Published in Endocr Relat Cancer on March 01, 2006
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A (2008) 17.41
Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer. JAMA (2013) 5.71
Association between BRAF V600E mutation and recurrence of papillary thyroid cancer. J Clin Oncol (2014) 4.75
Molecular pathogenesis and mechanisms of thyroid cancer. Nat Rev Cancer (2013) 4.46
Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer. N Engl J Med (2013) 3.21
BRAF mutation testing of thyroid fine-needle aspiration biopsy specimens for preoperative risk stratification in papillary thyroid cancer. J Clin Oncol (2009) 3.02
Molecular genetics and diagnosis of thyroid cancer. Nat Rev Endocrinol (2011) 2.96
Thyroid carcinoma: molecular pathways and therapeutic targets. Mod Pathol (2008) 2.58
Progress in molecular-based management of differentiated thyroid cancer. Lancet (2013) 2.44
Phase II efficacy and pharmacogenomic study of Selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma with or without follicular elements. Clin Cancer Res (2012) 2.02
Prognostic utility of BRAF mutation in papillary thyroid cancer. Mol Cell Endocrinol (2009) 1.96
Sorafenib in metastatic thyroid cancer: a systematic review. Oncologist (2014) 1.43
BRAF V600E mutation and its association with clinicopathological features of papillary thyroid cancer: a meta-analysis. J Clin Endocrinol Metab (2012) 1.39
Molecular pathology of thyroid cancer: diagnostic and clinical implications. Best Pract Res Clin Endocrinol Metab (2008) 1.31
The biology of the sodium iodide symporter and its potential for targeted gene delivery. Curr Cancer Drug Targets (2010) 1.25
Differential Clinicopathological Risk and Prognosis of Major Papillary Thyroid Cancer Variants. J Clin Endocrinol Metab (2015) 1.24
The Na+/I- symporter (NIS): mechanism and medical impact. Endocr Rev (2013) 1.21
The impact of distant metastases at presentation on prognosis in patients with differentiated carcinoma of the thyroid gland. Thyroid (2012) 1.19
Multikinase inhibitors: a new option for the treatment of thyroid cancer. Nat Rev Endocrinol (2011) 1.19
Recent advances in molecular biology of thyroid cancer and their clinical implications. Otolaryngol Clin North Am (2008) 1.19
Targeting BRAF in thyroid cancer. Br J Cancer (2006) 1.08
Potential utility and limitations of thyroid cancer cell lines as models for studying thyroid cancer. Thyroid (2009) 1.07
Induction of thyroid gene expression and radioiodine uptake in thyroid cancer cells by targeting major signaling pathways. J Clin Endocrinol Metab (2009) 1.06
Standard and emerging therapies for metastatic differentiated thyroid cancer. Oncologist (2010) 1.00
BRAF(V600E) mutation analysis in papillary thyroid carcinoma: is it useful for all patients? World J Surg (2014) 1.00
Optimizing therapy for radioactive iodine-refractory differentiated thyroid cancer: current state of the art and future directions. Minerva Endocrinol (2012) 1.00
Sodium iodide symporter and the radioiodine treatment of thyroid carcinoma. Nucl Med Mol Imaging (2010) 0.98
Diagnosis and treatment of patients with thyroid cancer. Am Health Drug Benefits (2015) 0.98
Histone deacetylation of NIS promoter underlies BRAF V600E-promoted NIS silencing in thyroid cancer. Endocr Relat Cancer (2014) 0.96
Prognostic biomarkers in thyroid cancer. Virchows Arch (2014) 0.95
MicroRNA Deregulation in Anaplastic Thyroid Cancer Biology. Int J Endocrinol (2014) 0.93
Thyroid cancer: pathogenesis and targeted therapy. Ther Adv Endocrinol Metab (2011) 0.91
What is New on Thyroid Cancer Biomarkers. Biomark Insights (2008) 0.91
Induction of thyroid gene expression and radioiodine uptake in melanoma cells: novel therapeutic implications. PLoS One (2009) 0.89
