Neuroplasticity of the hypothalamic-pituitary-adrenal axis early in life requires recurrent recruitment of stress-regulating brain regions.

PubWeight™: 1.76‹?› | Rank: Top 3%

🔗 View Article (PMC 2408688)

Published in J Neurosci on March 01, 2006

Authors

Kristina A Fenoglio1, Yuncai Chen, Tallie Z Baram

Author Affiliations

1: Department of Anatomy/Neurobiology, University of California, Irvine, California 92697-4475, USA.

Articles citing this

Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull (2011) 4.27

Dysfunctional nurturing behavior in rat dams with limited access to nesting material: a clinically relevant model for early-life stress. Neuroscience (2008) 1.62

Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone. J Neurosci (2008) 1.60

Local CRH signaling promotes synaptogenesis and circuit integration of adult-born neurons. Dev Cell (2014) 1.47

A novel mouse model for acute and long-lasting consequences of early life stress. Endocrinology (2008) 1.46

Fragmentation and unpredictability of early-life experience in mental disorders. Am J Psychiatry (2012) 1.23

Developing a neurobehavioral animal model of infant attachment to an abusive caregiver. Biol Psychiatry (2010) 1.23

Early-life experience reduces excitation to stress-responsive hypothalamic neurons and reprograms the expression of corticotropin-releasing hormone. J Neurosci (2010) 1.21

The pathways from mother's love to baby's future. Front Behav Neurosci (2009) 1.16

The central corticotropin releasing factor system during development and adulthood. Eur J Pharmacol (2008) 1.08

Brain plasticity and behaviour in the developing brain. J Can Acad Child Adolesc Psychiatry (2011) 1.08

Altered hypothalamic function in diet-induced obesity. Int J Obes (Lond) (2011) 1.08

Cellular and molecular mechanisms of hippocampal activation by acute stress are age-dependent. Mol Psychiatry (2006) 1.05

Plasticity of the stress response early in life: mechanisms and significance. Dev Psychobiol (2010) 0.98

Early life trauma and attachment: immediate and enduring effects on neurobehavioral and stress axis development. Front Endocrinol (Lausanne) (2014) 0.97

Brain corticotropin-releasing hormone (CRH) circuits in the developing rat: effect of maternal deprivation. Brain Res (2006) 0.96

Epigenetic Risk Factors in PTSD and Depression. Front Psychiatry (2013) 0.95

Epileptogenesis in the developing brain: what can we learn from animal models? Epilepsia (2007) 0.94

Early-life experience alters response of developing brain to seizures. Brain Res (2009) 0.89

Emerging roles of epigenetic mechanisms in the enduring effects of early-life stress and experience on learning and memory. Neurobiol Learn Mem (2011) 0.88

Cannabis use in pregnancy and early life and its consequences: animal models. Eur Arch Psychiatry Clin Neurosci (2009) 0.88

The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysis. Horm Behav (2009) 0.88

How Does a Neuron "know" to Modulate Its Epigenetic Machinery in Response to Early-Life Environment/Experience? Front Psychiatry (2013) 0.87

Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress. Mol Psychiatry (2014) 0.85

GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response. Front Neuroendocrinol (2014) 0.82

Female responses to acute and repeated restraint stress differ from those in males. Physiol Behav (2011) 0.81

NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience. Mol Psychiatry (2017) 0.79

Corticotropin releasing factor in neuroplasticity. Front Neuroendocrinol (2013) 0.79

Maternal care effects on SNB motoneuron development: the mediating role of sensory afferent distribution and activity. Dev Neurobiol (2009) 0.79

Effects of an Early Experience Involving Training in a T-Maze Under either Denial or Receipt of Expected Reward through Maternal Contact. Front Endocrinol (Lausanne) (2013) 0.78

Maternal care effects on the development of a sexually dimorphic motor system: the role of spinal oxytocin. Horm Behav (2010) 0.78

Differential contribution of CBP:CREB binding to corticotropin-releasing hormone expression in the infant and adult hypothalamus. Stress (2013) 0.77

