Published in Nat Rev Immunol on April 01, 2006
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science (2011) 15.45
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood (2009) 5.84
The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol (2010) 4.26
SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood (2007) 3.52
Oncogenic activation of NF-kappaB. Cold Spring Harb Perspect Biol (2010) 3.30
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia. Cancer Cell (2012) 2.69
Targeting pathological B cell receptor signalling in lymphoid malignancies. Nat Rev Drug Discov (2013) 2.31
Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Nature (2008) 2.06
Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal (2013) 1.73
New insights into pre-BCR and BCR signalling with relevance to B cell malignancies. Nat Rev Immunol (2013) 1.66
Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets. Blood (2008) 1.54
Targeting the B cell receptor pathway in chronic lymphocytic leukemia. Leuk Lymphoma (2012) 1.43
Diffuse large B-cell lymphoma: reduced CD20 expression is associated with an inferior survival. Blood (2008) 1.36
TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells. Eur J Immunol (2011) 1.33
SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas. Cancer Cell (2013) 1.30
Lipid rafts and B cell signaling. Semin Cell Dev Biol (2007) 1.29
Oligomeric organization of the B-cell antigen receptor on resting cells. Nature (2010) 1.27
Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia. Nat Immunol (2014) 1.23
The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells. Immunol Rev (2009) 1.23
BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt. Blood (2009) 1.15
Mouse IgM Fc receptor, FCMR, promotes B cell development and modulates antigen-driven immune responses. J Immunol (2012) 1.13
An immunoreceptor tyrosine activation motif in the mouse mammary tumor virus envelope protein plays a role in virus-induced mammary tumors. J Virol (2006) 1.10
Getting Syk: spleen tyrosine kinase as a therapeutic target. Trends Pharmacol Sci (2014) 1.10
CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis. J Clin Invest (2012) 1.09
Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment. Proc Natl Acad Sci U S A (2007) 1.09
B-cell receptor signaling in diffuse large B-cell lymphoma. Semin Hematol (2015) 1.08
Bruton tyrosine kinase inhibitors: a promising novel targeted treatment for B cell lymphomas. Br J Haematol (2013) 1.07
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2. J Biol Chem (2008) 1.06
B cell activator PAX5 promotes lymphomagenesis through stimulation of B cell receptor signaling. J Clin Invest (2007) 1.05
Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation. J Exp Med (2010) 1.05
Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor. Proc Natl Acad Sci U S A (2010) 1.02
The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85. EMBO J (2011) 1.00
A conformation-induced oligomerization model for B cell receptor microclustering and signaling. Curr Top Microbiol Immunol (2010) 0.99
EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathway. J Gen Virol (2008) 0.99
Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cells. Mol Immunol (2009) 0.99
Actin cytoskeleton reorganization by Syk regulates Fcγ receptor responsiveness by increasing its lateral mobility and clustering. Dev Cell (2014) 0.98
The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop. Blood (2013) 0.96
Self-antigen recognition by follicular lymphoma B-cell receptors. Blood (2012) 0.95
Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review. Mol Cancer (2015) 0.94
Syk activation of phosphatidylinositol 3-kinase/Akt prevents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein (XIAP) to promote survival of Epstein-Barr virus+ (EBV+) B cell lymphomas. J Biol Chem (2011) 0.94
Association of reactive oxygen species-mediated signal transduction with in vitro apoptosis sensitivity in chronic lymphocytic leukemia B cells. PLoS One (2011) 0.94
Time-resolved multidimensional NMR with non-uniform sampling. J Biomol NMR (2014) 0.93
CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk. EMBO J (2015) 0.91
Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer. Biochim Biophys Acta (2014) 0.89
Checkpoints that control B cell development. J Clin Invest (2015) 0.89
B-cell receptor signaling in the genesis and maintenance of B-cell lymphoma. Future Oncol (2008) 0.88
The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia. Leukemia (2015) 0.88
Ibrutinib: an evidence-based review of its potential in the treatment of advanced chronic lymphocytic leukemia. Core Evid (2013) 0.87
Somatic hypermutation analysis in follicular lymphoma provides evidence suggesting bidirectional cell migration between lymph node and bone marrow during disease progression and relapse. Haematologica (2013) 0.86
CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway. J Exp Med (2011) 0.85
Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire. Immunol Res (2013) 0.85
