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Prog Lipid Res
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2005
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3
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J Med Chem
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2007
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Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility.
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J Med Chem
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2004
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5
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Soluble epoxide hydrolase: a novel therapeutic target in stroke.
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J Cereb Blood Flow Metab
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2007
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6
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Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane.
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Nat Chem Biol
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2.40
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7
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Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies.
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Anal Biochem
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2005
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Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells.
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Arterioscler Thromb Vasc Biol
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2007
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2.17
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The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity.
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Proc Natl Acad Sci U S A
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2003
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2.13
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10
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The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase.
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Proc Natl Acad Sci U S A
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2005
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2.10
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11
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Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs).
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Prostaglandins Other Lipid Mediat
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2006
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2.03
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12
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Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice.
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J Biol Chem
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2006
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1.95
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13
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Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase.
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Bioorg Med Chem Lett
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2006
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1.77
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14
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Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways.
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Proc Natl Acad Sci U S A
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2008
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1.69
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15
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Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility.
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J Med Chem
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2005
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1.69
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16
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Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation.
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Br J Pharmacol
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2009
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1.60
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17
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Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis.
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Biochemistry
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2004
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1.59
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18
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Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation.
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Proc Natl Acad Sci U S A
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2002
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1.51
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19
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1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain.
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J Med Chem
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1.46
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20
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Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP.
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Proc Natl Acad Sci U S A
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1.45
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21
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Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model.
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J Cardiovasc Pharmacol
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2008
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1.42
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22
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Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis.
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J Pharmacol Exp Ther
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2010
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1.38
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23
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Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase.
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Cell Biochem Biophys
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2007
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1.38
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24
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1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties.
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J Med Chem
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2007
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1.32
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25
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Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids.
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Protein Sci
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2005
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1.32
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26
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Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects.
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Environ Sci Technol
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2011
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1.31
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27
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Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs.
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Eur J Pharm Sci
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2010
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1.29
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28
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QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds.
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J Med Chem
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2003
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1.28
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29
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Expression and regulation of soluble epoxide hydrolase in adipose tissue.
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Obesity (Silver Spring)
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2009
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1.27
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30
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High-throughput pharmacokinetic method: cassette dosing in mice associated with minuscule serial bleedings and LC/MS/MS analysis.
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Anal Chim Acta
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2006
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1.26
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31
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Vascular localization of soluble epoxide hydrolase in the human kidney.
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Am J Physiol Renal Physiol
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2003
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1.25
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32
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Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats.
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Am J Physiol Renal Physiol
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2007
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1.24
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33
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Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase.
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Bioorg Med Chem
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2006
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1.23
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34
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Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo.
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Mol Cancer Ther
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2009
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1.22
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35
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Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase.
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Biochemistry
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2005
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1.21
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36
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Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes.
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J Biol Chem
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2004
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1.20
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37
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Development of a high-throughput screen for soluble epoxide hydrolase inhibition.
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Anal Biochem
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2006
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1.19
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38
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Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2.
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Arch Biochem Biophys
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1.18
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39
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Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat.
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2005
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1.17
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40
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In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor, 1-cyclohexyl-3-dodecyl-urea.
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Drug Metab Dispos
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2003
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41
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Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors.
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Bioorg Med Chem Lett
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2006
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1.12
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42
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Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats.
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J Hypertens
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2009
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1.11
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43
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Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease.
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PLoS One
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2010
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1.11
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44
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Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes.
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Proc Natl Acad Sci U S A
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2012
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1.11
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45
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Corncob bedding alters the effects of estrogens on aggressive behavior and reduces estrogen receptor-α expression in the brain.
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Endocrinology
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2011
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1.10
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46
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Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats.
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Exp Diabetes Res
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2011
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47
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14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.
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J Med Chem
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48
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Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes.
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Anal Biochem
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2003
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1.08
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49
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The structure-activity relationship of urea derivatives as anti-tuberculosis agents.
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Bioorg Med Chem
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2011
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50
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Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase.
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Cell Biol Toxicol
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2008
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51
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Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models.
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Eur J Pharm Sci
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1.04
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52
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EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides.
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J Lipid Res
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2012
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1.03
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53
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Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels.
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J Pharmacol Exp Ther
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2006
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1.03
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54
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Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor.
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J Bacteriol
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2010
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1.01
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55
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Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase.
