol (2013) 1.26
Western-medicine-validated anti-tumor agents and traditional Chinese medicine. Trends Mol Med (2007) 1.24
A universal molecular clock of protein folds and its power in tracing the early history of aerobic metabolism and planet oxygenation. Mol Biol Evol (2010) 1.23
Where is the hope for drug discovery? Let history tell the future. Drug Discov Today (2008) 1.12
Evaluation of a new copper(II)-curcumin complex as superoxide dismutase mimic and its free radical reactions. Free Radic Biol Med (2005) 1.10
The anti-scar effects of basic fibroblast growth factor on the wound repair in vitro and in vivo. PLoS One (2013) 1.08
The evolution of genomes and language. EMBO Rep (2006) 1.07
Application of Molecular Adsorbents Recirculating System to remove NO and cytokines in severe liver failure patients with multiple organ dysfunction syndrome. Liver Int (2003) 1.07
Methylation of tumor associated genes in tissue and plasma samples from liver disease patients. Exp Mol Pathol (2008) 1.05
Marine natural products as sources of novel scaffolds: achievement and concern. Drug Discov Today (2010) 1.04
Occurrence of fumonisin B(1) in corn from the main corn-producing areas of China. Mycopathologia (2008) 1.00
Structure-antioxidant activity relationship of ferulic acid derivatives: effect of carbon side chain characteristic groups. J Agric Food Chem (2003) 1.00
How many traditional Chinese medicine components have been recognized by modern Western medicine? A chemoinformatic analysis and implications for finding multicomponent drugs. ChemMedChem (2008) 0.98
Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery. Genome Biol (2007) 0.98
Characters of very ancient proteins. Biochem Biophys Res Commun (2007) 0.97
The sequencing bias relaxed characteristics of Hi-C derived data and implications for chromatin 3D modeling. Nucleic Acids Res (2013) 0.96
Comparative study of copper(II)-curcumin complexes as superoxide dismutase mimics and free radical scavengers. Eur J Med Chem (2006) 0.96
Synergy in natural medicines: implications for drug discovery. Trends Pharmacol Sci (2008) 0.96
Cancer preventive mechanisms of the green tea polyphenol (-)-epigallocatechin-3-gallate. Molecules (2007) 0.96
Multiple rice microRNAs are involved in immunity against the blast fungus Magnaporthe oryzae. Plant Physiol (2013) 0.95
Proton dissociation is important to understanding structure-activity relationships of gallic acid antioxidants. Bioorg Med Chem Lett (2006) 0.95
Comparative proteomic analysis of differentially expressed proteins in the early milky stage of rice grains during high temperature stress. J Exp Bot (2013) 0.94
How many drugs are catecholics. Molecules (2007) 0.93
Direct correlation between proteins' folding rates and their amino acid compositions: an ab initio folding rate prediction. Proteins (2006) 0.92
Can medical genetics and evolutionary biology inspire drug target identification? Trends Mol Med (2011) 0.90
Gravity, a regulation factor in the differentiation of rat bone marrow mesenchymal stem cells. J Biomed Sci (2009) 0.90
Sterol biosynthesis and prokaryotes-to-eukaryotes evolution. Biochem Biophys Res Commun (2007) 0.88
Multicenter phase II study of capecitabine combined with nedaplatin for recurrent and metastatic nasopharyngeal carcinoma patients after failure of cisplatin-based chemotherapy. Cancer Chemother Pharmacol (2013) 0.88
The effects of low frequency electrical stimulation on satellite cell activity in rat skeletal muscle during hindlimb suspension. BMC Cell Biol (2010) 0.88
Beta-lactam antibiotics are multipotent agents to combat neurological diseases. Biochem Biophys Res Commun (2005) 0.87
Valproic acid as a promising agent to combat Alzheimer's disease. Brain Res Bull (2010) 0.87
Theoretical elucidation on the antioxidant mechanism of curcumin: a DFT study. Org Lett (2002) 0.87
A theoretical investigation on DPPH radical-scavenging mechanism of edaravone. Bioorg Med Chem Lett (2003) 0.86
The impact of oxygen on metabolic evolution: a chemoinformatic investigation. PLoS Comput Biol (2012) 0.86
Why Is the C-terminus of Abeta(1-42) more unfolded than that of Abeta(1-40)? Clues from hydrophobic interaction. J Phys Chem B (2008) 0.85
What determines protein folding type? An investigation of intrinsic structural properties and its implications for understanding folding mechanisms. J Mol Biol (2007) 0.85
8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells. Biochem Pharmacol (2006) 0.85
Antioxidative effect of schisanhenol on human low density lipoprotein and its quantum chemical calculation. Acta Pharmacol Sin (2004) 0.84
Methylation profile of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma. World J Gastroenterol (2004) 0.84
Organic cofactors participated more frequently than transition metals in redox reactions of primitive proteins. Bioessays (2008) 0.84
Serum level of TSGF, CA242 and CA19-9 in pancreatic cancer. World J Gastroenterol (2004) 0.84
Identification of candidate genes related to rice grain weight under high-temperature stress. Plant Sci (2012) 0.84
Exploring the biologically relevant chemical space for drug discovery. J Chem Inf Model (2013) 0.83
Dissecting the chromatin interactome of microRNA genes. Nucleic Acids Res (2013) 0.83
In vivo anthelmintic activity of Dryopteris crassirhizoma, Kochia scoparia, and Polygala tenuifolia against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). Parasitol Res (2011) 0.82
Where do health benefits of flavonoids come from? Insights from flavonoid targets and their evolutionary history. Biochem Biophys Res Commun (2013) 0.82
How similar are amino acid mutations in human genetic diseases and evolution. Biochem Biophys Res Commun (2007) 0.82
