PubRank

Earl R Kern

Author PubWeight™ 89.26‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir. Antimicrob Agents Chemother 2004 2.45
2 Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro. Antimicrob Agents Chemother 2002 2.34
3 National Institutes of Health Consensus Development Conference Statement: management of hepatitis B. Ann Intern Med 2009 2.19
4 Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice. Antimicrob Agents Chemother 2006 1.92
5 In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses. Antimicrob Agents Chemother 2003 1.83
6 Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides. J Med Chem 2004 1.71
7 Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro. Antimicrob Agents Chemother 2005 1.60
8 Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection. J Infect Dis 2004 1.55
9 Efficacy of multiple- or single-dose cidofovir against vaccinia and cowpox virus infections in mice. Antimicrob Agents Chemother 2003 1.53
10 Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro. Antimicrob Agents Chemother 2005 1.52
11 Human cytomegalovirus UL97 Kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesis. J Virol 2005 1.51
12 Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro. J Infect Dis 2004 1.50
13 Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes. J Virol 2008 1.48
14 National Institutes of Health consensus development conference statement: management of hepatitis B. Hepatology 2009 1.48
15 Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses. J Med Chem 2006 1.39
16 Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses. Antimicrob Agents Chemother 2007 1.38
17 In vitro and in vivo evaluation of isatin-beta-thiosemicarbazone and marboran against vaccinia and cowpox virus infections. Antiviral Res 2006 1.38
18 Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication. Antimicrob Agents Chemother 2003 1.37
19 Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections. Antimicrob Agents Chemother 2006 1.37
20 Inhibition of herpesvirus replication by a series of 4-oxo-dihydroquinolines with viral polymerase activity. Antiviral Res 2005 1.31
21 Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitro. Antimicrob Agents Chemother 2004 1.30
22 (Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a new class of methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity. J Med Chem 2004 1.19
23 Efficacy of methylenecyclopropane analogs of nucleosides against herpesvirus replication in vitro. Nucleosides Nucleotides Nucleic Acids 2003 1.14
24 N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors. J Med Chem 2007 1.13
25 Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies. J Infect Dis 2010 1.12
26 Evaluation of AD472, a live attenuated recombinant herpes simplex virus type 2 vaccine in guinea pigs. Vaccine 2005 1.12
27 Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity. J Med Chem 2005 1.11
28 Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA. Virol J 2005 1.09
29 A rapid DNA hybridization assay for the evaluation of antiviral compounds against Epstein-Barr virus. J Virol Methods 2007 1.08
30 Cutaneous infections of mice with vaccinia or cowpox viruses and efficacy of cidofovir. Antiviral Res 2004 1.08
31 Preclinical evaluation of a genetically engineered herpes simplex virus expressing interleukin-12. J Virol 2012 1.06
32 Synthesis of cyclopentenyl carbocyclic nucleosides as potential antiviral agents against orthopoxviruses and SARS. J Med Chem 2006 1.06
33 Structure-activity relationships of (S,Z)-2-aminopurine methylenecyclopropane analogues of nucleosides. Variation of purine-6 substituents and activity against herpesviruses and hepatitis B virus. J Med Chem 2003 1.04
34 Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus. Antiviral Res 2009 1.04
35 The enantiomers of carbocyclic 5'-norguanosine: activity towards Epstein-Barr virus. Bioorg Med Chem 2002 1.04
36 Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice. Antimicrob Agents Chemother 2007 1.03
37 Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase. Antimicrob Agents Chemother 2007 1.00
38 Genetically engineered herpes simplex viruses that express IL-12 or GM-CSF as vaccine candidates. Vaccine 2005 0.98
39 Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase. Antimicrob Agents Chemother 2011 0.98
40 9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1. J Med Chem 2006 0.97
41 Determination of antiviral efficacy against lymphotropic herpesviruses utilizing flow cytometry. Antiviral Res 2003 0.96
42 Combinatorial optimization of isatin-beta-thiosemicarbazones as anti-poxvirus agents. J Med Chem 2005 0.95
43 The 4',4'-difluoro analog of 5'-noraristeromycin: a new structural prototype for possible antiviral drug development toward orthopoxvirus and cytomegalovirus. Bioorg Med Chem 2005 0.95
44 The search for new therapies for human cytomegalovirus infections. Virus Res 2010 0.95
45 Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides. Antimicrob Agents Chemother 2009 0.95
46 Effect of immunization with herpes simplex virus type-1 (HSV-1) glycoprotein D (gD) plus the immune enhancer GPI-0100 on infection with HSV-1 or HSV-2. Vaccine 2005 0.94
