Published in Mol Endocrinol on March 30, 2006
Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev (2008) 5.28
A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3. J Biol Chem (2010) 1.67
Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res (2007) 1.56
Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry (2008) 1.54
VDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression. Mol Endocrinol (2011) 1.46
The vitamin D receptor: new paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D(3). Endocrinol Metab Clin North Am (2010) 1.39
Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k. Endocrinology (2008) 1.36
Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone. J Steroid Biochem Mol Biol (2010) 1.36
The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging. J Steroid Biochem Mol Biol (2010) 1.34
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiol Rev (2016) 1.25
Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice. Gastroenterology (2008) 1.15
Genomic determinants of gene regulation by 1,25-dihydroxyvitamin D3 during osteoblast-lineage cell differentiation. J Biol Chem (2014) 1.11
Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells. Biochem Biophys Res Commun (2011) 1.09
An enhancer 20 kilobases upstream of the human receptor activator of nuclear factor-kappaB ligand gene mediates dominant activation by 1,25-dihydroxyvitamin D3. Mol Endocrinol (2008) 1.08
1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1. BMC Genomics (2010) 1.05
Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. J Med Chem (2012) 1.05
Perspectives on mechanisms of gene regulation by 1,25-dihydroxyvitamin D3 and its receptor. J Steroid Biochem Mol Biol (2007) 1.04
Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention. J Nutr Biochem (2010) 1.02
Down-regulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2. J Biol Chem (2010) 1.00
Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption. Am J Physiol Gastrointest Liver Physiol (2009) 0.98
Action of vitamin D and the receptor, VDRa, in calcium handling in zebrafish (Danio rerio). PLoS One (2012) 0.94
Genome-wide (over)view on the actions of vitamin D. Front Physiol (2014) 0.93
Effects of MAPK signaling on 1,25-dihydroxyvitamin D-mediated CYP24 gene expression in the enterocyte-like cell line, Caco-2. J Cell Physiol (2009) 0.93
Suppression of aberrant transient receptor potential cation channel, subfamily V, member 6 expression in hyperproliferative colonic crypts by dietary calcium. Am J Physiol Gastrointest Liver Physiol (2010) 0.90
Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-derived Mesenchymal Stem Cells. J Biol Chem (2016) 0.89
Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor. Biochemistry (2013) 0.89
Evidence for a role of prolactin in calcium homeostasis: regulation of intestinal transient receptor potential vanilloid type 6, intestinal calcium absorption, and the 25-hydroxyvitamin D(3) 1alpha hydroxylase gene by prolactin. Endocrinology (2010) 0.89
Vitamin D and gene networks in human osteoblasts. Front Physiol (2014) 0.89
Vitamin D and the RNA transcriptome: more than mRNA regulation. Front Physiol (2014) 0.88
Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes. J Steroid Biochem Mol Biol (2012) 0.88
Selective Distal Enhancer Control of the Mmp13 Gene Identified through Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Genomic Deletions. J Biol Chem (2015) 0.87
Regulation of mouse Cyp24a1 expression via promoter-proximal and downstream-distal enhancers highlights new concepts of 1,25-dihydroxyvitamin D(3) action. Arch Biochem Biophys (2011) 0.87
Intestinal resistance to 1,25 dihydroxyvitamin D in mice heterozygous for the vitamin D receptor knockout allele. Endocrinology (2006) 0.86
1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium-regulating Components. J Biol Chem (2015) 0.86
Nutrigenomics, vitamin D and cancer prevention. J Nutrigenet Nutrigenomics (2011) 0.86
Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5. PLoS One (2013) 0.85
Villin promoter-mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild-type and vitamin D receptor knockout mice. J Bone Miner Res (2012) 0.85
The vitamin D receptor: new paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D3. Rheum Dis Clin North Am (2012) 0.85
Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D₃ function in human colon adenocarcinoma LS180 cells. Biochem Pharmacol (2012) 0.84
Role of proinflammatory cytokines on expression of vitamin D metabolism and target genes in colon cancer cells. J Steroid Biochem Mol Biol (2013) 0.83
Top Three Pharmacogenomics and Personalized Medicine Applications at the Nexus of Renal Pathophysiology and Cardiovascular Medicine. Curr Pharmacogenomics Person Med (2011) 0.83
SULT2B1b sulfotransferase: induction by vitamin D receptor and reduced expression in prostate cancer. Mol Endocrinol (2013) 0.83
1,25-Dihydroxyvitamin D3 induced histone profiles guide discovery of VDR action sites. J Steroid Biochem Mol Biol (2013) 0.83
Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease. Am J Physiol Cell Physiol (2012) 0.81
Phorbol esters enhance 1α,25-dihydroxyvitamin D3-regulated 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) gene expression through ERK-mediated phosphorylation of specific protein 3 (Sp3) in Caco-2 cells. Mol Cell Endocrinol (2012) 0.81
The enhanced hypercalcemic response to 20-epi-1,25-dihydroxyvitamin D3 results from a selective and prolonged induction of intestinal calcium-regulating genes. Endocrinology (2009) 0.80
Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemother Pharmacol (2014) 0.80
The effect of differentiation on 1,25 dihydroxyvitamin D-mediated gene expression in the enterocyte-like cell line, Caco-2. J Cell Physiol (2009) 0.80
Identification and characterization of a vitamin D₃ decomposition product bactericidal against Helicobacter pylori. Sci Rep (2015) 0.77
Pleiotropic Activities of Vitamin D Receptors - Adequate Activation for Multiple Health Outcomes. Clin Biochem Rev (2015) 0.76
Vitamin D receptor and RXR in the post-genomic era. J Cell Physiol (2015) 0.76
Effects of the Administration of 25(OH) Vitamin D3 in an Experimental Model of Chronic Kidney Disease in Animals Null for 1-Alpha-Hydroxylase. PLoS One (2017) 0.75
Development of a Whole Organism Platform for Phenotype-Based Analysis of IGF1R-PI3K-Akt-Tor Action. Sci Rep (2017) 0.75
The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights. J Clin Invest (2017) 0.75
Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D(3) in LNCaP Cells. J Clin Biochem Nutr (2009) 0.75
HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions. Nat Commun (2017) 0.75
Vitamin D: Musculoskeletal health. Rev Endocr Metab Disord (2016) 0.75
Distinct molecular mechanism for initiating TRAF6 signalling. Nature (2002) 3.82
Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization. J Clin Invest (2012) 2.10
Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers. Mol Cell Biol (2006) 1.92
1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts. J Bone Miner Res (2004) 1.90
Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D. J Clin Endocrinol Metab (2010) 1.72
A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3. J Biol Chem (2010) 1.67
Enhancers located within two introns of the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3. Mol Endocrinol (2006) 1.66
Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass. Endocrinology (2007) 1.47
VDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression. Mol Endocrinol (2011) 1.46
Molecular structure of the rat vitamin D receptor ligand binding domain complexed with 2-carbon-substituted vitamin D3 hormone analogues and a LXXLL-containing coactivator peptide. Biochemistry (2004) 1.42
Reliability of two different presurgical preparation methods for implant dentistry based on panoramic radiography and cone-beam computed tomography in cadavers. J Periodontal Implant Sci (2012) 1.36
Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone. J Steroid Biochem Mol Biol (2010) 1.36
Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription. Mol Endocrinol (2009) 1.35
Comparative chondrogenesis of human cell sources in 3D scaffolds. J Tissue Eng Regen Med (2009) 1.31
A potent analog of 1alpha,25-dihydroxyvitamin D3 selectively induces bone formation. Proc Natl Acad Sci U S A (2002) 1.27
Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo. Endocrinology (2008) 1.26