Identification of transcription factors for drug-associated gene modules and biomedical implications. Bioinformatics (2013) 0.81
How does gene expression level contribute to thermophilic adaptation of prokaryotes? An exploration based on predictors. Gene (2008) 0.81
Oxidative DNA damage is important to the evolution of antibiotic resistance: evidence of mutation bias and its medicinal implications. J Biomol Struct Dyn (2012) 0.81
Exploring the common molecular basis for the universal DNA mutation bias: revival of Löwdin mutation model. Biochem Biophys Res Commun (2011) 0.81
Chemical basis of metabolic network organization. PLoS Comput Biol (2011) 0.81
Anion of hypericin is crucial to understanding the photosensitive features of the pigment. Bioorg Med Chem Lett (2005) 0.81
Do biologically relevant compounds have more chance to be drugs? J Chem Inf Model (2009) 0.81
A theoretical elucidation on the solvent-dependent photosensitive behaviors of C60. Photochem Photobiol (2006) 0.81
A theoretical study on Cu(II) binding modes and antioxidant activity of mammalian normal prion protein. Chem Res Toxicol (2004) 0.81
Protein architecture chronology deduced from structures of amino acid synthases. J Biomol Struct Dyn (2007) 0.81
[Comparison of pharmacological effects of Fructus Mume and its processed products]. Zhong Yao Cai (2010) 0.81
Genome-wide high-frequency non-Mendelian loss of heterozygosity in rice. Genome (2007) 0.80
Convergent evolution of medicines. ChemMedChem (2008) 0.80
A comparative molecular dynamics study on thermostability of human and chicken prion proteins. Biochem Biophys Res Commun (2007) 0.80
How does oxygen rise drive evolution? Clues from oxygen-dependent biosynthesis of nuclear receptor ligands. Biochem Biophys Res Commun (2009) 0.80
[Long-term effects of early hyperbaric oxygen therapy on neonatal rats with hypoxic-ischemic brain damage]. Zhongguo Dang Dai Er Ke Za Zhi (2006) 0.80
Curcumin's potential to modulate stem cell fate. Trends Pharmacol Sci (2009) 0.80
Antidiabetic components contained in vegetables and legumes. Molecules (2008) 0.79
Nickel-Catalyzed C-P cross-coupling by C-CN bond cleavage. Chemistry (2011) 0.79
Why are prion diseases precluded by non-mammals? Trends Biochem Sci (2007) 0.79
Evolutionary formation of new protein folds is linked to metallic cofactor recruitment. Bioessays (2009) 0.79
Dissecting traditional Chinese medicines by omics and bioinformatics. Nat Prod Commun (2014) 0.79
beta-sheet constitution of prion proteins. Trends Biochem Sci (2010) 0.78
Human oncogene tissue-specific expression level significantly correlates with sequence compositional features. FEBS Lett (2007) 0.78
[Comparison between R-CHOP regimen and CHOP regimen in treating naive diffuse large B-cell lymphoma in China--a multi-center randomized trail]. Ai Zheng (2005) 0.78
Structure-activity relationships of tanshinones in activating Nrf2. A DFT study and implications for multifunctional antioxidant discovery. Nat Prod Commun (2014) 0.78
Structural and energetic analyses of SNPs in drug targets and implications for drug therapy. J Chem Inf Model (2013) 0.78
Synergistic inhibitory effect of berberine and d-limonene on human gastric carcinoma cell line MGC803. J Med Food (2014) 0.78
Chemoinformatics approaches for traditional Chinese medicine research and case application in anticancer drug discovery. Curr Drug Discov Technol (2010) 0.78
Nursing informatics in clinical practice in China. Comput Inform Nurs (2013) 0.78
Correlation between methylation profile of promoter cpg islands of seven metastasis-associated genes and their expression states in six cell lines of liver origin. Ai Zheng (2004) 0.77
tRNA-dependent cysteine biosynthetic pathway represents a strategy to increase cysteine contents by preventing it from thermal degradation: thermal adaptation of methanogenic archaea ancestor. J Biomol Struct Dyn (2009) 0.77
A gene's ability to buffer variation is predicted by its fitness contribution and genetic interactions. PLoS One (2011) 0.77
Antioxidants used by Deinococcus radiodurans and implications for antioxidant drug discovery. Nat Rev Microbiol (2009) 0.77
Western healers in traditional Chinese medicine. EMBO Rep (2008) 0.77
A theoretical study of the different radical-scavenging activities of catechin, quercetin, and a rationally designed planar catechin. Bioorg Chem (2005) 0.77
How to understand the dichotomy of antioxidants. Biochem Biophys Res Commun (2007) 0.77
DIGA--a database of improved gene annotation for phytopathogens. BMC Genomics (2010) 0.77
Potential anti-dementia agents in traditional Chinese medicine. Nat Prod Commun (2009) 0.77
Historical variation of structural novelty in a natural product library. Chem Biodivers (2011) 0.77
Unexpected amino acid composition of modern Reptilia and its implications in molecular mechanisms of dinosaur extinction. Biochem Biophys Res Commun (2005) 0.77
A new strategy to combat Alzheimer's disease. Combining radical-scavenging potential with metal-protein-attenuating ability in one molecule. Bioorg Med Chem Lett (2005) 0.77
Neighboring-site effects of amino acid mutation. Biochem Biophys Res Commun (2006) 0.77
Radical scavenging potential of phenolic compounds encountered in O. europaea products as indicated by calculation of bond dissociation enthalpy and ionization potential values. J Agric Food Chem (2005) 0.77
Phenotypic characterization, genetic analysis and gene-mapping for a brittle mutant in rice. J Integr Plant Biol (2008) 0.76
Bacterial community shift along with the changes in operational conditions in a membrane-aerated biofilm reactor. Appl Microbiol Biotechnol (2014) 0.76