Alkaline sphingomyelinase: an old enzyme with novel implications.

"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev (2008) 3.80

Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Chem Rev (2011) 1.93

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis. Biochim Biophys Acta (2010) 1.56

Ceramide-rich platforms in transmembrane signaling. FEBS Lett (2010) 1.46

Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses. Neuromolecular Med (2010) 1.30

Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology. Cardiovasc Res (2009) 1.12

Cancer treatment strategies targeting sphingolipid metabolism. Adv Exp Med Biol (2010) 1.09

Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease. Front Physiol (2014) 1.01

Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase). Invest Ophthalmol Vis Sci (2011) 1.00

Pretreatment with the probiotic VSL#3 delays transition from inflammation to dysplasia in a rat model of colitis-associated cancer. Am J Physiol Gastrointest Liver Physiol (2011) 0.93

Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice. J Lipid Res (2010) 0.89

Identification of aberrant forms of alkaline sphingomyelinase (NPP7) associated with human liver tumorigenesis. Br J Cancer (2007) 0.89

Lipid alterations in experimental murine colitis: role of ceramide and imipramine for matrix metalloproteinase-1 expression. PLoS One (2009) 0.88

Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis. Transl Oncogenomics (2008) 0.86

Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase. PLoS One (2011) 0.86

Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistance. Int J Mol Sci (2014) 0.84

Generating ceramide from sphingomyelin by alkaline sphingomyelinase in the gut enhances sphingomyelin-induced inhibition of cholesterol uptake in Caco-2 cells. Dig Dis Sci (2010) 0.84

Sterols and sphingolipids: dynamic duo or partners in crime? Prog Lipid Res (2010) 0.83

Re-configuration of sphingolipid metabolism by oncogenic transformation. Biomolecules (2014) 0.83

Metabolism, physiological role, and clinical implications of sphingolipids in gastrointestinal tract. Biomed Res Int (2013) 0.82

Sphingolipids in the DNA damage response. Adv Biol Regul (2014) 0.80

Sphingolipids in colon cancer. Biochim Biophys Acta (2013) 0.80

Role of Sphingolipids and Metabolizing Enzymes in Hematological Malignancies. Mol Cells (2015) 0.80

Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide. PLoS One (2014) 0.79

Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia. Lipids (2015) 0.79

Developmentally regulated sphingolipid degradation in Leishmania major. PLoS One (2012) 0.79

Boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells. Lipids Health Dis (2009) 0.78

Molecular modeling of human alkaline sphingomyelinase. Bioinformation (2011) 0.78

Effect of dietary sphingomyelin on absorption and fractional synthetic rate of cholesterol and serum lipid profile in humans. Lipids Health Dis (2013) 0.77

Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells. Lipids Health Dis (2015) 0.77

Fecal metabolome of the Hadza hunter-gatherers: a host-microbiome integrative view. Sci Rep (2016) 0.76

Harnessing the power of yeast to elucidate the role of sphingolipids in metabolic and signaling processes pertinent to psychiatric disorders. Clin Lipidol (2014) 0.75

Roles for biological membranes in regulating human immunodeficiency virus replication and progress in the development of HIV therapeutics that target lipid metabolism. J Neuroimmune Pharmacol (2011) 0.75

Changes of activity and isoforms of alkaline sphingomyelinase (nucleotide pyrophosphatase phosphodiesterase 7) in bile from patients undergoing endoscopic retrograde cholangiopancreatography. BMC Gastroenterol (2014) 0.75