Is neuroplasticity of the hypothalamic-pituitary-adrenal axis maternally mediated? J Neurosci (2006) 0.75

Developmental neurobiology of the rat attachment system and its modulation by stress. Behav Sci (Basel) (2012) 0.75

Articles cited by this

Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science (1997) 8.90

Brain corticosteroid receptor balance in health and disease. Endocr Rev (1998) 5.27

Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol (2003) 4.70

Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Brain Res Mol Brain Res (1993) 4.13

Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology (1985) 4.11

Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models. Dev Psychopathol (2001) 3.97

Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Proc Natl Acad Sci U S A (1998) 3.58

Regulation of transcription factors by neuronal activity. Nat Rev Neurosci (2002) 3.33

The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness. Brain Res Brain Res Rev (2002) 3.21

Neuroanatomical basis for facilitation of hypothalamic-pituitary-adrenal responses to a novel stressor after chronic stress. Neuroscience (1998) 2.52

Effect of neonatal handling on age-related impairments associated with the hippocampus. Science (1988) 2.41

Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring. Neuropsychopharmacology (2005) 2.35

Stressed-out, or in (utero)? Trends Neurosci (2002) 2.08

Mechanisms of late-onset cognitive decline after early-life stress. J Neurosci (2005) 1.98

Neuropeptide-mediated excitability: a key triggering mechanism for seizure generation in the developing brain. Trends Neurosci (1998) 1.96

Lesions of the posterior paraventricular thalamus block habituation of hypothalamic-pituitary-adrenal responses to repeated restraint. J Neuroendocrinol (2002) 1.91

Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress. Proc Natl Acad Sci U S A (2001) 1.78

Immunocytochemical distribution of corticotropin-releasing hormone receptor type-1 (CRF(1))-like immunoreactivity in the mouse brain: light microscopy analysis using an antibody directed against the C-terminus. J Comp Neurol (2000) 1.70

Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus. Proc Natl Acad Sci U S A (2004) 1.67

Infantile experience and resistance to physiological stress. Science (1957) 1.66

Corticotropin-releasing hormone mediates the response to cold stress in the neonatal rat without compensatory enhancement of the peptide's gene expression. Endocrinology (1994) 1.63

Partial reversal of the effect of maternal care on cognitive function through environmental enrichment. Neuroscience (2003) 1.58

The hardship of obesity: a soft-wired hypothalamus. Nat Neurosci (2005) 1.57

Novel and transient populations of corticotropin-releasing hormone-expressing neurons in developing hippocampus suggest unique functional roles: a quantitative spatiotemporal analysis. J Neurosci (2001) 1.54

Differential regulation of the expression of corticotropin-releasing factor receptor type 2 (CRF2) in hypothalamus and amygdala of the immature rat by sensory input and food intake. J Neurosci (1999) 1.51

Sequence of stress-induced alterations in indices of synaptic and transcriptional activation in parvocellular neurosecretory neurons. J Neurosci (1996) 1.51

The pituitary-adrenocortical system of neonatal rats is responsive to stress throughout development in a time-dependent and stressor-specific fashion. Endocrinology (1991) 1.50

Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats. Brain Res (2002) 1.47

Maternal care, gene expression, and the development of individual differences in stress reactivity. Ann N Y Acad Sci (1999) 1.44

Identification of a cyclic adenosine monophosphate-responsive element in the rat corticotropin-releasing hormone gene. Mol Endocrinol (1988) 1.36

Temporal patterns of fos expression in the dentate gyrus after spontaneous seizures in a mouse model of temporal lobe epilepsy. J Neurosci (2005) 1.36

The arginine vasopressin and corticotrophin-releasing hormone gene transcription responses to varied frequencies of repeated stress in rats. J Physiol (1998) 1.33

Influence of psychological variables on the activity of the hypothalamic-pituitary-adrenal axis. Eur J Pharmacol (2000) 1.33

Mapping brain response to social stress in rodents with c-fos expression: a review. Stress (2002) 1.31