47 Synthesis, physicochemical properties and antiviral activities of ester prodrugs of ganciclovir. Int J Pharm 2005 0.94
48 Isolation and characterization of cidofovir resistant vaccinia viruses. Virol J 2008 0.92
49 CMX001 potentiates the efficacy of acyclovir in herpes simplex virus infections. Antimicrob Agents Chemother 2011 0.92
50 A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity. Bioorg Med Chem Lett 2006 0.91
51 Amphipathic DNA polymers exhibit antiherpetic activity in vitro and in vivo. Antimicrob Agents Chemother 2008 0.91
52 Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models. Antiviral Res 2008 0.90
53 Orthopoxvirus targets for the development of antiviral therapies. Curr Drug Targets Infect Disord 2005 0.90
54 Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3-fluorocyclopropylidene]methyl}-adenines and guanines. Nucleosides Nucleotides Nucleic Acids 2007 0.89
55 Recurrent antiviral-resistant genital herpes in an immunocompetent patient. J Infect Dis 2005 0.89
56 Assembling a smallpox biodefense by interrogating 5-substituted pyrimidine nucleoside chemical space. Antiviral Res 2006 0.88
57 Synthesis of methylenecyclobutane analogues of nucleosides with axial chirality and their phosphoralaninates: a new pronucleotide effective against Epstein-Barr virus. Antivir Chem Chemother 2002 0.88
58 Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure. J Med Chem 2006 0.87
59 Distinct thymidine kinases encoded by cowpox virus and herpes simplex virus contribute significantly to the differential antiviral activity of nucleoside analogs. Antiviral Res 2006 0.87
60 Synthesis and biological activity of 2-aminopurine methylenecyclopropane analogues of nucleosides. Nucleosides Nucleotides Nucleic Acids 2003 0.87
61 5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity. J Med Chem 2006 0.87
62 Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates. Antimicrob Agents Chemother 2008 0.86
63 Phosphoralaninate pronucleotides of pyrimidine methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity. Nucleosides Nucleotides Nucleic Acids 2005 0.85
64 Human cytomegalovirus UL27 is not required for viral replication in human tissue implanted in SCID mice. Virol J 2006 0.85
65 Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters. Antimicrob Agents Chemother 2006 0.85
66 Benzimidazole analogs inhibit human herpesvirus 6. Antimicrob Agents Chemother 2011 0.85
67 Efficacy of ganciclovir and cidofovir against human cytomegalovirus replication in SCID mice implanted with human retinal tissue. Antiviral Res 2004 0.82
68 Synthesis and antiviral evaluation of alkoxyalkyl esters of phosphonopropoxymethyl-guanine and phosphonopropoxymethyl-diaminopurine. Antivir Chem Chemother 2006 0.82
69 Synthesis and antiviral activities of 1,2,3-triazole functionalized thymidines: 1,3-dipolar cycloaddition for efficient regioselective diversity generation. Antivir Chem Chemother 2005 0.81
70 Enhancement of humoral immune responses to a human cytomegalovirus DNA vaccine: adjuvant effects of aluminum phosphate and CpG oligodeoxynucleotides. J Med Virol 2003 0.81
71 Orthopoxvirus targets for the development of new antiviral agents. Antiviral Res 2012 0.81
72 Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir. Antiviral Res 2006 0.81
73 Synthesis of Methylenecyclopropane Analogues of Antiviral Nucleoside Phosphonates. Tetrahedron 2006 0.80
74 Effect of an immune enhancer, GPI-0100, on vaccination with live attenuated herpes simplex virus (HSV) type 2 or glycoprotein D on genital HSV-2 infections of guinea pigs. Antiviral Res 2008 0.80
75 Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine. Virol J 2008 0.79
76 Novel ring-expanded nucleoside analogs exhibit potent and selective inhibition of hepatitis B virus replication in cultured human hepatoblastoma cells. Antiviral Res 2002 0.78
77 Treatment of Vaccinia and Cowpox Virus Infections in Mice with CMX001 and ST-246. Viruses 2010 0.78
78 Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus). Bioorg Med Chem Lett 2005 0.77
79 Synthesis, antiviral, and antitumor activity of 2-substituted purine methylenecyclopropane analogues of nucleosides. Bioorg Med Chem 2005 0.77
80 Evidence for Epstein-Barr virus autoantibodies against human brain in demyelinating encephalitis. Neuropathol Appl Neurobiol 2002 0.76
81 Antiviral Activity of 4'-thioIDU and Thymidine Analogs against Orthopoxviruses. Viruses 2010 0.75
82 Tryptophanyl phosphoramidates as prodrugs of synadenol and its E-isomer: synthesis and biological activity. Bioorg Med Chem Lett 2002 0.75
83 Synthesis and biological activities of 2-functionalized purine nucleosides. Nucleosides Nucleotides Nucleic Acids 2003 0.75
84 Short communication inhibitory activity of 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N-(4,6-dimethylpyrimidin-2-yl) benzenesulphonamide and its derivatives against orthopoxvirus replication in vitro. Antivir Chem Chemother 2006 0.75
85 Synthesis and biological activity of 2-aminopurine methylenecyclopropane analogues of nucleosides. Nucleosides Nucleotides Nucleic Acids 2003 0.75