Molecular actions of 1,25-dihydroxyvitamin D3 on genes involved in calcium homeostasis. J Bone Miner Res (2007) 1.25
2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts. J Biol Chem (2003) 1.20
Characterizing early events associated with the activation of target genes by 1,25-dihydroxyvitamin D3 in mouse kidney and intestine in vivo. J Biol Chem (2007) 1.19
An enhancer 20 kilobases upstream of the human receptor activator of nuclear factor-kappaB ligand gene mediates dominant activation by 1,25-dihydroxyvitamin D3. Mol Endocrinol (2008) 1.08
Multiple enhancer regions located at significant distances upstream of the transcriptional start site mediate RANKL gene expression in response to 1,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol (2007) 1.06
A novel distal enhancer mediates cytokine induction of mouse RANKl gene expression. Mol Endocrinol (2009) 1.05
Isolation and characterization of unsaturated fatty acids as natural ligands for the retinoid-X receptor. Arch Biochem Biophys (2003) 1.05
1,25-Dihydroxyvitamin D3 regulates the expression of low-density lipoprotein receptor-related protein 5 via deoxyribonucleic acid sequence elements located downstream of the start site of transcription. Mol Endocrinol (2006) 1.05
Perspectives on mechanisms of gene regulation by 1,25-dihydroxyvitamin D3 and its receptor. J Steroid Biochem Mol Biol (2007) 1.04
Transcriptional control of receptor activator of nuclear factor-kappaB ligand by the protein kinase A activator forskolin and the transmembrane glycoprotein 130-activating cytokine, oncostatin M, is exerted through multiple distal enhancers. Mol Endocrinol (2006) 1.03
The osteoblast to osteocyte transition: epigenetic changes and response to the vitamin D3 hormone. Mol Endocrinol (2014) 1.02
Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol (2009) 1.01
Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells. Mol Endocrinol (2013) 1.00
Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells. J Cell Biochem (2004) 0.98
1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthase. J Bone Miner Res (2011) 0.97
Community management of acute malnutrition in the developing world. Pediatr Gastroenterol Hepatol Nutr (2012) 0.96
Human invariant natural killer T cells acquire transient innate responsiveness via histone H4 acetylation induced by weak TCR stimulation. J Exp Med (2012) 0.96
Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region. J Biol Chem (2011) 0.93
The mouse RANKL gene locus is defined by a broad pattern of histone H4 acetylation and regulated through distinct distal enhancers. J Cell Biochem (2011) 0.92
Multifactorial evaluation of implant failure: a 19-year retrospective study. Int J Oral Maxillofac Implants (2014) 0.92
Flt-1 tyrosine kinase-deficient homozygous mice result in decreased trabecular bone volume with reduced osteogenic potential. Bone (2007) 0.92
Evaluation of the correlation between insertion torque and primary stability of dental implants using a block bone test. J Periodontal Implant Sci (2013) 0.90
Evidence for a role of prolactin in calcium homeostasis: regulation of intestinal transient receptor potential vanilloid type 6, intestinal calcium absorption, and the 25-hydroxyvitamin D(3) 1alpha hydroxylase gene by prolactin. Endocrinology (2010) 0.89
Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes. J Steroid Biochem Mol Biol (2012) 0.88
Highly crosslinked vs conventional polyethylene particles--an in vitro comparison of biologic activities. J Arthroplasty (2008) 0.88
Osseointegration of dental implants installed without mechanical engagement: a histometric analysis in dogs. Clin Oral Implants Res (2011) 0.87
Mouse and human BAC transgenes recapitulate tissue-specific expression of the vitamin D receptor in mice and rescue the VDR-null phenotype. Endocrinology (2014) 0.85
Enhancers located in the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol (2007) 0.84
A humanized mouse model of hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia. Endocrinology (2014) 0.84
Dexamethasone enhances 1alpha,25-dihydroxyvitamin D3 effects by increasing vitamin D receptor transcription. J Biol Chem (2011) 0.84