Down-regulation of hypothalamic corticotropin-releasing hormone messenger ribonucleic acid (mRNA) precedes early-life experience-induced changes in hippocampal glucocorticoid receptor mRNA. Endocrinology (2001) 1.30

Tissue-specific regulation of glucocorticoid receptor mRNA by dexamethasone. J Biol Chem (1987) 1.28

Maternal deprivation effect on the infant's neural stress markers is reversed by tactile stimulation and feeding but not by suppressing corticosterone. J Neurosci (1998) 1.28

A cholecystokinin-mediated pathway to the paraventricular thalamus is recruited in chronically stressed rats and regulates hypothalamic-pituitary-adrenal function. J Neurosci (2000) 1.24

Maternal and environmental influences on the adrenocortical response to stress in weanling rats. Science (1967) 1.23

Studies on the cellular architecture of the bed nuclei of the stria terminalis in the rat: II. Chemoarchitecture. J Comp Neurol (1989) 1.23

Foster litters prevent hypothalamic-pituitary-adrenal axis sensitization mediated by neonatal maternal separation. Psychoneuroendocrinology (2004) 1.21

Involvement of the bed nucleus of the stria terminalis in tonic regulation of paraventricular hypothalamic CRH and AVP mRNA expression. J Neuroendocrinol (1994) 1.20

Effects of maternal and sibling deprivation on basal and stress induced hypothalamic-pituitary-adrenal components in the infant rat. Neurosci Lett (1995) 1.20

Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment. J Chem Neuroanat (2002) 1.17

Neuronal activity and stress differentially regulate hippocampal and hypothalamic corticotropin-releasing hormone expression in the immature rat. Neuroscience (2000) 1.15

Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing. J Neurosci (1993) 1.13

Thalamic paraventricular nucleus lesions facilitate central amygdala neuronal responses to acute psychological stress. Brain Res (2004) 1.12

The influence of postnatal handling on adult neuroendocrine and behavioural stress reactivity. J Neuroendocrinol (1999) 1.08

Corticotropin-releasing hormone and arginine vasopressin gene transcription in the hypothalamic paraventricular nucleus of unstressed rats: daily rhythms and their interactions with corticosterone. Endocrinology (2003) 1.07

Distribution of Fos immunoreactivity following mating versus anogenital investigation in the male rat brain. Neuroscience (1997) 1.05

Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptor. Endocrinology (2005) 1.04

Enhanced CREB phosphorylation in immature dentate gyrus granule cells precedes neurotrophin expression and indicates a specific role of CREB in granule cell differentiation. Eur J Neurosci (2001) 1.03

Rapid induction of corticotropin-releasing hormone gene transcription in the paraventricular nucleus of the developing rat. Endocrinology (2000) 1.01

Differential effect of amygdaloid lesions on CRF-41, ACTH and corticosterone responses following neural stimuli. Brain Res (1994) 0.99

Region-specific onset of handling-induced changes in corticotropin-releasing factor and glucocorticoid receptor expression. Endocrinology (2004) 0.96

Suckling and genital stroking induces Fos expression in hypothalamic oxytocinergic neurons of rabbit pups. Brain Res Dev Brain Res (2003) 0.93

Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites. Mol Cell Endocrinol (2001) 0.93

Persistent effects of maternal deprivation on HPA regulation can be reversed by feeding and stroking, but not by dexamethasone. J Neuroendocrinol (1999) 0.93

Rapid phosphorylation of the CRE binding protein precedes stress-induced activation of the corticotropin releasing hormone gene in medial parvocellular hypothalamic neurons of the immature rat. Brain Res Mol Brain Res (2001) 0.90

Glucocorticoid down-regulation of rat glucocorticoid receptor does not involve differential promoter regulation. J Endocrinol (2004) 0.90

Influence of the central nucleus of the amygdala on the content of corticotropin-releasing factor in the median eminence. Neuroendocrinology (1989) 0.90

Development neurobiology of the stress response: multilevel regulation of corticotropin-releasing hormone function. Ann N Y Acad Sci (1997) 0.89

