| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma.
|
Am Rev Respir Dis
|
1993
|
1.73
|
|
2
|
Characterization of a murine model of allergic pulmonary inflammation.
|
Int Arch Allergy Immunol
|
1994
|
1.66
|
|
3
|
Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine.
|
Clin Exp Allergy
|
2001
|
1.63
|
|
4
|
Effects of an antibody to interleukin-5 in a monkey model of asthma.
|
Am J Respir Crit Care Med
|
1995
|
1.40
|
|
5
|
Mast cells modulate allergic pulmonary eosinophilia in mice.
|
Am J Respir Cell Mol Biol
|
1995
|
1.32
|
|
6
|
Antitussive effects of GABAB agonists in the cat and guinea-pig.
|
Br J Pharmacol
|
1993
|
1.22
|
|
7
|
Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes.
|
Arzneimittelforschung
|
1996
|
1.22
|
|
8
|
Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL-5 antibody.
|
Am J Respir Cell Mol Biol
|
1995
|
1.18
|
|
9
|
Effect of anti-mIL-9 antibody on the development of pulmonary inflammation and airway hyperresponsiveness in allergic mice.
|
Am J Respir Cell Mol Biol
|
2001
|
1.16
|
|
10
|
Dependence on insulin of the apparent hydrocortisone activation of hepatic glycogen synthetase.
|
Proc Natl Acad Sci U S A
|
1967
|
1.12
|
|
11
|
Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig.
|
Br J Pharmacol
|
1994
|
1.11
|
|
12
|
Prejunctional GABA-B inhibition of cholinergic, neurally-mediated airway contractions in guinea-pigs.
|
Pulm Pharmacol
|
1991
|
1.10
|
|
13
|
Comparative analysis of the cardiotoxicity proclivities of second generation antihistamines in an experimental model predictive of adverse clinical ECG effects.
|
Arzneimittelforschung
|
1996
|
1.06
|
|
14
|
Role of nitric oxide on eosinophilic lung inflammation in allergic mice.
|
Am J Respir Cell Mol Biol
|
1997
|
1.04
|
|
15
|
Interleukin-5 modulates eosinophil accumulation in allergic guinea pig lung.
|
Am Rev Respir Dis
|
1992
|
1.03
|
|
16
|
Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity.
|
Arzneimittelforschung
|
1999
|
0.97
|
|
17
|
Effects of chronic anti-interleukin-5 monoclonal antibody treatment in a murine model of pulmonary inflammation.
|
Am J Respir Cell Mol Biol
|
1999
|
0.97
|
|
18
|
Inhibition of pulmonary eosinophilia and airway hyperresponsiveness in allergic mice by rolipram: involvement of endogenously released corticosterone and catecholamines.
|
Br J Pharmacol
|
2000
|
0.91
|
|
19
|
Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine.
|
Agents Actions
|
1984
|
0.90
|
|
20
|
Anaphylactic challenge causes eosinophil accumulation in bronchoalveolar lavage fluid of guinea pigs. Modulation by betamethasone, phenidone, indomethacin, WEB 2086, and a novel antiallergy agent, SCH 37224.
|
Am Rev Respir Dis
|
1990
|
0.90
|
|
21
|
The pharmacology of SCH 50911: a novel, orally-active GABA-beta receptor antagonist.
|
J Pharmacol Exp Ther
|
1995
|
0.89
|
|
22
|
Eosinophils retain their granule major basic protein in a murine model of allergic pulmonary inflammation.
|
Am J Respir Cell Mol Biol
|
1998
|
0.89
|
|
23
|
A novel pyrrolidine analog of histamine as a potent, highly selective histamine H3 receptor agonist.
|
J Med Chem
|
1995
|
0.88
|
|
24
|
Resistance of gluconeogenic and glycogenic pathways in obese-hyperglycemic mice.
|
Am J Physiol
|
1975
|
0.86
|
|
25
|
Effect of the PAF antagonists, CV-3988 and L-652,731 on the pulmonary and hematological responses to guinea pig anaphylaxis.
|
Pharmacol Res Commun
|
1988
|
0.86
|
|
26
|
Inhibition of sympathetic hypertensive responses in the guinea-pig by prejunctional histamine H3-receptors.
|
Br J Pharmacol
|
1992
|
0.86
|
|
27
|
A novel class of platelet activating factor antagonists from Phoma sp.