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Am J Physiol Endocrinol Metab
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2009
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56
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Anti-inflammatory effects of ω-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension.
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J Cardiovasc Pharmacol
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2013
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0.99
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57
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Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue.
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J Biol Chem
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2013
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58
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Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells.
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J Pharmacol Exp Ther
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Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.
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Bioorg Med Chem Lett
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2008
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Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models.
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Eur J Pharmacol
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Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice.
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Arterioscler Thromb Vasc Biol
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2010
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0.98
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Isolation of a strain of Agrobacterium tumefaciens (Rhizobium radiobacter) utilizing methylene urea (ureaformaldehyde) as nitrogen source.
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Can J Microbiol
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2004
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0.98
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63
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N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase.
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Cardiovasc Res
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2011
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0.98
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64
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Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors.
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Anal Bioanal Chem
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2011
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0.97
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65
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Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability.
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Bioorg Med Chem
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2012
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0.97
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66
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Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation.
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J Pharmacol Exp Ther
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2008
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0.96
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67
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Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis.
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Vet Anaesth Analg
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2013
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Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase.
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J Med Chem
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2011
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Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities.
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Bioorg Med Chem Lett
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2009
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70
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Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors.
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Bioorg Med Chem Lett
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2013
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71
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Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers.
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J Immunol
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Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model.
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Toxicol Appl Pharmacol
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Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats.
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Am J Physiol Endocrinol Metab
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Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties.
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Bioorg Med Chem
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Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide.
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Am J Physiol Heart Circ Physiol
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A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARγ to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction.
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Int J Cardiol
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2012
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Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase.
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Anal Biochem
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The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor.
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Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1.
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Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition.
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J Pharmacol Exp Ther
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Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation.
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Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties.
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Transcriptional regulation of the human soluble epoxide hydrolase gene EPHX2.
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Urea and amide-based inhibitors of the juvenile hormone epoxide hydrolase of the tobacco hornworm (Manduca sexta: Sphingidae).
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Insect Biochem Mol Biol
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The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase.
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Bioorg Med Chem
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Soluble epoxide hydrolase expression in a porcine model of arteriovenous graft stenosis and anti-inflammatory effects of a soluble epoxide hydrolase inhibitor.
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Am J Physiol Cell Physiol
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Inhibition of the soluble epoxide hydrolase by tyrosine nitration.
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Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase.
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Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.
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Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors.
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Differential subcellular distribution and colocalization of the microsomal and soluble epoxide hydrolases in cultured neonatal rat brain cortical astrocytes.
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Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ.
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A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase.
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Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism.
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Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A.
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Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis.
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Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase.
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Bioorg Med Chem Lett
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Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens.
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Insect Biochem Mol Biol
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Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury.
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Microcirculation
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Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase.
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J Med Chem
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Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties.
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J Med Chem
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High salt diet modulates vascular response in A2AAR (+/+) and A 2AAR (-/-) mice: role of sEH, PPARγ, and K ATP channels.
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Tryptophan fluorescence quenching by enzyme inhibitors as a tool for enzyme active site structure investigation: epoxide hydrolase.
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Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line.
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Toxicol Appl Pharmacol
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Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules.
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Toxicol Appl Pharmacol
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Novel and highly sensitive fluorescent assay for leucine aminopeptidases.
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Anal Biochem
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Identification and characterization of an ovary-selective isoform of epoxide hydrolase.
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Monoclonal antibodies reveal multiple forms of expression of human microsomal epoxide hydrolase.
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Toxicol Appl Pharmacol
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Biological evaluation of a novel sorafenib analogue, t-CUPM.
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Cancer Chemother Pharmacol
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Function of phenylalanine 259 and threonine 314 within the substrate binding pocket of the juvenile hormone esterase of Manduca sexta.
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Biochemistry
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Characterization of Hovi-mEH1, a microsomal epoxide hydrolase from the glassy-winged sharpshooter Homalodisca vitripennis.
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Effect of ionic liquids on epoxide hydrolase-catalyzed synthesis of chiral 1,2-diols.
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Aberrant soluble epoxide hydrolase and oxylipin levels in a porcine arteriovenous graft stenosis model.
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Development of On-line Liquid Chromatography-Biochemical Detection for Soluble Epoxide Hydrolase Inhibitors in Mixtures.
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