Activation of specific neuronal circuits by corticotropin releasing hormone as indicated by c-fos expression and glucose metabolism. J Cereb Blood Flow Metab (2000) 0.87

Long-term neuroplasticity and functional consequences of single versus recurrent early-life seizures. Ann Neurol (2003) 0.86

Alterations in corticotropin-releasing hormone gene expression of central amygdaloid neurons following long-term paraventricular lesions and adrenalectomy. Neuroscience (1998) 0.84

Interaction-induced reduction in differential maternal responsiveness: an effect of cue-reduction or behavior? Dev Psychobiol (1977) 0.83

BEHAVIOR OF ADULT RATS IS MODIFIED BY THE EXPERIENCES THEIR MOTHERS HAD AS INFANTS. Science (1963) 0.82

Lesion of the central nucleus of the amygdala decreases basal CRH mRNA expression and stress-induced ACTH release. Ann N Y Acad Sci (1994) 0.81

Articles by these authors

Infantile spasms: a U.S. consensus report. Epilepsia (2010) 4.62

The role of inflammation in epilepsy. Nat Rev Neurol (2010) 3.89

The neuro-symphony of stress. Nat Rev Neurosci (2009) 3.26

Early life programming and neurodevelopmental disorders. Biol Psychiatry (2010) 2.93

Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann Neurol (2005) 2.90

Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. J Neurosci (2002) 2.65

Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis. Brain (2006) 2.44

Stressed-out, or in (utero)? Trends Neurosci (2002) 2.08

Mechanisms of late-onset cognitive decline after early-life stress. J Neurosci (2005) 1.98

Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J Neurosci (2003) 1.94

Febrile seizures: mechanisms and relationship to epilepsy. Brain Dev (2009) 1.90

Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers. J Neurosci (2010) 1.87

Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J Biol Chem (2010) 1.70

Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation. Proc Natl Acad Sci U S A (2002) 1.69

Fever, febrile seizures and epilepsy. Trends Neurosci (2007) 1.67

Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus. Proc Natl Acad Sci U S A (2004) 1.67

The multiple personalities of h-channels. Trends Neurosci (2003) 1.64

Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. J Neurosci (2009) 1.63

Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors. J Neurosci (2010) 1.62

Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone. J Neurosci (2008) 1.60

Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann Neurol (2003) 1.54

New roles for interleukin-1 Beta in the mechanisms of epilepsy. Epilepsy Curr (2007) 1.50

Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol Dis (2005) 1.49

A novel mouse model for acute and long-lasting consequences of early life stress. Endocrinology (2008) 1.46

Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling. Proc Natl Acad Sci U S A (2010) 1.43

Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures. Hippocampus (2003) 1.41

Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects. Front Neuroendocrinol (2006) 1.37

Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy. Ann Neurol (2011) 1.37

The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci (2013) 1.36

Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus. Cereb Cortex (2006) 1.32

Cognitive dysfunction after experimental febrile seizures. Exp Neurol (2008) 1.28

Serial MRI after experimental febrile seizures: altered T2 signal without neuronal death. Ann Neurol (2004) 1.26

Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Neurobiol Dis (2007) 1.23

Early-life experience reduces excitation to stress-responsive hypothalamic neurons and reprograms the expression of corticotropin-releasing hormone. J Neurosci (2010) 1.21

Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons. J Biol Chem (2010) 1.16

The pathways from mother's love to baby's future. Front Behav Neurosci (2009) 1.16

Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus. Eur J Neurosci (2006) 1.15

Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy. J Physiol (2006) 1.15

Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. J Biol Chem (2011) 1.14

Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci (2007) 1.13

Sculpting the hippocampus from within: stress, spines, and CRH. Trends Neurosci (2012) 1.13

Stress and the developing hippocampus: a double-edged sword? Mol Neurobiol (2003) 1.12

The central corticotropin releasing factor system during development and adulthood. Eur J Pharmacol (2008) 1.08

Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. Neurobiol Dis (2011) 1.08

Towards an integrated view of HCN channel role in epilepsy. Curr Opin Neurobiol (2011) 1.08

Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A (2009) 1.07

Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptor. Endocrinology (2005) 1.04