B-lymphocyte calcium influx. Immunol Rev (2009) 0.84
Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3ζ, regulates shuttling, and attenuates both tonic and induced signaling in B cells. Mol Cell Biol (2013) 0.83
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. PLoS One (2011) 0.83
FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling. Proc Natl Acad Sci U S A (2013) 0.83
Novel Agents and Emerging Strategies for Targeting the B-Cell Receptor Pathway in CLL. Mediterr J Hematol Infect Dis (2012) 0.82
Tyrosine kinase inhibitors for the treatment of rheumatoid arthritis. Curr Top Med Chem (2013) 0.82
Bruton's tyrosine kinase inhibitors and their clinical potential in the treatment of B-cell malignancies: focus on ibrutinib. Ther Adv Hematol (2014) 0.82
Role of the Igh intronic enhancer Eμ in clonal selection at the pre-B to immature B cell transition. J Immunol (2013) 0.82
Glioblastoma-derived Macrophage Colony-stimulating Factor (MCSF) Induces Microglial Release of Insulin-like Growth Factor-binding Protein 1 (IGFBP1) to Promote Angiogenesis. J Biol Chem (2015) 0.82
Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects. PLoS One (2013) 0.82
Elucidation of tonic and activated B-cell receptor signaling in Burkitt's lymphoma provides insights into regulation of cell survival. Proc Natl Acad Sci U S A (2016) 0.81
Emerging therapeutic strategies for Epstein-Barr virus+ post-transplant lymphoproliferative disorder. Pediatr Transplant (2012) 0.81
Evasion of affinity-based selection in germinal centers by Epstein-Barr virus LMP2A. Proc Natl Acad Sci U S A (2015) 0.81
Mechanisms of central tolerance for B cells. Nat Rev Immunol (2017) 0.81
Oligomerization and nanocluster organization render specificity. Biol Rev Camb Philos Soc (2014) 0.80
Mouse mammary tumor virus suppresses apoptosis of mammary epithelial cells through ITAM-mediated signaling. J Virol (2012) 0.79
Primary immunoglobulin repertoire development: time and space matter. Curr Opin Immunol (2015) 0.79
A new hypersensitive site, HS10, and the enhancers, E3' and Ed, differentially regulate Igκ gene expression. J Immunol (2012) 0.79
Promising personalized therapeutic options for diffuse large B-cell Lymphoma Subtypes with oncogene addictions. Clin Cancer Res (2012) 0.79
Dipeptidyl peptidase 2 apoptosis assay determines the B-cell activation stage and predicts prognosis in chronic lymphocytic leukemia. Exp Hematol (2010) 0.79
Targeting CD19 in B-cell lymphoma: emerging role of SAR3419. Cancer Manag Res (2013) 0.79
Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing. J Immunol (2011) 0.78
A mouse variable gene fragment binds to DNA independently of the BCR context: a possible role for immature B-cell repertoire establishment. PLoS One (2013) 0.78
Proteomic changes during B cell maturation: 2D-DIGE approach. PLoS One (2013) 0.78
Sialic acids and autoimmune disease. Immunol Rev (2016) 0.78
Distinct patterns of B-cell receptor signaling in non-Hodgkins' lymphomas identified by single cell profiling. Blood (2016) 0.78
Patterns of receptor revision in the immunoglobulin heavy chains of a teleost fish. J Immunol (2009) 0.77
Beyond transitional selection: New roles for BLyS in peripheral tolerance. Drug Dev Res (2011) 0.76
Tyrosine phosphorylation within the intrinsically disordered cytosolic domains of the B-cell receptor: an NMR-based structural analysis. PLoS One (2014) 0.76
Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase. Blood (2014) 0.76
Multiple factors influence the contribution of individual immunoglobulin light chain genes to the naïve antibody repertoire. BMC Immunol (2014) 0.76
Phosphoinositide 3'-kinase inhibition in chronic lymphocytic leukemia. Hematol Oncol Clin North Am (2013) 0.75
Inhibition of human diffuse large B-cell lymphoma growth by JC polyomavirus-like particles delivering a suicide gene. J Transl Med (2015) 0.75
Augmented B lymphocyte response to antigen in the absence of antigen-induced B lymphocyte signaling in an IgG-transgenic mouse line. PLoS One (2010) 0.75
mTOR-Dependent and Independent Survival Signaling by PI3K in B Lymphocytes. PLoS One (2016) 0.75
Kras Is Critical for B Cell Lymphopoiesis. J Immunol (2016) 0.75
B Cell Development in the Bone Marrow Is Regulated by Homeostatic Feedback Exerted by Mature B Cells. Front Immunol (2016) 0.75
Micromanagement of lymphomas. PLoS Biol (2008) 0.75
Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma. J Hematol Oncol (2017) 0.75
DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk. Elife (2016) 0.75
Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia. Sci Signal (2016) 0.75
Role of the immunoreceptor tyrosine-based activation motif of latent membrane protein 2A (LMP2A) in Epstein-Barr virus LMP2A-induced cell transformation. J Virol (2014) 0.75
Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses. Nat Commun (2017) 0.75
The development of mature B lymphocytes requires the combined function of CD19 and the p110δ subunit of PI3K. Self Nonself (2010) 0.75