Host range, replicative, and cytopathic properties of human immunodeficiency virus type 1 are determined by very few amino acid changes in tat and gp120.

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Published in J Virol on December 01, 1991

Authors

C Cheng-Mayer1, T Shioda, J A Levy

Author Affiliations

1: Cancer Research Institute, University of California School of Medicine, San Francisco 94143-0128.

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Xenotropic type C viruses. Curr Top Microbiol Immunol (1978) 1.78

CD8+ cell anti-HIV activity: nonlytic suppression of virus replication. AIDS Res Hum Retroviruses (1992) 1.75

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Effect of cytokines on HIV replication in CD4+ lymphocytes: lack of identity with the CD8+ cell antiviral factor. Cell Immunol (1994) 1.70

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Minimal risk of transmission of AIDS-associated retrovirus infection by oral-genital contact. JAMA (1986) 1.62

Sendai virus C proteins are categorically nonessential gene products but silencing their expression severely impairs viral replication and pathogenesis. Genes Cells (1998) 1.62

Host range of murine xenotropic virus: replication in avian cells. Nature (1975) 1.61

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Importance of the cysteine-rich carboxyl-terminal half of V protein for Sendai virus pathogenesis. J Virol (1997) 1.58

An AIDS-related cytotoxic autoantibody reacts with a specific antigen on stimulated CD4+ T cells. Nature (1987) 1.57

Recovery and inactivation of infectious retroviruses from factor VIII concentration. Lancet (1984) 1.56

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Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein. Genes Dev (2001) 1.53

Highly purified quiescent human peripheral blood CD4+ T cells are infectible by human immunodeficiency virus but do not release virus after activation. J Virol (1995) 1.51

Measles virus attenuation associated with transcriptional impediment and a few amino acid changes in the polymerase and accessory proteins. J Virol (1998) 1.50

Social distance from the stigmatized. A test of two theories. Soc Sci Med (1982) 1.48

HIV pathogenesis and long-term survival. AIDS (1993) 1.47

Circulating immune complexes in patients with acquired immune deficiency syndrome contain the AIDS-associated retrovirus. Clin Immunol Immunopathol (1986) 1.44

Studies of FBJ osteosarcoma virus in tissue culture. I. Biologic characteristics of the "C"-type viruses. J Natl Cancer Inst (1973) 1.43

The restricted cellular host range of human herpesvirus 8. AIDS (2000) 1.41

Further studies on a glycolipid formed from dolichyl-D-glucosyl monophosphate. Carbohydr Res (1973) 1.40