Thyroid cancer: current molecular perspectives. J Oncol (2010) 0.87
Associations between BRAF(V600E) and prognostic factors and poor outcomes in papillary thyroid carcinoma: a meta-analysis. World J Surg Oncol (2016) 0.86
Diagnostic and prognostic markers in differentiated thyroid cancer. Curr Genomics (2011) 0.86
Novel approaches in anaplastic thyroid cancer therapy. Oncologist (2014) 0.86
Genetics and epigenetics of sporadic thyroid cancer. Mol Cell Endocrinol (2013) 0.85
The association between BRAF (V600E) mutation and pathological features in PTC. Eur Arch Otorhinolaryngol (2014) 0.84
Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules. Am J Surg (2010) 0.82
Molecular and other novel advances in treatment of metastatic epithelial and medullary thyroid cancers. J Oncol (2010) 0.80
mTOR Inhibition promotes TTF1-dependent redifferentiation and restores iodine uptake in thyroid carcinoma cell lines. J Clin Endocrinol Metab (2014) 0.80
Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAF(V600E)-induced thyroid tumors in a mouse model. Thyroid (2014) 0.80
Hemithyroidectomy increases the risk of disease recurrence in patients with ipsilateral multifocal papillary thyroid carcinoma. Oncol Lett (2013) 0.79
Detection of plasma BRAF(V600E) mutation is associated with lung metastasis in papillary thyroid carcinomas. Yonsei Med J (2015) 0.77
Detection of Circulating BRAF(V600E) in Patients with Papillary Thyroid Carcinoma. J Mol Diagn (2015) 0.77
MEK inhibition leads to lysosome-mediated Na+/I- symporter protein degradation in human breast cancer cells. Endocr Relat Cancer (2013) 0.77
Mutation Profile of Well-Differentiated Thyroid Cancer in Asians. Endocrinol Metab (Seoul) (2015) 0.77
Novel Approaches to Thyroid Cancer Treatment and Response Assessment. Semin Nucl Med (2016) 0.77
Association between BRAF V600E mutation and regional lymph node metastasis in papillary thyroid carcinoma. Int J Clin Exp Pathol (2015) 0.77
Integrated Analysis of Thyroid Cancer Public Datasets Reveals Role of Post-Transcriptional Regulation on Tumor Progression by Targeting of Immune System Mediators. PLoS One (2015) 0.77
miRNA-106a directly targeting RARB associates with the expression of Na(+)/I(-) symporter in thyroid cancer by regulating MAPK signaling pathway. J Exp Clin Cancer Res (2016) 0.77
Relation Between F-18 FDG Uptake of PET/CT and BRAFV600E Mutation in Papillary Thyroid Cancer. Medicine (Baltimore) (2015) 0.76
BRAF(V600E) Mutation is Associated with Decreased Disease-Free Survival in Papillary Thyroid Cancer. World J Surg (2016) 0.76
B-RafV600E inhibits sodium iodide symporter expression via regulation of DNA methyltransferase 1. Exp Mol Med (2014) 0.75
Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer. Oncotarget (2016) 0.75
Identification of Differentially Expressed Kinase and Screening Potential Anticancer Drugs in Papillary Thyroid Carcinoma. Dis Markers (2016) 0.75
Role of prophylactic central compartment lymph node dissection in clinically N0 differentiated thyroid cancer patients: analysis of risk factors and review of modern trends. World J Surg Oncol (2016) 0.75
BRAF Mutations in an Italian Regional Population: Implications for the Therapy of Thyroid Cancer. Int J Endocrinol (2015) 0.75
Interaction of Age at Diagnosis with Transcriptional Profiling in Papillary Thyroid Cancer. World J Surg (2016) 0.75
Ten novel mutations in the NR5A1 gene cause disordered sex development in 46,XY and ovarian insufficiency in 46,XX individuals. J Clin Endocrinol Metab (2012) 1.78
Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigen. J Biol Chem (1989) 1.41
IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer. Oncogene (2009) 1.27
