Published in Biochem J on September 15, 1991
Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem J (1995) 2.92
Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide. Biochem J (1995) 1.98
Adenine nucleotide translocase-1, a component of the permeability transition pore, can dominantly induce apoptosis. J Cell Biol (1999) 1.83
The role of mitochondria in protection of the heart by preconditioning. Biochim Biophys Acta (2007) 1.74
Mechanisms of cell death in heart disease. Arterioscler Thromb Vasc Biol (2012) 1.63
Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel. Biochem J (1994) 1.58
Mitochondria and reperfusion injury of the heart--a holey death but not beyond salvation. J Bioenerg Biomembr (2009) 1.23
Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis. J Clin Invest (1996) 1.09
What makes the mitochondria a killer? Can we condition them to be less destructive? Biochim Biophys Acta (2010) 0.94
Optimising cardioprotection during myocardial ischaemia: targeting potential intracellular pathways with glucagon-like peptide-1. Cardiovasc Diabetol (2014) 0.94
Glycine protects cardiomyocytes against lethal reoxygenation injury by inhibiting mitochondrial permeability transition. J Physiol (2004) 0.93
Calcium signaling as a mediator of cell energy demand and a trigger to cell death. Ann N Y Acad Sci (2015) 0.92
Ca2+ induces a cyclosporin A-insensitive permeability transition pore in isolated potato tuber mitochondria mediated by reactive oxygen species. J Bioenerg Biomembr (2001) 0.91
Targeting mitochondria for resuscitation from cardiac arrest. Crit Care Med (2008) 0.90
NCLX: the mitochondrial sodium calcium exchanger. J Mol Cell Cardiol (2013) 0.88
Mitochondrial handling of excess Ca2+ is substrate-dependent with implications for reactive oxygen species generation. Free Radic Biol Med (2012) 0.86
Increased potassium conductance of brain mitochondria induces resistance to permeability transition by enhancing matrix volume. J Biol Chem (2009) 0.86
Pyrophosphate metabolism in the perfused heart and isolated heart mitochondria and its role in regulation of mitochondrial function by calcium. Biochem J (1993) 0.86
Differential effects of buffer pH on Ca(2+)-induced ROS emission with inhibited mitochondrial complexes I and III. Front Physiol (2015) 0.85
A novel neuroprotective strategy for ischemic stroke: transient mild acidosis treatment by CO2 inhalation at reperfusion. J Cereb Blood Flow Metab (2013) 0.85
The role of hexokinase in cardioprotection - mechanism and potential for translation. Br J Pharmacol (2014) 0.84
Mitochondrial Ca(2+) and regulation of the permeability transition pore. J Bioenerg Biomembr (2016) 0.84
Protection of the ischemic myocardium during the reperfusion: between hope and reality. Am J Cardiovasc Dis (2012) 0.83
Modulation of the permeability transition pore by inhibition of the mitochondrial K(ATP) channel in liver vs. brain mitochondria. J Membr Biol (2007) 0.76
Serum acidosis prior to reperfusion facilitates hemodynamic recovery following liver transplantation. J Anesth (2015) 0.75
In vivo opening of the mitochondrial permeability transition pore in a rat model of ventricular fibrillation and closed-chest resuscitation. Am J Transl Res (2017) 0.75
Mechanisms by which mitochondria transport calcium. Am J Physiol (1990) 6.06
Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol Rev (1990) 5.94
Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem J (1988) 3.41
The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism. Biochim Biophys Acta (1989) 2.70
The Ca2+-induced membrane transition in mitochondria. I. The protective mechanisms. Arch Biochem Biophys (1979) 2.49
The Ca2+-induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site. Arch Biochem Biophys (1979) 2.44
Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia. Am J Pathol (1981) 2.28
Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria. J Biol Chem (1989) 2.21
Role of Ca2+ in toxic cell killing. Trends Pharmacol Sci (1989) 2.17
The regulation of the oxidation of fatty acids and other substrates in rat heart mitochondria by changes in the matrix volume induced by osmotic strength, valinomycin and Ca2+. Biochem J (1987) 1.77
Kinetic evidence for a heart mitochondrial pore activated by Ca2+, inorganic phosphate and oxidative stress. A potential mechanism for mitochondrial dysfunction during cellular Ca2+ overload. Eur J Biochem (1988) 1.59
Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death. J Clin Invest (1989) 1.53
A heart mitochondrial Ca2(+)-dependent pore of possible relevance to re-perfusion-induced injury. Evidence that ADP facilitates pore interconversion between the closed and open states. Biochem J (1990) 1.42
Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes. Am J Physiol (1988) 1.38
Regulation of citric acid cycle by calcium. J Biol Chem (1989) 1.35
Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart. Circ Res (1990) 1.35
Studies on mitochondrial Ca2+-transport and matrix Ca2+ using fura-2-loaded rat heart mitochondria. Biochim Biophys Acta (1989) 1.32
Involvement of the ADP/ATP carrier in calcium-induced perturbations of the mitochondrial inner membrane permeability: importance of the orientation of the nucleotide binding site. Arch Biochem Biophys (1988) 1.24
Liver mitochondrial pyrophosphate concentration is increased by Ca2+ and regulates the intramitochondrial volume and adenine nucleotide content. Biochem J (1987) 1.21
The role of glutathione in the retention of Ca2+ by liver mitochondria. J Biol Chem (1984) 1.20
Effects of glucagon and Ca2+ on the metabolism of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in isolated rat hepatocytes and plasma membranes. Biochem J (1987) 1.16
The presence of two classes of high-affinity cyclosporin A binding sites in mitochondria. Evidence that the minor component is involved in the opening of an inner-membrane Ca(2+)-dependent pore. Eur J Biochem (1990) 1.13
Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate. Evidence for two distinct swelling mechanisms. Biochem J (1990) 1.06
Pore-like and carrier-like properties of the mitochondrial aspartate/glutamate carrier after modification by SH-reagents: evidence for a performed channel as a structural requirement of carrier-mediated transport. Biochim Biophys Acta (1990) 1.06
Protection by acidotic pH against anoxic cell killing in perfused rat liver: evidence for a pH paradox. FASEB J (1991) 1.04
Membrane protein thiol cross-linking associated with the permeabilization of the inner mitochondrial membrane by Ca2+ plus prooxidants. J Biol Chem (1990) 1.04
Toxic consequence of the abrupt depletion of glutathione in cultured rat hepatocytes. Arch Biochem Biophys (1988) 1.03
Effects of metabolic acidosis on viability of cells exposed to anoxia. Am J Physiol (1985) 1.02
Regulation of intracellular pH in the myocardium; relevance to pathology. Mol Cell Biochem (1989) 1.02
Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibitors, ionophores and oxidant chemicals. Biochem Biophys Res Commun (1990) 1.02
Cyclosporin A-sensitive and insensitive mechanisms produce the permeability transition in mitochondria. Biochem Biophys Res Commun (1989) 1.01
The mitochondrial aspartate/glutamate and ADP/ATP carrier switch from obligate counterexchange to unidirectional transport after modification by SH-reagents. Biochim Biophys Acta (1990) 1.00
The beneficial effect of cyclosporine on liver ischemia in rats. Transplantation (1989) 1.00
The mechanism of action of FK 506. Transplant Proc (1990) 0.99
Calcium and pH in anoxic and toxic injury. Crit Rev Toxicol (1990) 0.99
Dependence of cardiac mitochondrial pyruvate dehydrogenase activity on intramitochondrial free Ca2+ concentration. Biochem J (1988) 0.98
Extracellular acidosis protects Ehrlich ascites tumor cells and rat renal cortex against anoxic injury. Science (1974) 0.96
Mitochondrial damage as a mechanism of cell injury in the killing of cultured hepatocytes by tert-butyl hydroperoxide. Arch Biochem Biophys (1989) 0.91
Mitochondrial glutathione status during Ca2+ ionophore-induced injury to isolated hepatocytes. Arch Biochem Biophys (1988) 0.88
A critical appraisal of the association between energy charge and cell damage. Biochim Biophys Acta (1989) 0.88
The influence of changes in pH of the perfusion fluid on the occurrence of the calcium paradox in the isolated rat heart. Cardiovasc Res (1969) 0.86
Mechanisms and regulation of lactate, pyruvate and ketone body transport across the plasma membrane of mammalian cells and their metabolic consequences. Biochem Soc Trans (1990) 0.86
Beneficial effect of cyclosporine pretreatment in preventing ischemic damage to the liver in dogs. Transplantation (1988) 0.84
Intracellular acidosis protects cultured hepatocytes from the toxic consequences of a loss of mitochondrial energization. Arch Biochem Biophys (1989) 0.79
The influence of pH on Ca2+ exchange in ferret heart mitochondria. Biochem Biophys Res Commun (1990) 0.78
Influence of pH on sulfhydryl groups and fluidity of the mitochondrial membrane. Arch Biochem Biophys (1990) 0.77
The beneficial effect of pretransplant cyclosporine therapy on recipient rats grafted with a 12-hour cold-stored liver. Transplantation (1990) 0.77
Lactate transport in heart in relation to myocardial ischemia. Am J Cardiol (1997) 1.03
Regulation of mitochondrial metabolism through changes in matrix volume. Biochem Soc Trans (1994) 1.02
Mitochondrial calcium handling and oxidative stress. Biochem Soc Trans (1993) 0.94
Mechanisms and regulation of lactate, pyruvate and ketone body transport across the plasma membrane of mammalian cells and their metabolic consequences. Biochem Soc Trans (1990) 0.86