1,25-Dihydroxyvitamin D3 induces expression of the Wnt signaling co-regulator LRP5 via regulatory elements located significantly downstream of the gene's transcriptional start site. J Steroid Biochem Mol Biol (2007) 0.83
The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs. Arch Biochem Biophys (2007) 0.83
Transcriptional regulation of the human TNFSF11 gene in T cells via a cell type-selective set of distal enhancers. J Cell Biochem (2015) 0.83
Ferrocene-appended aryl triazole for electrochemical recognition of phosphate ions. Org Lett (2011) 0.82
Vitamin D receptor-mediated gene regulation mechanisms and current concepts of vitamin D analog selectivity. Adv Ren Replace Ther (2002) 0.81
Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription. J Cell Biochem (2003) 0.81
Gingival coverage of iatrogenically denuded labial bone resulting from thermal trauma. Int J Periodontics Restorative Dent (2013) 0.81
Characterization of Oct4-GFP spermatogonial stem cell line and its application in the reprogramming studies. J Cell Biochem (2013) 0.81
Receptor activator of nuclear factor-kappaB ligand-induced nuclear factor of activated T cells (C1) autoregulates its own expression in osteoclasts and mediates the up-regulation of tartrate-resistant acid phosphatase. Mol Endocrinol (2007) 0.81
A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse. J Bone Miner Res (2015) 0.80
Improvement of osteogenic potential of biphasic calcium phosphate bone substitute coated with synthetic cell binding peptide sequences. J Periodontal Implant Sci (2012) 0.80
Improvement of osteogenic potential of biphasic calcium phosphate bone substitute coated with two concentrations of expressed recombinant human bone morphogenetic protein 2. J Periodontal Implant Sci (2012) 0.80
The enhanced hypercalcemic response to 20-epi-1,25-dihydroxyvitamin D3 results from a selective and prolonged induction of intestinal calcium-regulating genes. Endocrinology (2009) 0.80
1,25-Dihydroxyvitamin D3 and the aging-related forkhead box O and sestrin proteins in osteoblasts. J Steroid Biochem Mol Biol (2012) 0.78
Enhanced coactivator binding and transcriptional activation of mutant vitamin D receptors from patients with hereditary 1,25-dihydroxyvitamin D-resistant rickets by phosphorylation and vitamin D analogs. J Bone Miner Res (2005) 0.78
Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors. J Bone Miner Res (2002) 0.78
Secondary stability of microthickness hydroxyapatite-coated dental implants installed without primary stability in dogs. Clin Oral Implants Res (2013) 0.77
Long-term results of ethanol sclerotherapy with or without adjunctive surgery for head and neck arteriovenous malformations. Neuroradiology (2015) 0.76
Endogenous fluorescence signatures in living pluripotent stem cells change with loss of potency. PLoS One (2012) 0.76
Cre-LoxP-regulated expression of monoclonal antibodies driven by an ovalbumin promoter in primary oviduct cells. BMC Biotechnol (2011) 0.75
The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights. J Clin Invest (2017) 0.75
Bone apposition on implants coated with calcium phosphate by ion beam assisted deposition in oversized drilled sockets: a histologic and histometric analysis in dogs. J Periodontal Implant Sci (2013) 0.75
Reply on "Reliability of two different presurgical preparation methods for implant dentistry based on panoramic radiography and cone-beam computed tomography in cadavers". J Periodontal Implant Sci (2012) 0.75
CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis. Cancer Cell (2016) 0.75
A three-dimensional finite element analysis of short dental implants in the posterior maxilla. Int J Oral Maxillofac Implants (2014) 0.75
Profiling histone modifications by chromatin immunoprecipitation coupled to deep sequencing in skeletal cells. Methods Mol Biol (2015) 0.75
Brookite TiO2 thin film epitaxially grown on (110) YSZ substrate by atomic layer deposition. ACS Appl Mater Interfaces (2014) 0.75
[Regulation of bone mass for skeletal loading]. J UOEH (2002) 0.75
Effect of using a titanium washer on the removal torque of an abutment screw in the external connection type of dental implant. Implant Dent (2012) 0.75
Accuracy of impressions for internal-connection implant prostheses with various divergent angles. Int J Oral Maxillofac Implants (2011) 0.75