Cystic dysplasia of the testis. Light and electron microscopic study of three cases. Arch Pathol Lab Med (1984) 1.23
Thyroglobulin gene expression is regulated by insulin and insulin-like growth factor I, as well as thyrotropin, in FRTL-5 thyroid cells. J Biol Chem (1987) 1.16
Mapping and functional role of phosphorylation sites in the thyroid transcription factor-1 (TTF-1). J Biol Chem (1996) 1.15
Retinoic acid regulates growth hormone gene expression. Nature (1989) 1.10
Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins. Mol Endocrinol (1989) 1.09
MKP1/CL100 controls tumor growth and sensitivity to cisplatin in non-small-cell lung cancer. Oncogene (2006) 1.08
Thyroid-specific gene expression in the multi-step process of thyroid carcinogenesis. Biochimie (1999) 1.01
Adrenal gland leiomyoma in a child with acquired immunodeficiency syndrome. Pediatr Pathol Lab Med (1996) 1.01
Androgen receptor distribution in adult human testis. J Clin Endocrinol Metab (1999) 0.98
Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems. Eur J Endocrinol (2000) 0.97
Identification of a cis-regulatory element and a thyroid-specific nuclear factor mediating the hormonal regulation of rat thyroid peroxidase promoter activity. Mol Endocrinol (1993) 0.96
Adenomatous hyperplasia of the rete testis. A review and report of new cases. Histol Histopathol (2003) 0.96
Morphological and histometric study of human spermatogonia from birth to the onset of puberty. J Anat (1984) 0.96
IGFBP-3 methylation-derived deficiency mediates the resistance to cisplatin through the activation of the IGFIR/Akt pathway in non-small cell lung cancer. Oncogene (2012) 0.96
Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors. J Clin Endocrinol Metab (2004) 0.94
Monoclonal antibody studies defining the origin and properties of autoantibodies in Graves' disease. Ann N Y Acad Sci (1986) 0.93
Testicular microlithiasis in 2 children with bilateral cryptorchidism. J Urol (1979) 0.92
Postsurgical focal testicular infarct. Urol Int (1986) 0.92
Function of the homeo and paired domain proteins TTF-1 and Pax-8 in thyroid cell proliferation. J Biol Chem (1995) 0.91
Giant chondroid syringoma of the axilla. J Cutan Med Surg (1998) 0.91
The interaction between the forkhead thyroid transcription factor TTF-2 and the constitutive factor CTF/NF-1 is required for efficient hormonal regulation of the thyroperoxidase gene transcription. J Biol Chem (1999) 0.91
Characterization of phosphate residues on thyroglobulin. J Biol Chem (1987) 0.90
Decrease in the number of human Ap and Ad spermatogonia and in the Ap/ Ad ratio with advancing age. New data on the spermatogonial stem cell. J Androl (1987) 0.90
Thoracic duct cyst presenting as an hour-glass shaped mass in the left supraclavicular area: case report. Acta Otorhinolaryngol Belg (2001) 0.90
Morphological and histometric study on the human Sertoli cell from birth to the onset of puberty. J Anat (1982) 0.90
Ontogeny and cellular localization of the pyruvate recycling system in rat brain. J Neurochem (1998) 0.90
Transcriptional control of the forkhead thyroid transcription factor TTF-2 by thyrotropin, insulin, and insulin-like growth factor I. J Biol Chem (1997) 0.89
Histologic classification of undescended testes. Hum Pathol (1980) 0.89
Histological, histochemical and ultrastructural variations along the length of the human vas deferens before and after puberty. Acta Anat (Basel) (1982) 0.88
Occurrence of primary spermatocytes in the infant and child testis. Andrologia (1985) 0.88
Laminin, type IV collagen, and fibronectin in normal and cryptorchid human testes. An immunohistochemical study. Int J Androl (1990) 0.88
Presence of ribonucleoproteins and basic proteins in the nuage and intermitochondrial bars of human spermatogonia. J Anat (1985) 0.88