|
J Antibiot (Tokyo)
|
1993
|
0.86
|
|
28
|
Comparison of PDE 4 inhibitors, rolipram and SB 207499 (ariflo), in a rat model of pulmonary neutrophilia.
|
Pulm Pharmacol Ther
|
2001
|
0.86
|
|
29
|
(R)-alpha-methylhistamine augments neural, cholinergic bronchospasm in guinea pigs by histamine H1 receptor activation.
|
Eur J Pharmacol
|
1992
|
0.86
|
|
30
|
Mechanisms of allergic pulmonary eosinophilia in the mouse.
|
J Allergy Clin Immunol
|
1994
|
0.86
|
|
31
|
Glucocorticosteroids inhibit leukotriene production.
|
Ann Allergy Asthma Immunol
|
1997
|
0.86
|
|
32
|
5-HT3 receptors augment neuronal, cholinergic contractions in guinea pig trachea.
|
Eur J Pharmacol
|
1993
|
0.85
|
|
33
|
Histamine H2-receptors in guinea pig peripheral airway smooth muscle.
|
Life Sci
|
1979
|
0.84
|
|
34
|
In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids.
|
Arzneimittelforschung
|
1998
|
0.84
|
|
35
|
NK(2)-receptor mediated contraction in monkey, guinea-pig and human airway smooth muscle.
|
Neuropeptides
|
1999
|
0.83
|
|
36
|
Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines.
|
J Med Chem
|
1991
|
0.83
|
|
37
|
Combined histamine H1 and H3 receptor blockade produces nasal decongestion in an experimental model of nasal congestion.
|
Am J Rhinol
|
1999
|
0.83
|
|
38
|
Inhibition of experimental acute pulmonary inflammation by pirfenidone.
|
Pulm Pharmacol Ther
|
2003
|
0.83
|
|
39
|
Further evidence for prejunctional GABA-B inhibition of cholinergic and peptidergic bronchoconstriction in guinea pigs: studies with new agonists and antagonists.
|
Pharmacology
|
1993
|
0.82
|
|
40
|
Respiratory effects of baclofen and 3-aminopropylphosphinic acid in guinea-pigs.
|
Br J Pharmacol
|
1995
|
0.81
|
|
41
|
Antihistamine activity, central nervous system and cardiovascular profiles of histamine H1 antagonists: comparative studies with loratadine, terfenadine and sedating antihistamines in guinea-pigs.
|
Clin Exp Allergy
|
1995
|
0.81
|
|
42
|
Loratadine produces antihistamine activity without adverse CNS, ECG or cardiovascular effects in guinea pigs. Comparative studies with terfenadine and sedating antihistamines.
|
Int Arch Allergy Immunol
|
1995
|
0.81
|
|
43
|
Sch 50971, an orally active histamine H3 receptor agonist, inhibits central neurogenic vascular inflammation and produces sedation in the guinea pig.
|
J Pharmacol Exp Ther
|
1998
|
0.80
|
|
44
|
The role of neutrophils in LPS-induced changes in pulmonary function in conscious rats.
|
Pulm Pharmacol Ther
|
2004
|
0.79
|
|
45
|
Sulfur-dioxide exposure increases TRPV1-mediated responses in nodose ganglia cells and augments cough in guinea pigs.
|
Pulm Pharmacol Ther
|
2006
|
0.78
|
|
46
|
Antiallergic activity of loratadine, a non-sedating antihistamine.
|
Allergy
|
1987
|
0.78
|
|
47
|
The guinea pig model for assessing cardiotoxic proclivities of second generation antihistamines.
|
Arzneimittelforschung
|
1996
|
0.78
|
|
48
|
Anti-inflammatory activity of inhaled mometasone furoate in allergic mice.
|
Arzneimittelforschung
|
1998
|
0.77
|
|
49
|
Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique.
|
Allergy
|
2005
|
0.77
|
|
50
|
Histamine H3 receptors inhibit sympathetic modulation of airway microvascular leakage in allergic guinea pigs.
|
Eur J Pharmacol
|
1994
|
0.77
|
|
51
|
Selective inhibition of peripheral histamine responses by loratadine and terfenadine.
|
Eur J Pharmacol
|
1990
|
0.77
|
|
52
|
Effect of inhibition of arachidonic acid metabolism on anaphylaxis of guinea pig lung strips.
