Published in Am J Respir Cell Mol Biol on February 23, 2006
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science (2005) 5.20
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet (2012) 3.73
Behavioral phenotypes of Disc1 missense mutations in mice. Neuron (2007) 3.68
The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond. BMC Geriatr (2007) 3.33
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Speeding disease gene discovery by sequence based candidate prioritization. BMC Bioinformatics (2005) 2.99
Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene. Nat Genet (2013) 2.91
Genetic contributions to stability and change in intelligence from childhood to old age. Nature (2012) 2.63
Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei. J Cell Biol (2004) 2.43
Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation. Thorax (2013) 2.42
A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms. Nat Neurosci (2006) 2.16
SNP genotyping on pooled DNAs: comparison of genotyping technologies and a semi automated method for data storage and analysis. Nucleic Acids Res (2002) 2.12
Solubilizing mutations used to crystallize one CFTR domain attenuate the trafficking and channel defects caused by the major cystic fibrosis mutation. Chem Biol (2008) 1.97
Conspiracist ideation in Britain and Austria: evidence of a monological belief system and associations between individual psychological differences and real-world and fictitious conspiracy theories. Br J Psychol (2011) 1.82
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression. Nat Biotechnol (2008) 1.73
Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness. Int J Epidemiol (2012) 1.67
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels. J Neurosci (2007) 1.64
Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin. Mol Cell Biol (2005) 1.58
Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms. Proc Natl Acad Sci U S A (2006) 1.56
Yeast two-hybrid screens implicate DISC1 in brain development and function. Biochem Biophys Res Commun (2003) 1.47
Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells. Genes Dev (2007) 1.43
Transfection efficiency and toxicity following delivery of naked plasmid DNA and cationic lipid-DNA complexes to ovine lung segments. Mol Ther (2003) 1.43
Sputum proteomics in inflammatory and suppurative respiratory diseases. Am J Respir Crit Care Med (2008) 1.40
DISC1, PDE4B, and NDE1 at the centrosome and synapse. Biochem Biophys Res Commun (2008) 1.34
The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator by Hsp70. Biochem J (2002) 1.31
Role of DISC1 in neural development and schizophrenia. Curr Opin Neurobiol (2007) 1.27
DISC1-binding proteins in neural development, signalling and schizophrenia. Neuropharmacology (2010) 1.27
Five percent of normal cystic fibrosis transmembrane conductance regulator mRNA ameliorates the severity of pulmonary disease in cystic fibrosis. Am J Respir Cell Mol Biol (2002) 1.26
Changes in metal levels and chromosome aberrations in the peripheral blood of patients after metal-on-metal hip arthroplasty. J Arthroplasty (2004) 1.24
Adenovirus-mediated in utero expression of CFTR does not improve survival of CFTR knockout mice. Mol Ther (2008) 1.21
Proteomic analysis of nasal cells from cystic fibrosis patients and non-cystic fibrosis control individuals: search for novel biomarkers of cystic fibrosis lung disease. Proteomics (2006) 1.21
Polygenic risk for schizophrenia is associated with cognitive change between childhood and old age. Biol Psychiatry (2013) 1.20
A genetic screening strategy identifies novel regulators of the proteostasis network. PLoS Genet (2011) 1.19
Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTR. Proc Natl Acad Sci U S A (2007) 1.17
Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness. J Physiol (2007) 1.15
Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time. Am J Hum Genet (2010) 1.15
Evaluation of the clinical significance of homB, a novel candidate marker of Helicobacter pylori strains associated with peptic ulcer disease. J Infect Dis (2008) 1.14
DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness. ACS Chem Neurosci (2011) 1.13
The NPAS3 gene--emerging evidence for a role in psychiatric illness. Ann Med (2006) 1.13
NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction. Neurosci Lett (2008) 1.11
Disrupted in schizophrenia 1 (DISC1): subcellular targeting and induction of ring mitochondria. Mol Cell Neurosci (2005) 1.10
HIV-1 Tat protein transduction domain peptide facilitates gene transfer in combination with cationic liposomes. J Control Release (2004) 1.08
A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression. Am J Hum Genet (2009) 1.08
Genome-wide association uncovers shared genetic effects among personality traits and mood states. Am J Med Genet B Neuropsychiatr Genet (2012) 1.08
The PDE4B gene confers sex-specific protection against schizophrenia. Psychiatr Genet (2007) 1.07
Whole genome association scan for genetic polymorphisms influencing information processing speed. Biol Psychol (2010) 1.07
Antibodies for CFTR studies. J Cyst Fibros (2004) 1.06
Computational comparison of human genomic sequence assemblies for a region of chromosome 4. Genome Res (2002) 1.06
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. Am J Hum Genet (2012) 1.05
Evolutionary constraints on the Disrupted in Schizophrenia locus. Genomics (2003) 1.05
Genetic predictors of fibrin D-dimer levels in healthy adults. Circulation (2011) 1.05
PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1. J Neurosci (2011) 1.05
Pedigree and genotyping quality analyses of over 10,000 DNA samples from the Generation Scotland: Scottish Family Health Study. BMC Med Genet (2013) 1.04
DISC1 in schizophrenia: genetic mouse models and human genomic imaging. Schizophr Bull (2010) 1.04
CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis. Gastroenterology (2004) 1.04
Sputum trace metals are biomarkers of inflammatory and suppurative lung disease. Chest (2009) 1.03
Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo. Respir Res (2006) 1.03
Revertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D-CFTR. J Physiol (2014) 1.00
Biochemical methods to assess CFTR expression and membrane localization. J Cyst Fibros (2004) 1.00
Association analysis of Neuregulin 1 candidate regions in schizophrenia and bipolar disorder. Neurosci Lett (2010) 1.00
Diagnostic and prognostic biomarker discovery strategies for autoimmune disorders. J Proteomics (2009) 0.99
Enhanced lung gene expression after aerosol delivery of concentrated pDNA/PEI complexes. Mol Ther (2008) 0.99
Common genetic variants explain the majority of the correlation between height and intelligence: the generation Scotland study. Behav Genet (2014) 0.98
Biomarkers for cystic fibrosis lung disease: application of SELDI-TOF mass spectrometry to BAL fluid. J Cyst Fibros (2008) 0.98
Are some genetic risk factors common to schizophrenia, bipolar disorder and depression? Evidence from DISC1, GRIK4 and NRG1. Neurotox Res (2007) 0.98
Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation. PLoS One (2009) 0.97
Aerosol delivery of DNA/liposomes to the lung for cystic fibrosis gene therapy. Hum Gene Ther Clin Dev (2014) 0.97