Insulin-induced early growth response gene (Egr-1) mediates a short term repression of rat malic enzyme gene transcription. J Biol Chem (1999) 0.87
[Absolute teratozoospermia in a family. Irregular microcephalic spermatozoa without acrosome]. Andrologia (1978) 0.87
[Myofibroblastic inflammatory tumor of the lung]. Radiologia (2007) 0.86
Quantification of immunocompetent cells in testicular germ cell tumours. Histopathology (1997) 0.86
Protozoan infections in the male genital tract. J Urol (1996) 0.86
Hyperplasia and the immature appearance of Sertoli cells in primary testicular disorders. Hum Pathol (1982) 0.85
Seminiferous tubule involution in elderly men. Biol Reprod (1987) 0.85
Malignant fibrous histiocytoma in a child's hand. J Hand Surg Am (1986) 0.85
Cystic intra-abdominal testicular torsion in an infant. J Urol (1985) 0.85
Ultrastructure of the aging human testis. J Electron Microsc Tech (1991) 0.85
Iodine suppression of iodide uptake in FRTL-5 thyroid cells. Endocrinology (1986) 0.85
A quantitative morphological study of human Leydig cells from birth to adulthood. Cell Tissue Res (1986) 0.85
The nigrostriatal system in the presymptomatic and symptomatic stages in the MPTP monkey model: a PET, histological and biochemical study. Neurobiol Dis (2012) 0.84
Changes in surface area and number of Leydig cells in relation to the 6 stages of the cycle of the human seminiferous epithelium. Anat Embryol (Berl) (1988) 0.84
Ossifying hemangioma of the temporal bone. Arch Otolaryngol Head Neck Surg (1990) 0.84
Down-regulation of thyroid transcription factor-1 gene expression in fetal lung hypoplasia is restored by glucocorticoids. Endocrinology (2000) 0.84
Evidence, by in vitro enzymatic iodination of thyroglobulin, that the efficiency of coupling is determined by the initial iodide concentration. Endocrinology (1986) 0.83
Hemangiopericytoma of the trachea. J Laryngol Otol (1987) 0.83
Testis, epididymis, and spermatic cord in elderly men. Correlation of angiographic and histologic studies with systemic arteriosclerosis. Arch Pathol Lab Med (1985) 0.83
Involution of human fetal Leydig cells. An immunohistochemical, ultrastructural and quantitative study. J Anat (1990) 0.83
Molecular biology of thyroid cancer initiation. Clin Transl Oncol (2007) 0.83
Epididymal growth and differentiation are altered in human cryptorchidism. J Androl (2001) 0.83
Elastic fibres of the human ductus deferens. J Anat (1983) 0.83
Testicular involution in elderly men: comparison of histologic quantitative studies with hormone patterns. Fertil Steril (1987) 0.83
Brain malformations in the sheep model of myelomeningocele are similar to those found in human disease: preliminary report. Pediatr Surg Int (2008) 0.82
The MDM2 oncoprotein promotes apoptosis in p53-deficient human medullary thyroid carcinoma cells. Endocrinology (2000) 0.82
Morphometric and immunocytochemical study of the fetal, infant, and adult human vas deferens. J Androl (1998) 0.82
Ultrastructural observations on nucleoli and related structures during human spermatogenesis. Anat Embryol (Berl) (1986) 0.82
Apical mitochondria-rich cells in the human epididymis: an ultrastructural, enzymohistochemical, and immunohistochemical study. Anat Rec (1991) 0.82
Lung hypoplasia caused by nitrofen is mediated by down-regulation of thyroid transcription factor TTF-1. Pediatr Surg Int (1999) 0.81
Infertility in adult males with retractile testes. Fertil Steril (1984) 0.81
Are iodine-deficient rats euthyroid? Endocrinology (1982) 0.81
Histology and fertility after microsurgical anastomosis of the rabbit fallopian tube with nylon and polyglactin sutures. Fertil Steril (1983) 0.81