|
Agents Actions
|
1980
|
0.76
|
|
53
|
Terfenadine, astemizole, and ebastine produce QTc interval prolongation in an experimental model predictive of adverse clinical ECG effects.
|
Ann Allergy Asthma Immunol
|
1996
|
0.75
|
|
54
|
Potentiation of the hypoglycemic effect of insulin by thiorphan, an enkephalinase inhibitor.
|
Eur J Pharmacol
|
1984
|
0.75
|
|
55
|
Trans-4-methyl-3-imidazoyl pyrrolidine as a potent, highly selective histamine H3 receptor agonist in vivo.
|
Bioorg Med Chem Lett
|
1998
|
0.75
|
|
56
|
Antibronchoconstrictor activity of the intracellular calcium antagonist HA 1004 in guinea pigs.
|
Pharmacology
|
1988
|
0.75
|
|
57
|
Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine. 1984.
|
Agents Actions
|
1994
|
0.75
|
|
58
|
Sch 37370: a potent, orally active, dual antagonist of platelet-activating factor and histamine.
|
J Pharmacol Exp Ther
|
1990
|
0.75
|
|
59
|
Effect of SCH 15280, a new bronchodilator, on cyclic 3',5'-nucleotide phosphodiesterase activity and cyclic 3',5'-adenosine monophosphate levels in guinea pig lung.
|
Biochem Pharmacol
|
1977
|
0.75
|
|
60
|
Combined NK(1)and NK(2)receptor antagonists on the bronchoconstrictor response to NKA in dogs.
|
Pulm Pharmacol Ther
|
1999
|
0.75
|
|
61
|
Effect of epinephrine on hepatic glycogen phosphorylase and synthetase activities in normal and pertussis-sensitized rats.
|
Biochem Pharmacol
|
1970
|
0.75
|
|
62
|
Labetalol protects against the potentiation by propranolol of the bronchospasm to norepinephrine in guinea-pigs.
|
Arch Int Pharmacodyn Ther
|
1987
|
0.75
|
|
63
|
Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine.
|
Lipids
|
1991
|
0.75
|
|
64
|
Comparison of the protective effect of orciprenaline with an orciprenaline-oxymetazoline combination on experimental bronchospasm in guinea pigs.
|
Arzneimittelforschung
|
1985
|
0.75
|
|
65
|
Bronchodilator and antiallergy activity of forskolin.
|
Eur J Pharmacol
|
1985
|
0.75
|
|
66
|
Sch 37370: a new drug combining antagonism of platelet-activating factor (PAF) with antagonism of histamine.
|
Agents Actions Suppl
|
1991
|
0.75
|
|
67
|
Studies on the pharmacology of the novel histamine H3 receptor agonist Sch 50971.
|
Arzneimittelforschung
|
1998
|
0.75
|
|
68
|
Sch 37224, an experimental antiallergy compound, inhibits the neuropeptide component of hyperventilation- and nicotine-induced bronchoconstriction in guinea pigs.
|
Pharmacology
|
1997
|
0.75
|
|
69
|
Cardiovascular profile of loratadine.
|
Clin Exp Allergy
|
1999
|
0.75
|
|
70
|
Alteration in second phase platelet aggregation associated with an emotionally stressful activity.
|
Thromb Haemost
|
1977
|
0.75
|
|
71
|
Bronchoconstrictor reactivity to NKA in allergic dogs: a comparison to histamine and methacholine.
|
Pulm Pharmacol Ther
|
2001
|
0.75
|
|
72
|
Pharmacology of non-sedating H1 antihistamines.
|
Agents Actions Suppl
|
1991
|
0.75
|
|
73
|
A method to measure dual NK1/NK2-antagonist activity in dogs.
|
J Pharmacol Toxicol Methods
|
1998
|
0.75
|
|
74
|
Interferon-gamma and antibodies to interleukin-5 and interleukin-4 inhibit the pulmonary eosinophilia in allergic mice.
|
Inflamm Res
|
1995
|
0.75
|
|
75
|
A magnetic resonance imaging evaluation of histamine-mediated allergic response in the guinea pig nasopharynx.
|
J Allergy Clin Immunol
|
1993
|
0.75
|
|
76
|
Antiallergy agents. 1. Substituted 1,8-naphthyridin-2(1H)-ones as inhibitors of SRS-A release.
|
J Med Chem
|
1988
|
0.75
|