Tuning synaptic transmission in the hippocampus by stress: the CRH system. Front Cell Neurosci (2012) 1.03

Origins of temporal lobe epilepsy: febrile seizures and febrile status epilepticus. Neurotherapeutics (2014) 1.03

Epileptogenesis after prolonged febrile seizures: mechanisms, biomarkers and therapeutic opportunities. Neurosci Lett (2011) 1.02

Febrile seizures and mechanisms of epileptogenesis: insights from an animal model. Adv Exp Med Biol (2004) 1.02

Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits. J Neurosci (2011) 1.00

Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation. J Neurochem (2007) 1.00

Augmented currents of an HCN2 variant in patients with febrile seizure syndromes. Ann Neurol (2010) 0.98

Synchronized network activity in developing rat hippocampus involves regional hyperpolarization-activated cyclic nucleotide-gated (HCN) channel function. Eur J Neurosci (2005) 0.98

Plasticity of the stress response early in life: mechanisms and significance. Dev Psychobiol (2010) 0.98

Treatment of infantile spasms: emerging insights from clinical and basic science perspectives. J Child Neurol (2011) 0.97

NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH. J Neurosci (2013) 0.97

Region-specific onset of handling-induced changes in corticotropin-releasing factor and glucocorticoid receptor expression. Endocrinology (2004) 0.96

Models for infantile spasms: an arduous journey to the Holy Grail... Ann Neurol (2007) 0.95

Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites. J Biol Chem (2012) 0.95

Endogenous neuropeptide Y prevents recurrence of experimental febrile seizures by increasing seizure threshold. J Mol Neurosci (2005) 0.94

Postnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations. J Neurosci (2009) 0.94

Epileptogenesis in the developing brain: what can we learn from animal models? Epilepsia (2007) 0.94

Corticotropin-releasing hormone (CRH) downregulates the function of its receptor (CRF1) and induces CRF1 expression in hippocampal and cortical regions of the immature rat brain. Exp Neurol (2002) 0.93

Dorsoventral differences in intrinsic properties in developing CA1 pyramidal cells. J Neurosci (2012) 0.93

Hyperpolarization activated cyclic-nucleotide gated (HCN) channels in developing neuronal networks. Prog Neurobiol (2008) 0.93

Finding a better drug for epilepsy: antiinflammatory targets. Epilepsia (2012) 0.91

Emerging roles of epigenetic mechanisms in the enduring effects of early-life stress and experience on learning and memory. Neurobiol Learn Mem (2011) 0.88

Naturalistic rodent models of chronic early-life stress. Dev Psychobiol (2014) 0.87

How Does a Neuron "know" to Modulate Its Epigenetic Machinery in Response to Early-Life Environment/Experience? Front Psychiatry (2013) 0.87

Long-term neuroplasticity and functional consequences of single versus recurrent early-life seizures. Ann Neurol (2003) 0.86

Temperature elevation increases GABA(A) -mediated cortical inhibition in a mouse model of genetic epilepsy. Epilepsia (2010) 0.84

Distinct regional and subcellular localization of the actin-binding protein filamin A in the mature rat brain. J Comp Neurol (2012) 0.82

The mystery of the Doctor's son, or the riddle of West syndrome. Neurology (2002) 0.82

Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem (2014) 0.81

Hippocampal neurogenesis is not enhanced by lifelong reduction of glucocorticoid levels. Hippocampus (2005) 0.81

Treatment of infantile spasms: the ideal and the mundane. Epilepsia (2003) 0.81

Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner. PLoS One (2013) 0.80

Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy. Biochem Biophys Res Commun (2012) 0.79

Go "West," young man...The quest for animal models of infantile spasms (West syndrome). Epilepsy Curr (2007) 0.78

Ps in the (channel) pod are not alike... Epilepsy Curr (2008) 0.75

Hyperpolarized views on the roles of the hyperpolarization-activated channels in neuronal excitability. Epilepsy Curr (2010) 0.75

When a rat runs cold and hot... Epilepsy Curr (2005) 0.75