Androgen receptor expression in sertoli cells as a function of seminiferous tubule maturation in the human cryptorchid testis. J Clin Endocrinol Metab (2001) 0.81
The peritubular myoid cells in the testes from men with varicocele: an ultrastructural, immunohistochemical and quantitative study. Histopathology (1992) 0.81
Somatostatin interferes with thyrotropin-induced G1-S transition mediated by cAMP-dependent protein kinase and phosphatidylinositol 3-kinase. Involvement of RhoA and cyclin E x cyclin-dependent kinase 2 complexes. J Biol Chem (2000) 0.81
Testicular biopsy and hormonal study in a male with Noonan's syndrome. Andrologia (1984) 0.81
Congenital human thyroglobulin defect due to low expression of the thyroid-specific transcription factor TTF-1. J Clin Invest (1995) 0.81
Ectopic seminiferous tubules in the tunica albuginea of normal and dysgenetic testes. Appl Pathol (1985) 0.81
New insights in beta-tubulin sequence analysis in non-small cell lung cancer. Lung Cancer (2003) 0.81
Leydig cell types in primary testicular disorders. Hum Pathol (1984) 0.80
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma. Free Radic Res (2007) 0.80
Ultrastructural changes in Sertoli cells in ageing humans. Int J Androl (1985) 0.80
Multi-tailed spermatozoa in a case with asthenospermia and teratospermia. Virchows Arch B Cell Pathol (1977) 0.80
Histogenesis of human extraparenchymal Leydig cells. Acta Anat (Basel) (1979) 0.80
Norepinephrine, tri-iodothyronine and insulin upregulate glyceraldehyde-3-phosphate dehydrogenase mRNA during Brown adipocyte differentiation. Eur J Endocrinol (1999) 0.80
Development of the endoplasmic reticulum during human spermatogenesis. Acta Anat (Basel) (1980) 0.80
Adenomatoid tumour of the epididymis: histochemical and ultrastructural study of 2 cases. Br J Urol (1978) 0.79
Two cases of laryngeal leishmaniasis in patients infected with HIV. Eur J Clin Microbiol Infect Dis (1994) 0.79
Androgen insensitivity syndrome: an immunohistochemical, ultrastructural, and morphometric study. Arch Pathol Lab Med (1999) 0.79
Hexachlorobenzene, a dioxin-type compound, increases malic enzyme gene transcription through a mechanism involving the thyroid hormone response element. Endocrinology (1999) 0.79
Immunohistochemical and quantitative study of interstitial and intratubular Leydig cells in normal men, cryptorchidism, and Klinefelter's syndrome. J Pathol (1991) 0.79
Testicular lymphangiectasis in Noonan's syndrome. J Urol (1984) 0.79
Testicular capillary haemangioma. Br J Urol (1982) 0.79
Changes in the lipid inclusion/Sertoli cell cytoplasm area ratio during the cycle of the human seminiferous epithelium. J Reprod Fertil (1987) 0.79
Granular changes in vascular leiomyosarcoma. Virchows Arch A Pathol Anat Histol (1980) 0.79
Neural variant of fetal rhabdomyoma and naevoid basal cell carcinoma syndrome. Histopathology (1996) 0.79
47,XXY Klinefelter's syndrome with low FSH and LH levels and absence of Leydig cells. Andrologia (1981) 0.78
The apical mitochondria-rich cells of the mammalian epididymis. Andrologia (1995) 0.78
[Aniridia associated with gonadoblastoma in Smith-Lemli-Opitz syndrome (author's transl)]. An Esp Pediatr (1976) 0.78
Circannual somatostatin gene and somatostatin receptor gene expression in the early post-natal rat pineal gland. Neuroendocrinology (1997) 0.78
Septate junctions between digestive vacuoles in human malacoplakia. Tissue Cell (1978) 0.78
Multinucleate spermatids in aging human testes. Arch Androl (1986) 0.78
Testicular toxoplasmosis in two men with the acquired immunodeficiency syndrome (AIDS). Arch Pathol Lab Med (1986) 0.78
Somatostatin is expressed in FRTL-5 thyroid cells and prevents thyrotropin-mediated down-regulation of the cyclin-dependent kinase inhibitor p27kip1. Endocrinology (1999) 0.78